DK1268522T3 - LH-RH antagonists as well as their preparation and use thereof as drugs - Google Patents

LH-RH antagonists as well as their preparation and use thereof as drugs

Info

Publication number
DK1268522T3
DK1268522T3 DK01933682T DK01933682T DK1268522T3 DK 1268522 T3 DK1268522 T3 DK 1268522T3 DK 01933682 T DK01933682 T DK 01933682T DK 01933682 T DK01933682 T DK 01933682T DK 1268522 T3 DK1268522 T3 DK 1268522T3
Authority
DK
Denmark
Prior art keywords
antagonists
drugs
preparation
well
hormone
Prior art date
Application number
DK01933682T
Other languages
Danish (da)
Inventor
Michael Bernd
Bernhard Kutscher
Eckhard Guenther
Peter Romeis
Thomas Reissmann
Thomas Beckers
Original Assignee
Aeterna Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/525,007 external-priority patent/US6627609B1/en
Application filed by Aeterna Zentaris Gmbh filed Critical Aeterna Zentaris Gmbh
Application granted granted Critical
Publication of DK1268522T3 publication Critical patent/DK1268522T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Reproductive Health (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to peptides, comprising an N-methylated amino acid component and an improved water solubility. According to the invention, medicaments containing the said peptides can be used for treatment of hormone-dependant tumours and hormone-influenced non-malignant disease states.
DK01933682T 2000-03-14 2001-03-12 LH-RH antagonists as well as their preparation and use thereof as drugs DK1268522T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/525,007 US6627609B1 (en) 1999-03-17 2000-03-14 LHRH antagonists having improved solubility properties
PCT/EP2001/002719 WO2001068676A2 (en) 2000-03-14 2001-03-12 Lhrh-antagonists, production and use thereof as medicament

Publications (1)

Publication Number Publication Date
DK1268522T3 true DK1268522T3 (en) 2009-01-12

Family

ID=24091545

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01933682T DK1268522T3 (en) 2000-03-14 2001-03-12 LH-RH antagonists as well as their preparation and use thereof as drugs

Country Status (25)

Country Link
EP (1) EP1268522B1 (en)
JP (1) JP3805679B2 (en)
KR (1) KR100607396B1 (en)
CN (2) CN1443195A (en)
AT (1) ATE408619T1 (en)
AU (2) AU6011001A (en)
BG (1) BG107121A (en)
BR (1) BR0109279A (en)
CA (1) CA2402193C (en)
DE (1) DE50114335D1 (en)
DK (1) DK1268522T3 (en)
ES (1) ES2312435T3 (en)
HR (1) HRP20020810A2 (en)
HU (1) HUP0300222A3 (en)
IL (1) IL151647A0 (en)
MX (1) MXPA02008870A (en)
NO (1) NO20024363L (en)
NZ (1) NZ521273A (en)
PL (1) PL357999A1 (en)
PT (1) PT1268522E (en)
RU (1) RU2248982C9 (en)
SK (1) SK14332002A3 (en)
UA (1) UA79070C2 (en)
WO (1) WO2001068676A2 (en)
ZA (1) ZA200207248B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100340572C (en) * 2004-12-01 2007-10-03 中国人民解放军军事医学科学院毒物药物研究所 Novel LHRH antagonist
CN101037472B (en) * 2006-03-14 2013-03-27 中国人民解放军军事医学科学院毒物药物研究所 LHRH antagonist with low-histamine releasing function
WO2009094634A1 (en) 2008-01-24 2009-07-30 Esperance Pharmaceuticals Lytic domain fusion constructs and methods of making and using same
CN101597321B (en) * 2008-06-03 2013-04-24 中国人民解放军军事医学科学院毒物药物研究所 LHRH antagonist with long-acting low-histamine release side effect
WO2010142060A1 (en) * 2009-06-11 2010-12-16 中国人民解放军军事医学科学院毒物药物研究所 Lhrh antagonist with long potency and low histamine releasing effect
US9492563B2 (en) 2012-10-30 2016-11-15 Esperance Pharmaceuticals, Inc. Antibody/drug conjugates and methods of use
CN104418936B (en) * 2013-08-20 2018-06-05 中国人民解放军军事医学科学院毒物药物研究所 Lhrh antagonist derivative and its medicinal usage
FR3024612B1 (en) * 2014-08-04 2018-03-09 Alstom Transp Tech POWER SUPPLY MODULE OF A MOTOR BLOCK, TRACTION SYSTEM AND ELECTRIC VEHICLE
RU2585367C1 (en) * 2014-11-05 2016-05-27 Наталья Владимировна Спиридонова Method of treating infertility in females suffering from uterine myoma

