EA200900811A1 - Имидазолы в качестве ингибиторов альдостеронсинтазы - Google Patents
Имидазолы в качестве ингибиторов альдостеронсинтазыInfo
- Publication number
- EA200900811A1 EA200900811A1 EA200900811A EA200900811A EA200900811A1 EA 200900811 A1 EA200900811 A1 EA 200900811A1 EA 200900811 A EA200900811 A EA 200900811A EA 200900811 A EA200900811 A EA 200900811A EA 200900811 A1 EA200900811 A1 EA 200900811A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compound
- cyp11b1
- aromatase
- hypertension
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Настоящее изобретение относится к соединению формулы (I)где указанное соединение является ингибитором альдостеронсинтазы (CYP11В2), и/или 11β-гидроксилазы (CYP11В1), и/или ароматазы и, таким образом, может использоваться для лечения нарушения или заболевания, опосредованного альдостеронсинтазой, ароматазой и/или CYP11B1. Соответственно, соединение формулы I может использоваться для лечения гипокалиемии, гипертензии, застойной сердечной недостаточности, почечной недостаточности, в частности хронической почечной недостаточности, рестеноза, атеросклероза, синдрома X, ожирения, нефропатии, постинфаркта миокарда, коронарной болезни, повышенного образования коллагена, фиброза и ремоделирования вследствие гипертензии и эндотелиальной дисфункции. Наконец, настоящее изобретение также относится к фармацевтической композиции.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87049906P | 2006-12-18 | 2006-12-18 | |
PCT/US2007/025556 WO2008076336A2 (en) | 2006-12-18 | 2007-12-14 | Imidazoles as aldosterone synthase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200900811A1 true EA200900811A1 (ru) | 2009-12-30 |
Family
ID=39232829
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200900811A EA200900811A1 (ru) | 2006-12-18 | 2007-12-14 | Имидазолы в качестве ингибиторов альдостеронсинтазы |
Country Status (11)
Country | Link |
---|---|
US (1) | US8436035B2 (ru) |
EP (2) | EP2213668A3 (ru) |
JP (1) | JP2010513482A (ru) |
KR (1) | KR20090091817A (ru) |
CN (1) | CN101605777A (ru) |
AU (1) | AU2007334416A1 (ru) |
BR (1) | BRPI0721284A2 (ru) |
CA (1) | CA2672269A1 (ru) |
EA (1) | EA200900811A1 (ru) |
MX (1) | MX2009006631A (ru) |
WO (1) | WO2008076336A2 (ru) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101605777A (zh) * | 2006-12-18 | 2009-12-16 | 诺瓦提斯公司 | 作为醛固酮合酶抑制剂的咪唑类化合物 |
EA200900812A1 (ru) | 2006-12-18 | 2009-12-30 | Новартис Аг | Производные 4-имидазолил-1,2,3,4-тетрагидрохинолина и их применение в качестве ингибиторов альдостерон/11-бета-гидроксилазы |
CA2761853A1 (en) * | 2009-05-15 | 2010-11-18 | Novartis Ag | Benzoxazolone derivatives as aldosterone synthase inhibitors |
KR101442897B1 (ko) | 2009-05-28 | 2014-09-23 | 노파르티스 아게 | 네프릴리신 억제제로서의 치환된 아미노프로피온산 유도체 |
KR20120041702A (ko) | 2009-05-28 | 2012-05-02 | 노파르티스 아게 | 네프릴리신 억제제로서의 치환된 아미노부티르산 유도체 |
JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
US20120130129A1 (en) * | 2010-11-16 | 2012-05-24 | Baylor University | Efficient Method for Preparing Functionalized Benzosuberenes |
US8673974B2 (en) | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
ES2683350T3 (es) | 2011-07-08 | 2018-09-26 | Novartis Ag | Método para tratar la aterosclerosis en sujetos con alto nivel de triglicéridos |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
SI2838883T1 (en) * | 2012-04-17 | 2018-02-28 | F. Hoffmann-La Roche Ag | New derivatives of phenyl-tetrahydroisoquinoline |
UY35144A (es) | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
PT2956464T (pt) | 2013-02-14 | 2018-07-04 | Novartis Ag | Derivados de ácido bisfenil butanóico fosfónico substituído como inibidores de nep (endopeptidase neutra |
AU2014293386B2 (en) | 2013-07-25 | 2016-11-17 | Novartis Ag | Cyclic polypeptides for the treatment of heart failure |
EP3024492A2 (en) | 2013-07-25 | 2016-06-01 | Novartis AG | Bioconjugates of synthetic apelin polypeptides |
