EP1150737A1 - Disposable device for transferring an active liquid into a body cavity - Google Patents

Disposable device for transferring an active liquid into a body cavity

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Publication number
EP1150737A1
EP1150737A1 EP00901703A EP00901703A EP1150737A1 EP 1150737 A1 EP1150737 A1 EP 1150737A1 EP 00901703 A EP00901703 A EP 00901703A EP 00901703 A EP00901703 A EP 00901703A EP 1150737 A1 EP1150737 A1 EP 1150737A1
Authority
EP
European Patent Office
Prior art keywords
central element
liquid
cavity
intracorporeal cavity
peripheral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00901703A
Other languages
German (de)
French (fr)
Inventor
Bernard Chaffringeon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP1150737A1 publication Critical patent/EP1150737A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/20—Tampons, e.g. catamenial tampons; Accessories therefor
    • A61F13/2022—Tampons, e.g. catamenial tampons; Accessories therefor characterised by the shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/20—Tampons, e.g. catamenial tampons; Accessories therefor
    • A61F13/2051—Tampons, e.g. catamenial tampons; Accessories therefor characterised by the material or the structure of the inner absorbing core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/20—Tampons, e.g. catamenial tampons; Accessories therefor
    • A61F13/2074—Tampons, e.g. catamenial tampons; Accessories therefor impregnated with hydrophobic, hydrophilic, skin enhancers, medicinal etc. substances
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S604/00—Surgery
    • Y10S604/904—Tampons

Definitions

  • the present invention relates to the transfer or circulation of an active liquid in or inside an intracorporeal cavity of the human body or of an animal, in particular in contact with the mucosa of said cavity.
  • intracorporeal cavity any body cavity, in particular an elongated one, which can be accessed externally for various purposes, in particular clinical, therapeutic, prophylactic, or diagnostic, but also for cosmetic or personal hygiene purposes.
  • intracorporeal cavity mention may be made of the woman's vagina which extends from the vulva to the cervix, into which one wishes to transfer or circulate an active liquid, in contact with the mucous membrane or tissues of said cavity.
  • active liquid any treatment liquid or fluid, both topically local and systemic, generally comprising a liquid or fluid phase in which an agent is distributed, in solution or suspension. treatment.
  • the latter is chosen from the group consisting of wetting agents, solubilizing and fluidifying agents, in particular of a liquid or bodily fluid present in the intracorporeal cavity, therapeutic, prophylactic and diagnostic agents, cosmetic or hygiene agents body, antiseptic agents, bactericides, fungicides, and spermicides (in the case of the woman's vaginal cavity for example).
  • the present invention relates to a disposable device, allowing increased availability of the active ingredient (s) in contact with the mucosa of the wall of the intracorporeal cavity, when in particular the treatment agent is a therapeutic agent.
  • the invention also relates to a device ensuring an almost total absence of external flow, of the active liquid and / or of the bodily fluid, or of any liquid present in the intracorporeal cavity considered, during the whole time when said device is present or maintained in this cavity, by simple constriction of the latter.
  • the single-use device has a sufficient intrinsic consistency, to allow its introduction by thrust into the intracorporeal cavity, and comprises:
  • a central element at the source of at least part of the active liquid, in that it comprises a relatively solid substrate, at ambient temperature and outside the intracorporeal cavity, and becoming relatively liquid or fluid, inside this same cavity and at body temperature, so that, within the latter, the central element at least partially liquefies, to generate at least part of the liquid phase of the active liquid,
  • peripheral element disposed around the central element, in the solid state, comprising a buffer arranged to collect and absorb the active liquid having circulated in the intracorporeal cavity, expanding and thereby coming in sealed support against the mucosa of said intracorporeal cavity.
  • FIG. 1 shows a disposable device according to the invention, in position in an intracorporeal cavity, and just after its introduction by pushing in the latter, and this according to a first embodiment of the invention
  • Figure 1 is an axial section of a device according to the invention, the latter having a symmetry of revolution about an axis
  • - Figures 2 to 4 show respectively three other embodiments of the present invention, still in axial section.
  • a disposable device In accordance with FIG. 1, a disposable device according to the invention is referenced by the reference numeral 1. In general, it makes it possible to dispense or release an active liquid, as defined above, in an intracorporeal cavity designated by the reference numeral 2.
  • This device has an intrinsic and overall consistency, relatively solid but soft, and sufficiently stiff or resistant to allow its introduction by pushing into the cavity, and this without altering the structure of said device, in particular dissociating its various components and / or breaking any capsule containing a liquid, which can be included inside said device (cf. embodiment according to figure 4).
  • the device according to the invention essentially comprises two components assembled to each other definitively, namely: - a central element 3, at the source of at least part of the liquid, active as defined above; - And a peripheral element 4, arranged around the central element 3, comprising a pad 5 arranged to absorb the active liquid having circulated or dispensed in the intracorporeal cavity, by expanding and thereby coming into relatively tight support against the mucosa of the intracorporeal cavity (cf. conformation in dotted lines according to Figure 1).
  • the central element 3 comprises a substrate, for example based on gelatin, relatively solid at room temperature and outside the intracorporeal cavity and at body temperature, and becoming relatively liquid, inside the intracorporeal cavity and at body temperature, so that, within the latter, the central element at least partially liquefies, to generate at least part of the liquid phase of the active liquid.
