EA201391632A1 - AMINO ACID SEQUENCES ARE DIRECTED AGAINST IL-17A, IL-17F AND / OR IL-17A / F AND CONTAINING THEIR POLYPEPTIDES - Google Patents

AMINO ACID SEQUENCES ARE DIRECTED AGAINST IL-17A, IL-17F AND / OR IL-17A / F AND CONTAINING THEIR POLYPEPTIDES

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Publication number
EA201391632A1
EA201391632A1 EA201391632A EA201391632A EA201391632A1 EA 201391632 A1 EA201391632 A1 EA 201391632A1 EA 201391632 A EA201391632 A EA 201391632A EA 201391632 A EA201391632 A EA 201391632A EA 201391632 A1 EA201391632 A1 EA 201391632A1
Authority
EA
Eurasian Patent Office
Prior art keywords
amino acid
acid sequences
polypeptides
directed against
compounds
Prior art date
Application number
EA201391632A
Other languages
Russian (ru)
Other versions
EA035973B9 (en
EA035973B1 (en
Inventor
Хейди Роммеларе
Йост Александер Колкман
Майкл Джон Скотт Сондерс
Анн Юньон
Йоланд Шватшко
Аманда Е.и. Праудфут
Ален Викари
Дени Брюникель
Лоран Шевале
Оливье Лежер
Original Assignee
Мерк Патент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of EA201391632A1 publication Critical patent/EA201391632A1/en
Publication of EA035973B1 publication Critical patent/EA035973B1/en
Publication of EA035973B9 publication Critical patent/EA035973B9/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Изобретение относится к аминокислотным последовательностям, направленным против (как определено в настоящем документе) любого из IL-17A, IL-17F и/или IL-17A/F, включая их сочетания, а также к соединениям или конструкциям и, в частности, белкам и полипептидам, которые содержат или, по существу, состоят из одной или нескольких таких аминокислотных последовательностей (также обозначаемых в настоящем документе как "аминокислотные последовательности по изобретению", "соединения по изобретению" и "полипептиды по изобретению", соответственно).The invention relates to amino acid sequences directed against (as defined herein) any of IL-17A, IL-17F and / or IL-17A / F, including combinations thereof, as well as compounds or constructs and, in particular, proteins and polypeptides that contain or essentially consist of one or more of these amino acid sequences (also referred to herein as "amino acid sequences of the invention", "compounds of the invention" and "polypeptides of the invention", respectively).

EA201391632A 2011-05-05 2012-05-04 Amino acid sequences directed against il-17a, il-17f and/or il-17a/f and polypeptides comprising the same EA035973B9 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161482802P 2011-05-05 2011-05-05
PCT/EP2012/058313 WO2012156219A1 (en) 2011-05-05 2012-05-04 Amino acid sequences directed against il-17a, il-17f and/or il17-a/f and polypeptides comprising the same

Publications (3)

Publication Number Publication Date
EA201391632A1 true EA201391632A1 (en) 2014-07-30
EA035973B1 EA035973B1 (en) 2020-09-08
EA035973B9 EA035973B9 (en) 2021-03-30

Family

ID=46245559

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201391632A EA035973B9 (en) 2011-05-05 2012-05-04 Amino acid sequences directed against il-17a, il-17f and/or il-17a/f and polypeptides comprising the same

Country Status (24)

Country Link
US (4) US10017568B2 (en)
EP (3) EP4105231A1 (en)
JP (4) JP6628965B2 (en)
KR (1) KR102083230B1 (en)
CN (2) CN103717618B (en)
AU (1) AU2012257942B8 (en)
BR (1) BR112013028407B1 (en)
CA (1) CA2834907C (en)
CL (1) CL2013003090A1 (en)
DK (1) DK2705058T3 (en)
EA (1) EA035973B9 (en)
ES (1) ES2662371T3 (en)
HR (1) HRP20180380T1 (en)
HU (1) HUE037225T2 (en)
IL (1) IL228813B (en)
LT (1) LT2705058T (en)
MX (1) MX2013012844A (en)
MY (1) MY167231A (en)
NZ (1) NZ616761A (en)
PT (1) PT2705058T (en)
SG (2) SG194632A1 (en)
SI (1) SI2705058T1 (en)
UA (1) UA117218C2 (en)
WO (1) WO2012156219A1 (en)

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UA117218C2 (en) 2011-05-05 2018-07-10 Мерк Патент Гмбх Amino acid sequences directed against il-17a, il-17f and/or il17-a/f and polypeptides comprising the same
US10526384B2 (en) 2012-11-19 2020-01-07 Pieris Pharmaceuticals Gmbh Interleukin-17A-specific and interleukin-23-specific binding polypeptides and uses thereof
FR3007411B1 (en) * 2013-06-21 2015-07-03 Agronomique Inst Nat Rech MONOCATENARY ANTIBODY TO CAMPHIDE HEAVY CHAIN AGAINST CHROMATIN AND USES THEREOF
AU2015218631A1 (en) 2014-02-21 2016-08-11 Genentech, Inc. Anti-IL-13/IL-17 bispecific antibodies and uses thereof
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CN117642423A (en) * 2021-09-13 2024-03-01 深圳华普药物研发有限公司 IL17 antibody and preparation method and application thereof
CN114380906B (en) * 2022-03-25 2022-06-14 南京融捷康生物科技有限公司 anti-IL-17A single-domain antibody and application thereof
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