DK2706988T3 - Liposomer omfattende polymer konjugerede lipider og relateret brug - Google Patents
Liposomer omfattende polymer konjugerede lipider og relateret brug Download PDFInfo
- Publication number
- DK2706988T3 DK2706988T3 DK12781987.8T DK12781987T DK2706988T3 DK 2706988 T3 DK2706988 T3 DK 2706988T3 DK 12781987 T DK12781987 T DK 12781987T DK 2706988 T3 DK2706988 T3 DK 2706988T3
- Authority
- DK
- Denmark
- Prior art keywords
- liposomes
- polymer conjugated
- related use
- conjugated lipids
- comprehensive polymer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pathology (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161485192P | 2011-05-12 | 2011-05-12 | |
PCT/IL2012/050168 WO2012153338A2 (en) | 2011-05-12 | 2012-05-10 | Liposomes comprising polymer-conjugated lipids and related uses |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2706988T3 true DK2706988T3 (da) | 2020-01-20 |
Family
ID=47139753
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK12781987.8T DK2706988T3 (da) | 2011-05-12 | 2012-05-10 | Liposomer omfattende polymer konjugerede lipider og relateret brug |
Country Status (9)
Country | Link |
---|---|
US (4) | US10179106B2 (da) |
EP (1) | EP2706988B1 (da) |
JP (1) | JP2014519493A (da) |
CN (1) | CN104023708A (da) |
AU (1) | AU2012254842A1 (da) |
CA (1) | CA2834918C (da) |
DK (1) | DK2706988T3 (da) |
ES (1) | ES2762224T3 (da) |
WO (1) | WO2012153338A2 (da) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8822663B2 (en) | 2010-08-06 | 2014-09-02 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
EP2625189B1 (en) | 2010-10-01 | 2018-06-27 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
JP2014511687A (ja) | 2011-03-31 | 2014-05-19 | モデルナ セラピューティクス インコーポレイテッド | 工学操作された核酸の送達および製剤 |
WO2012153338A2 (en) * | 2011-05-12 | 2012-11-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Liposomes comprising polymer-conjugated lipids and related uses |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
HUE057725T2 (hu) | 2011-10-03 | 2022-06-28 | Modernatx Inc | Módosított nukleozidok, nukleotidok és nukleinsavak és ezek felhasználása |
HRP20220717T1 (hr) | 2011-12-16 | 2022-07-22 | Modernatx, Inc. | Modificirani pripravci mrna |
US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
AU2013243947A1 (en) | 2012-04-02 | 2014-10-30 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
ES2921623T3 (es) | 2012-11-26 | 2022-08-30 | Modernatx Inc | ARN modificado terminalmente |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
ITMI20130576A1 (it) * | 2013-04-11 | 2014-10-12 | Labomar S R L | Composizione comprendente un poliamminoglicoside |
EP3052106A4 (en) | 2013-09-30 | 2017-07-19 | ModernaTX, Inc. | Polynucleotides encoding immune modulating polypeptides |
EP3052521A1 (en) | 2013-10-03 | 2016-08-10 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
WO2015068155A1 (en) * | 2013-11-06 | 2015-05-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Lipid-polysaccharide conjugates, their preparation and uses thereof |
EP3116479A1 (en) * | 2014-03-12 | 2017-01-18 | GlaxoSmithKline Biologicals S.A. | Liposomal compositions for mucosal delivery |
RU2642786C2 (ru) * | 2015-01-30 | 2018-01-26 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Стабилизатор липосомальных суспензий |
WO2016123365A1 (en) | 2015-01-30 | 2016-08-04 | The Regents Of The University Of Michigan | Liposomal particles comprising biological molecules and uses thereof |
JP2018516847A (ja) | 2015-03-25 | 2018-06-28 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 生体高分子薬を送達するための組成物及び方法 |
ES2910425T3 (es) | 2015-09-17 | 2022-05-12 | Modernatx Inc | Compuestos y composiciones para la administración intracelular de agentes terapéuticos |
SI3386484T1 (sl) | 2015-12-10 | 2022-06-30 | Modernatx, Inc. | Sestave in metode za dovajanje terapevtskih sredstev |
