DK0519327T3 - N-Acyl-S-(2-hydroxyalkyl) -cysteiner, deres fremstilling samt deres anvendelse som mellemprodukter til fremstilling af synt - Google Patents
N-Acyl-S-(2-hydroxyalkyl) -cysteiner, deres fremstilling samt deres anvendelse som mellemprodukter til fremstilling af syntInfo
- Publication number
- DK0519327T3 DK0519327T3 DK92109834T DK92109834T DK0519327T3 DK 0519327 T3 DK0519327 T3 DK 0519327T3 DK 92109834 T DK92109834 T DK 92109834T DK 92109834 T DK92109834 T DK 92109834T DK 0519327 T3 DK0519327 T3 DK 0519327T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- synth
- cysteines
- hydroxyalkyl
- intermediates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/067—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for sulfur-containing functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4119856A DE4119856A1 (de) | 1991-06-17 | 1991-06-17 | N-acyl-s-(2-hydroxyalkyl)-cysteine, deren herstellung sowie deren verwendung als zwischenprodukte zur herstellung von synthetischen immunadjuvantien und synthetischen impfstoffen |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0519327T3 true DK0519327T3 (da) | 2000-03-20 |
Family
ID=6434074
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK92109834T DK0519327T3 (da) | 1991-06-17 | 1992-06-11 | N-Acyl-S-(2-hydroxyalkyl) -cysteiner, deres fremstilling samt deres anvendelse som mellemprodukter til fremstilling af synt |
Country Status (8)
Country | Link |
---|---|
US (1) | US5700910A (da) |
EP (1) | EP0519327B1 (da) |
JP (1) | JP3358827B2 (da) |
AT (1) | ATE184274T1 (da) |
DE (2) | DE4119856A1 (da) |
DK (1) | DK0519327T3 (da) |
ES (1) | ES2137166T3 (da) |
GR (1) | GR3031849T3 (da) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4329309A1 (de) * | 1993-08-31 | 1995-03-09 | Rapp Polymere Gmbh | Lipopeptid-Verbindungen |
DE19652586A1 (de) * | 1996-12-17 | 1998-06-18 | Biotechnolog Forschung Gmbh | Dhc-Peptid und Mittel |
US6706693B1 (en) | 1997-08-13 | 2004-03-16 | The Uab Research Foundation | Vaccination by topical application of genetic vectors |
US20030045492A1 (en) * | 1997-08-13 | 2003-03-06 | Tang De-Chu C. | Vaccination by topical application of recombinant vectors |
US6348450B1 (en) | 1997-08-13 | 2002-02-19 | The Uab Research Foundation | Noninvasive genetic immunization, expression products therefrom and uses thereof |
US6716823B1 (en) | 1997-08-13 | 2004-04-06 | The Uab Research Foundation | Noninvasive genetic immunization, expression products therefrom, and uses thereof |
KR20010075000A (ko) | 1998-10-09 | 2001-08-09 | 에가시라 구니오 | 시스테인 유도체 |
US20040009936A1 (en) * | 1999-05-03 | 2004-01-15 | Tang De-Chu C. | Vaccine and drug delivery by topical application of vectors and vector extracts |
US6783947B1 (en) * | 1999-09-09 | 2004-08-31 | Dade Behring Marburg Gmbh | Protecting groups for biological labeling |
KR100898844B1 (ko) * | 1999-12-22 | 2009-05-21 | 옴 파르마 | 작용기화된 보조 아암을 가진 아실 슈도디펩티드 |
WO2001046127A1 (fr) | 1999-12-22 | 2001-06-28 | Om Pharma | Pseudodipeptides acyles porteurs d'un bras auxiliaire fonctionnalise |
GB0210183D0 (en) * | 2002-05-03 | 2002-06-12 | Avecia Ltd | Process |
CN1688606A (zh) | 2002-08-12 | 2005-10-26 | 昆士兰医学研究所理事会 | 含有辅助t细胞和b细胞表位的新的免疫原性脂肽 |
CN101113178A (zh) | 2002-08-12 | 2008-01-30 | 昆士兰医学研究所理事会 | 包含辅助t细胞和细胞毒性t淋巴细胞(ctl)表位的新免疫原性脂肽 |
CA2598806A1 (en) | 2005-02-23 | 2006-08-31 | Uab Research Foundation | Alkyl-glycoside enhanced vaccination |
US20080076476A1 (en) * | 2006-09-22 | 2008-03-27 | Broadcom Corporation, A California Corporation | RF transceiver with a plurality of programmable antennas and methods for use therewith |
US9138470B2 (en) * | 2007-11-02 | 2015-09-22 | The Johns Hopkins University | Multi-component L2 vaccine for prevention of human papilloma virus infection |