  • Gelatin can be replaced by any other substrate having the same properties, for example a lipid. Consequently, according to an essential characteristic of the present invention, it is therefore the substrate of the central element which makes it possible to obtain by liquefaction within the intracorporeal cavity, and therefore of the human or animal body, all or part of the liquid phase of the active liquid.
  • an agent for treating the intracorporeal cavity is distributed in discrete form in the solid substrate of the central element, and this regardless of the physical form or the nature of said treatment agent outside the substrate.
  • an agent for treating the intracorporeal cavity is distributed in discrete form in the solid substrate of the central element, and this regardless of the physical form or the nature of said treatment agent outside the substrate.
  • an oily, solid, or liquid physical form, or its hydrophobic or hydrophilic nature can be made by incorporating it into the previously defined substrate, in the liquid state, during the manufacture of a disposable device according to the invention.
  • the central element 3 is in a way a molded part, by solidification of the liquid substrate, for example gelatin.
  • the pad 5 is a sleeve also molded or shaped, from a material capable of absorbing a liquid or fluid while expanding. This material is for example a foam of a biocompatible plastic material, or else a fibrous material (cellulosic for example), worked (for example folded) around the central element 3.
  • the central element 3 and the peripheral element 4 are thus adjusted relative to each other, to fit into one another, by simple axial thrust from the central element towards the peripheral element, or vice versa.
  • the peripheral element 4 has a hole 4a, or bore, in particular a blind hole as shown in FIG. 1, the shape and dimensions of which are adapted for the corresponding reception of the body 3a of the central element 3.
  • the head 3b of the central element 3, of convex external shape, for example spherical, comprises a collar 6, while the peripheral element 4 comprises a neck 7 whose shape and dimensions are adapted to definitively retain the collar 6, by axial thrust of the elements central 3 and peripheral 4, one towards the other.
  • the neck 7 includes a draft receiving the collar 6 directed inwardly, and also externally convex, for example spherical.
  • the foot 3c of the central element 3 has a bulged shape, while the peripheral element 4 has a flared part 4d in correspondence, the shape and dimensions of which are adapted for retaining the foot 3c of the central element 3.
  • the absorbent material of the pad 5 is expandable and / or spongy, and consists for example of filaments, hair fibers, or natural fibers (cellulose or viscose, for example), etc. As indicated above, it is the liquefaction or melting of the substrate of the central element 3, which at least partially generates the liquid phase of the active liquid within the intracorporeal cavity 2, then allows the expansion of the buffer 5, by collecting said liquid in the latter, and this at body temperature and in the intracorporeal cavity 2.
  • the buffer 5 is hollowed out for example by four radial channels 1 1 in cross, arranged below of the hole 4a, opening onto the outer face of the pad 5, and possibly communicating with the bottom of the hole 4a.
  • the collar 6 extends towards the base 3c of the central element 3 by a skirt 6a covering the part 4b of the peripheral element 4 opposite the neck 7.
  • a link 1 2 attached to the peripheral element 4 makes it possible to extract the device 1 for single use from the intracorporeal cavity 2, after treatment of the latter, that is to say after liquefaction of the substrate of the central element 3.
  • an envelope 1 0 of temporary protection closed, envelops the central 3 and peripheral 4 elements assembled together as described above.
  • This envelope is constituted for example by a substrate having the properties described above, for example based on gelatin.
  • the envelope is constituted by a relatively solid material, at room temperature and outside the intracorporeal cavity, so that within the latter and at body temperature, this material melts and thus constitutes another part of the liquid phase of the active liquid previously defined.
  • this envelope 1 0 may consist of a solid and hard excipient, for example sucrose, as used in galenic form to obtain sugared almonds, and capable of dissolving or disintegrating on contact with any body liquid present in the cavity 2.
  • the central element 3 is a capsule, the wall 8 of which is constituted by the previously defined substrate, and the interior of which comprises another liquid 1 5, active or not, the wall 8 being closed and sealed, at room temperature and outside the body.
  • the liquid thus contained in the capsule makes it possible to increase the quantity of liquid phase of the active liquid.
  • This liquid 1 5 can have any suitable form, oily for example, and contain all or part of a treatment agent as defined above, in solution or suspension in said liquid.
  • the casing 1 0 shown in Figure 4 can be omitted, while the wall 8 forms a breakable appendage at its end opposite to the pad 5, which allows the user to open the capsule just before the introduction of the device into the intracorporeal cavity, and to benefit from a small amount of the liquid 1 5 for moisten the exterior of said device at the time of its introduction into said cavity.
  • a device according to the invention before its introduction into the intracorporeal cavity 2, comprises a proximal part 1 a, through which the introduction into the intracorporeal cavity 2 takes place, and a distal part 1 b , the largest transverse diameter of which is smaller than the largest transverse diameter of the distal part 1 a. This allows the device to be temporarily held in the cavity, before the active liquid takes over by swelling the buffer 5.
  • the absorption of the treatment agent (s) by the mucosa of the intracorporeal cavity is more complete and rapid; the incorporation of this treatment agent into the substrate of the central element makes it possible to have a precise and uniform quantity of the treatment agent, which is moreover protected by the substrate, which makes it possible to remove it from any oxidation or hydrolysis for example; a complete contact is obtained between the mucosa of the cavity, and the active liquid.

