EP0523141A4 - Substituted pyrazoles, isoxazoles and isothiazoles - Google Patents
Substituted pyrazoles, isoxazoles and isothiazolesInfo
- Publication number
- EP0523141A4 EP0523141A4 EP19910907490 EP91907490A EP0523141A4 EP 0523141 A4 EP0523141 A4 EP 0523141A4 EP 19910907490 EP19910907490 EP 19910907490 EP 91907490 A EP91907490 A EP 91907490A EP 0523141 A4 EP0523141 A4 EP 0523141A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- isothiazoles
- isoxazoles
- substituted pyrazoles
- pyrazoles
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50146990A | 1990-03-30 | 1990-03-30 | |
US501469 | 1990-03-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0523141A1 EP0523141A1 (en) | 1993-01-20 |
EP0523141A4 true EP0523141A4 (en) | 1993-04-21 |
Family
ID=23993680
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19910907490 Withdrawn EP0523141A4 (en) | 1990-03-30 | 1991-03-27 | Substituted pyrazoles, isoxazoles and isothiazoles |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0523141A4 (en) |
JP (1) | JPH05505822A (en) |
CA (1) | CA2079343A1 (en) |
WO (1) | WO1991015479A1 (en) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5591761A (en) * | 1993-05-20 | 1997-01-07 | Texas Biotechnology Corporation | Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5962490A (en) | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
GB9110623D0 (en) * | 1991-05-16 | 1991-07-03 | Glaxo Group Ltd | Chemical compounds |
AP254A (en) * | 1991-09-05 | 1993-05-05 | Glaxo Group Ltd | C-Linked pyrazole derivatives. |
WO1993005025A1 (en) * | 1991-09-06 | 1993-03-18 | Glaxo Group Limited | C-linked pyrazole derivatives |
GB2263638A (en) * | 1992-01-28 | 1993-08-04 | Merck & Co Inc | Substituted pyrazoles, isoxazoles and isothiazoles as neurotensin antagonists |
FR2687675B1 (en) * | 1992-01-31 | 1997-04-18 | Roussel Uclaf | NOVEL BICYCLIC PYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THE NEW INTERMEDIATES OBTAINED, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
US5326776A (en) * | 1992-03-02 | 1994-07-05 | Abbott Laboratories | Angiotensin II receptor antagonists |
US5514696A (en) * | 1992-05-06 | 1996-05-07 | Bristol-Myers Squibb Co. | Phenyl sulfonamide endothelin antagonists |
JPH06239859A (en) * | 1992-09-14 | 1994-08-30 | Takeda Chem Ind Ltd | Cyclic compound having angiotensin i antagonism and its use |
ATE204276T1 (en) * | 1992-12-22 | 2001-09-15 | Takeda Chemical Industries Ltd | HETEROCYCLIC COMPOUNDS HAVING ANGIOTENSIN II ANTAGONISTIC ACTION AND THEIR APPLICATION |
JP3412887B2 (en) * | 1992-12-22 | 2003-06-03 | 武田薬品工業株式会社 | Heterocyclic compounds having angiotensin II antagonistic activity and uses thereof |
US5262412A (en) * | 1993-03-10 | 1993-11-16 | Merck & Co., Inc. | Substituted pyrazoles, compositions and use |
US6376523B1 (en) | 1994-05-20 | 2002-04-23 | Texas Biotechnology Corporation | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
US6541498B2 (en) | 1993-05-20 | 2003-04-01 | Texas Biotechnology | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
US5612359A (en) * | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
US5780473A (en) * | 1995-02-06 | 1998-07-14 | Bristol-Myers Squibb Company | Substituted biphenyl sulfonamide endothelin antagonists |
US5760038A (en) * | 1995-02-06 | 1998-06-02 | Bristol-Myers Squibb Company | Substituted biphenyl sulfonamide endothelin antagonists |
US5846990A (en) * | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
JPH09124620A (en) | 1995-10-11 | 1997-05-13 | Bristol Myers Squibb Co | Substituted biphenylsulfonamide endothelin antagonist |
US5856507A (en) * | 1997-01-21 | 1999-01-05 | Bristol-Myers Squibb Co. | Methods for the preparation of biphenyl isoxazole sulfonamides |
HUP0002351A3 (en) | 1996-02-20 | 2001-10-29 | Bristol Myers Squibb Co | Methods for the preparation of biphenyl isoxazole sulfonamides, intermediates and process for preparing them |
