DE60313350D1 - Pyrimidin-2,4-dion-derivate als matrix-metalloproteinase-hemmer - Google Patents
Pyrimidin-2,4-dion-derivate als matrix-metalloproteinase-hemmerInfo
- Publication number
- DE60313350D1 DE60313350D1 DE60313350T DE60313350T DE60313350D1 DE 60313350 D1 DE60313350 D1 DE 60313350D1 DE 60313350 T DE60313350 T DE 60313350T DE 60313350 T DE60313350 T DE 60313350T DE 60313350 D1 DE60313350 D1 DE 60313350D1
- Authority
- DE
- Germany
- Prior art keywords
- sup
- pyrimidin
- matrix metalloproteinase
- metalloproteinase inhibitors
- dion derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40302302P | 2002-08-13 | 2002-08-13 | |
US403023P | 2002-08-13 | ||
PCT/IB2003/003525 WO2004014868A2 (en) | 2002-08-13 | 2003-08-04 | Pyrimidine-2,4-dione derivatives as matrix metalloproteinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60313350D1 true DE60313350D1 (de) | 2007-05-31 |
DE60313350T2 DE60313350T2 (de) | 2008-01-03 |
Family
ID=31715924
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60313350T Expired - Fee Related DE60313350T2 (de) | 2002-08-13 | 2003-08-04 | Pyrimidin-2,4-dion-derivate als matrix-metalloproteinase-hemmer |
Country Status (11)
Country | Link |
---|---|
US (1) | US7160893B2 (de) |
EP (1) | EP1553949B1 (de) |
JP (1) | JP2006500351A (de) |
AT (1) | ATE359791T1 (de) |
AU (1) | AU2003250471A1 (de) |
BR (1) | BR0313385A (de) |
CA (1) | CA2497656A1 (de) |
DE (1) | DE60313350T2 (de) |
ES (1) | ES2283851T3 (de) |
MX (1) | MXPA05001783A (de) |
WO (1) | WO2004014868A2 (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2462442A1 (en) | 2001-10-12 | 2003-04-24 | Warner-Lambert Company Llc | Alkyne matrix metalloproteinase inhibitors |
PA8578101A1 (es) * | 2002-08-13 | 2004-05-07 | Warner Lambert Co | Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz |
US20040142950A1 (en) * | 2003-01-17 | 2004-07-22 | Bunker Amy Mae | Amide and ester matrix metalloproteinase inhibitors |
US7183287B2 (en) * | 2003-04-03 | 2007-02-27 | Pharmacia Corporation | Substituted pyrimidinones |
US20070167621A1 (en) | 2003-04-03 | 2007-07-19 | Pharmacia Corporation | Substituted pyrimidinones |
US20060247231A1 (en) * | 2003-12-18 | 2006-11-02 | Warner-Lambert Company Llc | Amide and ester matrix metalloproteinase inhibitors |
NZ549716A (en) * | 2004-03-15 | 2010-04-30 | Takeda Pharmaceutical | Pyrimidin-dione derivatives as dipeptidyl peptidase inhibitors |
EP2708531A1 (de) | 2004-10-13 | 2014-03-19 | Pharmacia & Upjohn Company LLC | Kristalline Formen Von 3-[5-Chloro-4-[(2,4-difluorbenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-N-(2-hydroxyethyl)-4-methylbenzamid |
KR20070116915A (ko) * | 2005-03-24 | 2007-12-11 | 얀센 파마슈티카 엔.브이. | 프로키네티신 2 수용체 길항제로서의 피리미딘디온 유도체 |
CL2006003736A1 (es) * | 2005-12-29 | 2008-05-16 | Janssen Pharmaceutica Nv | Compuestos derivados de triazina o pirimidina sustituida, antagonistas del receptor de prokineticina 1, composicion farmaceutica; y uso en el tratamiento de trastornos gastrointestinales. |
CA2635845A1 (en) * | 2005-12-29 | 2007-07-12 | Janssen Pharmaceutica N.V. | Prokineticin 2 receptor antagonists |
TWI394747B (zh) | 2006-06-23 | 2013-05-01 | Smithkline Beecham Corp | 脯胺醯基羥化酶抑制劑 |
TW200918507A (en) * | 2007-06-29 | 2009-05-01 | Gilead Sciences Inc | Novel HIV reverse transcriptase inhibitors |
CA2758587A1 (en) * | 2009-04-13 | 2010-10-21 | Irm Llc | Compositions and methods for modulating retinol binding to retinol binding protein 4 (rbp4) |
WO2012006004A1 (en) * | 2010-06-28 | 2012-01-12 | Janssen Pharmaceutica Nv | Prokineticin 1 receptor antagonists for the treatment of pain |
KR20150123917A (ko) * | 2013-03-05 | 2015-11-04 | 에프. 호프만-라 로슈 아게 | 항바이러스 화합물 |
US9199945B2 (en) | 2013-06-21 | 2015-12-01 | MyoKardia, Inc. | Cycloalkyl-substituted pyrimidinedione compounds |
CN105473576B (zh) | 2013-06-21 | 2018-10-30 | 迈奥卡迪亚公司 | 针对心脏病症的嘧啶二酮化合物 |
CN105777653A (zh) * | 2014-12-26 | 2016-07-20 | 中国科学院上海药物研究所 | 用作Lp-PLA2抑制剂的嘧啶酮类化合物及其药物组合物 |
KR101676158B1 (ko) * | 2015-03-02 | 2016-11-23 | 동국대학교 산학협력단 | 신규한 6-아미노-5-(치환)피리미딘-2,4(1h,3h)-디온 유도체, 이의 제조방법 및 이의 용도 |
CN111116492B (zh) * | 2019-01-25 | 2021-07-09 | 青岛吉澳医药科技有限公司 | 氘代苯甲氨嘧啶二酮衍生物及其用途 |