WO2010111485A1 (en) | 2009-03-25 | 2010-09-30 | The Board Of Regents Of The University Of Texas System | Compositions for stimulation of mammalian innate immune resistance to pathogens |
DE102009034779A1 (de) | 2009-07-25 | 2011-02-03 | Emc Microcollections Gmbh | Synthetische Analoga bakterieller Lipopeptide und ihre Anwendung zur Therapie und Prophylaxe allergischer Erkrankungen |
CN103189072B (zh) | 2010-09-22 | 2018-02-09 | 因纳瓦克私人有限公司 | 免疫刺激方法 |
DE102011018499A1 (de) | 2011-04-23 | 2012-10-25 | Emc Microcollections Gmbh | Topische Nanopartikel-Vakzine zur Immunstimulation der dendritischen Zellen in der Haut |
CN102321002B (zh) * | 2011-06-08 | 2014-04-23 | 成都圣诺科技发展有限公司 | 半胱氨酸衍生物及其制备方法和用途 |
EP2732825B1 (en) | 2012-11-19 | 2015-07-01 | Invivogen | Conjugates of a TLR7 and/or TLR8 agonist and a TLR2 agonist |
EP2769738B1 (en) | 2013-02-22 | 2016-07-20 | Invivogen | Conjugated TLR7 and/or TLR8 and TLR2 polycationic agonists |
KR20160147960A (ko) | 2014-04-25 | 2016-12-23 | 아지노모토 가부시키가이샤 | 면역자극제 |
WO2016044839A2 (en) | 2014-09-19 | 2016-03-24 | The Board Of Regents Of The University Of Texas System | Compositions and methods for treating viral infections through stimulated innate immunity in combination with antiviral compounds |
DE102016005550A1 (de) | 2016-05-09 | 2017-11-09 | Emc Microcollections Gmbh | Adjuvans zur lnduzierung einer zellulären lmmunantwort |
AU2018241248A1 (en) | 2017-03-31 | 2019-09-05 | Ena Respiratory Pty Ltd | Treatment of respiratory infection with a TLR2 agonist |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2860893D1 (en) * | 1977-06-20 | 1981-11-05 | Ciba Geigy Ag | Lipopeptides, process for their preparation and pharmaceutical compositions containing them |
EP0014815A3 (de) * | 1978-12-20 | 1980-10-29 | Ciba-Geigy Ag | Peptidderivate, Verfahren zu deren Herstellung und Zwischenprodukte sowie pharmazeutische Präparate mit einer dieser Verbindungen |
US4318905A (en) * | 1980-06-23 | 1982-03-09 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide agonists of luteinizing hormone releasing hormone containing heterocyclic amino acid residues |
EP0114787B1 (de) * | 1983-01-25 | 1991-09-25 | Ciba-Geigy Ag | Neue Peptidderivate |
DE3546150A1 (de) * | 1985-06-24 | 1987-01-22 | Hoechst Ag | Membrananker-wirkstoffkonjugat, seine herstellung sowie seine verwendung |
US4696946A (en) * | 1985-08-30 | 1987-09-29 | Schering Corporation | Topical Treatment of hyperproliferative skin diseases |
US4767853A (en) * | 1986-07-21 | 1988-08-30 | Schering Corporation | Synthesis of 1-(allyloxycarbonyl)-methyl-3-(hydroxyethyl)-4-beta-naphthoxythiocarbonylthio-2-azetidinones and hydroxy protected analogs thereof |
-
1991
- 1991-06-17 DE DE4119856A patent/DE4119856A1/de not_active Withdrawn
-
1992
- 1992-06-11 DK DK92109834T patent/DK0519327T3/da active
- 1992-06-11 DE DE59209742T patent/DE59209742D1/de not_active Expired - Fee Related
- 1992-06-11 AT AT92109834T patent/ATE184274T1/de not_active IP Right Cessation
- 1992-06-11 EP EP92109834A patent/EP0519327B1/de not_active Expired - Lifetime
- 1992-06-11 ES ES92109834T patent/ES2137166T3/es not_active Expired - Lifetime
- 1992-06-16 JP JP15626892A patent/JP3358827B2/ja not_active Expired - Fee Related
-
1995
- 1995-06-07 US US08/475,437 patent/US5700910A/en not_active Expired - Fee Related
-
1999
- 1999-11-17 GR GR990402943T patent/GR3031849T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0519327B1 (de) | 1999-09-08 |
EP0519327A1 (de) | 1992-12-23 |
GR3031849T3 (en) | 2000-02-29 |
US5700910A (en) | 1997-12-23 |
ATE184274T1 (de) | 1999-09-15 |
ES2137166T3 (es) | 1999-12-16 |
JP3358827B2 (ja) | 2002-12-24 |
DE59209742D1 (de) | 1999-10-14 |
DE4119856A1 (de) | 1992-12-24 |
JPH05186419A (ja) | 1993-07-27 |
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