EP0975969A4 - Methods for screening compounds using encapsulated cells - Google Patents

Methods for screening compounds using encapsulated cells

Info

Publication number
EP0975969A4
EP0975969A4 EP98911863A EP98911863A EP0975969A4 EP 0975969 A4 EP0975969 A4 EP 0975969A4 EP 98911863 A EP98911863 A EP 98911863A EP 98911863 A EP98911863 A EP 98911863A EP 0975969 A4 EP0975969 A4 EP 0975969A4
Authority
EP
European Patent Office
Prior art keywords
methods
screening compounds
encapsulated cells
encapsulated
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98911863A
Other languages
German (de)
French (fr)
Other versions
EP0975969A1 (en
Inventor
Nicole M Nasby
Todd C Peterson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chromaxome Corp
Original Assignee
Chromaxome Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chromaxome Corp filed Critical Chromaxome Corp
Publication of EP0975969A1 publication Critical patent/EP0975969A1/en
Publication of EP0975969A4 publication Critical patent/EP0975969A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/36—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Actinomyces; from Streptomyces (G)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP98911863A 1997-03-18 1998-03-18 Methods for screening compounds using encapsulated cells Withdrawn EP0975969A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4088897P 1997-03-18 1997-03-18
US40888P 1997-03-18
US7104698P 1998-01-13 1998-01-13
US71046P 1998-01-13
PCT/US1998/005462 WO1998041869A1 (en) 1997-03-18 1998-03-18 Methods for screening compounds using encapsulated cells

Publications (2)

Publication Number Publication Date
EP0975969A1 EP0975969A1 (en) 2000-02-02
EP0975969A4 true EP0975969A4 (en) 2002-07-31

Family

ID=26717558

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98911863A Withdrawn EP0975969A4 (en) 1997-03-18 1998-03-18 Methods for screening compounds using encapsulated cells

Country Status (4)

Country Link
EP (1) EP0975969A4 (en)
AU (1) AU6571598A (en)
CA (1) CA2284066A1 (en)
WO (1) WO1998041869A1 (en)

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US20030215798A1 (en) * 1997-06-16 2003-11-20 Diversa Corporation High throughput fluorescence-based screening for novel enzymes
EP1801214B1 (en) 1997-07-07 2010-11-10 Medical Research Council In vitro sorting method
GB9900298D0 (en) * 1999-01-07 1999-02-24 Medical Res Council Optical sorting method
IT1318605B1 (en) * 2000-06-30 2003-08-27 Uni Degli Studi Di Modena E Re PROCESS FOR THE DOSAGE OF TOXINS DSP OF THE DYNOPHYSITOSSINE GROUP AND YESSOTTOSSINS.
US8008459B2 (en) 2001-01-25 2011-08-30 Evolva Sa Concatemers of differentially expressed multiple genes
ATE501251T1 (en) 2001-01-25 2011-03-15 Evolva Ltd CELL LIBRARY
GB0127564D0 (en) 2001-11-16 2002-01-09 Medical Res Council Emulsion compositions
FR2842747B1 (en) * 2002-07-23 2004-10-15 Commissariat Energie Atomique METHOD AND DEVICE FOR SCREENING MOLECULES IN CELLS
CA2513889A1 (en) 2003-01-29 2004-08-19 454 Corporation Double ended sequencing
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
US20100022414A1 (en) 2008-07-18 2010-01-28 Raindance Technologies, Inc. Droplet Libraries
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
WO2005010145A2 (en) 2003-07-05 2005-02-03 The Johns Hopkins University Method and compositions for detection and enumeration of genetic variations
US7459294B2 (en) 2003-08-08 2008-12-02 Kosan Biosciences Incorporated Method of producing a compound by fermentation
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
AU2006335290A1 (en) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
EP4190448A3 (en) 2006-05-11 2023-09-20 Bio-Rad Laboratories, Inc. Microfluidic devices
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
WO2008021123A1 (en) 2006-08-07 2008-02-21 President And Fellows Of Harvard College Fluorocarbon emulsion stabilizing surfactants
WO2008097559A2 (en) 2007-02-06 2008-08-14 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
WO2010003086A1 (en) 2008-07-02 2010-01-07 University Of Wyoming Methods for natural product optimization
US8528589B2 (en) 2009-03-23 2013-09-10 Raindance Technologies, Inc. Manipulation of microfluidic droplets
US10520500B2 (en) 2009-10-09 2019-12-31 Abdeslam El Harrak Labelled silica-based nanomaterial with enhanced properties and uses thereof
US10837883B2 (en) 2009-12-23 2020-11-17 Bio-Rad Laboratories, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
EP2534267B1 (en) 2010-02-12 2018-04-11 Raindance Technologies, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
EP2622103B2 (en) 2010-09-30 2022-11-16 Bio-Rad Laboratories, Inc. Sandwich assays in droplets
MX2013008062A (en) * 2011-01-28 2013-08-09 Amyris Inc Gel-encapsulated microcolony screening.
EP2673614B1 (en) 2011-02-11 2018-08-01 Raindance Technologies, Inc. Method for forming mixed droplets
EP3736281A1 (en) 2011-02-18 2020-11-11 Bio-Rad Laboratories, Inc. Compositions and methods for molecular labeling
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
DE202012013668U1 (en) 2011-06-02 2019-04-18 Raindance Technologies, Inc. enzyme quantification
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
ES2527256B1 (en) * 2013-06-20 2015-11-10 Biomedal S.L. QUICK DETERMINATION OF SUSCEPTIBILITY TO COMPOUNDS ANTIMICROBIALS
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
US11193176B2 (en) 2013-12-31 2021-12-07 Bio-Rad Laboratories, Inc. Method for detecting and quantifying latent retroviral RNA species
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
CN113166973A (en) 2018-10-08 2021-07-23 安伯斯顿生物科学股份有限公司 Compartmentalization assay for bispecific and multispecific biologies

