DE69233408D1 - Production of antibodies on phage surfaces based on antibody segment libraries. - Google Patents
Production of antibodies on phage surfaces based on antibody segment libraries.Info
- Publication number
- DE69233408D1 DE69233408D1 DE69233408T DE69233408T DE69233408D1 DE 69233408 D1 DE69233408 D1 DE 69233408D1 DE 69233408 T DE69233408 T DE 69233408T DE 69233408 T DE69233408 T DE 69233408T DE 69233408 D1 DE69233408 D1 DE 69233408D1
- Authority
- DE
- Germany
- Prior art keywords
- antibodies
- production
- surfaces based
- antibody segment
- phage surfaces
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
- C07K16/3092—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/34—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood group antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/41—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a Myc-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9125579 | 1991-12-02 | ||
GB919125579A GB9125579D0 (en) | 1991-07-10 | 1991-12-02 | Binding molecules 1 |
GB919125582A GB9125582D0 (en) | 1991-12-02 | 1991-12-02 | Binding molecules 2 |
GB9125582 | 1991-12-02 | ||
GB929206372A GB9206372D0 (en) | 1992-03-24 | 1992-03-24 | Binding substances |
GB9206318 | 1992-03-24 | ||
GB929206318A GB9206318D0 (en) | 1992-03-24 | 1992-03-24 | Binding substances |
PCT/GB1992/001755 WO1993006213A1 (en) | 1991-09-23 | 1992-09-23 | Production of chimeric antibodies - a combinatorial approach |
WOPCT/GB92/01755 | 1992-09-23 | ||
GB9206372 | 1992-09-23 | ||
PCT/GB1992/002240 WO1993011236A1 (en) | 1991-12-02 | 1992-12-02 | Production of anti-self antibodies from antibody segment repertoires and displayed on phage |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69233408D1 true DE69233408D1 (en) | 2004-10-07 |
DE69233408T2 DE69233408T2 (en) | 2005-09-22 |
Family
ID=27517085
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69233408T Expired - Lifetime DE69233408T2 (en) | 1991-12-02 | 1992-12-02 | Production of Antibodies on Phage Surfaces Starting from Antibody Segment Libraries. |
Country Status (6)
Country | Link |
---|---|
EP (3) | EP1024191B8 (en) |
JP (1) | JP3949712B2 (en) |
AU (1) | AU665221B2 (en) |
CA (1) | CA2124460C (en) |
DE (1) | DE69233408T2 (en) |
DK (1) | DK0616640T3 (en) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5885793A (en) | 1991-12-02 | 1999-03-23 | Medical Research Council | Production of anti-self antibodies from antibody segment repertoires and displayed on phage |
CA2229043C (en) * | 1995-08-18 | 2016-06-07 | Morphosys Gesellschaft Fur Proteinoptimierung Mbh | Protein/(poly)peptide libraries |
GB9722131D0 (en) * | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
JP2001275682A (en) * | 2000-03-31 | 2001-10-09 | Kankyo Meneki Gijutsu Kenkyusho:Kk | Gene encoding antimalathion monoclonal antibody |
JP4213586B2 (en) | 2001-09-13 | 2009-01-21 | 株式会社抗体研究所 | Camel antibody library production method |
EP2141228A1 (en) | 2001-12-18 | 2010-01-06 | Cancer Research Technology Limited | Method for the generation of proliferating and differentiating B cell lines |
DE10346627A1 (en) * | 2003-10-08 | 2005-05-19 | Weiss, Stefan, PD Dr. | Single-chain antibodies against the 37 kDa / 67 kDa laminin receptor as tools for the diagnosis and treatment of prion diseases and cancer, their production and use |
