EA200700807A1 - Новые циклические и ациклические пропеноны для лечения заболеваний цнс - Google Patents

Новые циклические и ациклические пропеноны для лечения заболеваний цнс

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Publication number
EA200700807A1
EA200700807A1 EA200700807A EA200700807A EA200700807A1 EA 200700807 A1 EA200700807 A1 EA 200700807A1 EA 200700807 A EA200700807 A EA 200700807A EA 200700807 A EA200700807 A EA 200700807A EA 200700807 A1 EA200700807 A1 EA 200700807A1
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EA
Eurasian Patent Office
Prior art keywords
propenons
acyclic
cns diseases
new cyclic
treating cns
Prior art date
Application number
EA200700807A
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English (en)
Inventor
Кристофер Грахам Рафаэль Парсонс
Иварс Калвиньш
Валерьянс Каусс
Дина Трифанова
Роналдс Земрибо
Войцех Даныш
Маркус Хенрих
Таня Вайль
Original Assignee
Мерц Фарма Гмбх Унд Ко. Кгаа
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Publication date
Application filed by Мерц Фарма Гмбх Унд Ко. Кгаа filed Critical Мерц Фарма Гмбх Унд Ко. Кгаа
Publication of EA200700807A1 publication Critical patent/EA200700807A1/ru

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    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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Abstract

Изобретение относится к новым циклическим и нециклическим производным пропенона, а также их фармацевтически приемлемым солям. Дополнительно изобретение относится к способу получения таких соединений. Соединения по изобретению могут использоваться в качестве лекарственных средств.
EA200700807A 2004-10-05 2005-10-05 Новые циклические и ациклические пропеноны для лечения заболеваний цнс EA200700807A1 (ru)

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Publication number Priority date Publication date Assignee Title
US20100197800A1 (en) * 2007-04-23 2010-08-05 Richard Friedman Treatment and/or Prevention of Presbycusis by Modulation of Metabotropic Glutamate Receptor 7
ES2507517T3 (es) * 2008-01-31 2014-10-15 Takeda Pharmaceutical Company Limited Agente profiláctico o terapéutico para trastorno de déficit de atención con hiperactividad
KR101449785B1 (ko) 2008-04-21 2014-10-14 오토노미, 인코포레이티드 귀 질환 및 병태를 치료하기 위한 귀 조제물
US11969501B2 (en) 2008-04-21 2024-04-30 Dompé Farmaceutici S.P.A. Auris formulations for treating otic diseases and conditions
US8496957B2 (en) 2008-07-21 2013-07-30 Otonomy, Inc Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders
CA2751761A1 (en) * 2008-10-22 2010-04-29 House Ear Institute Treatment and/or prevention of inner ear conditions by modulation of a metabotropic glutamate receptor
US9095596B2 (en) 2009-10-15 2015-08-04 Southern Research Institute Treatment of neurodegenerative diseases, causation of memory enhancement, and assay for screening compounds for such
WO2014017803A1 (ko) * 2012-07-23 2014-01-30 주식회사 유한양행 퓨란-함유 융합 고리 화합물 또는 그의 염 및 이를 포함하는 약학 조성물

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1474907A (en) * 1973-09-27 1977-05-25 Hexachimie Pyrolidine derivatives
ATE175667T1 (de) * 1994-05-31 1999-01-15 Bayer Ag Aminobenzofuryl- und -thienylderivate
AU6514296A (en) * 1995-07-31 1997-02-26 Novo Nordisk A/S Heterocyclic compounds, their preparation and use
US20020037867A1 (en) * 1999-02-26 2002-03-28 James M. Wilson Method for recombinant adeno-associated virus-directed gene therapy
EP1015619A1 (en) * 1997-09-19 2000-07-05 The Trustees Of The University Of Pennsylvania Methods and cell line useful for production of recombinant adeno-associated viruses
CA2303768C (en) * 1997-09-19 2009-11-24 The Trustees Of The University Of Pennsylvania Methods and vector constructs useful for production of recombinant aav
US6429207B1 (en) * 1997-11-21 2002-08-06 Nps Pharmaceuticals, Inc. Metabotropic glutamate receptor antagonists and their use for treating central nervous system diseases
JP4693244B2 (ja) * 1999-03-18 2011-06-01 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 組換えアデノ随伴ウイルスのヘルパー無しの生産のための組成物および方法
US6365394B1 (en) * 1999-09-29 2002-04-02 The Trustees Of The University Of Pennsylvania Cell lines and constructs useful in production of E1-deleted adenoviruses in absence of replication competent adenovirus
JP2004514407A (ja) * 2000-04-28 2004-05-20 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 異種キャプシド中にシュードタイピングされたaav5キャプシドおよびaav5ベクターを含む組換えaavベクター
WO2001082909A2 (de) * 2000-04-28 2001-11-08 Baxter Healthcare Sa 2-acyl-indolderivate und deren verwendung als antitumormittel
US6429005B1 (en) * 2000-08-03 2002-08-06 Cytokinetics, Inc. Motor proteins and methods for their use
CN1703403A (zh) * 2000-10-02 2005-11-30 詹森药业有限公司 趋代谢的谷氨酸盐受体拮抗剂
CA2406745C (en) * 2001-11-13 2006-01-10 The Trustees Of The University Of Pennsylvania A method of detecting and/or identifying adeno-associated virus (aav) sequences and isolating novel sequences identified thereby
KR101061561B1 (ko) * 2002-03-29 2011-09-02 얀센 파마슈티카 엔.브이. 대사자극성 글루타메이트 수용체 리간드로서 방사능표지된 퀴놀린 및 퀴놀리논 유도체 및 그의 용도
US6864264B1 (en) * 2002-08-20 2005-03-08 Gloria L. Anderson 1-adamantyl chalcones for the treatment of proliferative disorders
US20050245489A1 (en) * 2004-05-03 2005-11-03 Pinney Kevin G Chromene-containing compounds with anti-tubulin and vascular targeting activity

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CA2580221A1 (en) 2006-04-13
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MX2007003922A (es) 2007-06-07
EP1804781A1 (en) 2007-07-11
BRPI0517549A (pt) 2008-10-14
WO2006037996A1 (en) 2006-04-13
IL182356A0 (en) 2007-07-24
US20060074083A1 (en) 2006-04-06
JP2008515867A (ja) 2008-05-15

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