EP1095002A4 - Method of vitamin production - Google Patents

Method of vitamin production

Info

Publication number
EP1095002A4
EP1095002A4 EP99932295A EP99932295A EP1095002A4 EP 1095002 A4 EP1095002 A4 EP 1095002A4 EP 99932295 A EP99932295 A EP 99932295A EP 99932295 A EP99932295 A EP 99932295A EP 1095002 A4 EP1095002 A4 EP 1095002A4
Authority
EP
European Patent Office
Prior art keywords
geranylgeraniol
microorganism
farnesol
vitamin production
phosphate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99932295A
Other languages
German (de)
French (fr)
Other versions
EP1095002A1 (en
Inventor
James R Millis
Gabriel G Saucy
Julie Maurina-Brunker
Thomas W Mcmullin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DCV Inc
Original Assignee
DCV Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DCV Inc filed Critical DCV Inc
Priority to EP09004155A priority Critical patent/EP2100963B1/en
Priority to DK08003596.7T priority patent/DK1947189T3/en
Priority to EP10180179.3A priority patent/EP2305825B1/en
Priority to EP08003596A priority patent/EP1947189B1/en
Publication of EP1095002A1 publication Critical patent/EP1095002A1/en
Publication of EP1095002A4 publication Critical patent/EP1095002A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/08—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/24—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01Q—ANTENNAS, i.e. RADIO AERIALS
    • H01Q1/00—Details of, or arrangements associated with, antennas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

The invention relates to methods for producing farnesol or geranylgeraniol comprising: (a) culturing a microorganism in a fermentation medium to produce a product selected from the group consisting of farnesyl phosphate and farnesol or geranylgeranyl phosphate and geranylgeraniol, wherein the action of squalene synthase of said microorganism is reduced; and (b) recovering said product.
EP99932295A 1998-07-06 1999-07-06 Method of vitamin production Withdrawn EP1095002A4 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP09004155A EP2100963B1 (en) 1998-07-06 1999-07-06 Method of vitamin production
DK08003596.7T DK1947189T3 (en) 1998-07-06 1999-07-06 Process for Vitamin Preparation
EP10180179.3A EP2305825B1 (en) 1998-07-06 1999-07-06 Method of vitamin production
EP08003596A EP1947189B1 (en) 1998-07-06 1999-07-06 Method of vitamin production

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US9198398P 1998-07-06 1998-07-06
US9196498P 1998-07-06 1998-07-06
US9195198P 1998-07-06 1998-07-06
US91964P 1998-07-06
US91983P 1998-07-06
US91951P 1998-07-06
PCT/US1999/015264 WO2000001650A1 (en) 1998-07-06 1999-07-06 Method of vitamin production

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP10180179.3A Division EP2305825B1 (en) 1998-07-06 1999-07-06 Method of vitamin production
EP08003596A Division EP1947189B1 (en) 1998-07-06 1999-07-06 Method of vitamin production

Publications (2)

Publication Number Publication Date
EP1095002A1 EP1095002A1 (en) 2001-05-02
EP1095002A4 true EP1095002A4 (en) 2005-08-03

Family

ID=27377004

Family Applications (3)

Application Number Title Priority Date Filing Date
EP99932295A Withdrawn EP1095002A4 (en) 1998-07-06 1999-07-06 Method of vitamin production
EP08003596A Expired - Lifetime EP1947189B1 (en) 1998-07-06 1999-07-06 Method of vitamin production
EP09004155A Expired - Lifetime EP2100963B1 (en) 1998-07-06 1999-07-06 Method of vitamin production

Family Applications After (2)

Application Number Title Priority Date Filing Date
EP08003596A Expired - Lifetime EP1947189B1 (en) 1998-07-06 1999-07-06 Method of vitamin production
EP09004155A Expired - Lifetime EP2100963B1 (en) 1998-07-06 1999-07-06 Method of vitamin production

Country Status (11)