US5939446A (en) * | 1996-04-09 | 1999-08-17 | Bristol-Myers Squibb Co. | Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists |
US6297198B1 (en) | 1996-05-14 | 2001-10-02 | Syngenta Participations Ag | Isoxazole derivatives and their use as herbicides |
TW536540B (en) * | 1997-01-30 | 2003-06-11 | Bristol Myers Squibb Co | Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe |
AU6187898A (en) * | 1997-01-30 | 1998-08-25 | Bristol-Myers Squibb Company | Method for preventing or treating low renin hypertension by administering an endothelin antagonist |
US6638937B2 (en) | 1998-07-06 | 2003-10-28 | Bristol-Myers Squibb Co. | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
DE69940958D1 (en) | 1998-12-23 | 2009-07-16 | Glaxo Group Ltd | DETERMINATION METHOD FOR LIGANDS OF NUCLEAR RECEPTORS |
WO2000056685A1 (en) | 1999-03-19 | 2000-09-28 | Bristol-Myers Squibb Company | Methods for the preparation of biphenyl isoxazole sulfonamides |
SE9903028D0 (en) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
NZ519717A (en) | 1999-12-31 | 2003-06-30 | Texas Biotechnology Corp | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
GB0225548D0 (en) | 2002-11-01 | 2002-12-11 | Glaxo Group Ltd | Compounds |
MX354786B (en) | 2007-06-04 | 2018-03-21 | Synergy Pharmaceuticals Inc | AGONISTS OF GUANYLATE CYCLASE USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS, INFLAMMATION, CANCER and OTHER DISORDERS. |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
ES2627848T3 (en) | 2008-06-04 | 2017-07-31 | Synergy Pharmaceuticals Inc. | Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
ES2624828T3 (en) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer and others |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
US9486494B2 (en) | 2013-03-15 | 2016-11-08 | Synergy Pharmaceuticals, Inc. | Compositions useful for the treatment of gastrointestinal disorders |
EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
KR102272746B1 (en) | 2013-06-05 | 2021-07-08 | 보슈 헬스 아일랜드 리미티드 | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
AU2019387370A1 (en) | 2018-11-30 | 2021-06-10 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0446062A1 (en) * | 1990-03-09 | 1991-09-11 | Glaxo Group Limited | C-Linked pyrazole derivatives |
EP0449699A2 (en) * | 1990-03-19 | 1991-10-02 | Laboratoires Upsa | Pyrazole derivatives as angiotensin II-receptor antagonists, process for their preparation and pharmaceutical compositions containing them |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2823011A1 (en) * | 1978-05-26 | 1979-11-29 | Wacker Chemie Gmbh | TO ELASTOMER CROSSLINKABLE DIMENSIONS |
-
1991
- 1991-03-27 WO PCT/US1991/001952 patent/WO1991015479A1/en not_active Application Discontinuation
- 1991-03-27 JP JP91507326A patent/JPH05505822A/en active Pending
- 1991-03-27 CA CA002079343A patent/CA2079343A1/en not_active Abandoned
- 1991-03-27 EP EP19910907490 patent/EP0523141A4/en not_active Withdrawn
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0446062A1 (en) * | 1990-03-09 | 1991-09-11 | Glaxo Group Limited | C-Linked pyrazole derivatives |
EP0449699A2 (en) * | 1990-03-19 | 1991-10-02 | Laboratoires Upsa | Pyrazole derivatives as angiotensin II-receptor antagonists, process for their preparation and pharmaceutical compositions containing them |
Non-Patent Citations (1)
Title |
---|
See also references of WO9115479A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO1991015479A1 (en) | 1991-10-17 |
EP0523141A1 (en) | 1993-01-20 |
CA2079343A1 (en) | 1991-10-01 |
JPH05505822A (en) | 1993-08-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19920923 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): CH DE FR GB IT LI NL |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19930303 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): CH DE FR GB IT LI NL |
|
17Q | First examination report despatched |
Effective date: 19950210 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19950822 |