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention concerns a disposable device (1) for transferring an active liquid into a body cavity (2), having sufficient intrinsic consistency for being inserted by being thrust into said cavity, said device comprising: a central element (3), at the source of at least part of the active liquid, a peripheral element (4) arranged around the central element, comprising a pad (5) arranged to collect and absorb the active liquid delivered into the body cavity, by expanding and thereby being urged to press sealingly against the mucous membrane of the body cavity (2). The central element (3) comprises a substrate relatively solid at room temperature outside the body cavity, and turning relatively liquid inside the body cavity, such that therein, said central element is liquefied at least partly to generate at least part of the active liquid.

Description

DISPOSITIF A USAGE UNIQUE DE TRANSFERT D' UN LIQUIDE ACTIF DANS UNE CAVITE INTRACORPORELLE SINGLE USE DEVICE FOR TRANSFERRING AN ACTIVE LIQUID IN AN INTRACORPOREAL CAVITY
La présente invention concerne le transfert ou circulation d'un liquide actif dans ou à l'intérieur d'une cavité intracorporelle du corps humain ou d'un animal, notamment au contact de la muqueuse de ladite cavité.The present invention relates to the transfer or circulation of an active liquid in or inside an intracorporeal cavity of the human body or of an animal, in particular in contact with the mucosa of said cavity.
Par "cavité intracorporelle", on entend toute cavité du corps, notamment allongée, à laquelle on peut accéder de manière externe à différentes fins, notamment cliniques, thérapeutiques, prophylactiques, ou de diagnostic, mais aussi à des fins cosmétiques ou d 'hygiène corporelle. A titre d'exemple d'une telle cavité, on peut citer le vagin de la femme qui s'étend de la vulve jusqu'au col utérin, dans lequel on désire transférer ou faire circuler un liquide actif, au contact de la muqueuse ou des tissus de ladite cavité.By "intracorporeal cavity" is meant any body cavity, in particular an elongated one, which can be accessed externally for various purposes, in particular clinical, therapeutic, prophylactic, or diagnostic, but also for cosmetic or personal hygiene purposes. . As an example of such a cavity, mention may be made of the woman's vagina which extends from the vulva to the cervix, into which one wishes to transfer or circulate an active liquid, in contact with the mucous membrane or tissues of said cavity.
En conséquence, par "liquide actif", on entend tout liquide ou fluide de traitement, aussi bien local par voie topique, que systémique, comprenant de manière générale, une phase liquide ou fluide dans laquelle est distribué, en solution ou suspension, un agent de traitement. Ce dernier est choisi dans le groupe constitué par les agents de mouillage, les agents solubilisants et fluidifiants, notamment d'un liquide ou fluide corporel présent dans la cavité intracorporelle, les agents thérapeutiques, prophylactiques et de diagnostic, les agents cosmétiques ou d'hygiène corporelle, les agents antiseptiques, bactéricides, fongicides, et spermicides (dans le cas de la cavité vaginale de la femme par exemple) .Consequently, by "active liquid" is meant any treatment liquid or fluid, both topically local and systemic, generally comprising a liquid or fluid phase in which an agent is distributed, in solution or suspension. treatment. The latter is chosen from the group consisting of wetting agents, solubilizing and fluidifying agents, in particular of a liquid or bodily fluid present in the intracorporeal cavity, therapeutic, prophylactic and diagnostic agents, cosmetic or hygiene agents body, antiseptic agents, bactericides, fungicides, and spermicides (in the case of the woman's vaginal cavity for example).
La présente invention a pour objet un dispositif à usage unique, permettant une disponibilité accrue du ou des principes actifs au contact de la muqueuse de la paroi de la cavité intracorporelle, lorsque en particulier l'agent de traitement est un agent thérapeutique.The present invention relates to a disposable device, allowing increased availability of the active ingredient (s) in contact with the mucosa of the wall of the intracorporeal cavity, when in particular the treatment agent is a therapeutic agent.
L'invention a également pour objet un dispositif assurant une absence quasi totale d'écoulement externe, du liquide actif et/ou du fluide corporel, ou de tout liquide présent dans la cavité intracorporelle considérée, pendant tout le temps où ledit dispositif est présent ou maintenu dans cette cavité, par simple constriction de cette dernière. A cette fin, conformément à l'invention, le dispositif a usage unique présente une consistance intrinsèque suffisante, pour permettre son introduction par poussée dans la cavité intracorporelle, et comprend :The invention also relates to a device ensuring an almost total absence of external flow, of the active liquid and / or of the bodily fluid, or of any liquid present in the intracorporeal cavity considered, during the whole time when said device is present or maintained in this cavity, by simple constriction of the latter. To this end, in accordance with the invention, the single-use device has a sufficient intrinsic consistency, to allow its introduction by thrust into the intracorporeal cavity, and comprises:
- un élément central, à la source d'au moins une partie du liquide actif, en ce qu'il comprend un substrat relativement solide, à température ambiante et à l'extérieur de la cavité intracorporelle, et devenant relativement liquide ou fluide, à l'intérieur de cette même cavité et à la température du corps, en sorte que, au sein de cette dernière, l'élément central se liquéfie au moins en partie, pour générer au moins une partie de la phase liquide du liquide actif,a central element, at the source of at least part of the active liquid, in that it comprises a relatively solid substrate, at ambient temperature and outside the intracorporeal cavity, and becoming relatively liquid or fluid, inside this same cavity and at body temperature, so that, within the latter, the central element at least partially liquefies, to generate at least part of the liquid phase of the active liquid,
- un élément périphérique disposé autour de l'élément central, à l'état solide, comprenant un tampon agencé pour recueillir et absorber le liquide actif ayant circulé dans la cavité intracorporelle, en s'expansant et venant de ce fait en appui étanche contre la muqueuse de ladite cavité intracorporelle.- a peripheral element disposed around the central element, in the solid state, comprising a buffer arranged to collect and absorb the active liquid having circulated in the intracorporeal cavity, expanding and thereby coming in sealed support against the mucosa of said intracorporeal cavity.
