EP1201296A1 - Device for introducing a gas into a liquid - Google Patents

Device for introducing a gas into a liquid Download PDF

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Publication number
EP1201296A1
EP1201296A1 EP01811037A EP01811037A EP1201296A1 EP 1201296 A1 EP1201296 A1 EP 1201296A1 EP 01811037 A EP01811037 A EP 01811037A EP 01811037 A EP01811037 A EP 01811037A EP 1201296 A1 EP1201296 A1 EP 1201296A1
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EP
European Patent Office
Prior art keywords
gas
distributor
treatment chamber
treatment room
nozzle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01811037A
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German (de)
French (fr)
Inventor
Roland Hänggi
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Individual
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Individual
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Publication date
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/20—Mixing gases with liquids
    • B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
    • B01F23/233—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/20—Mixing gases with liquids
    • B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
    • B01F23/233—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements
    • B01F23/2331—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements characterised by the introduction of the gas along the axis of the stirrer or along the stirrer elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/20—Mixing gases with liquids
    • B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
    • B01F23/233—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements
    • B01F23/2331—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements characterised by the introduction of the gas along the axis of the stirrer or along the stirrer elements
    • B01F23/23311—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements characterised by the introduction of the gas along the axis of the stirrer or along the stirrer elements through a hollow stirrer axis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/20—Mixing gases with liquids
    • B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
    • B01F23/233—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements
    • B01F23/2331—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements characterised by the introduction of the gas along the axis of the stirrer or along the stirrer elements
    • B01F23/23314—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements characterised by the introduction of the gas along the axis of the stirrer or along the stirrer elements through a hollow stirrer element
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/20—Mixing gases with liquids
    • B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
    • B01F23/233—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements
    • B01F23/2334—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements provided with stationary guiding means surrounding at least partially the stirrer
    • B01F23/23341—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements provided with stationary guiding means surrounding at least partially the stirrer with tubes surrounding the stirrer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/20—Mixing gases with liquids
    • B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
    • B01F23/233—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements
    • B01F23/2336—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements characterised by the location of the place of introduction of the gas relative to the stirrer
    • B01F23/23362—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements characterised by the location of the place of introduction of the gas relative to the stirrer the gas being introduced under the stirrer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/20—Mixing gases with liquids
    • B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
    • B01F23/2366—Parts; Accessories
    • B01F23/2368—Mixing receptacles, e.g. tanks, vessels or reactors, being completely closed, e.g. hermetically closed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/07—Stirrers characterised by their mounting on the shaft
    • B01F27/072—Stirrers characterised by their mounting on the shaft characterised by the disposition of the stirrers with respect to the rotating axis
    • B01F27/0721—Stirrers characterised by their mounting on the shaft characterised by the disposition of the stirrers with respect to the rotating axis parallel with respect to the rotating axis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/11—Stirrers characterised by the configuration of the stirrers
    • B01F27/112—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades
    • B01F27/1121—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades pin-shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/11—Stirrers characterised by the configuration of the stirrers
    • B01F27/113—Propeller-shaped stirrers for producing an axial flow, e.g. shaped like a ship or aircraft propeller
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/11—Stirrers characterised by the configuration of the stirrers
    • B01F27/19—Stirrers with two or more mixing elements mounted in sequence on the same axis
    • B01F27/192—Stirrers with two or more mixing elements mounted in sequence on the same axis with dissimilar elements