WO2005097832A2 (en) | 2004-03-31 | 2005-10-20 | Genentech, Inc. | Humanized anti-tgf-beta antibodies |
GB0611116D0 (en) | 2006-06-06 | 2006-07-19 | Oxford Genome Sciences Uk Ltd | Proteins |
EA200970250A1 (en) | 2006-09-05 | 2010-02-26 | Медарекс, Инк. | ANTIBODIES TO BONE MORPHOGENETIC PROTEINS AND THEIR RECEPTORS AND METHODS OF THEIR APPLICATION |
EA018836B1 (en) | 2006-10-02 | 2013-11-29 | Медарекс, Л.Л.К. | Human antibodies that bind cxcr4 and uses thereof |
ES2678060T3 (en) | 2006-12-01 | 2018-08-08 | E. R. Squibb & Sons, L.L.C. | Antibodies, in particular, human antibodies, which bind to CD22 and uses thereof |
CL2007003622A1 (en) | 2006-12-13 | 2009-08-07 | Medarex Inc | Human anti-cd19 monoclonal antibody; composition comprising it; and tumor cell growth inhibition method. |
WO2008074004A2 (en) | 2006-12-14 | 2008-06-19 | Medarex, Inc. | Human antibodies that bind cd70 and uses thereof |
EP2121745A2 (en) | 2007-02-26 | 2009-11-25 | Oxford Genome Sciences (UK) Limited | Proteins |
WO2008104803A2 (en) | 2007-02-26 | 2008-09-04 | Oxford Genome Sciences (Uk) Limited | Proteins |
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EP2316030B1 (en) | 2008-07-25 | 2019-08-21 | Wagner, Richard W. | Protein screeing methods |
US20120058131A1 (en) | 2009-01-21 | 2012-03-08 | Oxford Biotherapeutics Ltd | Pta089 protein |
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US8921281B2 (en) | 2009-05-20 | 2014-12-30 | Novimmune S.A. | Synthetic polypeptide libraries and methods for generating naturally diversified polypeptide variants |
EP2470569A1 (en) | 2009-10-13 | 2012-07-04 | Oxford Biotherapeutics Ltd. | Antibodies against epha10 |
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SG10201506906VA (en) | 2010-09-09 | 2015-10-29 | Pfizer | 4-1bb binding molecules |
JP6113721B2 (en) | 2011-06-28 | 2017-04-12 | オックスフォード ビオトヘラペウトイクス エルティーディー. | Therapeutic and diagnostic targets |
ES2640960T3 (en) | 2011-06-28 | 2017-11-07 | Oxford Biotherapeutics Ltd. | Antibodies for ADP-ribosyl cyclase 2 |
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US10112988B2 (en) | 2012-01-09 | 2018-10-30 | Icb International, Inc. | Methods of assessing amyloid-beta peptides in the central nervous system by blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an anti-amyloid-beta peptide |
US10112987B2 (en) | 2012-01-09 | 2018-10-30 | Icb International, Inc. | Blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an amyloid-beta peptide |
BR112014029274B1 (en) | 2012-05-24 | 2022-02-15 | Mountgate Innotech (Hk) Limited | ISOLATED ANTIBODY, PHARMACEUTICAL COMPOSITION, ANTIBODY USE, AND, KIT TO TREAT RABIC INFECTION |
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GB201302447D0 (en) | 2013-02-12 | 2013-03-27 | Oxford Biotherapeutics Ltd | Therapeutic and diagnostic target |
JP6416793B2 (en) | 2013-02-28 | 2018-10-31 | カプリオン プロテオミクス インコーポレーテッド | Tuberculosis biomarkers and uses thereof |
JP2016514130A (en) | 2013-03-14 | 2016-05-19 | ノバルティス アーゲー | Antibody against Notch3 |
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KR101809072B1 (en) | 2013-08-02 | 2017-12-14 | 화이자 인코포레이티드 | Anti-cxcr4 antibodies and antibody-drug conjugates |
