EA200001248A1 - Новые линейные и циклические производные мочевины, способ их получения и их содержащие фармацевтические композиции - Google Patents

Новые линейные и циклические производные мочевины, способ их получения и их содержащие фармацевтические композиции

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Publication number
EA200001248A1
EA200001248A1 EA200001248A EA200001248A EA200001248A1 EA 200001248 A1 EA200001248 A1 EA 200001248A1 EA 200001248 A EA200001248 A EA 200001248A EA 200001248 A EA200001248 A EA 200001248A EA 200001248 A1 EA200001248 A1 EA 200001248A1
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EA
Eurasian Patent Office
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group
denotes
description
aryl
groups
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EA200001248A
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English (en)
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EA004040B1 (ru
Inventor
Жан-Луи Пеглион
Кристоф Пуатевин
Жан-Поль Вилен
Николь Вийнёв
Мари-Пьер Бургюиньон
Катрин Толлон
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Адир Э Компани
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Publication of EA200001248A1 publication Critical patent/EA200001248A1/ru
Publication of EA004040B1 publication Critical patent/EA004040B1/ru

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F21—LIGHTING
    • F21S—NON-PORTABLE LIGHTING DEVICES; SYSTEMS THEREOF; VEHICLE LIGHTING DEVICES SPECIALLY ADAPTED FOR VEHICLE EXTERIORS
    • F21S8/00—Lighting devices intended for fixed installation
    • F21S8/03—Lighting devices intended for fixed installation of surface-mounted type
    • F21S8/033—Lighting devices intended for fixed installation of surface-mounted type the surface being a wall or like vertical structure, e.g. building facade
    • F21S8/036—Lighting devices intended for fixed installation of surface-mounted type the surface being a wall or like vertical structure, e.g. building facade by means of a rigid support, e.g. bracket or arm
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F21—LIGHTING
    • F21V—FUNCTIONAL FEATURES OR DETAILS OF LIGHTING DEVICES OR SYSTEMS THEREOF; STRUCTURAL COMBINATIONS OF LIGHTING DEVICES WITH OTHER ARTICLES, NOT OTHERWISE PROVIDED FOR
    • F21V21/00—Supporting, suspending, or attaching arrangements for lighting devices; Hand grips
    • F21V21/02—Wall, ceiling, or floor bases; Fixing pendants or arms to the bases
    • F21V21/04—Recessed bases
    • F21V21/041—Mounting arrangements specially adapted for false ceiling panels or partition walls made of plates
    • F21V21/042—Mounting arrangements specially adapted for false ceiling panels or partition walls made of plates using clamping means, e.g. for clamping with panel or wall
    • F21V21/043—Mounting arrangements specially adapted for false ceiling panels or partition walls made of plates using clamping means, e.g. for clamping with panel or wall actuated by screwing

Abstract

В заявке описаны соединения формулыв которой V обозначает одинарную связь или алкиленовую цепь,M обозначает одинарную связь или алкиленовую цепь,A и E каждый обозначает азотный атом или группу СН, но, по меньшей мере, одной из двух групп, обозначенных A и E, является азотный атом,W обозначает группу формулы (i), (ii) или (iii)в которых X обозначает карбонильную, сульфонильную или сульфоксидную группу,G, Gи Gимеют значения, указанные в описании,T обозначает сконденсированную фенильную группу или сконденсированную пиридильную группу,Rобозначает атом водорода, линейную или разветвленную (C-C)алкильную группу, арильную группу или арил(C-C)алкильную группу, в которой алкильный остаток является линейным или разветвленным,Rи R, которые одинаковы или различны, имеют значения, указанные в описании,Rобозначает арильную или гетероарильную группу A, имеющую значения, указанные в описании, причем каждая из этих групп может быть необязательно замещенной,Y обозначает арилокси, гетероарилокси или гетероарильную группу B, имеющую значения, указанные в описании, причем каждая из этих групп может быть необязательно замещенной,их изомеры, их гидраты, их сольваты и их аддитивные соли фармацевтически приемлемой кислоты; а также лекарственные средства.
EA200001248A 1999-12-30 2000-12-29 Линейные и циклические производные мочевины, способ их получения и их содержащие фармацевтические композиции EA004040B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9916701A FR2803298A1 (fr) 1999-12-30 1999-12-30 Nouvelles urees lineaires ou cycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

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EA200001248A1 true EA200001248A1 (ru) 2001-08-27
EA004040B1 EA004040B1 (ru) 2003-12-25

Family

ID=9554011

Family Applications (1)

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EA200001248A EA004040B1 (ru) 1999-12-30 2000-12-29 Линейные и циклические производные мочевины, способ их получения и их содержащие фармацевтические композиции

Country Status (24)

