EA199801031A1 - PROTEINFARNESILTRANSFERASE INHIBITORS - Google Patents

PROTEINFARNESILTRANSFERASE INHIBITORS

Info

Publication number
EA199801031A1
EA199801031A1 EA199801031A EA199801031A EA199801031A1 EA 199801031 A1 EA199801031 A1 EA 199801031A1 EA 199801031 A EA199801031 A EA 199801031A EA 199801031 A EA199801031 A EA 199801031A EA 199801031 A1 EA199801031 A1 EA 199801031A1
Authority
EA
Eurasian Patent Office
Prior art keywords
inhibitors
proteinfarnesiltransferase
proteinfarnesyltransferase
endometriosis
restenosis
Prior art date
Application number
EA199801031A
Other languages
Russian (ru)
Inventor
Эллен М. Добрузин
Аннетта Мэриан Дохерти
Джеймс Стенли Кальтенбронн
Даниель М. Леонард
Дэннис Джозеф Макнамара
Юдит Седолт-Леопольд
Кевон Р. Шулер
Original Assignee
Варнер-Ламберт Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Варнер-Ламберт Компани filed Critical Варнер-Ламберт Компани
Publication of EA199801031A1 publication Critical patent/EA199801031A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Описываются новые ингибиторы ферментов протеинфарнезилтрансферазы, а также способы для их получения и фармацевтические композиции на их основе, которые являются пригодными для лечения рака, рестеноза, псориаза, эндометриоза, атеросклероза или вирусных инфекций.Международная заявка была опубликована вместе с отчетом о международном поиске.New inhibitors of proteinfarnesyltransferase enzymes are described, as well as methods for their preparation and pharmaceutical compositions based on them that are suitable for treating cancer, restenosis, psoriasis, endometriosis, atherosclerosis, or viral infections. The international application was published together with an international search report.

EA199801031A 1996-05-22 1997-04-29 PROTEINFARNESILTRANSFERASE INHIBITORS EA199801031A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1611096P 1996-05-22 1996-05-22
US3366296P 1996-12-17 1996-12-17
PCT/US1997/006591 WO1997044350A1 (en) 1996-05-22 1997-04-29 Inhibitors of protein farnesyl transferase

Publications (1)

Publication Number Publication Date
EA199801031A1 true EA199801031A1 (en) 1999-06-24

Family

ID=26688183

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199801031A EA199801031A1 (en) 1996-05-22 1997-04-29 PROTEINFARNESILTRANSFERASE INHIBITORS

Country Status (18)

Country Link
EP (1) EP0938494A1 (en)
JP (1) JP2000511527A (en)
CN (1) CN1219174A (en)
AU (1) AU728477B2 (en)
BG (1) BG102936A (en)
BR (1) BR9709354A (en)
CA (1) CA2253934A1 (en)
CO (1) CO4960642A1 (en)
CZ (1) CZ376498A3 (en)
EA (1) EA199801031A1 (en)
EE (1) EE9800408A (en)
GE (1) GEP20012500B (en)
IL (1) IL126833A0 (en)
NO (1) NO985405L (en)
NZ (1) NZ332712A (en)
PL (1) PL330120A1 (en)
SK (1) SK161098A3 (en)
WO (1) WO1997044350A1 (en)

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DE69914893T2 (en) * 1998-04-27 2004-07-22 Warner-Lambert Co. Llc GLYCINAMIDE DERIVATIVES WITH FUNCTIONALIZED ALKYL AND ALKENYL SIDE CHAIN AS INHIBITORS OF FARNESYL TRANSFERASE
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MX2009009304A (en) 2007-03-01 2009-11-18 Novartis Ag Pim kinase inhibitors and methods of their use.
CN101754965B (en) 2007-05-21 2014-03-19 诺华股份有限公司 CSF-1R inhibitors, compositions, and methods of use
US8389553B2 (en) 2007-06-27 2013-03-05 Merck Sharp & Dohme Corp. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
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EP2488028B1 (en) 2009-10-14 2020-08-19 Merck Sharp & Dohme Corp. Substituted piperidines that increase p53 activity and the uses thereof
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CN103068980B (en) 2010-08-02 2017-04-05 瑟纳治疗公司 Using short interfering nucleic acid（siNA）The connection albumen led of mediated rnai（Cadherin related protein matter）, β 1（CTNNB1）The suppression of gene expression
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Also Published As

Publication number Publication date
NO985405L (en) 1999-01-19
CA2253934A1 (en) 1997-11-27
AU2805897A (en) 1997-12-09
BR9709354A (en) 1999-08-10
AU728477B2 (en) 2001-01-11
WO1997044350A1 (en) 1997-11-27
CZ376498A3 (en) 1999-02-17
BG102936A (en) 1999-09-30
SK161098A3 (en) 2000-06-12
PL330120A1 (en) 1999-04-26
EP0938494A1 (en) 1999-09-01
NZ332712A (en) 2000-07-28
NO985405D0 (en) 1998-11-20
CN1219174A (en) 1999-06-09
GEP20012500B (en) 2001-07-25
CO4960642A1 (en) 2000-09-25
EE9800408A (en) 1999-06-15
IL126833A0 (en) 1999-08-17
JP2000511527A (en) 2000-09-05

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