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2159171A (en) * 1984-05-24 1985-11-27 Damon Biotech Inc Process for screening or selecting cells
WO1989010786A2 (en) * 1988-04-22 1989-11-16 Microdrop, Inc. Process for forming and using microdroplets
WO1994028119A1 (en) * 1993-05-21 1994-12-08 Smithkline Beecham P.L.C. Novel process and apparatus
WO1996034112A1 (en) * 1995-04-24 1996-10-31 Chromaxome Corp. Methods for generating and screening novel metabolic pathways

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4401755A (en) * 1981-01-29 1983-08-30 Massachusetts Institute Of Technology Process for measuring microbiologically active material
US4399219A (en) * 1981-01-29 1983-08-16 Massachusetts Institute Of Technology Process for isolating microbiologically active material
SE441009B (en) * 1982-03-08 1985-09-02 Kjell Nilsson WAY TO IMMOBILIZE LIVING BIOMATERIAL IN PEARLY POLYMERS
CA1196862A (en) * 1983-06-01 1985-11-19 Anthony M.F. Sun Microencapsulation of living tissue and cells
US4801529A (en) * 1985-06-18 1989-01-31 Brandeis University Methods for isolating mutant microoganisms using microcapsules coated with indicator material
ATE76331T1 (en) * 1987-02-25 1992-06-15 Hoechst Ag MICROENCAPSULATION OF BIOLOGICALLY ACTIVE MATERIAL.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2159171A (en) * 1984-05-24 1985-11-27 Damon Biotech Inc Process for screening or selecting cells
WO1989010786A2 (en) * 1988-04-22 1989-11-16 Microdrop, Inc. Process for forming and using microdroplets
WO1994028119A1 (en) * 1993-05-21 1994-12-08 Smithkline Beecham P.L.C. Novel process and apparatus
WO1996034112A1 (en) * 1995-04-24 1996-10-31 Chromaxome Corp. Methods for generating and screening novel metabolic pathways

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MC DANIEL R. ET AL.: "Engineered biosynthesis of novel polyketides.", SCIENCE, vol. 262, 3 December 1993 (1993-12-03), pages 1546 - 1550, XP000910221 *
RYAN C. ET AL.: "Rapid assay for mycobacterial growth and antibiotic susceptibility using gel microdrop encapsulation.", J. CLIN. MICROBIOL., vol. 33, no. 7, July 1995 (1995-07-01), pages 1720 - 1726, XP002190454 *
See also references of WO9841869A1 *

Also Published As

Publication number Publication date
AU6571598A (en) 1998-10-12
CA2284066A1 (en) 1998-09-24
WO1998041869A1 (en) 1998-09-24
EP0975969A1 (en) 2000-02-02

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