Definitions

  • the invention relates to a device for gassing, in particular fine-bubble fumigation, of liquid media, such as reaction solutions, Cell cultures and the like.
  • the device has a treatment room and gas supply to a To lead gas up into the treatment room and one gassing liquid or solution contained in it.
  • the Treatment of the liquid medium can be carried out batchwise, continuously or quasi-continuously, the flow rate of the gas passed through the swirl chamber during the treatment process should be stopped in such a way that the liquid medium to be treated during the intended Swirling time is optimally interspersed with the gas.
  • Known devices for gassing liquid media have a wall surrounding the treatment room a window, one at the lower end of the treatment room Gas distributor with at least two by one vertical Axis rotatable divider arms, and at least one vent valve, that has at least one filter.
  • the gas is through a vertical hollow shaft is introduced into the device and with the divider arms rotatable about this shaft, which with are each provided with at least one gas outlet opening into which liquid to be treated introduced.
  • agitators do not have the Requirements for the homogeneity and formulation stability of the product to be manufactured.
  • This process is below the water surface a ventilation gas, namely pure oxygen or an oxygen-containing one Gas mixture, blown into the waste water and it the wastewater is treated centrally from above the tank introduced agitator set in motion.
  • the latter movement in particular does not serve the effect of Increase gas distributor and the degree of distribution of the gas to increase within the treatment room.
  • the invention is based on the object, disadvantages the known devices for gassing liquid media to fix and propose a device in which due to a high degree of division into a liquid or solution introduced gas the efficiency of the fumigation is improved.
  • the gas bubbles rising in the liquid by means of the splitter arms or the distributor plate in helical Orbits are moved before entering the area of effect of the jet mixer.
  • the latter works Formation of an unfavorable gas concentration gradient within of the treatment room by using the medium and the gas floats down in the vertical direction.
  • the jet mixer has a fast-running one Rotor, for example, vertical in a stator Liquid flow generated, which in turn directly on the bottom of the container is directed.
  • jet mixers are suitable for Example the jet stream mixers from Ystral GmbH, DE-Ballrechte-Dottingen.
  • the gas distributor has several, but at least two, preferably three to four, symmetrically having mutually arranged divider arms, or if the distribution plate at least two, preferably three to eight gas outlet openings arranged symmetrically to each other or has gas nozzles.
  • the splitter arms can be made of steel, plastic or the like Materials exist and are round, tubular or polygonal his. Conveniently, they are tubular and they each have a top in the area of the container wall angled end section, at the free end of which at least a gas outlet opening or gas nozzle is arranged.
  • the drive unit for the drive shaft of the Jet mixer and the drive unit for the distribution plate or the splitter arms as independently manageable units trained so that the latter at the desired Place in the liquid pool arranged and fastened can be.
  • the device according to the invention preferably designed so that they are modular can be composed of several components, whereby the elements, if necessary, additionally with an agitator, a homogenizer, or with an integrated in the wall Heating and / or cooling device can be equipped.
  • the device there are additional sensors in the interior of the container available, which can be arranged at different heights and optionally, the gas entry rate, the internal pressure and the Measure inside temperature so that based on the from the measured values measured by various sensors, the gas entry rate, the speed of rotation of the gas distributor and the Speed of the jet mixer manually and / or automatically according to can be controlled according to a predetermined criterion.
  • the criterion can be fixed for the entire treatment be or in the course of treatment in a particular Way, for example according to a time-dependent program, be changed.
  • the device according to the invention can be used, for example, as Fermenter, i.e. for the cultivation of cell and microbe cultures as well as for the biotechnological production of pharmaceutical Active ingredients are used.
  • the device can but also as a reaction container for the production of polymers and the like can be used, that is, wherever a Reaction gas is required to manufacture a product.
  • the device 1 shown in FIG. 1 has a container 2. This is generally rotationally symmetrical to a vertical central axis 3 and has a wall 4. This has a lower, generally cylindrical Wall part 4a with a bottom, two middle, also cylindrical Wall parts 4b and 4c and a lid 4d. The wall parts 4a, 4b, 4c and the cover 4d are detachable as well as tightly connected and can still possibly composed of further detachably connected parts his.
  • the container 2 contains an approximately arranged at the upper end of the lower wall part 4a, horizontal Gas distribution plate described in more detail below 5. This is part of a whole designated 6 Gas separation device, in addition to which a drive unit 7 with a vertical hollow shaft 8 for turning heard of the gas distribution plate 5.
  • the wall 4 of the container 2 borders an interior 9, hereinafter also called treatment room, gastight against the Surroundings.
  • the wall part 4b also has two sight glasses 10 and 11 through which a person enters the treatment room 9 can look into it, and it has the upper middle Wall part 4c a jacket 12 made of glass.
  • the device 1 also has gas guiding means 13 around Process gas, namely air, from bottom to top in the container 2 and in particular to direct its treatment room 9.
  • the gas guide means 13 have an air inlet 14, for example on that over a not drawn filter, also one not shown conditioning and flow control device and a line 15 integrated in the hollow shaft 8 is connected to the gas distribution plate 5.
  • the gas distribution plate 5 is made of stainless steel, for example Steel and has gas pipe means 5b, which at least a gas outlet opening or gas nozzle 16 with the gas line 15 connect the hollow shaft 8, which in turn in the ground of the wall part 4a is used.
  • the gas distribution plate 5 preferably has at least two, for example four to eight or even more symmetrical mutually arranged gas outlet openings 6. These are for example vertical, open at the bottom and closed at the top as well as releasably attached to the distribution plate 5 Caps 17 made of a gas-permeable or porous, textile, metallic or ceramic material covered.
  • the device 1 also has a jet mixer 18 with a high-speed rotor 19, which is in a stator 20 creates a vertical flow of liquid, which is direct is directed to the bottom of the container.
  • the jet mixer 18 is with a holder on a not shown, detachable on the Ceiling 4d attached flange attached.
  • The is driven Jet mixer 18 through a gear unit placed on the cover 4d 21st
  • the treatment room 9 also contains at least one Good inlet, a good outlet and at least one of the Venting gas outlet, further sensors for Measuring the gas entry rate, the internal pressure and the internal temperature.
  • the device additionally has a not shown Control device on.
  • This has, for example, electrical, electronic and possibly pneumatic and / or hydraulic components, manually operated controls, Switching means for the automatic control of the Fumigation, optical signaling devices, analog and / or digital display devices and registration and / or storage devices.
  • the sensors mentioned are through electrical wires connected to the control device. This is also through electrical lines and possibly through fluid lines, i.e. Compressed air and / or hydraulic fluid lines with the controllable motors and / or other drive and / or Actuators of the gas distributor 6, the jet mixer 18 and the gas guide means 13 connected.
  • fluid lines i.e. Compressed air and / or hydraulic fluid lines with the controllable motors and / or other drive and / or Actuators of the gas distributor 6, the jet mixer 18 and the gas guide means 13 connected.
  • the control device is used in particular to Operation depending on different, optionally adjustable or mutually adjustable parameters, such as Pressure of the gas to be introduced, speed of the gas distribution plate 5, speed of the jet mixer 18 and pore size of the Control gas nozzles 16.
  • the device 101 shown in FIG. 2 is in the designed essentially the same as the device 1, thus has an essentially cylindrical container 102 with a vertical central axis 103.
  • the container 102 of the device 101 has a gas separation device arranged in the lower wall part 104a 106 with two rotatable about the axis 103, Gas splitter arms 105 arranged symmetrically to one another. These are connected to the hollow shaft of the gear unit 107 and are formed by uniformly curved pipe bends 108.
  • the pipe bends 108 are hollow stirring bodies, the Interior of the gas line 115 of the hollow shaft with the gas outlet opening 116 connects.
  • the latter is in the present one Case also with one open at the bottom and one closed at the top and detachably attached to the pipe bend 108 Cap 117 made of a gas-permeable or porous, textile, metallic or ceramic material covered.
  • the device according to the invention can be applied to different Species are modified.
  • a stirrer and / or a honing machine be used in the treatment room additionally a stirrer and / or a honing machine.
  • the wall parts of the container 2 and 102 additionally with a heating and / or cooling device, for example a heating and / or Cooling coil, be provided, like that for dryers, Mixer and the like is known.
  • the container wall and / or the heating and / or cooling device can finally also be provided with thermal insulation if the intended operating modes require this.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)

