EP0616612A4 - Nuclease stable and binding competent oligomers and methods for their use. - Google Patents

Nuclease stable and binding competent oligomers and methods for their use.

Info

Publication number
EP0616612A4
EP0616612A4 EP93900169A EP93900169A EP0616612A4 EP 0616612 A4 EP0616612 A4 EP 0616612A4 EP 93900169 A EP93900169 A EP 93900169A EP 93900169 A EP93900169 A EP 93900169A EP 0616612 A4 EP0616612 A4 EP 0616612A4
Authority
EP
European Patent Office
Prior art keywords
methods
binding competent
nuclease stable
oligomers
competent oligomers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93900169A
Other languages
German (de)
French (fr)
Other versions
EP0616612A1 (en
Inventor
Sundaramoorthi Swaminathan
Robert J Jones
Mark Matteucci
John Munger
Jeff Pudlo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilead Sciences Inc
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of EP0616612A1 publication Critical patent/EP0616612A1/en
Publication of EP0616612A4 publication Critical patent/EP0616612A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6839—Triple helix formation or other higher order conformations in hybridisation assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
EP93900169A 1991-12-12 1992-12-11 Nuclease stable and binding competent oligomers and methods for their use. Withdrawn EP0616612A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80671091A 1991-12-12 1991-12-12
US806710 1991-12-12
PCT/US1992/010793 WO1993012135A1 (en) 1991-12-12 1992-12-11 Nuclease stable and binding competent oligomers and methods for their use

Publications (2)

Publication Number Publication Date
EP0616612A1 EP0616612A1 (en) 1994-09-28
EP0616612A4 true EP0616612A4 (en) 1995-01-11

Family

ID=25194664

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93900169A Withdrawn EP0616612A4 (en) 1991-12-12 1992-12-11 Nuclease stable and binding competent oligomers and methods for their use.

Country Status (3)

Country Link
EP (1) EP0616612A4 (en)
AU (1) AU3250093A (en)
WO (1) WO1993012135A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378825A (en) * 1990-07-27 1995-01-03 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs
EP0830368A1 (en) 1995-06-07 1998-03-25 Genta Incorporated Novel carbamate-based cationic lipids
US6331617B1 (en) 1996-03-21 2001-12-18 University Of Iowa Research Foundation Positively charged oligonucleotides as regulators of gene expression
US6274313B1 (en) 1996-03-21 2001-08-14 Pioneer-Hybrid International, Inc. Oligonucleotides with cationic phosphoramidate internucleoside linkages and methods of use
US8785409B2 (en) 2007-01-30 2014-07-22 Geron Corporation Compounds having anti-adhesive effects on cancer cells

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US327501A (en) 1885-09-29 Wet-grinding mill
US3282920A (en) * 1963-03-19 1966-11-01 Asahi Chemical Ind Method for producing 5'-nucleotides
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4415732A (en) 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes
DE3329892A1 (en) 1983-08-18 1985-03-07 Köster, Hubert, Prof. Dr., 2000 Hamburg METHOD FOR PRODUCING OLIGONUCLEOTIDES
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
ATE171185T1 (en) 1985-03-15 1998-10-15 Antivirals Inc POLYNUCLEOTIDE IMMUNOTESTING AGENTS AND METHODS
US4959463A (en) 1985-10-15 1990-09-25 Genentech, Inc. Intermediates
EP0476071A4 (en) 1989-06-05 1992-11-04 Gilead Sciences, Inc. Exonuclease-resistant oligonucleotides and methods for preparing the same
US5264562A (en) 1989-10-24 1993-11-23 Gilead Sciences, Inc. Oligonucleotide analogs with novel linkages
US5495009A (en) 1989-10-24 1996-02-27 Gilead Sciences, Inc. Oligonucleotide analogs containing thioformacetal linkages
US5177198A (en) 1989-11-30 1993-01-05 University Of N.C. At Chapel Hill Process for preparing oligoribonucleoside and oligodeoxyribonucleoside boranophosphates
US5470967A (en) 1990-04-10 1995-11-28 The Dupont Merck Pharmaceutical Company Oligonucleotide analogs with sulfamate linkages
EP0531436A4 (en) 1990-05-25 1993-06-16 Gilead Sciences, Inc. Sequence-specific nonphotoactivated crosslinking agents which bind to the major groove of duplex dna
JPH0874B2 (en) 1990-07-27 1996-01-10 アイシス・ファーマシューティカルス・インコーポレーテッド Nuclease-resistant, pyrimidine-modified oligonucleotides that detect and modulate gene expression
CA2092002A1 (en) 1990-09-20 1992-03-21 Mark Matteucci Modified internucleoside linkages
AU669103B2 (en) 1990-10-26 1996-05-30 Genta Incorporated Improved process for the synthesis of oligomers
WO1992009705A1 (en) 1990-11-23 1992-06-11 Gilead Sciences, Inc. Triplex-forming oligomers containing modified bases
WO1992014842A1 (en) 1991-02-21 1992-09-03 Gilead Sciences, Inc. Aptamers specific for thrombin and methods of use
IE920562A1 (en) 1991-02-21 1992-08-26 Gilead Sciences Aptamer specific for biomolecules and method of making
DK51092D0 (en) 1991-05-24 1992-04-15 Ole Buchardt OLIGONUCLEOTIDE ANALOGUE DESCRIBED BY PEN, MONOMERIC SYNTHONES AND PROCEDURES FOR PREPARING THEREOF, AND APPLICATIONS THEREOF
WO1993009127A1 (en) 1991-11-07 1993-05-13 Gilead Sciences, Inc. Enhanced triple-helix formation directed by oligonucleotides composed of 2'-deoxy-7-deazaxanthosine and 2'-deoxy-7-deazaguanosine and related analogs
AU4525093A (en) 1992-05-28 1993-12-30 Gilead Sciences, Inc. Conformationally restrained oligomers containing amide or carbamate linkages for sequence-specific binding
US5817781A (en) 1992-06-01 1998-10-06 Gilead Sciences, Inc. Modified internucleoside linkages (II)
TWI515034B (en) 2013-09-16 2016-01-01 cheng wei Liu Magic blocks of dynamic fault-tolerant structures
KR20170023000A (en) 2014-06-20 2017-03-02 삼성전자주식회사 Method and device for transmitting prediction mode of depth image for interlayer video encoding and decoding
US10881198B1 (en) 2020-03-09 2021-01-05 You Yun Ren Jia (Shenzhen) Service Co., Ltd. Sink shelf organizer

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
PRITCHARD A.E.: "Nucleic Acids Symposium Series No. 10", 1981, INFORMATION RETRIEVAL LIMITED, LONDON GB *
See also references of WO9312135A1 *
TANIMURA H. ET AL, CHEMISTRY LETTERS, 1987, TOKYO JP, pages 1057 - 1060 *

Also Published As

Publication number Publication date
AU3250093A (en) 1993-07-19
EP0616612A1 (en) 1994-09-28
WO1993012135A1 (en) 1993-06-24

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