RS63051B1 (sr) | 2015-12-22 | 2022-04-29 | Modernatx Inc | Jedinjenja i kompozicije za intracelularnu isporuku agenasa |
US11583504B2 (en) | 2016-11-08 | 2023-02-21 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
CN110214005A (zh) * | 2016-11-11 | 2019-09-06 | DNALite治疗学公司 | 用于基因治疗的结构和方法 |
WO2018170336A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Lipid nanoparticle formulation |
KR20190132405A (ko) | 2017-03-15 | 2019-11-27 | 모더나티엑스, 인크. | 치료제의 세포내 전달을 위한 화합물 및 조성물 |
AU2018234814B2 (en) | 2017-03-15 | 2022-06-30 | Modernatx, Inc. | Crystal forms of amino lipids |
EP3638215A4 (en) | 2017-06-15 | 2021-03-24 | Modernatx, Inc. | RNA FORMULATIONS |
AU2018326799A1 (en) | 2017-08-31 | 2020-02-27 | Modernatx, Inc. | Methods of making lipid nanoparticles |
CN109833297B (zh) * | 2017-11-27 | 2021-10-29 | 张正风 | 一种微脂体组合物 |
EP3812376A4 (en) * | 2018-06-20 | 2022-08-17 | Santolecan Pharmaceuticals LLC | PACLITAXEL-LIPID-POLYSACCHARIDE DOUBLE-TYPE CONJUGATE, METHOD FOR PREPARING IT AND ITS USE |
US11273124B2 (en) * | 2019-05-23 | 2022-03-15 | Brown University | Antifungal nanoparticles for targeted treatment of fungal infections |
CA3154618A1 (en) | 2019-09-19 | 2021-03-25 | Modernatx, Inc. | Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents |
US11524023B2 (en) | 2021-02-19 | 2022-12-13 | Modernatx, Inc. | Lipid nanoparticle compositions and methods of formulating the same |
IT202100022253A1 (it) * | 2021-08-24 | 2023-02-24 | Univ Degli Studi Di Torino | Liposomi, composizioni che li comprendono, relativi usi |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US5688488A (en) | 1989-04-03 | 1997-11-18 | Purdue Research Foundation | Composition and method for tumor imaging |
US5603872A (en) * | 1991-02-14 | 1997-02-18 | Baxter International Inc. | Method of binding recognizing substances to liposomes |
DK0525132T3 (da) * | 1991-02-14 | 1996-02-05 | Baxter Int | Binding af genkendende stoffer til liposomer |
US5395619A (en) * | 1993-03-03 | 1995-03-07 | Liposome Technology, Inc. | Lipid-polymer conjugates and liposomes |
US5785975A (en) * | 1995-06-26 | 1998-07-28 | Research Triangle Pharmaceuticals | Adjuvant compositions and vaccine formulations comprising same |
TW520297B (en) * | 1996-10-11 | 2003-02-11 | Sequus Pharm Inc | Fusogenic liposome composition and method |
US6071532A (en) | 1996-10-15 | 2000-06-06 | Emory University | Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof |
US7311924B2 (en) * | 1999-04-01 | 2007-12-25 | Hana Biosciences, Inc. | Compositions and methods for treating cancer |
US6852334B1 (en) * | 1999-04-20 | 2005-02-08 | The University Of British Columbia | Cationic peg-lipids and methods of use |
US7141552B2 (en) | 2000-01-10 | 2006-11-28 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of diseases |
EP2845596A3 (en) | 2000-01-10 | 2015-07-15 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Use of lipid conjugates in the treatment of disease |
JP2004529315A (ja) | 2000-11-03 | 2004-09-24 | ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システム | 抗癌処置の効力を検出するための方法 |
US8883761B2 (en) | 2001-01-10 | 2014-11-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of diseases associated with vasculature |
US20070185052A1 (en) * | 2005-08-03 | 2007-08-09 | Saul Yedgar | Use of lipid conjugates in cystic fibrosis and applications thereof |
DE10252614A1 (de) * | 2002-11-12 | 2004-05-27 | Infineon Technologies Ag | Verfahren, Vorrichtung, computerlesbares Speichermedium und Computerprogramm-Element zum Überwachen eines Herstellungsprozesses einer Mehrzahl von physikalischen Objekten |
CA2560941A1 (en) * | 2004-03-24 | 2005-10-20 | Telos Pharmaceuticals Llc | Compositions as adjuvants to improve immune responses to vaccines and methods of use |
CN101282733A (zh) * | 2005-08-03 | 2008-10-08 | 莫里亚生物制药公司 | 脂质结合物在囊性纤维化病中的用途及其应用 |
US20110269942A1 (en) | 2007-08-09 | 2011-11-03 | Daiichi Sankyo Company, Limited | Antibodies modified with hydrophobic molecule |