Abstract

Device for gasifying a liquid medium comprising a treatment chamber, gas deviating devices to deviate air upward into the treatment chamber, a gas distributor rotating about a vertical axis and containing a gas outlet opening and/or gas nozzle and a stream mixer locally arranged in the upper region of the treatment chamber, where the circulating path of the opening and/or nozzle lies directly opposite the mixer, is new. <??>Device for gasifying a liquid medium comprising a treatment chamber, gas deviating devices to deviate air upward into the treatment chamber, a gas distributor rotating about a vertical axis and containing a gas outlet opening and/or gas nozzle and a stream mixer locally arranged in the upper region of the treatment chamber, where the circulating path of the opening and/or nozzle lies directly opposite the mixer and the gas distributor has a distributor with two symmetrically arranged gas outlet openings and/or nozzles and four symmetrically arranged distribution chambers, is new.

Description

Die Erfindung betrifft eine Vorrichtung zum Begasen, insbesondere feinblasigen Begasen, von flüssigen Medien, wie Reaktionslösungen, Zellkulturen und dergleichen. Die Vorrichtung besitzt einen Behandlungsraum und Gasleitmittel, um ein Gas aufwärts in den Behandlungsraum hinein zu leiten und eine in diesem enthaltene Flüssigkeit oder Lösung zu begasen. Die Behandlung des flüssigen Mediums kann chargenweise, kontinuierlich oder quasikontinuierlich erfolgen, wobei die Durchflussrate des durch die Wirbelkammer geleiteten Gases während des Behandlungsprozesses derart eingestellt werden sollte, dass das zu behandelnde flüssige Medium während der vorgesehenen Verwirbelungsdauer optimal mit dem Gas durchsetzt wird.The invention relates to a device for gassing, in particular fine-bubble fumigation, of liquid media, such as reaction solutions, Cell cultures and the like. The device has a treatment room and gas supply to a To lead gas up into the treatment room and one gassing liquid or solution contained in it. The Treatment of the liquid medium can be carried out batchwise, continuously or quasi-continuously, the flow rate of the gas passed through the swirl chamber during the treatment process should be stopped in such a way that the liquid medium to be treated during the intended Swirling time is optimally interspersed with the gas.

Bekannte Vorrichtungen zum Begasen von flüssigen Medien besitzen eine den Behandlungsraum umschliessende Wandung mit einem Fenster, einen am unteren Ende des Behandlungsraums angeordneten Gasverteiler mit mindestens zwei um eine vertikale Achse rotierbaren Zerteilerarmen, und mindestens ein Entlüftungsventil, das allenfalls mindestens einen Filter besitzt.Known devices for gassing liquid media have a wall surrounding the treatment room a window, one at the lower end of the treatment room Gas distributor with at least two by one vertical Axis rotatable divider arms, and at least one vent valve, that has at least one filter.

Bei diesen bekannten Vorrichtungen wird das Gas durch eine vertikale Hohlwelle in die Vorrichtung eingeleitet und mit den um diese Welle rotierbaren Zerteilerarmen, welche mit je mindestens einer Gasaustrittsöffnung versehen sind, in die zu behandelnde Flüssigkeit eingeleitet. Es hat sich nun gezeigt, dass bei den bekannten Vorrichtungen die Wirkung der rotierenden Arme hinsichtlich des gewünschten Zerteilungsgrades sehr oft ungenügend ist. So endet die Wirkung des Gasverteilers knapp oberhalb der Zerteilerarme, was bedeutet, dass das Gas innerhalb des Behandlungsraumes ohne zusätzliche Zwangsbewegung aufsteigt. Ein Begasen mittels sehr feiner Gasblasen innerhalb des ganzen Behandlungsraumes kann mit den bekannten Vorrichtungen nicht erreicht werden. Auch der Einsatz handelsüblicher Rührwerke können das Gas nicht optimal im flüssigen Medium verteilen. So genügen die konventionellen Rührwerke bei vielen erfindungsgemässen Anwendungen nicht den Anforderungen an die Homogenität und Rezepturstabilität des herzustellenden Produktes. Dies trifft unter anderem für das aus der deutschen Offenlegungsschrift 29 04 101 bekannte Verfahren zur Behandlung von Abwässern in Belebtschlammbecken zu. Bei diesem Verfahren wird unterhalb der Wasseroberfläche ein Belüftungsgas, nämlich reiner Sauerstoff oder ein sauerstoffhaltiges Gasgemisch, in das Abwasser eingeblasen und es wird das Abwasser durch Einwirkung eines zentral von oben in das Becken eingeführten Rührwerkes in Bewegung gesetzt. Gerade letztere Bewegung dient nicht dazu, die Wirkung des Gasverteilers zu erhöhen und den Verteilungsgrad des Gases innerhalb des Behandlungsraumes zu erhöhen.In these known devices, the gas is through a vertical hollow shaft is introduced into the device and with the divider arms rotatable about this shaft, which with are each provided with at least one gas outlet opening into which liquid to be treated introduced. It has now been shown that in the known devices, the effect of rotating arms with regard to the desired degree of division very often is insufficient. This is how the effect of the gas distributor ends just above the splitter arms, which means that the gas inside the treatment room without additional Forced movement rises. Fumigation using very fine Gas bubbles within the entire treatment room can with the known devices can not be achieved. The use too Commercial agitators cannot optimally use the gas distribute in the liquid medium. So the conventional ones are sufficient In many applications according to the invention, agitators do not have the Requirements for the homogeneity and formulation stability of the product to be manufactured. This applies, among other things, to the methods known from German Offenlegungsschrift 29 04 101 for the treatment of waste water in activated sludge tanks to. This process is below the water surface a ventilation gas, namely pure oxygen or an oxygen-containing one Gas mixture, blown into the waste water and it the wastewater is treated centrally from above the tank introduced agitator set in motion. The latter movement in particular does not serve the effect of Increase gas distributor and the degree of distribution of the gas to increase within the treatment room.