Country Link
EP (3) EP1095002A4 (en)
JP (1) JP4579415B2 (en)
CN (1) CN1330621A (en)
AT (2) ATE537265T1 (en)
AU (1) AU4863099A (en)
CA (2) CA2831321C (en)
DE (1) DE69943009D1 (en)
DK (3) DK2100963T3 (en)
ES (2) ES2379212T3 (en)
MX (2) MX219130B (en)
WO (1) WO2000001650A1 (en)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2305825B1 (en) 1998-07-06 2015-01-14 DCV Inc. doing business as Bio-Technical Resourses Method of vitamin production
ES2253220T3 (en) 1999-04-15 2006-06-01 Calgene Llc SEQUENCES OF NUCLEIC ACID OF PROTEINS INVOLVED IN THE SYNTHESIS OF TOCOFEROL.
EP1260590B1 (en) * 2000-03-02 2007-02-14 TOUDAI TLO, Ltd. Method of screening substance specifically inhibiting non-mevalonate pathway
US6872815B1 (en) 2000-10-14 2005-03-29 Calgene Llc Nucleic acid sequences to proteins involved in tocopherol synthesis
EP1360300A2 (en) 2000-07-31 2003-11-12 Frederick M. Hahn Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
EP1356033B1 (en) 2000-08-07 2009-10-28 Monsanto Technology LLC Methyl-d-erythritol phosphate pathway genes
EP1354955A4 (en) * 2000-12-28 2005-01-05 Toyota Motor Co Ltd Process for producing prenyl alcohol
JP2003088368A (en) * 2001-09-18 2003-03-25 Toyota Motor Corp Method for producing prenyl alcohol
EP1354956A4 (en) 2000-12-28 2004-10-27 Toyota Motor Co Ltd Process for producing prenyl alcohol
JP3838033B2 (en) * 2000-12-28 2006-10-25 トヨタ自動車株式会社 Method for producing prenyl alcohol
JP2002253284A (en) * 2000-12-28 2002-09-10 Toyota Motor Corp Method for producing geranylgeraniol and analogous compound thereof by microorganism
JP4013535B2 (en) 2000-12-28 2007-11-28 トヨタ自動車株式会社 High production method of prenyl alcohol by microorganisms
US7161061B2 (en) 2001-05-09 2007-01-09 Monsanto Technology Llc Metabolite transporters
US7238855B2 (en) 2001-05-09 2007-07-03 Monsanto Technology Llc TyrA genes and uses thereof
ATE405638T1 (en) * 2001-06-06 2008-09-15 Dsm Ip Assets Bv IMPROVED ISOPRENOID PRODUCTION
WO2003016482A2 (en) 2001-08-17 2003-02-27 Monsanto Technology Llc Methyltransferase genes and uses thereof
ATE456657T1 (en) 2001-10-25 2010-02-15 Monsanto Technology Llc AROMATIC METHYL TRANSFERASES AND THEIR USE
US7192751B2 (en) 2001-12-06 2007-03-20 The Regents Of The University Of California Biosynthesis of amorpha-4,11-diene
US7172886B2 (en) 2001-12-06 2007-02-06 The Regents Of The University Of California Biosynthesis of isopentenyl pyrophosphate
EP1527180A4 (en) 2002-03-19 2006-02-15 Monsanto Technology Llc Homogentisate prenyl transferase ("hpt") nucleic acids and polypeptides, and uses thereof
WO2004001057A1 (en) * 2002-06-21 2003-12-31 Dsm Ip Assets B.V. Process for producing carotenoids
WO2004013312A2 (en) 2002-08-05 2004-02-12 Monsanto Technology, Llc Tocopherol biosynthesis related genes and uses thereof
ATE394477T1 (en) * 2002-09-27 2008-05-15 Dsm Ip Assets Bv SQUALENE SYNTHASE (SQS) GENE
MXPA06013502A (en) 2004-05-21 2007-03-01 Univ California Method for enhancing production of isoprenoid compounds.
JP5590769B2 (en) 2004-07-27 2014-09-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Genetically modified host cells and methods of using the host cells for producing isoprenoid compounds
CN103589650A (en) 2005-03-18 2014-02-19 米克罗比亚公司 Production of carotenoids in oleaginous yeast and fungi
JP4824985B2 (en) * 2005-10-13 2011-11-30 株式会社Ａｄｅｋａ Method for producing farnesyl diphosphate
US8691555B2 (en) 2006-09-28 2014-04-08 Dsm Ip Assests B.V. Production of carotenoids in oleaginous yeast and fungi
MY154965A (en) 2007-06-01 2015-08-28 Solazyme Inc Production of oil in microorganisms
MX302107B (en) 2007-09-20 2012-08-08 Amyris Biotechnologies Inc Production of isoprenoids.
JP5174430B2 (en) * 2007-11-06 2013-04-03 花王株式会社 Method for producing 2-phenylethyl alcohol
WO2010031076A2 (en) * 2008-09-15 2010-03-18 Danisco Us Inc. Conversion of prenyl derivatives to isoprene
SG171428A1 (en) * 2008-11-28 2011-07-28 Solazyme Inc Manufacturing of tailored oils in recombinant heterotrophic microorganisms