La présente invention est maintenant décrite, à titre d'exemple non limitatif, par référence au dessin annexé, à caractère schématique, dans lequel :The present invention is now described, by way of nonlimiting example, with reference to the appended drawing, of schematic nature, in which:
- la figure 1 représente un dispositif à usage unique conforme à l'invention, en position dans une cavité intracorporelle, et juste après son introduction par poussée dans cette dernière, et ceci selon un premier mode d'exécution de l'invention ; la figure 1 est une coupe axiale d'un dispositif selon l'invention, ce dernier présentant une symétrie de révolution autour d'un axe ; - les figures 2 à 4 représentent respectivement trois autres modes d'exécution de la présente invention, toujours en coupe axiale.- Figure 1 shows a disposable device according to the invention, in position in an intracorporeal cavity, and just after its introduction by pushing in the latter, and this according to a first embodiment of the invention; Figure 1 is an axial section of a device according to the invention, the latter having a symmetry of revolution about an axis; - Figures 2 to 4 show respectively three other embodiments of the present invention, still in axial section.
Conformément à la figure 1 , un dispositif à usage unique selon l'invention est référencé par la référence numérique 1 . De manière générale, il permet de dispenser ou libérer un liquide actif, tel que précédemment défini, dans une cavité intracorporelle désignée par la référence numérique 2. Ce dispositif a une consistance intrinsèque et globale, relativement solide mais molle, et suffisamment raide ou résistante pour permettre son introduction par poussée dans la cavité, et ce sans altérer la structure dudit dispositif, notamment dissocier ses différents composants et/ou rompre toute capsule contenant un liquide, pouvant être comprise à l'intérieur dudit dispositif (cf. mode d'exécution selon figure 4). Le dispositif selon l'invention comprend essentiellement deux composants assemblés l'un à l'autre de manière définitive, à savoir : - un élément central 3, à la source d'au moins une partie du liquide, actif tel que précédemment défini ; - et un élément périphérique 4, disposé autour de l'élément central 3, comprenant un tampon 5 agencé pour absorber le liquide actif ayant circulé ou dispensé dans la cavité intracorporelle, en s'expansant et venant de ce fait en appui relativement étanche contre la muqueuse de la cavité intracorporelle (cf. conformation en traits pointillés selon figure 1 ).In accordance with FIG. 1, a disposable device according to the invention is referenced by the reference numeral 1. In general, it makes it possible to dispense or release an active liquid, as defined above, in an intracorporeal cavity designated by the reference numeral 2. This device has an intrinsic and overall consistency, relatively solid but soft, and sufficiently stiff or resistant to allow its introduction by pushing into the cavity, and this without altering the structure of said device, in particular dissociating its various components and / or breaking any capsule containing a liquid, which can be included inside said device (cf. embodiment according to figure 4). The device according to the invention essentially comprises two components assembled to each other definitively, namely: - a central element 3, at the source of at least part of the liquid, active as defined above; - And a peripheral element 4, arranged around the central element 3, comprising a pad 5 arranged to absorb the active liquid having circulated or dispensed in the intracorporeal cavity, by expanding and thereby coming into relatively tight support against the mucosa of the intracorporeal cavity (cf. conformation in dotted lines according to Figure 1).
L'élément central 3 comprend un substrat, par exemple à base de gélatine, relativement solide à température ambiante et à l'extérieur de la cavité intracorporelle et à la température du corps, et devenant relativement liquide, à l'intérieur de la cavité intracorporelle et à la température du corps, en sorte que, au sein de cette dernière, l'élément central se liquéfie au moins en partie, pour générer au moins une partie de la phase liquide du liquide actif.The central element 3 comprises a substrate, for example based on gelatin, relatively solid at room temperature and outside the intracorporeal cavity and at body temperature, and becoming relatively liquid, inside the intracorporeal cavity and at body temperature, so that, within the latter, the central element at least partially liquefies, to generate at least part of the liquid phase of the active liquid.
La gélatine peut être remplacée par tout autre substrat ayant les mêmes propriétés, par exemple un lipide. Par conséquent, selon une caractéristique essentielle de la présente invention, c'est donc le substrat de l'élément central qui permet d'obtenir par liquéfaction au sein de la cavité intracorporelle, et donc du corps humain ou animal, tout ou partie de la phase liquide du liquide actif.Gelatin can be replaced by any other substrate having the same properties, for example a lipid. Consequently, according to an essential characteristic of the present invention, it is therefore the substrate of the central element which makes it possible to obtain by liquefaction within the intracorporeal cavity, and therefore of the human or animal body, all or part of the liquid phase of the active liquid.