Der Erfindung liegt nun die Aufgabe zugrunde, Nachteile der bekannten Vorrichtungen zum Begasen von flüssigen Medien zu beheben und eine Vorrichtung vorzuschlagen, bei welcher durch einen hohen Zerteilungsgrad des in eine Flüssigkeit oder Lösung eingebrachten Gases der Wirkungsgrad der Begasung verbessert wird.The invention is based on the object, disadvantages the known devices for gassing liquid media to fix and propose a device in which due to a high degree of division into a liquid or solution introduced gas the efficiency of the fumigation is improved.

Diese Aufgabe wird gemäss der Erfindung durch eine Vorrichtung mit den Merkmalen des Anspruchs 1 gelöst.This object is achieved according to the invention by a device solved with the features of claim 1.

Vorteilhafte Ausgestaltungen der Erfindung gehen aus den abhängigen Ansprüchen hervor.Advantageous embodiments of the invention are shown in the dependent claims.

Die erfindungsgemässe Vorrichtung besitzt

  • einen vertikalachsigen Behandlungsraum, Gasleitmittel, um Gas, beispielsweise Luft, aufwärts in den Behandlungsraum zu leiten und das in diesem enthaltene flüssige Medium zu begasen,
  • einen Gas-Verteiler mit mindestens einem um eine vertikale Achse rotierbaren, wenigstens eine Gasaustrittsöffnung bzw. Gasdüse enthaltenden Zerteilerarm, oder mit einer um die vertikale Achse rotierbaren Verteilteller enthaltend die mindestens eine Gasdüse, und
  • mindestens einen vertikalachsigen Strahlmischer, um das Medium und das Gas von oben nach unten zu bewegen, wobei der Strahlmischer dezentral angeordnet ist und der Umlaufbahn der sich beim Betrieb der Vorrichtung rotierenden, mindestens einen Gasaustrittsöffnung bzw. Gasdüse direkt gegenüber liegt.
The device according to the invention has
  • a vertical-axis treatment room, gas guide means for leading gas, for example air, upwards into the treatment room and for gassing the liquid medium contained therein,
  • a gas distributor with at least one distributor arm rotatable about a vertical axis and containing at least one gas outlet opening or gas nozzle, or with a distributor plate rotatable about the vertical axis containing the at least one gas nozzle, and
  • at least one vertical-axis jet mixer in order to move the medium and the gas from top to bottom, the jet mixer being arranged decentrally and directly opposite the orbit of the at least one gas outlet opening or gas nozzle rotating during operation of the device.

Erfindungsgemäss wird auf baulich einfache Art und Weise erreicht, dass die in der Flüssigkeit aufsteigenden Gasblasen mittels der Zerteilerarme bzw. des Verteiltellers in wendelförmige Umlaufbahnen versetzt werden, bevor sie in den Wirkungsbereich des Strahlmischers gelangen. Letzterer wirkt der Bildung eines ungünstigen Gas-Konzentrationsgradienten innerhalb des Behandlungsraumes entgegen, indem er das Medium und das Gas in Vertikalrichtung nach unten treibt. Der Strahlmischer besitzt hierzu insbesondere einen schnell-laufenden Rotor, der in einem Stator einen beispielsweise vertikalen Flüssigkeitsstrom erzeugt, der seinerseits direkt auf den Behälterboden gerichtet ist. Als Strahlmischer eignen sich zum Beispiel die Leitstrahlmischer der Firma Ystral GmbH, DE-Ballrechten-Dottingen.According to the invention is structurally simple achieved that the gas bubbles rising in the liquid by means of the splitter arms or the distributor plate in helical Orbits are moved before entering the area of effect of the jet mixer. The latter works Formation of an unfavorable gas concentration gradient within of the treatment room by using the medium and the gas floats down in the vertical direction. The jet mixer has a fast-running one Rotor, for example, vertical in a stator Liquid flow generated, which in turn directly on the bottom of the container is directed. As jet mixers are suitable for Example the jet stream mixers from Ystral GmbH, DE-Ballrechte-Dottingen.

