EA201300759A1 - Новые производные nip тиазола в качестве ингибиторов 11-бета-гидроксистероид дегидрогеназы-1 - Google Patents

Новые производные nip тиазола в качестве ингибиторов 11-бета-гидроксистероид дегидрогеназы-1

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Publication number
EA201300759A1
EA201300759A1 EA201300759A EA201300759A EA201300759A1 EA 201300759 A1 EA201300759 A1 EA 201300759A1 EA 201300759 A EA201300759 A EA 201300759A EA 201300759 A EA201300759 A EA 201300759A EA 201300759 A1 EA201300759 A1 EA 201300759A1
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EA
Eurasian Patent Office
Prior art keywords
beta
hydroxysteroid dehydrogenase
inhibitors
thiazole
nip
Prior art date
Application number
EA201300759A
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English (en)
Inventor
Каролине Лериш
Денис Карньато
Дидье Роше
Кристине Шарон
Лильяне Доаре
Original Assignee
Мерк Патент Гмбх
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Publication date
Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of EA201300759A1 publication Critical patent/EA201300759A1/ru

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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Abstract

Настоящее изобретение относится к производным NIP тиазола формулы (I)в качестве селективных ингибиторов фермента 11-бета-гидроксистероид дегидрогеназа 1 типа (11-β-HSD-1) и к применению таких соединений для лечения и предотвращения метаболического синдрома, диабета, резистентности к инсулину, ожирения, нарушения обмена липидов, глаукомы, остеопороза, нарушений познавательной способности, тревоги, депрессии, иммунных нарушений, гипертонии и других заболеваний и состояний.
EA201300759A 2008-05-05 2009-04-08 Новые производные nip тиазола в качестве ингибиторов 11-бета-гидроксистероид дегидрогеназы-1 EA201300759A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08290424 2008-05-05

Publications (1)

Publication Number Publication Date
EA201300759A1 true EA201300759A1 (ru) 2013-11-29

Family

ID=40935480

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201300759A EA201300759A1 (ru) 2008-05-05 2009-04-08 Новые производные nip тиазола в качестве ингибиторов 11-бета-гидроксистероид дегидрогеназы-1
EA201001737A EA018920B1 (ru) 2008-05-05 2009-04-08 Производные тиазола в качестве ингибиторов 11-бета-гидроксистероид дегидрогеназы-1

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201001737A EA018920B1 (ru) 2008-05-05 2009-04-08 Производные тиазола в качестве ингибиторов 11-бета-гидроксистероид дегидрогеназы-1

Country Status (18)

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US (1) US8546575B2 (ru)
EP (1) EP2271405B1 (ru)
JP (1) JP5735412B2 (ru)
KR (1) KR101604366B1 (ru)
CN (1) CN102015026B (ru)
AR (1) AR072666A1 (ru)
AU (1) AU2009243812B2 (ru)
BR (1) BRPI0911497B8 (ru)
CA (1) CA2723431C (ru)
CO (1) CO6331305A2 (ru)
EA (2) EA201300759A1 (ru)
EC (1) ECSP10010656A (ru)
ES (1) ES2432383T3 (ru)
IL (1) IL208989A (ru)
MX (1) MX2010011917A (ru)
NZ (1) NZ589691A (ru)
WO (1) WO2009135581A2 (ru)
ZA (1) ZA201008723B (ru)

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WO2008145596A1 (en) * 2007-06-01 2008-12-04 F. Hoffmann-La Roche Ag Piperidine-amide derivatives
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
JP6354757B2 (ja) 2013-07-09 2018-07-11 小野薬品工業株式会社 Ａｌｘｒ作動化合物
CN104910083A (zh) * 2015-07-13 2015-09-16 佛山市赛维斯医药科技有限公司 烷氧苯基三氮唑亚砜类11β-HSD1抑制剂、制备方法及其用途
CN104910084A (zh) * 2015-07-13 2015-09-16 佛山市赛维斯医药科技有限公司 末端胺基取代的三氮唑亚砜类化合物、其制备方法及其用途
EP3235813A1 (en) 2016-04-19 2017-10-25 Cidqo 2012, S.L. Aza-tetra-cyclo derivatives
CN111655687A (zh) * 2017-09-08 2020-09-11 Pi工业有限公司 新型杀真菌杂环化合物

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* Cited by examiner, † Cited by third party
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US7754709B2 (en) * 2003-06-10 2010-07-13 Solvay Pharmaceuticals Bv Tetracyclic thiophenepyrimidinone compounds as inhibitors of 17β hydroxysteroid dehydrogenase compounds
US20070231263A1 (en) 2004-04-13 2007-10-04 Jun Qiu Human G protein-coupled receptor and modulators thereof for the treatment of hyperglycemia and related disorders
EP1637529A1 (en) 2004-09-20 2006-03-22 4Sc Ag Novel piperidin-4-yl-thiazole-carboxamide analogues as inhibitors of T-cell proliferation and uses thereof
DE102006010923A1 (de) * 2006-03-09 2007-09-13 Saltigo Gmbh Verfahren zur Herstellung von Chlor-1,4-dimethoxybenzol
BRPI0709595A2 (pt) * 2006-03-15 2011-07-19 4Sc Ag inibidores de nf-kapab heterocìclicos
CN101405278A (zh) * 2006-03-15 2009-04-08 4Sc股份公司 新颖的杂环NF-κB抑制剂

Also Published As

Publication number Publication date
EP2271405A2 (en) 2011-01-12
CA2723431A1 (en) 2009-11-12
US8546575B2 (en) 2013-10-01
AU2009243812A1 (en) 2009-11-12
BRPI0911497B8 (pt) 2021-05-25
KR101604366B1 (ko) 2016-03-17
JP2011521907A (ja) 2011-07-28
EA018920B1 (ru) 2013-11-29
CA2723431C (en) 2016-11-22
WO2009135581A3 (en) 2010-08-19
EA201001737A1 (ru) 2011-06-30
IL208989A0 (en) 2011-01-31
ECSP10010656A (es) 2011-01-31
CN102015026A (zh) 2011-04-13
WO2009135581A9 (en) 2010-11-11
IL208989A (en) 2014-01-30
US20110060007A1 (en) 2011-03-10
NZ589691A (en) 2012-11-30
WO2009135581A2 (en) 2009-11-12
MX2010011917A (es) 2010-11-26
BRPI0911497A2 (pt) 2019-01-15
ZA201008723B (en) 2012-01-25
AU2009243812B2 (en) 2014-06-05
EP2271405B1 (en) 2013-07-24
BRPI0911497B1 (pt) 2021-01-26
CO6331305A2 (es) 2011-10-20
JP5735412B2 (ja) 2015-06-17
ES2432383T3 (es) 2013-12-03
CN102015026B (zh) 2015-11-25
KR20110004468A (ko) 2011-01-13
AR072666A1 (es) 2010-09-15

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