Préférentiellement, un agent de traitement de la cavité intracorporelle, tel que précédemment défini, est distribué sous forme discrète dans le substrat solide de l'élément central, et ceci quelle que soit la forme physique ou la nature dudit agent de traitement en dehors du substrat, par exemple une forme physique huileuse, solide, ou liquide, ou son caractère hydrophobe ou hydrophile. Cette distribution sous forme discrète de l'agent de traitement peut être faite par incorporation de celui-ci au sein du substrat précédemment défini, à l'état liquide, lors de la fabrication d'un dispositif à usage unique selon l'invention.Preferably, an agent for treating the intracorporeal cavity, as defined above, is distributed in discrete form in the solid substrate of the central element, and this regardless of the physical form or the nature of said treatment agent outside the substrate. , for example an oily, solid, or liquid physical form, or its hydrophobic or hydrophilic nature. This distribution in discrete form of the treatment agent can be made by incorporating it into the previously defined substrate, in the liquid state, during the manufacture of a disposable device according to the invention.
Comme le montre bien la figure 1 , l'élément central 3 est en quelque sorte une pièce moulée, par solidification du substrat liquide, par exemple de la gélatine. Et le tampon 5 est un manchon également moulé ou façonné, à partir d'un matériau susceptible d'absorber un liquide ou fluide en s'expansant. Ce matériau est par exemple une mousse d'une matière plastique biocompatible, ou encore une matière fibreuse (cellulosique par exemple), ouvrée (par exemple pliée) autour de l'élément central 3. L'élément central 3 et l'élément périphérique 4 sont ainsi ajustés l'un par rapport à l'autre, pour venir s'emboîter l'un dans l'autre, par simple poussée axiale de l'élément central vers l'élément périphérique, ou inversement.As clearly shown in FIG. 1, the central element 3 is in a way a molded part, by solidification of the liquid substrate, for example gelatin. And the pad 5 is a sleeve also molded or shaped, from a material capable of absorbing a liquid or fluid while expanding. This material is for example a foam of a biocompatible plastic material, or else a fibrous material (cellulosic for example), worked (for example folded) around the central element 3. The central element 3 and the peripheral element 4 are thus adjusted relative to each other, to fit into one another, by simple axial thrust from the central element towards the peripheral element, or vice versa.
L'élément périphérique 4 comporte un trou 4a, ou alésage, notamment borgne comme montré à la figure 1 , dont la forme et les dimensions sont adaptées pour la réception en correspondance du corps 3a de l'élément central 3. La tête 3b de l'élément central 3, de forme externe convexe, par exemple sphérique, comporte une collerette 6, tandis que l'élément périphérique 4 comporte un col 7 dont la forme et les dimensions sont adaptées pour retenir définitivement la collerette 6, par poussée axiale des éléments central 3 et périphérique 4, l'un vers l'autre. Comme montré par la figure 1 , le col 7 comporte une dépouille recevant la collerette 6 dirigée vers l'intérieur, et de forme externe également convexe, par exemple sphérique. Le pied 3c de l'élément central 3 a une forme renflée, tandis que l'élément périphérique 4 comporte une partie évasée 4d en correspondance, dont la forme et les dimensions sont adaptées pour la retenue du pied 3c de l'élément central 3.The peripheral element 4 has a hole 4a, or bore, in particular a blind hole as shown in FIG. 1, the shape and dimensions of which are adapted for the corresponding reception of the body 3a of the central element 3. The head 3b of the central element 3, of convex external shape, for example spherical, comprises a collar 6, while the peripheral element 4 comprises a neck 7 whose shape and dimensions are adapted to definitively retain the collar 6, by axial thrust of the elements central 3 and peripheral 4, one towards the other. As shown in Figure 1, the neck 7 includes a draft receiving the collar 6 directed inwardly, and also externally convex, for example spherical. The foot 3c of the central element 3 has a bulged shape, while the peripheral element 4 has a flared part 4d in correspondence, the shape and dimensions of which are adapted for retaining the foot 3c of the central element 3.
Le matériau absorbant du tampon 5 est expansible et/ou spongieux, et consiste par exemple en des filaments, des fibres capillaires, ou des fibres naturelles (cellulose ou viscose, par exemple), etc.... Comme indiqué précédemment, c'est la liquéfaction ou fusion du substrat de l'élément central 3, qui générant au moins pour partie la phase liquide du liquide actif au sein de la cavité intracorporelle 2, permet ensuite l'expansion du tampon 5, par recueil dudit liquide dans ce dernier, et ceci à la température du corps et dans la cavité intracorporelle 2. De manière à recycler éventuellement le liquide actif au contact de la cavité intracorporelle 2, le tampon 5 est évidé par exemple par quatre canaux radiaux 1 1 en croix, disposés au-dessous du trou 4a, débouchant sur la face extérieure du tampon 5, et communiquant éventuellement avec le fond du trou 4a. Conformément à la figure 2, la collerette 6 se prolonge vers le pied- 3c de l'élément central 3 par une jupe 6a coiffant la partie 4b de l'élément périphérique 4 opposée au col 7.The absorbent material of the pad 5 is expandable and / or spongy, and consists for example of filaments, hair fibers, or natural fibers (cellulose or viscose, for example), etc. As indicated above, it is the liquefaction or melting of the substrate of the central element 3, which at least partially generates the liquid phase of the active liquid within the intracorporeal cavity 2, then allows the expansion of the buffer 5, by collecting said liquid in the latter, and this at body temperature and in the intracorporeal cavity 2. In order to possibly recycle the active liquid in contact with the intracorporeal cavity 2, the buffer 5 is hollowed out for example by four radial channels 1 1 in cross, arranged below of the hole 4a, opening onto the outer face of the pad 5, and possibly communicating with the bottom of the hole 4a. In accordance with FIG. 2, the collar 6 extends towards the base 3c of the central element 3 by a skirt 6a covering the part 4b of the peripheral element 4 opposite the neck 7.