Von besonderem Vorteil ist es, wenn der Gasverteiler mehrere, mindestens aber zwei, vorzugsweise drei bis vier, symmetrisch zueinander angeordnete Zerteilerarme aufweist, oder wenn der Verteilteller mindestens zwei, vorzugsweise drei bis acht, symmetrisch zueinander angeordnete Gasaustrittsöffnungen bzw. Gasdüsen aufweist. It is particularly advantageous if the gas distributor has several, but at least two, preferably three to four, symmetrically having mutually arranged divider arms, or if the distribution plate at least two, preferably three to eight gas outlet openings arranged symmetrically to each other or has gas nozzles.

Die Zerteilerarme können aus Stahl, Kunststoff oder ähnlichen Materialien bestehen und rund, rohrförmig oder mehreckig sein. Zweckmässigerweise sind sie rohrförmig und sie besitzen je einen im Bereich der Behälterwandung noch oben abgewinkelten Endabschnitt, an dessen freiem Ende die mindestens eine Gasaustrittsöffnung oder Gasdüse angeordnet ist.The splitter arms can be made of steel, plastic or the like Materials exist and are round, tubular or polygonal his. Conveniently, they are tubular and they each have a top in the area of the container wall angled end section, at the free end of which at least a gas outlet opening or gas nozzle is arranged.

Solche Gas-Zerteilerarme sowie auch die Gas-Zerteilteller der vorgenannten Art sind dem Fachmann bekannt und werden daher nachfolgend nicht weiter im Detail beschrieben.Such gas splitter arms as well as the gas splitter plates of the aforementioned type are known to the person skilled in the art and will be therefore not described in further detail below.

Bei einer besonders wirtschaftlichen Ausgestaltung der Erfindung sind das Antriebsaggregat für die Antriebswelle des Strahlmischers und das Antriebsaggregat für den Verteilteller bzw. die Zerteilerarme als selbständig handhabbare Baueinheiten ausgebildet, so dass jeweils letztere an der gewünschten Stelle in dem Flüssigkeitsbecken angeordnet und befestigt werden können. Des weiteren ist die erfindungsgemässe Vorrichtung vorzugsweise so ausgebildet, dass sie baukastenartig aus mehreren Bauelementen zusammengesetzt werden kann, wobei die Elemente allenfalls noch zusätzlich mit einem Rührwerk, einem Homogenisator, oder mit einer in der Wandung integrierten Heiz- und/oder Kühlvorrichtung ausgestattet sein können.With a particularly economical design of the Invention are the drive unit for the drive shaft of the Jet mixer and the drive unit for the distribution plate or the splitter arms as independently manageable units trained so that the latter at the desired Place in the liquid pool arranged and fastened can be. Furthermore, the device according to the invention preferably designed so that they are modular can be composed of several components, whereby the elements, if necessary, additionally with an agitator, a homogenizer, or with an integrated in the wall Heating and / or cooling device can be equipped.

Bei einer besonders vorteilhaften Ausbildung der Vorrichtung sind im Innenraum des Behälters noch zusätzlich Sensoren vorhanden, die in verschiedenen Höhen angeordnet sein können und wahlweise, die Gaseintrittsrate, den Innendruck und die Innentemperatur messen, so dass basierend auf den von den verschiedenen Sensoren gemessenen Messwerten die Gaseintrittsrate, die Drehgeschwindigkeit des Gasverteilers und die Drehzahl des Strahlmischers manuell und/oder automatisch gemäss einem vorgegebenen Kriterium gesteuert werden können. Das Kriterium kann dabei für die ganze Behandlung fest vorgegeben sein oder im Verlauf der Behandlung in einer bestimmten Weise, beispielsweise gemäss einem zeitabhängigen Programm, geändert werden.In a particularly advantageous embodiment of the device there are additional sensors in the interior of the container available, which can be arranged at different heights and optionally, the gas entry rate, the internal pressure and the Measure inside temperature so that based on the from the measured values measured by various sensors, the gas entry rate, the speed of rotation of the gas distributor and the Speed of the jet mixer manually and / or automatically according to can be controlled according to a predetermined criterion. The criterion can be fixed for the entire treatment be or in the course of treatment in a particular Way, for example according to a time-dependent program, be changed.

Die erfindungsgemässe Vorrichtung kann beispielsweise als Fermenter, also zur Kultivierung von Zell- und Mikrobenkulturen sowie zur biotechnologischen Herstellung von pharmazeutischen Wirkstoffen eingesetzt werden. Die Vorrichtung kann aber auch als Reaktionsbehälter zur Herstellung von Polymeren und dergleichen verwendet werden, also über all dort, wo ein Reaktionsgas zur Herstellung eines Produktes benötigt wird.The device according to the invention can be used, for example, as Fermenter, i.e. for the cultivation of cell and microbe cultures as well as for the biotechnological production of pharmaceutical Active ingredients are used. The device can but also as a reaction container for the production of polymers and the like can be used, that is, wherever a Reaction gas is required to manufacture a product.

Der Erfindungsgegenstand wird nachfolgend anhand zweier in der Zeichnung dargestellten Ausführungsbeispiele näher erläutert. In der Zeichnung zeigt

  • die Figur 1 eine schematische Darstellung einer ersten erfindungsgemässen Vorrichtung zum Begasen eines flüssigen Mediums und
  • die Figur 2 einen Ausschnitt aus dem unteren Behälterbereich einer zweiten erfindungsgemässen Vorrichtung.
    • The subject matter of the invention is explained in more detail below with reference to two exemplary embodiments shown in the drawing. In the drawing shows
  • 1 shows a schematic representation of a first device according to the invention for gassing a liquid medium and
  • 2 shows a section of the lower container area of a second device according to the invention.