EP3049084A4 (en) * | 2013-09-25 | 2017-03-15 | Cortendo AB (publ) | Novel functionalized 5-(phenoxymethyl)-1,3-dioxane analogs exhibitng cytochrome p450 inhibition |
CN104496870A (zh) * | 2014-12-25 | 2015-04-08 | 湖南大学 | 含硫羧酸化合物和含硫酰胺化合物的催化合成方法 |
SG11201704758XA (en) | 2015-01-23 | 2017-08-30 | Novartis Ag | Synthetic apelin fatty acid conjugates with improved half-life |
US20160287565A1 (en) | 2015-04-06 | 2016-10-06 | Millendo Therapeutics, Inc. | Combination therapy for treating disorders associated with excess cortisol production |
JOP20190086A1 (ar) | 2016-10-21 | 2019-04-18 | Novartis Ag | مشتقات نافثيريدينون جديدة واستخدامها في معالجة عدم انتظام ضربات القلب |
CN110582278B (zh) | 2017-03-10 | 2023-04-18 | 伊姆贝拉神经疗法公司 | 药物组合物及其用途 |
UY38072A (es) | 2018-02-07 | 2019-10-01 | Novartis Ag | Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos |
EP3887363A1 (en) | 2018-11-27 | 2021-10-06 | Novartis AG | Cyclic pentamer compounds as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorder |
EP3887388A1 (en) | 2018-11-27 | 2021-10-06 | Novartis AG | Cyclic peptides as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorders |
UY38485A (es) | 2018-11-27 | 2020-06-30 | Novartis Ag | Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9), método de tratamiento, uso y su preparación |
CN112079826B (zh) * | 2020-09-17 | 2022-07-29 | 广州中医药大学(广州中医药研究院) | 一类甾体合成酶抑制剂及其治疗应用 |
TW202333563A (zh) | 2021-11-12 | 2023-09-01 | 瑞士商諾華公司 | 用於治療疾病或障礙之二胺基環戊基吡啶衍生物 |
AR127698A1 (es) | 2021-11-23 | 2024-02-21 | Novartis Ag | Derivados de naftiridinona para el tratamiento de una enfermedad o un trastorno |
Family Cites Families (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1518330A (fr) * | 1966-04-14 | 1968-03-22 | Janssen Pharmaceutica Nv | Procédé de production de carboxylates d'imidazole et de leurs sels d'addition avec les acides |
US3485917A (en) * | 1966-04-14 | 1969-12-23 | Janssen Pharmaceutica Nv | Composition and method for combating fungus with imidazole carboxylates |
US4659730A (en) * | 1984-06-18 | 1987-04-21 | Eli Lilly And Company | Aromatase inhibiting imidazole derivatives |
GB8516573D0 (en) * | 1985-07-01 | 1985-08-07 | Janssen Pharmaceuticaa Nv | Controlling weeds |
US4813998A (en) * | 1986-02-27 | 1989-03-21 | Janssen Pharmaceutica N.V. | Herbicidal 1H-imidazole-5-carboxylic acid derivatives |
NZ219311A (en) * | 1986-02-27 | 1989-04-26 | Janssen Pharmaceutica Nv | Imidazoles and herbicidal compositions |
GB8630759D0 (en) * | 1986-12-23 | 1987-02-04 | Janssen Pharmaceutica Nv | Carboxylic acid derivatives |
EP0277384A3 (en) * | 1986-12-24 | 1990-05-23 | Janssen Pharmaceutica N.V. | 1h-imidazole-5-carboxylic acid derivatives |
US4878940A (en) * | 1987-04-02 | 1989-11-07 | Janssen Pharmaceutica N.V. | Herbicidal 1,5-substituted 1H-imidazoles |
EP0287512A3 (de) * | 1987-04-13 | 1990-11-22 | Ciba-Geigy Ag | Pflanzenwuchsregulatoren |
EP0305330A1 (de) * | 1987-08-25 | 1989-03-01 | Ciba-Geigy Ag | Imidazolderivate |
EP0305332A3 (de) * | 1987-08-26 | 1990-04-04 | Ciba-Geigy Ag | Imidazol-Derivate |
EP0314852B1 (de) * | 1987-11-06 | 1993-11-18 | Ciba-Geigy Ag | Verfahren zur Synthese von 1-substituierten Imidazol-5-carbonsäuren und -carbonsäure-derivaten |
EP0348343A3 (de) * | 1988-06-20 | 1991-08-28 | Ciba-Geigy Ag | Synergistisches Mittel und Verfahren zur selektiven Unkrautbekämpfung in Getreide, Mais und Reis |
WO1992011713A1 (en) * | 1990-12-21 | 1992-07-09 | Gte Service Corporation | Method for providing video programming nearly on demand |
IL117580A0 (en) * | 1995-03-29 | 1996-07-23 | Merck & Co Inc | Inhibitors of farnesyl-protein transferase and pharmaceutical compositions containing them |
US5969748A (en) * | 1996-05-29 | 1999-10-19 | Starsight Telecast, Inc. | Television schedule system with access control |
WO1998010589A1 (en) * | 1996-09-03 | 1998-03-12 | Starsight Telecast, Inc. | Schedule system with enhanced recording capability |