Par ailleurs, toujours conformément à la figure 2, un lien 1 2 attaché à l'élément périphérique 4 permet d 'extraire le dispositif 1 à usage unique de la cavité intracorporelle 2, après traitement de cette dernière, c'est-à-dire après liquéfaction du substrat de l'élément central 3.Furthermore, still in accordance with FIG. 2, a link 1 2 attached to the peripheral element 4 makes it possible to extract the device 1 for single use from the intracorporeal cavity 2, after treatment of the latter, that is to say after liquefaction of the substrate of the central element 3.
Conformément à la figure 3, une enveloppe 1 0 de protection temporaire, fermée, enveloppe les éléments central 3 et périphérique 4 assemblés l'un à l'autre comme décrit précédemment. Cette enveloppe est constituée par exemple par un substrat ayant les propriétés décrites précédemment, par exemple à base de gélatine. Ceci veut dire que l'enveloppe est constituée par une matière relativement solide, à température ambiante et à l'extérieur de la cavité intracorporelle, en sorte qu'au sein de cette dernière et à la température du corps, cette matière fond et constitue ainsi une autre partie de la phase liquide du liquide actif précédemment défini. Mais cette enveloppe 1 0 peut être constituée par un excipient solide et dur, par exemple sucrose, tel qu' utilisé en galénique pour obtenir des dragées, et susceptible de se dissoudre ou se déliter au contact de tout liquide corporel présent dans la cavité 2.In accordance with FIG. 3, an envelope 1 0 of temporary protection, closed, envelops the central 3 and peripheral 4 elements assembled together as described above. This envelope is constituted for example by a substrate having the properties described above, for example based on gelatin. This means that the envelope is constituted by a relatively solid material, at room temperature and outside the intracorporeal cavity, so that within the latter and at body temperature, this material melts and thus constitutes another part of the liquid phase of the active liquid previously defined. However, this envelope 1 0 may consist of a solid and hard excipient, for example sucrose, as used in galenic form to obtain sugared almonds, and capable of dissolving or disintegrating on contact with any body liquid present in the cavity 2.
Conformément à la figure 4, l'élément central 3 est une capsule, dont la paroi 8 est constituée par le substrat précédemment défini, et dont l'intérieur comprend un autre liquide 1 5 actif ou non, la paroi 8 étant fermée et étanche, à température ambiante et à l'extérieur du corps. Le liquide ainsi contenu dans la capsule permet d'augmenter la quantité de phase liquide du liquide actif. Ce liquide 1 5 peut avoir toute forme appropriée, huileuse par exemple, et contenir tout ou partie d ' un agent de traitement tel que précédemment défini, en solution ou suspension dans ledit liquide. Comme non représenté, selon encore un autre mode d'exécution de l'invention, l'enveloppe 1 0 représentée à la Figure 4 peut être supprimée, tandis que la paroi 8 forme un appendice sécable à son extrémité opposée au tampon 5, ce qui permet à l'utilisateur d'ouvrir la capsule juste avant l'introduction du dispositif dans la cavité intracorporelle, et de bénéficier d'une petite quantité du liquide 1 5 pour humidifier l'extérieur dudit dispositif au moment de son introduction dans ladite cavité.In accordance with FIG. 4, the central element 3 is a capsule, the wall 8 of which is constituted by the previously defined substrate, and the interior of which comprises another liquid 1 5, active or not, the wall 8 being closed and sealed, at room temperature and outside the body. The liquid thus contained in the capsule makes it possible to increase the quantity of liquid phase of the active liquid. This liquid 1 5 can have any suitable form, oily for example, and contain all or part of a treatment agent as defined above, in solution or suspension in said liquid. As not shown, according to yet another embodiment of the invention, the casing 1 0 shown in Figure 4 can be omitted, while the wall 8 forms a breakable appendage at its end opposite to the pad 5, which allows the user to open the capsule just before the introduction of the device into the intracorporeal cavity, and to benefit from a small amount of the liquid 1 5 for moisten the exterior of said device at the time of its introduction into said cavity.
Conformément aux figures 1 à 4, un dispositif selon l'invention, avant son introduction dans la cavité intracorporelle 2, comprend une partie proximale 1 a, par laquelle s'effectue l' introduction dans la cavité intracorporelle 2, et une partie distale 1 b, dont le diamètre transversal le plus important est plus faible que le diamètre transversal le plus important de la partie distale 1 a. Ceci permet un maintien temporaire du dispositif dans la cavité, avant que le liquide actif ne prenne le relais en faisant gonfler le tampon 5.In accordance with FIGS. 1 to 4, a device according to the invention, before its introduction into the intracorporeal cavity 2, comprises a proximal part 1 a, through which the introduction into the intracorporeal cavity 2 takes place, and a distal part 1 b , the largest transverse diameter of which is smaller than the largest transverse diameter of the distal part 1 a. This allows the device to be temporarily held in the cavity, before the active liquid takes over by swelling the buffer 5.