    • Die in der Figur 1 dargestellte Vorrichtung 1 besitzt einen Behälter 2. Dieser ist im allgemeinen rotationssymmetrisch zu einer vertikalen Mittelachse 3 und hat eine Wandung 4. Diese weist einen unteren, im allgemeinen zylindrischen Wandungsteil 4a mit einem Boden, zwei mittlere, ebenfalls zylindrische Wandungsteile 4b und 4c und einen Deckel 4d auf. Die Wandungsteile 4a, 4b, 4c und der Deckel 4d sind lösbar sowie dicht miteinander verbunden und können eventuell noch aus weiteren lösbar miteinander verbundenen Teilen zusammengesetzt sein. Der Behälter 2 enthält einen ungefähr beim oberen Ende des unteren Wandungsteils 4a angeordneten, horizontalen, nachfolgend noch näher beschriebenen Gas-Verteilteller 5. Dieser ist Teil einer als ganzes mit 6 bezeichneten Gaszerteilungseinrichtung, zu welcher noch zusätzlich ein Antriebsaggregat 7 mit einer vertikalen Hohlwelle 8 zum Drehen des Gas-Verteiltellers 5 gehört.The device 1 shown in FIG. 1 has a container 2. This is generally rotationally symmetrical to a vertical central axis 3 and has a wall 4. This has a lower, generally cylindrical Wall part 4a with a bottom, two middle, also cylindrical Wall parts 4b and 4c and a lid 4d. The wall parts 4a, 4b, 4c and the cover 4d are detachable as well as tightly connected and can still possibly composed of further detachably connected parts his. The container 2 contains an approximately arranged at the upper end of the lower wall part 4a, horizontal Gas distribution plate described in more detail below 5. This is part of a whole designated 6 Gas separation device, in addition to which a drive unit 7 with a vertical hollow shaft 8 for turning heard of the gas distribution plate 5.

    Die Wandung 4 des Behälters 2 grenzt einen Innenraum 9, nachfolgend auch Behandlungsraum genannt, gasdicht gegen die Umgebung ab. Der Wandungsteil 4b weist ferner zwei Schaugläser 10 und 11 auf, durch die eine Person in den Behandlungsraum 9 hineinsehen kann, und es besitzt der obere mittlere Wandungsteil 4c einen Mantel 12 aus Glas.The wall 4 of the container 2 borders an interior 9, hereinafter also called treatment room, gastight against the Surroundings. The wall part 4b also has two sight glasses 10 and 11 through which a person enters the treatment room 9 can look into it, and it has the upper middle Wall part 4c a jacket 12 made of glass.

    Die Vorrichtung 1 besitzt ferner Gasleitmittel 13 um ein Prozess-Gas, nämlich Luft, von unten nach oben in den Behälter 2 und insbesondere dessen Behandlungsraum 9 zu leiten. Die Gasleitmittel 13 weisen zum Beispiel einen Lufteinlass 14 auf, der über einen nicht gezeichneten Filter, eine ebenfalls nicht gezeichnete Konditionierungs- und Durchfluss-Steuervorrichtung und eine in der Hohlwelle 8 integrierte Leitung 15 mit dem Gas-Verteilteller 5 verbunden ist.The device 1 also has gas guiding means 13 around Process gas, namely air, from bottom to top in the container 2 and in particular to direct its treatment room 9. The gas guide means 13 have an air inlet 14, for example on that over a not drawn filter, also one not shown conditioning and flow control device and a line 15 integrated in the hollow shaft 8 is connected to the gas distribution plate 5.

    Der Gas-Verteilteller 5 besteht beispielsweise aus rostfreiem Stahl und besitzt Gasleitungsmittel 5b, welche mindestens eine Gasaustrittsöffnung bzw. Gasdüse 16 mit der Gasleitung 15 der Hohlwelle 8 verbinden, die ihrerseits im Boden des Wandungsteils 4a eingesetzt ist.The gas distribution plate 5 is made of stainless steel, for example Steel and has gas pipe means 5b, which at least a gas outlet opening or gas nozzle 16 with the gas line 15 connect the hollow shaft 8, which in turn in the ground of the wall part 4a is used.

    Der Gas-Verteilteller 5 besitzt vorzugsweise mindestens zwei, beispielsweise vier bis acht oder noch mehr symmetrisch zueinander angeordnete Gasaustrittsöffnungen 6. Diese sind beispielsweise durch vertikale, unten offene und oben geschlossene sowie lösbar auf dem Verteilteller 5 befestigte Kappen 17 aus einem gasdurchlässigen bzw. porösen, textilen, metallischen oder keramischen Material abgedeckt. The gas distribution plate 5 preferably has at least two, for example four to eight or even more symmetrical mutually arranged gas outlet openings 6. These are for example vertical, open at the bottom and closed at the top as well as releasably attached to the distribution plate 5 Caps 17 made of a gas-permeable or porous, textile, metallic or ceramic material covered.