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5140009A (en) 1988-02-10 1992-08-18 Tap Pharmaceuticals, Inc. Octapeptide LHRH antagonists
US5110904A (en) * 1989-08-07 1992-05-05 Abbott Laboratories Lhrh analogs
US5300492A (en) 1988-02-10 1994-04-05 Tap Pharmaceuticals LHRH analogs
IL101074A (en) 1991-03-14 1997-09-30 Salk Inst For Biological Studi GnRH ANALOGS AND THEIR PREPARATION
US5516887A (en) 1991-04-25 1996-05-14 Romano Deghenghi Luteinizing hormone releasing hormone antagonist peptides
JPH08504209A (en) 1992-12-04 1996-05-07 アボツト・ラボラトリーズ 6-position modified decapeptide LHRH antagonist
ES2164096T3 (en) 1992-12-18 2002-02-16 Abbott Lab LHRH ANTAGONISTS UNDERSTANDING AMINOACIT REMAINS MODIFIED IN POSITION 5 AND 6.
IL108509A0 (en) 1993-02-22 1994-05-30 Salk Inst For Biological Studi GnRH antagonist peptides
DE4320201A1 (en) * 1993-06-18 1995-01-12 Asta Medica Ag Use of Cetrorelix and other nona and decapeptides for the manufacture of a medicament for combating AIDS and for growth stimulation
DE19544212A1 (en) * 1995-11-28 1997-06-05 Asta Medica Ag New LH-RH antagonists with improved effects
DE19911771B4 (en) 1999-03-17 2006-03-30 Zentaris Gmbh LHRH antagonist, process for its preparation and its use

Also Published As

Publication number Publication date
PL357999A1 (en) 2004-08-09
BR0109279A (en) 2002-12-17
AU2001260110B2 (en) 2005-05-05
HUP0300222A2 (en) 2003-07-28
CN100500692C (en) 2009-06-17
JP3805679B2 (en) 2006-08-02
HRP20020810A2 (en) 2004-12-31
ATE408619T1 (en) 2008-10-15
EP1268522A2 (en) 2003-01-02
KR20020083179A (en) 2002-11-01
NZ521273A (en) 2005-01-28
UA79070C2 (en) 2007-05-25
CA2402193C (en) 2010-05-18
KR100607396B1 (en) 2006-08-02
HUP0300222A3 (en) 2004-08-30
RU2248982C2 (en) 2005-03-27
JP2003535044A (en) 2003-11-25
ES2312435T3 (en) 2009-03-01
AU6011001A (en) 2001-09-24
NO20024363L (en) 2002-11-13
CA2402193A1 (en) 2002-09-09
DE50114335D1 (en) 2008-10-30
CN1443195A (en) 2003-09-17
EP1268522B1 (en) 2008-09-17
IL151647A0 (en) 2003-04-10
BG107121A (en) 2003-05-30
WO2001068676A3 (en) 2002-10-24
WO2001068676A2 (en) 2001-09-20
ZA200207248B (en) 2003-02-21
RU2248982C9 (en) 2005-06-10
SK14332002A3 (en) 2003-09-11
NO20024363D0 (en) 2002-09-12
PT1268522E (en) 2008-12-22
MXPA02008870A (en) 2003-06-24
CN1876677A (en) 2006-12-13

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