EA201792000A1 - GRELIN-O-ACYLTRANSFERASE INHIBITORS - Google Patents

GRELIN-O-ACYLTRANSFERASE INHIBITORS

Info

Publication number
EA201792000A1
EA201792000A1 EA201792000A EA201792000A EA201792000A1 EA 201792000 A1 EA201792000 A1 EA 201792000A1 EA 201792000 A EA201792000 A EA 201792000A EA 201792000 A EA201792000 A EA 201792000A EA 201792000 A1 EA201792000 A1 EA 201792000A1
Authority
EA
Eurasian Patent Office
Prior art keywords
grelin
acyltransferase inhibitors
inhibitors
acyltransferase
salts
Prior art date
Application number
EA201792000A
Other languages
Russian (ru)
Inventor
Кристофер Стэнли Галка
Эрик Джеймс Хембр
Николас Аллан Хонигшмидт
Стейси Джо Кединг
Мария Анджелес Мартинез-Грау
Джема Руано Плаза
Алмудена Рубио
Дарил Линн Смит
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA201792000A1 publication Critical patent/EA201792000A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

В данном изобретении представлены новые ингибиторы GOAT и их соли, а также их фармацевтические композиции.The present invention presents new GOAT inhibitors and their salts, as well as their pharmaceutical compositions.

EA201792000A 2015-04-15 2016-04-13 GRELIN-O-ACYLTRANSFERASE INHIBITORS EA201792000A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15382182 2015-04-15
PCT/US2016/027180 WO2016168225A1 (en) 2015-04-15 2016-04-13 Ghrelin o-acyl transferase inhibitors

Publications (1)

Publication Number Publication Date
EA201792000A1 true EA201792000A1 (en) 2018-02-28

Family

ID=52991670

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201792000A EA201792000A1 (en) 2015-04-15 2016-04-13 GRELIN-O-ACYLTRANSFERASE INHIBITORS

Country Status (16)

Country Link
US (1) US10227310B2 (en)
EP (1) EP3283474B1 (en)
JP (1) JP6462151B2 (en)
KR (1) KR20170123694A (en)
CN (1) CN107454898B (en)
AR (1) AR104673A1 (en)
AU (1) AU2016247964A1 (en)
BR (1) BR112017018342A2 (en)
CA (1) CA2977837A1 (en)
EA (1) EA201792000A1 (en)
ES (1) ES2773994T3 (en)
IL (1) IL254021A0 (en)
MX (1) MX2017013072A (en)
TW (1) TWI592407B (en)
WO (1) WO2016168225A1 (en)
ZA (1) ZA201705678B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA037277B1 (en) 2016-08-05 2021-03-03 Бёрингер Ингельхайм Интернациональ Гмбх Oxadiazolopyridine derivates for use as ghrelin o-acyl transferase (goat) inhibitors
SG11202006302TA (en) 2018-02-02 2020-07-29 Boehringer Ingelheim Int Triazolopyrimidine derivatives for use as ghrelin o-acyl transferase (goat) inhibitors
MX2020008053A (en) 2018-02-02 2020-09-07 Boehringer Ingelheim Int Benzyl-, (pyridin-3-yl)methyl- or (pyridin-4-yl)methyl-substitute d oxadiazolopyridine derivatives as ghrelin o-acyl transferase (goat) inhibitors.
PE20210175A1 (en) 2018-02-02 2021-01-29 Boehringer Ingelheim Int OXADIAZOLOPYRIDINE DERIVATIVES REPLACED WITH HETEROCYCLYL FOR USE AS GHRELIN O-ACILTRANSFERASE (GOAT) INHIBITORS
JP7225253B2 (en) 2018-02-02 2023-02-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Pyrazole- and indazole-substituted oxadiazolopyridine derivatives for use as ghrelin O-acyltransferase (GOAT) inhibitors
WO2021233884A1 (en) 2020-05-22 2021-11-25 Boehringer Ingelheim International Gmbh Continuous process for manufacturing alkyl 7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridine-carboxylate
JP2023526351A (en) 2020-05-22 2023-06-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Method for producing alkyl 7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridine carboxylate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1670827A2 (en) 2003-09-05 2006-06-21 Eli Lilly And Company Anti-ghrelin antibodies
US20050070712A1 (en) * 2003-09-26 2005-03-31 Christi Kosogof Pyrimidine derivatives as ghrelin receptor modulators
KR20070034583A (en) 2004-07-14 2007-03-28 일라이 릴리 앤드 캄파니 Anti-ghrelin antibodies
EP1814916A2 (en) 2004-11-15 2007-08-08 Eli Lilly And Company Desacyl ghrelin antibodies and therapeutic uses thereof
US7479271B2 (en) 2005-02-23 2009-01-20 Eli Lilly And Company Humanized anti-ghrelin antibodies
US9238639B2 (en) 2012-02-24 2016-01-19 Takeda Pharmaceutical Company Limited Aromatic ring compound
UA118034C2 (en) 2013-11-14 2018-11-12 Елі Ліллі Енд Компані Substituted piperidyl-ethyl-pyrimidine as ghrelin o-acyl transferase inhibitor

