DE69216003D1 - METHOD FOR PRODUCING TAXOL BY MEANS OF TAXUS SPECIES CELL CULTURE - Google Patents

METHOD FOR PRODUCING TAXOL BY MEANS OF TAXUS SPECIES CELL CULTURE

Info

Publication number
DE69216003D1
DE69216003D1 DE69216003T DE69216003T DE69216003D1 DE 69216003 D1 DE69216003 D1 DE 69216003D1 DE 69216003 T DE69216003 T DE 69216003T DE 69216003 T DE69216003 T DE 69216003T DE 69216003 D1 DE69216003 D1 DE 69216003D1
Authority
DE
Germany
Prior art keywords
taxol
callus
cell culture
cells containing
suspension culture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69216003T
Other languages
German (de)
Inventor
Koji Saito
Hiroaki Ohashi
Masaaki Hibi
Makoto Tahara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Steel Corp
Original Assignee
Nippon Steel Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Steel Corp filed Critical Nippon Steel Corp
Application granted granted Critical
Publication of DE69216003D1 publication Critical patent/DE69216003D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/04—Plant cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms

Abstract

A callus and suspension culture cells containing taxol as an effective component, and a process for producing taxol therefrom, are provided. The callus and suspension culture cells containing taxol in a high content can be induced and proliferated by culturing a tissue of a plant belonging to the genus Taxus, particularly its female gametophyte. The process for cell culture is advantageously carried out in the presence of a particular combination of plant growth regulators known per se in a growth medium. A callus or suspension culture cells containing at least taxol as an effective component can be stably provided, making it possible to effectively produce taxol.
DE69216003T 1991-02-12 1992-02-10 METHOD FOR PRODUCING TAXOL BY MEANS OF TAXUS SPECIES CELL CULTURE Expired - Lifetime DE69216003D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1901091 1991-02-12
PCT/JP1992/000132 WO1992013961A1 (en) 1991-02-12 1992-02-10 Process for producing taxol by cell culture of taxus species

Publications (1)

Publication Number Publication Date
DE69216003D1 true DE69216003D1 (en) 1997-01-30

Family

ID=11987535

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69216003T Expired - Lifetime DE69216003D1 (en) 1991-02-12 1992-02-10 METHOD FOR PRODUCING TAXOL BY MEANS OF TAXUS SPECIES CELL CULTURE

Country Status (6)

Country Link
EP (1) EP0529083B1 (en)
JP (1) JPH05507629A (en)
AT (1) ATE146527T1 (en)
CA (1) CA2080000A1 (en)
DE (1) DE69216003D1 (en)
WO (1) WO1992013961A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5407816A (en) * 1992-02-20 1995-04-18 Phyton Catalytic, Inc. Enhanced production of taxol and taxanes by cell cultures of taxus species
US7264951B1 (en) 1992-02-20 2007-09-04 Phyton, Inc. Enhanced production of taxol and taxanes by cell cultures of Taxus species
CA2434692A1 (en) * 1992-04-07 1993-10-08 Paul M. Cino Callus cell induction and the preparation of taxanes
CA2136213A1 (en) * 1992-05-21 1993-11-25 Richard N. Arteca Cultured taxu tissues as a source of taxol, related taxanes and other novel anti-tumor/anti-viral compounds
US5279949A (en) * 1992-12-07 1994-01-18 Board Of Trustees Operating Michigan State University Process for the isolation and purification of taxol and taxanes from Taxus spp
KR950005081B1 (en) * 1993-07-06 1995-05-18 산림청임목육종연구소 Method for producing taxol and its derivatives from embryo cultures of taxus species
US5547866A (en) * 1994-07-20 1996-08-20 The Regents Of The University Of California Taxane production in haploid-derived cell cultures
KR960037826A (en) * 1995-04-27 1996-11-19 김경환 Semi-continuous culture method of Taxus plant cells
BR9709361B1 (en) 1996-05-24 2009-05-05 increased taxane production by taxus species cell cultures.
CN102687667B (en) * 2012-06-19 2013-09-04 湖南农业大学 Method for inducing haploid endosperm callus tissues by using ripe endosperms of taxales chinensis var.mairei
CN108841778B (en) * 2018-04-28 2022-05-17 大连普瑞康生物技术有限公司 Taxus chinensis cell tissue culture

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5019504A (en) * 1989-03-23 1991-05-28 The United States Of America As Represented By The Secretary Of Agriculture Production of taxol or taxol-like compounds in cell culture

Also Published As

Publication number Publication date
ATE146527T1 (en) 1997-01-15
EP0529083B1 (en) 1996-12-18
CA2080000A1 (en) 1992-08-13
JPH05507629A (en) 1993-11-04
EP0529083A1 (en) 1993-03-03
WO1992013961A1 (en) 1992-08-20

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Legal Events

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