AU2011257983B2 (en) 2010-05-28 2016-02-11 Corbion Biotech, Inc. Food compositions comprising tailored oils
BR122021005283B1 (en) 2010-06-02 2022-02-22 Evolva, Inc RECOMBINANT HOST COMPRISING RECOMBINANT GENES FOR PRODUCTION OF STEVIOL OR STEVIOL GLYCOSIDE, METHOD FOR PRODUCING STEVIOL, STEVIOL GLYCOSIDE OR STEVIOL GLYCOSIDE COMPOSITION AND METHOD FOR SYNTHESISTING STEVIOL OR STEVIOL GLYCOSIDE
ES2909143T3 (en) 2010-11-03 2022-05-05 Corbion Biotech Inc Genetically modified Chlorella or Prototheca microbes and oil produced from these
KR101964965B1 (en) 2011-02-02 2019-04-03 테라비아 홀딩스 인코포레이티드 Tailored oils produced from recombinant oleaginous microorganisms
MX339607B (en) 2011-05-06 2016-05-31 Solazyme Inc Genetically engineered microorganisms that metabolize xylose.
DK2707475T3 (en) * 2011-05-09 2016-01-11 Amyris Inc Preparation of Acetyl-Coenzyme α-Derived Compounds
KR20200057799A (en) 2011-08-08 2020-05-26 에볼바 에스아 Recombinant production of steviol glycosides
SG11201406711TA (en) 2012-04-18 2014-11-27 Solazyme Inc Tailored oils
CA2899276C (en) 2013-02-06 2022-11-01 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m
EP2954061B1 (en) 2013-02-11 2023-11-22 Evolva SA Efficient production of steviol glycosides in recombinant hosts
EP2993993A2 (en) 2013-04-26 2016-03-16 Solazyme, Inc. Low polyunsaturated fatty acid oils and uses thereof
US10053715B2 (en) 2013-10-04 2018-08-21 Corbion Biotech, Inc. Tailored oils
ES2764273T3 (en) 2014-07-10 2020-06-02 Corbion Biotech Inc Novel Ketoacyl ACP Synthase Genes and Their Use
CN106572688B (en) 2014-08-11 2022-01-25 埃沃尔瓦公司 Production of steviol glycosides in recombinant hosts
JP2017528134A (en) 2014-09-09 2017-09-28 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． Production of steviol glycosides in recombinant hosts
WO2016120486A1 (en) 2015-01-30 2016-08-04 Evolva Sa Production of steviol glycosides in recombinant hosts
BR112017019625A2 (en) 2015-03-16 2018-05-08 Dsm Ip Assets Bv udp-glycosyltransferases
WO2017025362A1 (en) 2015-08-07 2017-02-16 Evolva Sa Production of steviol glycosides in recombinant hosts
CN105153102A (en) * 2015-09-30 2015-12-16 宜春大海龟生命科学有限公司 Method for using mixed tocopherol as raw material to prepare alpha-tocopherol
SG11201808856TA (en) 2016-04-13 2018-11-29 Evolva Sa Production of steviol glycosides in recombinant hosts
EP3458599A1 (en) 2016-05-16 2019-03-27 Evolva SA Production of steviol glycosides in recombinant hosts
US11396669B2 (en) 2016-11-07 2022-07-26 Evolva Sa Production of steviol glycosides in recombinant hosts
CA3084263A1 (en) 2017-12-07 2019-06-13 Zymergen Inc. Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation
EP3728212A1 (en) 2017-12-21 2020-10-28 Zymergen Inc. Nepetalactol oxidoreductases, nepetalactol synthases, and microbes capable of producing nepetalactone
CN109609579B (en) * 2018-12-31 2022-04-05 陕西师范大学 Genetically engineered bacterium for producing beta-carotene and construction method thereof
CN109884216A (en) * 2019-04-10 2019-06-14 西南医科大学 A kind of method that high performance liquid chromatography measures method Buddhist nun's aldehyde in carrier micelle
CN110903190B (en) * 2019-12-09 2022-07-12 万华化学集团股份有限公司 Preparation method of vitamin A and vitamin A ester
CN110950791B (en) * 2019-12-09 2021-12-14 万华化学集团股份有限公司 Vitamin A and preparation method of vitamin A ester
JP2023506144A (en) * 2019-12-23 2023-02-15 ディーエスエム アイピー アセッツ ビー．ブイ． Dehydrogenation method
CN113621631A (en) * 2021-08-11 2021-11-09 昆明理工大学 Mevalonate kinase gene RKMK and application thereof
CN113969288A (en) * 2021-10-29 2022-01-25 湖北冠众通科技有限公司 High-yield farnesol gene engineering bacterium and construction method and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2404621A1 (en) * 1974-01-29 1975-08-07 Teijin Ltd Cpds. contg. chroman rings - from hydroquinones and carboxylic acid derivs in the presence of an insol solid acid catalyst
GB1479272A (en) * 1974-12-23 1977-07-13 Kuraray Co Process for preparing a stereospecific farnesol