    Die Vorrichtung 1 besitzt ferner einen Strahlmischer 18 mit einem schnell-laufenden Rotor 19, der in einem Stator 20 einen vertikalen Flüssigkeitsstrom erzeugt, welcher direkt auf den Behälterboden gerichtet ist. Der Strahlmischer 18 ist mit einem Halter an einem nicht gezeichneten, lösbar an der Decke 4d befestigten Flansch befestigt. Angetrieben wird der Strahlmischer 18 durch eine auf dem Deckel 4d aufgesetzte Getriebeeinheit 21.The device 1 also has a jet mixer 18 with a high-speed rotor 19, which is in a stator 20 creates a vertical flow of liquid, which is direct is directed to the bottom of the container. The jet mixer 18 is with a holder on a not shown, detachable on the Ceiling 4d attached flange attached. The is driven Jet mixer 18 through a gear unit placed on the cover 4d 21st

    Der Behandlungsraum 9 enthält ferner mindestens einen Gut-Einlass, einen Gut-Auslass sowie mindestens einen der Entlüftungen dienenden Gas-Auslass, ferner Sensoren zum Messen der Gaseintrittsrate, des Innendrucks und der Innentemperatur.The treatment room 9 also contains at least one Good inlet, a good outlet and at least one of the Venting gas outlet, further sensors for Measuring the gas entry rate, the internal pressure and the internal temperature.

    Die Vorrichtung weist noch zusätzlich eine nicht gezeichnete Steuereinrichtung auf. Diese besitzt zum Beispiel elektrische, elektronische sowie eventuell pneumatische und/oder hydraulische Bauteile, manuell betätigbare Bedienungselemente, Schaltungsmittel für die automatische Steuerung der Begasung, optische Signalgeber, analog und/oder digitale Anzeigegeräte sowie Registrier- und/oder Speichergeräte.The device additionally has a not shown Control device on. This has, for example, electrical, electronic and possibly pneumatic and / or hydraulic components, manually operated controls, Switching means for the automatic control of the Fumigation, optical signaling devices, analog and / or digital display devices and registration and / or storage devices.

    Die genannten Sensoren sind durch elektrische Leitungen mit der Steuervorrichtung verbunden. Diese ist ferner durch elektrische Leitungen sowie eventuell durch Fluidleitungen, d.h. Druckluft- und/oder Hydraulikflüssigkeitsleitungen mit den steuerbaren Motoren und/oder sonstigen Antriebs- und/oder Stellvorrichtungen des Gasverteilers 6, des Strahlmischers 18 und der Gasleitmittel 13 verbunden.The sensors mentioned are through electrical wires connected to the control device. This is also through electrical lines and possibly through fluid lines, i.e. Compressed air and / or hydraulic fluid lines with the controllable motors and / or other drive and / or Actuators of the gas distributor 6, the jet mixer 18 and the gas guide means 13 connected.

    Die Steuereinrichtung dient dabei insbesondere dazu, den Betrieb in Abhängigkeit von verschiedenen, wahlweise einstellbaren bzw. aufeinander abgleichbaren Parametern, wie Druck des einzuleitenden Gases, Drehzahl des Gasverteiltellers 5, Drehzahl des Strahlmischers 18 und Porenweite des Gasdüsen 16, zu steuern.The control device is used in particular to Operation depending on different, optionally adjustable or mutually adjustable parameters, such as Pressure of the gas to be introduced, speed of the gas distribution plate 5, speed of the jet mixer 18 and pore size of the Control gas nozzles 16.

    Die in der Figur 2 dargestellte Vorrichtung 101 ist im wesentlichen gleichartig ausgebildet wie die Vorrichtung 1, besitzt also einen im wesentlichen zylindrischen Behälter 102 mit einer vertikalen Mittelachse 103. Im Gegensatz zur Vorrichtung 1 besitzt der Behälter 102 der Vorrichtung 101 jedoch eine im unteren Wandungsteil 104a angeordnete Gaszerteilungseinrichtung 106 mit zwei um die Achse 103 drehbaren, symmetrisch zueinander angeordneten Gas-Zerteilerarmen 105. Diese sind mit der Hohlwelle der Getriebeeinheit 107 verbunden und werden durch gleichmässig gekrümmte Rohrbögen 108 gebildet.The device 101 shown in FIG. 2 is in the designed essentially the same as the device 1, thus has an essentially cylindrical container 102 with a vertical central axis 103. In contrast to the device 1, however, the container 102 of the device 101 has a gas separation device arranged in the lower wall part 104a 106 with two rotatable about the axis 103, Gas splitter arms 105 arranged symmetrically to one another. These are connected to the hollow shaft of the gear unit 107 and are formed by uniformly curved pipe bends 108.

    Die Rohrbögen 108 sind hohl ausgebildete Rührkörper, deren Innenraum die Gasleitung 115 der Hohlwelle mit der Gasaustrittsöffnung 116 verbindet. Letztere ist im hier vorliegenden Fall ebenfalls mit einer unten offene und oben geschlossene sowie lösbar auf dem Rohrbogen 108 aufgesteckten Kappe 117 aus einem gasdurchlässigen bzw. porösen, textilen, metallischen oder keramischen Material abgedeckt.The pipe bends 108 are hollow stirring bodies, the Interior of the gas line 115 of the hollow shaft with the gas outlet opening 116 connects. The latter is in the present one Case also with one open at the bottom and one closed at the top and detachably attached to the pipe bend 108 Cap 117 made of a gas-permeable or porous, textile, metallic or ceramic material covered.