US6199076B1 (en) * | 1996-10-02 | 2001-03-06 | James Logan | Audio program player including a dynamic program selection controller |
US5982445A (en) * | 1996-10-21 | 1999-11-09 | General Instrument Corporation | Hypertext markup language protocol for television display and control |
AR020608A1 (es) * | 1998-07-17 | 2002-05-22 | United Video Properties Inc | Un metodo y una disposicion para suministrar a un usuario acceso remoto a una guia de programacion interactiva por un enlace de acceso remoto |
US6658469B1 (en) * | 1998-12-18 | 2003-12-02 | Microsoft Corporation | Method and system for switching between network transport providers |
US6680730B1 (en) * | 1999-01-25 | 2004-01-20 | Robert Shields | Remote control of apparatus using computer networks |
US7143430B1 (en) * | 1999-11-15 | 2006-11-28 | Lucent Technologies Inc. | Method and apparatus for remote audiovisual signal recording service |
US6763247B1 (en) * | 1999-12-01 | 2004-07-13 | Telefonaktiebolaget Lm Ericsson (Publ) | Portable telecommunication apparatus for controlling an electronic utility device |
US6968365B2 (en) * | 1999-12-01 | 2005-11-22 | Telefonaktiebolaget L M Ericsson (Publ) | Device and a method for operating an electronic utility device from a portable telecommunication apparatus |
US20020019984A1 (en) * | 2000-01-14 | 2002-02-14 | Rakib Selim Shlomo | Headend cherrypicker with digital video recording capability |
US20010047516A1 (en) * | 2000-02-01 | 2001-11-29 | Compaq Computer Corporation | System for time shifting live streamed video-audio distributed via the internet |
US20020046407A1 (en) * | 2000-02-18 | 2002-04-18 | Alexander Franco | Use of web pages to remotely program a broadcast content recording system |
US7117259B1 (en) * | 2000-03-03 | 2006-10-03 | International Business Machines Corporation | Server time window for multiple selectable servers in a graphical user interface |
US7143429B2 (en) * | 2000-06-02 | 2006-11-28 | Sony Corporation | Program information providing apparatus and method, program recording preset system and method, and program recording system and method |
US20020056114A1 (en) * | 2000-06-16 | 2002-05-09 | Fillebrown Lisa A. | Transmitter for a personal wireless network |
JP4576675B2 (ja) * | 2000-06-30 | 2010-11-10 | ソニー株式会社 | 制御システム、制御機器及びサーバ |
US6871063B1 (en) * | 2000-06-30 | 2005-03-22 | Intel Corporation | Method and apparatus for controlling access to a computer system |
US7349967B2 (en) * | 2000-07-21 | 2008-03-25 | Samsung Electronics Co., Ltd. | Architecture for home network on world wide web with private-public IP address/URL mapping |
US20020177453A1 (en) * | 2000-11-15 | 2002-11-28 | Ming-Feng Chen | Mobile device server |
US20040203592A1 (en) * | 2000-11-15 | 2004-10-14 | Motorola, Inc. | Introduction device, smart appliance and method of creating a federation thereof |
US20020103898A1 (en) * | 2001-01-31 | 2002-08-01 | Moyer Stanley L. | System and method for using session initiation protocol (SIP) to communicate with networked appliances |
US20020103850A1 (en) * | 2001-01-31 | 2002-08-01 | Moyer Stanley L. | System and method for out-sourcing the functionality of session initiation protocol (SIP) user agents to proxies |
US20040008972A1 (en) * | 2001-03-29 | 2004-01-15 | Koninklijke Philips Electronics N.V. | Personal TV receiver (PTR) with program recommendation forwarding function |
US8190670B2 (en) * | 2001-04-16 | 2012-05-29 | Microsoft Corporation | Web site cobrowsing |
US20020184635A1 (en) * | 2001-05-31 | 2002-12-05 | Istvan Anthony F. | Setting events for a set-top box using a browser-enabled device |
US6801604B2 (en) * | 2001-06-25 | 2004-10-05 | International Business Machines Corporation | Universal IP-based and scalable architectures across conversational applications using web services for speech and audio processing resources |
US7463615B2 (en) * | 2001-07-13 | 2008-12-09 | Qualcomm, Incorporated | System and method for extended SIP headers for CDMA parameters |