Cette configuration permet aussi de limiter ou de supprimer tout contact entre la muqueuse de la cavité corporelle 2 avec le matériau absorbant à l'état sec du tampon 5, au moment de l'introduction du dispositif 1 ; un tel contact pourrait non seulement générer un frottement non négligeable, mais aussi être source de gène ou douleur pour l'utilisateur. Au contraire, grâce à la configuration retenue, c'est seulement la partie proximale 1 a, revêtue par la collerette 7 relativement glissante, qui glisse au contact de la muqueuse de la cavité intracorporelle, lors de l'introduction du dispositif. Un dispositif à usage unique tel que précédemment décrit apporte les avantages essentiels suivants :This configuration also makes it possible to limit or eliminate any contact between the mucosa of the body cavity 2 with the absorbent material in the dry state of the tampon 5, when the device 1 is introduced; such contact could not only generate significant friction, but also be a source of discomfort or pain for the user. On the contrary, thanks to the configuration chosen, it is only the proximal part 1a, coated by the relatively slippery collar 7, which slides in contact with the mucosa of the intracorporeal cavity, during the introduction of the device. A single-use device as described above provides the following essential advantages:
- l'absorption du ou des agents de traitement par la muqueuse de la cavité intracorporelle, est plus complète et rapide ; l'incorporation de cet agent de traitement dans le substrat de l'élément central permet de disposer d'une quantité précise et uniforme de l'agent de traitement, lequel est par ailleurs protégé par le substrat, ce qui permet de le soustraire à toute oxydation ou hydrolyse par exemple ; on obtient une mise en contact complète entre la muqueuse de la cavité, et le liquide actif. - the absorption of the treatment agent (s) by the mucosa of the intracorporeal cavity is more complete and rapid; the incorporation of this treatment agent into the substrate of the central element makes it possible to have a precise and uniform quantity of the treatment agent, which is moreover protected by the substrate, which makes it possible to remove it from any oxidation or hydrolysis for example; a complete contact is obtained between the mucosa of the cavity, and the active liquid.

Claims

REVENDICATIONS
1 ) - Dispositif ( 1 ) à usage unique de transfert d'un liquide actif dans une cavité intracorporelle (2), présentant une consistance intrinsèque suffisante pour permettre son introduction par poussée dans ladite cavité, ledit dispositif comprenant :1) - Single-use device (1) for transferring an active liquid into an intracorporeal cavity (2), having an intrinsic consistency sufficient to allow its introduction by pushing into said cavity, said device comprising:
- un élément central (3), à la source d'au moins une partie du liquide actif ;- a central element (3), at the source of at least part of the active liquid;
- un élément périphérique (4) disposé autour de l'élément central, comprenant un tampon (5) agencé pour recueillir et absorber le liquide actif dispensé dans la cavité intracorporelle, en s'expansant et venant de ce fait en appui étanche contre la muqueuse de la cavité intracorporelle (2) ; caractérisé en ce que l'élément central (3) comprend un substrat relativement solide à température ambiante, à l'extérieur de la cavité intracorporelle, et devenant relativement liquide à l'intérieur de la cavité intracorporelle, en sorte que au sein de cette dernière, ledit élément central se liquéfie au moins en partie pour générer au moins une partie de la phase- a peripheral element (4) disposed around the central element, comprising a buffer (5) arranged to collect and absorb the active liquid dispensed in the intracorporeal cavity, expanding and thereby coming into tight support against the mucosa intracorporeal cavity (2); characterized in that the central element (3) comprises a relatively solid substrate at room temperature, outside the intracorporeal cavity, and becoming relatively liquid inside the intracorporeal cavity, so that within the latter , said central element at least partially liquefies to generate at least part of the phase
.liquide du liquide actif.liquid of the active liquid.
2) Dispositif selon la revendication 1 , caractérisé en ce qu'un agent de traitement de la cavité intracorporelle (2) est distribué dans le substrat solide de l'élément central (3) .2) Device according to claim 1, characterized in that an agent for treating the intracorporeal cavity (2) is distributed in the solid substrate of the central element (3).
3) Dispositif selon la revendication 2, caractérisé en ce que l'agent de traitement est choisi dans le groupe constitué par les agents de mouillage, les agents solubilisants et fluidifiants, notamment d'un liquide ou fluide corporel présent dans la cavité intracorporelle (2), les agents thérapeutiques, prophylactiques et de diagnostic, les agents cosmétiques ou d 'hygiène corporelle, les agents antiseptiques, bactéricides, fongicides, et spermicides.3) Device according to claim 2, characterized in that the treatment agent is chosen from the group consisting of wetting agents, solubilizing and thinning agents, in particular of a liquid or body fluid present in the intracorporeal cavity (2 ), therapeutic, prophylactic and diagnostic agents, cosmetic or personal hygiene agents, antiseptic, bactericidal, fungicidal, and spermicidal agents.