CA2761590C (en) | 2009-05-11 | 2018-08-28 | Morria Biopharmaceuticals | Lipid-polymer conjugates, their preparation and uses thereof |
WO2011003834A1 (en) * | 2009-07-09 | 2011-01-13 | Marina Biotech, Inc. | Amphoteric liposomes comprising imino lipids |
US9937128B2 (en) | 2009-08-03 | 2018-04-10 | The University Of North Carolina At Chapel Hill | Liposomes comprising a calcium phosphate-containing precipitate |
JP5337722B2 (ja) | 2010-01-07 | 2013-11-06 | ヤマハ発動機株式会社 | 船舶用推進制御装置および船舶 |
WO2012153338A2 (en) * | 2011-05-12 | 2012-11-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Liposomes comprising polymer-conjugated lipids and related uses |
-
2012
- 2012-05-10 WO PCT/IL2012/050168 patent/WO2012153338A2/en active Application Filing
- 2012-05-10 US US14/115,869 patent/US10179106B2/en active Active
- 2012-05-10 AU AU2012254842A patent/AU2012254842A1/en not_active Abandoned
- 2012-05-10 CN CN201280022911.3A patent/CN104023708A/zh active Pending
- 2012-05-10 CA CA2834918A patent/CA2834918C/en active Active
- 2012-05-10 EP EP12781987.8A patent/EP2706988B1/en active Active
- 2012-05-10 JP JP2014509889A patent/JP2014519493A/ja active Pending
- 2012-05-10 DK DK12781987.8T patent/DK2706988T3/da active
- 2012-05-10 ES ES12781987T patent/ES2762224T3/es active Active
-
2019
- 2019-01-14 US US16/246,920 patent/US10624851B2/en active Active
-
2020
- 2020-04-20 US US16/853,635 patent/US20200246265A1/en not_active Abandoned
-
2021
- 2021-07-15 US US17/377,134 patent/US11911507B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20190142751A1 (en) | 2019-05-16 |
US10624851B2 (en) | 2020-04-21 |
WO2012153338A2 (en) | 2012-11-15 |
WO2012153338A3 (en) | 2014-06-12 |
JP2014519493A (ja) | 2014-08-14 |
US20200246265A1 (en) | 2020-08-06 |
US20210338582A1 (en) | 2021-11-04 |
US20140199241A1 (en) | 2014-07-17 |
EP2706988B1 (en) | 2019-12-04 |
US10179106B2 (en) | 2019-01-15 |
ES2762224T3 (es) | 2020-05-22 |
US11911507B2 (en) | 2024-02-27 |
EP2706988A2 (en) | 2014-03-19 |
CA2834918A1 (en) | 2012-11-15 |
CA2834918C (en) | 2020-03-24 |
CN104023708A (zh) | 2014-09-03 |
AU2012254842A1 (en) | 2013-05-02 |
EP2706988A4 (en) | 2015-06-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK2706988T3 (da) | Liposomer omfattende polymer konjugerede lipider og relateret brug | |
IL286546A (en) | Balloon-equipped endoscopic devices and methods thereof | |
SMT201600022B (it) | Pirrolobenzodiazepine e loro coniugati | |
PL2691443T3 (pl) | Sprzężone lipomery i ich zastosowania | |
DK3597644T3 (da) | Kationiske aminlipider og anvendelser deraf | |
IL233051B (en) | Anti-phf-tau antibodies and uses thereof | |
EP2750686A4 (en) | MITOCHONDRIAL TARGETING AND THERAPEUTIC USE THEREOF | |
BR112013023156A2 (pt) | artigos para cuidados pessoais | |
FI20116181A (fi) | Uusia terapeuttisia vektoreita | |
IL228113A (en) | Couplings of protein and polymer cigars | |
DK2401930T3 (da) | Et par bukser | |
HK1201454A1 (en) | Therapeutic agents and uses thereof | |
BR112013012191A2 (pt) | instrumento para esticar a pele | |
DK2715253T3 (da) | Ejektorer og fremstillingsfremgangsmåder | |
DK2704744T3 (da) | Komplementfaktor-b-analoger og anvendelser deraf | |
PL2667880T3 (pl) | Oligopeptydy metaloproteinaz i ich zastosowanie terapeutyczne | |
EP2688412A4 (en) | INSECTICIDES AND APPLICATIONS THEREOF | |
DK2758074T3 (da) | Bakteriestammer der udtrykker methylasegener og anvendelser deraf | |
DK2764708T3 (da) | Højttaler | |
BR112014010152A2 (pt) | formulação esporicida e lenço | |
ES1075554Y (es) | Stand modular reutilizable y ecologico | |
IL229325A0 (en) | Liposomes containing lipid-polymer conjugates, and their use | |
GB201108435D0 (en) | Patterning of conducting polymers and use thereof | |
TH1301004883B (th) | เครื่องกำเนิดสนามไฟฟ้า และการปล่อยประจุ | |
TH134203B (th) | วิธีการทำความสะอาดและอุปกรณ์ทำความสะอาด |