Also Published As

Publication number Publication date
AU2016247964A1 (en) 2017-09-14
CA2977837A1 (en) 2016-10-20
WO2016168225A1 (en) 2016-10-20
CN107454898A (en) 2017-12-08
US20180079729A1 (en) 2018-03-22
JP2018511632A (en) 2018-04-26
ZA201705678B (en) 2019-07-31
US10227310B2 (en) 2019-03-12
JP6462151B2 (en) 2019-01-30
ES2773994T3 (en) 2020-07-16
AR104673A1 (en) 2017-08-09
CN107454898B (en) 2020-05-05
MX2017013072A (en) 2017-12-04
EP3283474A1 (en) 2018-02-21
IL254021A0 (en) 2017-10-31
EP3283474B1 (en) 2019-12-18
TWI592407B (en) 2017-07-21
BR112017018342A2 (en) 2018-04-17
KR20170123694A (en) 2017-11-08
TW201710249A (en) 2017-03-16

Similar Documents

Publication Publication Date Title
EA201890749A1 (en) ACETHYL-COA-CARBOXYLASE INHIBITORS (ACC) AND THEIR APPLICATION
CY1124215T1 (en) MK2 INHIBITORS AND THEIR USES
EA201891024A1 (en) TANK-BINDING KINASE INHIBITOR COMPOUNDS
EA201890493A1 (en) Htt repressors and their use
EA201690764A1 (en) INHIBITOR GRELIN-O-Aciltransferase
EA202092435A3 (en) MONOCLONAL ANTIBODIES AGAINST BCMA
EA201692203A1 (en) TANK-BINDING KINAZ INHIBITING COMPOUNDS
EA201891211A1 (en) CXCR2 INHIBITORS
EA201791992A1 (en) GRELIN-O-ACYLTRANSFERASE INHIBITORS
EA201591420A1 (en) Heteroaryl Compounds and Their Use
EA201591137A1 (en) MK2 INHIBITORS AND THEIR APPLICATIONS
EA201591961A1 (en) ACC INHIBITORS AND THEIR APPLICATION
EA201792000A1 (en) GRELIN-O-ACYLTRANSFERASE INHIBITORS
EA201591959A1 (en) ACC INHIBITORS AND THEIR APPLICATION
EA201591960A1 (en) ACC INHIBITORS AND THEIR APPLICATION
EA201591728A1 (en) HETEROCYCLIC COMPOUNDS AND METHODS OF THEIR APPLICATION
EA201792021A1 (en) JAK INHIBITOR
EA202091397A1 (en) BENZOQUINOLONE VMAT2 INHIBITORS
EA201591962A1 (en) ACC INHIBITORS AND THEIR APPLICATION
EA201791454A1 (en) DRUG FORMS FOR TRANSDERMAL ADMINISTRATION
CY1124338T1 (en) 3-PHOSPHOGLYCERATE DEHYDROGENATION INHIBITORS AND THEIR USES
EA201792262A1 (en) PIROGLUTAMAT VORTIOKSETINA
EA201790312A1 (en) COMBINATION OF MEDICINES FOR THE TREATMENT OF MULTIPLE MYELOMA
EA201890364A1 (en) COMPOUNDS SUITABLE FOR INHIBITING ROR-GAMMA-t
CY1122578T1 (en) PHARMACEUTICAL PREPARATION COMPRISING AN ANTIBODY