Country Link
US (4) US6566364B2 (ru)
EP (2) EP1113014B1 (ru)
JP (2) JP3396671B2 (ru)
KR (2) KR100511134B1 (ru)
CN (1) CN1189466C (ru)
AT (1) ATE294170T1 (ru)
AU (1) AU776125B2 (ru)
BR (1) BR0007348A (ru)
CA (1) CA2330351C (ru)
CY (1) CY1106396T1 (ru)
DE (2) DE60019716T2 (ru)
DK (2) DK1266896T3 (ru)
EA (1) EA004040B1 (ru)
ES (2) ES2280482T3 (ru)
FR (1) FR2803298A1 (ru)
HK (1) HK1037183A1 (ru)
HU (1) HUP0005014A2 (ru)
MX (1) MXPA00012672A (ru)
NO (1) NO20006708L (ru)
NZ (1) NZ509119A (ru)
PL (1) PL344854A1 (ru)
PT (2) PT1266896E (ru)
SI (2) SI1113014T1 (ru)
ZA (1) ZA200100022B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6627645B2 (en) * 2000-04-28 2003-09-30 Acadia Pharmaceuticals, Inc. Muscarinic agonists
EP1535912A1 (en) * 2000-04-28 2005-06-01 Arcadia Pharmaceuticals Inc. Muscarinic agonists
AU2003248122A1 (en) * 2002-07-25 2004-02-16 Kotobuki Pharmaceutical Co., Ltd. Sodium channel inhibitor
CN106661009B (zh) * 2014-04-28 2019-11-26 江苏康缘药业股份有限公司 抗肠病毒71噻二唑烷衍生物
WO2015184222A1 (en) * 2014-05-30 2015-12-03 Southern Research Institute Inhibitors of hepatocyte growth factor [hgf] and macrophage stimulating protein [msp] maturation
CN109824600B (zh) * 2017-11-23 2020-10-02 中国科学院大连化学物理研究所 一种钯催化2-羟基嘧啶化合物的不对称氢化合成手性环状脲的方法

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FR2300563A1 (fr) * 1975-02-13 1976-09-10 Sandoz Sa Nouveaux derives du thiazole, leur preparation et leur application comme medicaments
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Also Published As

Publication number Publication date
DE60033060D1 (de) 2007-03-08
EP1113014A1 (fr) 2001-07-04
US6903103B2 (en) 2005-06-07
SI1113014T1 (ru) 2005-08-31
JP3942935B2 (ja) 2007-07-11
PT1266896E (pt) 2007-03-30
NO20006708L (no) 2001-07-02
ES2240035T3 (es) 2005-10-16
CA2330351C (fr) 2005-11-15
US20030225105A1 (en) 2003-12-04
ZA200100022B (en) 2001-07-18
US6908922B2 (en) 2005-06-21
MXPA00012672A (es) 2003-04-25
JP2001187782A (ja) 2001-07-10
CA2330351A1 (fr) 2001-06-30
DE60033060T2 (de) 2007-10-31
EA004040B1 (ru) 2003-12-25
SI1266896T1 (sl) 2007-04-30
HU0005014D0 (en) 2001-03-28
NZ509119A (en) 2001-09-28
DE60019716D1 (de) 2005-06-02
DE60019716T2 (de) 2006-01-19
AU7259400A (en) 2001-07-05
KR20010082612A (ko) 2001-08-30
ATE294170T1 (de) 2005-05-15
EP1266896B1 (fr) 2007-01-17
CN1301699A (zh) 2001-07-04
JP2002338566A (ja) 2002-11-27
US20010009911A1 (en) 2001-07-26
ES2280482T3 (es) 2007-09-16
KR100511134B1 (ko) 2005-08-31
DK1113014T3 (da) 2005-08-29
HK1037183A1 (en) 2002-02-01
HUP0005014A2 (en) 2002-06-29
US20030191132A1 (en) 2003-10-09
KR100477384B1 (ko) 2005-03-18
CN1189466C (zh) 2005-02-16
US20030229100A1 (en) 2003-12-11
EP1113014B1 (fr) 2005-04-27
US6780868B2 (en) 2004-08-24
CY1106396T1 (el) 2011-10-12
PT1113014E (pt) 2005-07-29
BR0007348A (pt) 2001-12-04
FR2803298A1 (fr) 2001-07-06
AU776125B2 (en) 2004-08-26
DK1266896T3 (da) 2007-05-21
KR20040030038A (ko) 2004-04-08
US6566364B2 (en) 2003-05-20
NO20006708D0 (no) 2000-12-29
EP1266896A1 (fr) 2002-12-18
PL344854A1 (en) 2001-07-02
JP3396671B2 (ja) 2003-04-14

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