US6983312B1 (en) * | 2001-07-16 | 2006-01-03 | At&T Corp. | Method for using scheduled hyperlinks to record multimedia content |
RU2008142600A (ru) * | 2006-03-29 | 2010-05-10 | Новартис АГ (CH) | Органическое соединение |
TW200801513A (en) | 2006-06-29 | 2008-01-01 | Fermiscan Australia Pty Ltd | Improved process |
EP2094669A2 (en) | 2006-12-18 | 2009-09-02 | Novartis AG | 1-substituted imidazole derivatives and their use as aldosterone synthase inhibitors |
CN101605777A (zh) * | 2006-12-18 | 2009-12-16 | 诺瓦提斯公司 | 作为醛固酮合酶抑制剂的咪唑类化合物 |
EA200900812A1 (ru) * | 2006-12-18 | 2009-12-30 | Новартис Аг | Производные 4-имидазолил-1,2,3,4-тетрагидрохинолина и их применение в качестве ингибиторов альдостерон/11-бета-гидроксилазы |
-
2007
- 2007-12-14 CN CNA2007800513424A patent/CN101605777A/zh active Pending
- 2007-12-14 AU AU2007334416A patent/AU2007334416A1/en not_active Abandoned
- 2007-12-14 EP EP10160718A patent/EP2213668A3/en not_active Withdrawn
- 2007-12-14 KR KR1020097014924A patent/KR20090091817A/ko not_active Application Discontinuation
- 2007-12-14 BR BRPI0721284-4A patent/BRPI0721284A2/pt not_active IP Right Cessation
- 2007-12-14 US US12/519,697 patent/US8436035B2/en not_active Expired - Fee Related
- 2007-12-14 MX MX2009006631A patent/MX2009006631A/es not_active Application Discontinuation
- 2007-12-14 CA CA002672269A patent/CA2672269A1/en not_active Abandoned
- 2007-12-14 EP EP07862890A patent/EP2094680A2/en not_active Withdrawn
- 2007-12-14 EA EA200900811A patent/EA200900811A1/ru unknown
- 2007-12-14 WO PCT/US2007/025556 patent/WO2008076336A2/en active Search and Examination
- 2007-12-14 JP JP2009542812A patent/JP2010513482A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP2094680A2 (en) | 2009-09-02 |
US8436035B2 (en) | 2013-05-07 |
WO2008076336A3 (en) | 2008-12-04 |
CA2672269A1 (en) | 2008-06-26 |
JP2010513482A (ja) | 2010-04-30 |
CN101605777A (zh) | 2009-12-16 |
BRPI0721284A2 (pt) | 2014-04-08 |
MX2009006631A (es) | 2009-06-30 |
EP2213668A2 (en) | 2010-08-04 |
US20100048562A1 (en) | 2010-02-25 |
KR20090091817A (ko) | 2009-08-28 |
EP2213668A3 (en) | 2010-11-24 |
WO2008076336A2 (en) | 2008-06-26 |
AU2007334416A1 (en) | 2008-06-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA200900811A1 (ru) | Имидазолы в качестве ингибиторов альдостеронсинтазы | |
WO2007117982A3 (en) | Organic compounds | |
DK1537114T3 (da) | Organiske forbindelser som midler til behandling af aldosteronmedierede tilstande | |
TW200740822A (en) | Organic compounds | |
EA201070339A1 (ru) | Активаторы растворимой гуанилатциклазы | |
DE60321593D1 (de) | Imidazoä1,5üa pyridin-derivate und methoden zur behandlung von krankheiten in verbindung mit aldosteron | |
NZ596302A (en) | Aryl pyridine as aldosterone synthase inhibitors | |
EA200900812A1 (ru) | Производные 4-имидазолил-1,2,3,4-тетрагидрохинолина и их применение в качестве ингибиторов альдостерон/11-бета-гидроксилазы | |
MX2011008952A (es) | Activadores de guanilato ciclasa solubles. | |
DE602006008945D1 (de) | Isochinolinderivate als inhibitoren von rho-kinase | |
EA201000915A1 (ru) | Ингибиторы пролилгидроксилазы | |
PE20081372A1 (es) | COMPOSICION FARMACEUTICA QUE COMPRENDE 2-[4-(7-ETIL-5H-PIRROLO[2,3-b]PIRAZIN-6-IL)-FENIL]-PROPAN-2-OL COMO INHIBIDOR DE QUINASA | |
ATE520690T1 (de) | Piperidinderivate als renin-inhibitoren | |
MY152042A (en) | 3,4- substituted piperidine derivatives as renin inhibitors | |
ATE532786T1 (de) | Spirobenzazepine als vasopressinantagonisten | |
WO2010066028A8 (en) | 3,4 - substituted piperidine derivatives as renin inhibitors | |
ATE473211T1 (de) | Renininhibitoren | |
CY1114349T1 (el) | Συμπυκνωμενα παραγωγα ιμιδαζολης για την αναστολη της συνθασης της αλδοστερονης και της αρωματασης | |
NZ741335A (en) | New bicyclic dihydroisoquinoline-1-one derivatives | |
TN2010000490A1 (en) | 3,4-substituted piperidine derivatives as renin inhibitors |