CN107663240B (en) * | 2016-07-29 | 2021-01-12 | 中国人民解放军第四军医大学 | Single-chain antibody specifically bound by highly glycosylated CEA and application thereof in detection and treatment |
BR112019001693A2 (en) | 2016-07-29 | 2019-07-02 | Ct Hospitalier Universitaire Toulouse | antibodies targeting tumor-associated macrophages and their uses |
CN110392697A (en) | 2017-03-02 | 2019-10-29 | 国家医疗保健研究所 | There is the antibody and application thereof of specificity to NECTIN-4 |
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CN111511762A (en) | 2017-08-21 | 2020-08-07 | 天演药业公司 | anti-CD137 molecules and uses thereof |
AU2018364630A1 (en) | 2017-11-09 | 2020-05-21 | Pinteon Therapeutics Inc. | Methods and compositions for the generation and use of humanized conformation-specific phosphorylated tau antibodies |
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WO2019148444A1 (en) | 2018-02-02 | 2019-08-08 | Adagene Inc. | Anti-ctla4 antibodies and methods of making and using the same |
TW202016144A (en) | 2018-06-21 | 2020-05-01 | 日商第一三共股份有限公司 | Compositions including cd3 antigen binding fragments and uses thereof |
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Family Cites Families (7)
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DE3852304T3 (en) * | 1987-03-02 | 1999-07-01 | Enzon Lab Inc | Organism as carrier for "Single Chain Antibody Domain (SCAD)". |
ATE102631T1 (en) * | 1988-11-11 | 1994-03-15 | Medical Res Council | CLONING OF IMMUNOGLOBULIN SEQUENCES FROM THE VARIABLE DOMAINS. |
CA2016841C (en) * | 1989-05-16 | 1999-09-21 | William D. Huse | A method for producing polymers having a preselected activity |
EP0478627A4 (en) * | 1989-05-16 | 1992-08-19 | William D. Huse | Co-expression of heteromeric receptors |
CA2016842A1 (en) * | 1989-05-16 | 1990-11-16 | Richard A. Lerner | Method for tapping the immunological repertoire |
GB9015198D0 (en) * | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
ES2139598T3 (en) * | 1990-07-10 | 2000-02-16 | Medical Res Council | PROCEDURES FOR THE PRODUCTION OF SPECIFIC UNION COUPLE MEMBERS. |
-
1992
- 1992-12-02 JP JP50996793A patent/JP3949712B2/en not_active Expired - Lifetime
- 1992-12-02 EP EP00107845A patent/EP1024191B8/en not_active Expired - Lifetime
- 1992-12-02 EP EP10002988A patent/EP2224006A1/en not_active Withdrawn
- 1992-12-02 AU AU30890/92A patent/AU665221B2/en not_active Expired
- 1992-12-02 EP EP92924775A patent/EP0616640B1/en not_active Expired - Lifetime
- 1992-12-02 CA CA002124460A patent/CA2124460C/en not_active Expired - Lifetime
- 1992-12-02 DE DE69233408T patent/DE69233408T2/en not_active Expired - Lifetime
- 1992-12-02 DK DK92924775T patent/DK0616640T3/en active
Also Published As
Publication number | Publication date |
---|---|
EP1024191B8 (en) | 2008-11-05 |
JP3949712B2 (en) | 2007-07-25 |
EP1024191A3 (en) | 2004-03-31 |
DE69233408T2 (en) | 2005-09-22 |
EP1024191A2 (en) | 2000-08-02 |
JPH07502167A (en) | 1995-03-09 |
CA2124460C (en) | 2007-08-28 |
EP0616640B1 (en) | 2004-09-01 |
EP2224006A1 (en) | 2010-09-01 |
AU3089092A (en) | 1993-06-28 |
EP0616640A1 (en) | 1994-09-28 |
AU665221B2 (en) | 1995-12-21 |
CA2124460A1 (en) | 1993-06-10 |
EP1024191B1 (en) | 2008-09-10 |
DK0616640T3 (en) | 2004-12-20 |
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