    Die erfindungsgemässe Vorrichtung kann auf verschiedene Arten modifiziert werden. Beispielsweise kann im Behandlungsraum noch zusätzlich ein Rührer und/oder ein Honmogenisator eingesetzt sein. Ferner können die Wandungsteile der Behälter 2 und 102 noch zusätzlich mit einer nicht gezeichneten Heiz- und/oder Kühlvorrichtung, beispielsweise einer Heiz- und/oder Kühlschlange, versehen sein, und zwar so, wie das für Trockner, Mischer und dergleichen bekannt ist. Die Behälterwandung und/oder die Heiz- und/oder Kühlvorrichtung können schliesslich auch mit einer Wärmeisolation versehen sein, falls die vorgesehenen Betriebsarten dies erfordern.The device according to the invention can be applied to different Species are modified. For example, in the treatment room additionally a stirrer and / or a honing machine be used. Furthermore, the wall parts of the container 2 and 102 additionally with a heating and / or cooling device, for example a heating and / or Cooling coil, be provided, like that for dryers, Mixer and the like is known. The container wall and / or the heating and / or cooling device can finally also be provided with thermal insulation if the intended operating modes require this.

    Claims (7)

    Vorrichtung zum Begasen eines flüssigen Mediums, mit einem Behandlungsraum (9), Gasleitmitteln (13), um das Gas, beispielsweise Luft, aufwärts in den Behandlungsraum (9b) einzuleiten, und einem um eine vertikale Achse rotierbaren, wenigstens eine Gasaustrittsöffnung bzw. Gasdüse (16, 116) enthaltenden Gas-Verteiler (6, 106), der mit den Gasleitmitteln (13) fluidmässig verbunden und im unteren Bereich des vorzugsweise rotationssymmetrischen Behandlungsraumes (9) angeordnet ist, einen im oberen Bereich des Behandlungsraumes (9) angeordneten, vertikalachsigen Strahlmischer (18), um das Medium und das Gas von oben nach unten zu bewegen, dadurch gekennzeichnet, dass der Strahlmischer (18) dezentral angeordnet ist und der Umlaufbahn der mindestens einen Gasaustrittsöffnung bzw. Gasdüse (16, 116) direkt gegenüber liegt.Device for gassing a liquid medium, with a treatment chamber (9), gas guide means (13) for introducing the gas, for example air, upwards into the treatment chamber (9b), and an at least one gas outlet opening or gas nozzle (rotatable about a vertical axis) 16, 116) containing gas distributor (6, 106), which is fluidly connected to the gas guide means (13) and is arranged in the lower area of the preferably rotationally symmetrical treatment room (9), a vertical-axis jet mixer arranged in the upper area of the treatment room (9) (18) in order to move the medium and the gas from top to bottom, characterized in that the jet mixer (18) is arranged decentrally and is directly opposite the orbit of the at least one gas outlet opening or gas nozzle (16, 116). Vorrichtung nach Anspruch 1, dadurch gekennzeichnet dass der Gas-Verteiler (6) einen Verteilteller (5) mit mindestens zwei, vorzugsweise drei bis acht, symmetrisch zueinander angeordnete Gasaustrittsöffnungen bzw. Gasdüsen (16) aufweist.Device according to claim 1, characterized in that the gas distributor (6) has a distributor plate (5) with at least two, preferably three to eight, gas outlet openings or gas nozzles (16) arranged symmetrically to one another. Vorrichtung nach Anspruch 1, dadurch gekennzeichnet dass der Gas-Verteiler (106) mehrere, vorzugsweise drei bis vier, symmetrisch zueinander angeordnete Zerteilerarme (108) aufweist.Device according to claim 1, characterized in that the gas distributor (106) has several, preferably three to four, symmetrically arranged divider arms (108). Vorrichtung nach einem der Ansprüche 1 bis 3, dadurch gekennzeichnet, dass sie baukastenartig aus mehreren Bauelementen zusammengesetzt ist.Device according to one of claims 1 to 3, characterized in that it is composed of several components in a modular manner. Vorrichtung nach einem der Ansprüche 1 bis 4, dadurch gekennzeichnet, dass im Behandlungsraum noch zusätzlich Sensoren vorhanden sind, die die Gaseintrittsrate, den Innendruck und die Innentemperatur messen, so dass basierend auf den von den verschiedenen Sensoren gemessenen Messwerten die Gaseintrittsrate, die Drehgeschwindigkeit des Gasverteilers und die Drehzahl des Strahlmischers manuell und/oder automatisch gemäss einem vorgegebenen Kriterium gesteuert werden können.Device according to one of claims 1 to 4, characterized in that sensors are additionally present in the treatment room, which measure the gas entry rate, the internal pressure and the internal temperature, so that, based on the measured values measured by the various sensors, the gas entry rate, the rotational speed of the gas distributor and the speed of the jet mixer can be controlled manually and / or automatically according to a predetermined criterion. Vorrichtung nach einem der Ansprüche 1 bis 5, zur Kultivierung von Zell- und Mikrobenkulturen sowie zur biotechnologischen Herstellung von pharmazeutischen Wirkstoffen.Device according to one of claims 1 to 5, for cultivation of cell and microbe cultures as well as for biotechnological Manufacture of active pharmaceutical ingredients. Vorrichtung nach einem der Ansprüche 1 bis 5, als Reaktionsbehälter zur Herstellung von Polymeren und dergleichen.Device according to one of claims 1 to 5, as a reaction container for the production of polymers and the like.
    EP01811037A 2000-10-23 2001-10-23 Device for introducing a gas into a liquid Withdrawn EP1201296A1 (en)

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