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3917710A (en) 1974-05-23 1975-11-04 Eastman Kodak Co Preparation of phytone via the addition of dimethylketene to 4,8-dimethyl-12-oxotridecanal
US3862988A (en) 1974-05-23 1975-01-28 Eastman Kodak Co 4,8 Dimethyl- 12-oxotridecanal
US4225734A (en) 1978-08-08 1980-09-30 The Regents Of The University Of California Process for producing symmetrical olefins
US4743546A (en) 1985-02-13 1988-05-10 Biotechnica International, Inc. Controlled gene excision
US4871721A (en) 1988-01-11 1989-10-03 E. R. Squibb & Sons, Inc. Phosphorus-containing squalene synthetase inhibitors
US5589372A (en) 1990-09-26 1996-12-31 E. R. Squibb & Sons, Inc. Squalene synthetase
US5460949A (en) * 1990-11-15 1995-10-24 Amoco Corporation Method and composition for increasing the accumulation of squalene and specific sterols in yeast
US5475029A (en) 1993-07-08 1995-12-12 The Board Of Trustees Of The Leland Stanford Junior University Farnesyl compounds as cholesterol lowering agents
JP3657298B2 (en) 1994-11-08 2005-06-08 株式会社クラレ Method for producing geranylgeraniol
US5556990A (en) 1994-12-16 1996-09-17 Rhone-Poulenc Rorer Pharmaceuticals Inc. Polyarylcarbamoylaza- and -carbamoylalkanedioic acids
JP3120684B2 (en) 1995-02-14 2000-12-25 トヨタ自動車株式会社 Mutant farnesyl diphosphate synthase that synthesizes geranylgeranyl diphosphate and DNA encoding the same
JP3151371B2 (en) * 1995-03-10 2001-04-03 麒麟麦酒株式会社 DNA strands useful for increasing carotenoid production
US5912154A (en) 1995-12-07 1999-06-15 Yale University Geranylgeranyl diphosphate synthase proteins, nucleic acid molecules and uses thereof
CA2241267C (en) * 1995-12-22 2012-12-04 Gist-Brocades B.V. Improved methods for transforming phaffia strains, transformed phaffia strains so obtained and recombinant dna in said methods
US5744341A (en) * 1996-03-29 1998-04-28 University Of Maryland College Park Genes of carotenoid biosynthesis and metabolism and a system for screening for such genes
EP0955363A3 (en) * 1998-05-06 2004-01-28 F. Hoffmann-La Roche Ag Dna sequences encoding enzymes involved in production of isoprenoids