4) Dispositif selon la revendication 1 , caractérisé en ce que l'élément périphérique (4) comporte un trou (4a), notamment borgne, dont la forme et les dimensions sont adaptées pour la réception du corps (3a) de l'élément central (3a). 5) Dispositif selon la revendication 1 , caractérisé en ce que la tête (3b) de l'élément central (3) comporte une collerette (6), tandis que l'élément périphérique (4) comporte un col (7) dont la forme et les dimensions sont adaptées pour retenir définitivement ladite collerette, par poussée axiale des éléments central (3) et périphérique (4), l'un vers l'autre.4) Device according to claim 1, characterized in that the peripheral element (4) has a hole (4a), in particular blind, whose shape and dimensions are suitable for receiving the body (3a) of the central element (3a). 5) Device according to claim 1, characterized in that the head (3b) of the central element (3) comprises a flange (6), while the peripheral element (4) comprises a neck (7) whose shape and the dimensions are adapted to definitively retain said collar, by axial thrust of the central (3) and peripheral (4) elements, towards one another.
6) Dispositif selon la revendication 1 , caractérisé en ce que le pied (3c) de l'élément central (3) a une forme renflée, tandis que l'élément périphérique (4) comporte une partie évasée (4d) dont la forme et les dimensions sont adaptées, pour la retenue du pied (3c) de l'élément central (3).6) Device according to claim 1, characterized in that the foot (3c) of the central element (3) has a bulged shape, while the peripheral element (4) has a flared part (4d) whose shape and the dimensions are adapted, for the retention of the foot (3c) of the central element (3).
7) Dispositif selon la revendication 5, caractérisé en ce que la collerette (6) se prolonge vers le pied (3c) de l'élément central (3) par une jupe (6a) coiffant la partie (4b) de l'élément périphérique (4) opposée au col (7) .7) Device according to claim 5, characterized in that the collar (6) extends towards the foot (3c) of the central element (3) by a skirt (6a) covering the part (4b) of the peripheral element (4) opposite the neck (7).
8) Dispositif selon la revendication 1 , caractérisé en ce que l'élément central (3) est une capsule, dont la paroi (8) est constituée par undit substrat, et dont l'intérieur comprend un autre liquide (9), actif ou non, ladite paroi (8) étant fermée et étanche vis-à-vis dudit liquide, à température ambiante et à l'extérieur de la cavité intracorporelle (2) .8) Device according to claim 1, characterized in that the central element (3) is a capsule, whose wall (8) is constituted by said substrate, and whose interior comprises another liquid (9), active or no, said wall (8) being closed and leaktight with respect to said liquid, at ambient temperature and outside the intracorporeal cavity (2).
9) Dispositif selon la revendication 1 , caractérisé en ce qu'il comprend une enveloppe ( 1 0) de protection temporaire, enveloppant les éléments central (3) et périphérique (4) assemblés l'un à l'autre.9) Device according to claim 1, characterized in that it comprises an envelope (1 0) of temporary protection, enveloping the central elements (3) and peripheral (4) assembled to one another.
10) Dispositif selon la revendication 1 , caractérisé en ce que ledit substrat comprend de la gélatine.10) Device according to claim 1, characterized in that said substrate comprises gelatin.
1 1 ) Dispositif selon la revendication 1 , caractérisé en ce que le tampon (5) est évidé par au moins un canal radial ( 1 1 ), disposé au-dessous du trou (4a), débouchant sur la face extérieure dudit tampon, et communiquant éventuellement avec le trou (4a) . 1 1) Device according to claim 1, characterized in that the pad (5) is hollowed out by at least one radial channel (1 1), disposed below the hole (4a), opening onto the outer face of said pad, and possibly communicating with the hole (4a).
EP00901703A 1999-02-03 2000-02-02 Disposable device for transferring an active liquid into a body cavity Withdrawn EP1150737A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9901419 1999-02-03
FR9901419A FR2788987B1 (en) 1999-02-03 1999-02-03 SINGLE-USE DEVICE FOR TRANSFERRING AN ACTIVE LIQUID IN AN INTRACORPOREAL CAVITY
PCT/FR2000/000245 WO2000045887A1 (en) 1999-02-03 2000-02-02 Disposable device for transferring an active liquid into a body cavity

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EP1150737A1 true EP1150737A1 (en) 2001-11-07

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EP (1) EP1150737A1 (en)
JP (1) JP2002536082A (en)
CN (1) CN1338957A (en)
AU (1) AU763780B2 (en)
BR (1) BR0007981A (en)
CA (1) CA2361491A1 (en)
FR (1) FR2788987B1 (en)
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JP2002536082A (en) 2002-10-29
US6558362B1 (en) 2003-05-06
FR2788987A1 (en) 2000-08-04
AU763780B2 (en) 2003-07-31
NO20013793D0 (en) 2001-08-02
NO20013793L (en) 2001-09-26
CA2361491A1 (en) 2000-08-10
HK1043948A1 (en) 2002-10-04
CN1338957A (en) 2002-03-06
AU2301900A (en) 2000-08-25
BR0007981A (en) 2001-11-06
US20030191439A1 (en) 2003-10-09
FR2788987B1 (en) 2001-05-04
WO2000045887A1 (en) 2000-08-10

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