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2404621A1 (en) * 1974-01-29 1975-08-07 Teijin Ltd Cpds. contg. chroman rings - from hydroquinones and carboxylic acid derivs in the presence of an insol solid acid catalyst
GB1479272A (en) * 1974-12-23 1977-07-13 Kuraray Co Process for preparing a stereospecific farnesol

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHAMBON C ET AL: "ISOLATION AND PROPERTIES OF YEAST MUTANTS AFFECTED IN FARNESYL DIPHOSPHATE SYNTHETASE", CURRENT GENETICS, NEW YORK, NY, US, vol. 18, 1990, pages 41 - 46, XP002909498, ISSN: 0172-8083 *

Also Published As

Publication number Publication date
DK1947189T3 (en) 2011-03-14
CA2331343A1 (en) 2000-01-13
ATE537265T1 (en) 2011-12-15
EP2100963A1 (en) 2009-09-16
CA2331343C (en) 2014-01-14
MX276941B (en) 2010-06-28
CA2831321A1 (en) 2000-01-13
EP1095002A1 (en) 2001-05-02
DK2305825T3 (en) 2015-03-02
ATE490332T1 (en) 2010-12-15
CA2831321C (en) 2018-05-15
WO2000001650A1 (en) 2000-01-13
ES2379212T3 (en) 2012-04-23
MX219130B (en) 2004-02-10
JP2002519049A (en) 2002-07-02
DE69943009D1 (en) 2011-01-13
CN1330621A (en) 2002-01-09
EP2100963B1 (en) 2011-12-14
EP1947189A3 (en) 2008-10-08
ES2534937T3 (en) 2015-04-30
DK2100963T3 (en) 2012-04-02
EP1947189B1 (en) 2010-12-01
AU4863099A (en) 2000-01-24
JP4579415B2 (en) 2010-11-10
EP1947189A2 (en) 2008-07-23
MXPA01000216A (en) 2002-10-17

Similar Documents

Publication Publication Date Title
EP1095002A4 (en) Method of vitamin production
EP1130043A3 (en) Polyhydroxyalkanoate containing 3-hydroxythienylalkanoic acid as monomer unit and method for producing the same
MY127948A (en) L-glutamic acid producing bacterium and process for producing l-glutamic acid
GR900100566A (en) Production of zeaxanthin and zeaxanthin-containing compositions
EP1067191A3 (en) DNA coding for mutant isopropylmalate synthase, L-leucine-producing microorganism and method for producing L-leucine
GR3034722T3 (en) ENHANCED PRODUCTION OF TAXOL AND TAXANES BY CELL CULTURES OF -i(TAXUS) SPECIES.
AU3799195A (en) Method for production of arachidonic acid
EP1233068A3 (en) Method for producing L-glutamic acid
HU0302357D0 (en) Method for production of taxanes by cell cultures of taxus species
EP0887420A3 (en) Process for producing L-amino acids by fermentation
MY123972A (en) Method for producing l-glutamic acid by fermentation
AU2001272562A1 (en) Method for the production of beta-carotene
ZA888962B (en) Process for producing a microbial polysaccharide
EP1233070A3 (en) Method for producing L-glutamic acid
CA2177785A1 (en) A method for producing l-isoleucine with a fermentation process
EP0765938A3 (en) Fermentative production of vitamin B6
AU2001281018A1 (en) Enhanced 2-keto-l-gulonic acid production
EP0140714A3 (en) Method for the production of phenylalanine ammonia-lyase by fermentation
HU9302568D0 (en) Method for producing biotin
AU1839795A (en) L-ascorbic acid production in microorganisms
EP0979876A3 (en) Method for producing fermentative product and stress-resistant microorganism
GR3033866T3 (en) H. pylori fermentation process
BR9703055A (en) Biotin fermentative production
AU4631797A (en) A process for the production of aspartic acid condensate
AU1157092A (en) Method of preparing dulcite form lactose

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20010202

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

RIC1 Information provided on ipc code assigned before grant

Ipc: 7C 07D 311/72 B

Ipc: 7C 07D 303/04 B

Ipc: 7C 07C 45/41 B

Ipc: 7C 12P 1/02 A

A4 Supplementary search report drawn up and despatched

Effective date: 20050621

17Q First examination report despatched

Effective date: 20050929

17Q First examination report despatched

Effective date: 20050929

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20080307