Family Cites Families (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE284226C (de) | ||||
JPS61205261A (ja) * | 1985-03-08 | 1986-09-11 | Sagami Chem Res Center | 6―置換―5―フルオロウラシル誘導体 |
DD284226A5 (de) * | 1989-06-07 | 1990-11-07 | Akademie Der Wissenschaften Der Ddr,Dd | Verfahren zur herstellung von 6-aminosubstituierten 5-methyluracilen |
US5425289A (en) | 1993-10-21 | 1995-06-20 | Snap-On Incorporated | Bung tool |
DE3931432A1 (de) | 1989-09-21 | 1991-04-04 | Hoechst Ag | Pyrimidin-4,6-dicarbonsaeurediamide, verfahren zu deren herstellung sowie verwendung derselben sowie arzneimittel auf basis dieser verbindungen |
HU205917B (en) * | 1989-09-29 | 1992-07-28 | Mitsubishi Chem Ind | Process for producing 6-substituted pyrimidine derivatives and antiviral pharmaceutical compositions containing them as active components |
US5260323A (en) | 1990-06-28 | 1993-11-09 | Hoechst Aktiengesellschaft | 2,4- and 2,5-substituted pyridine-N-oxides, processes for their preparation and their use |
EP0541042A1 (de) | 1991-11-05 | 1993-05-12 | Hoechst Aktiengesellschaft | Pyridin-2,4- und 2,5-dicarbonsäureamide und deren Derivate, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel |
JP3153387B2 (ja) * | 1993-04-28 | 2001-04-09 | 富士写真フイルム株式会社 | 感光材料 |
US6008243A (en) | 1996-10-24 | 1999-12-28 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use |
JPH11199512A (ja) | 1997-10-24 | 1999-07-27 | Pfizer Prod Inc | 変形性関節症および他のmmp媒介疾患の治療のためのmmp−13選択的阻害剤の使用 |
NZ507187A (en) * | 1998-04-03 | 2002-10-25 | Sankyo Co | Aryloxy or heteroaryloxy substituted sulfonamide derivatives useful as matrix metalloproteinase inhibitors |
UA59453C2 (uk) | 1998-08-12 | 2003-09-15 | Пфайзер Продактс Інк. | Похідні гідроксипіпеколат гідроксамової кислоти як інгібітори матричних металопротеїназ |
US6177437B1 (en) * | 1998-09-04 | 2001-01-23 | University Of Massachusetts Medical Center | Inhibitors of Herpes Simplex virus uracil-DNA glycosylase |
WO2000051990A1 (en) * | 1999-03-04 | 2000-09-08 | Korea Research Institute Of Chemical Technology | Antiviral 2,4-pyrimidinedione derivatives and process for the preparation thereof |
PA8498701A1 (es) | 1999-08-12 | 2002-08-26 | Pfizer Prod Inc | Pirimidina-2,4,6-trionas inhibidores de metaloproteinasas |
WO2001029010A1 (en) * | 1999-10-21 | 2001-04-26 | Merck & Co., Inc. | Gram-positive selective antibacterial compounds, compositions containing such compounds and methods of treatment |
US6934639B1 (en) | 2000-02-25 | 2005-08-23 | Wyeth | Methods for designing agents that interact with MMP-13 |
WO2001072718A1 (fr) * | 2000-03-29 | 2001-10-04 | Ishihara Sangyo Kaisha, Ltd. | Compositions pharmaceutiques contenant comme ingredient actif des derives de nitropyrimidine ou leurs sels |
EP1138680A1 (de) | 2000-03-29 | 2001-10-04 | Pfizer Products Inc. | Gem substituierte Sulfonylhydroxamsäuren mit MMP inhibierender Wirkung |
KR20040004412A (ko) | 2000-10-26 | 2004-01-13 | 화이자 프로덕츠 인크. | 스피로-피리미딘-2,4,6-트리온 메탈로프로테이나제 억제제 |
PL362919A1 (en) | 2000-10-26 | 2004-11-02 | Pfizer Products Inc. | Pyrimidine-2,4,6-trione metalloproteinase inhibitors |
MXPA03004926A (es) | 2001-02-14 | 2005-02-14 | Warner Lambert Co | Inhibidores de metaloproteinasas de matriz basados en pirimidinonas fusionadas. |
DOP2002000332A (es) | 2001-02-14 | 2002-08-30 | Warner Lambert Co | Inhibidores de piridina de metaloproteinasas de la matriz |
EP1368327B1 (de) | 2001-02-14 | 2004-10-20 | Warner-Lambert Company LLC | Benzothiadiazine als matrix metallproteinase inhibitoren |
PA8539401A1 (es) | 2001-02-14 | 2002-10-28 | Warner Lambert Co | Quinazolinas como inhibidores de mmp-13 |
PA8539301A1 (es) | 2001-02-14 | 2002-09-30 | Warner Lambert Co | Inhibidores de la metaloproteinasa de la matriz |
DOP2002000333A (es) | 2001-02-14 | 2002-09-30 | Warner Lambert Co | Derivados de acido isoftalico como inhibidores de metaloproteinasas de la matriz |
PA8539501A1 (es) | 2001-02-14 | 2002-09-30 | Warner Lambert Co | Compuestos triazolo como inhibidores de mmp |
EP1368323B1 (de) | 2001-02-14 | 2010-06-30 | Warner-Lambert Company LLC | Pyrimidinmatrixmetalloproteinaseinhibitoren |
DOP2002000334A (es) | 2001-02-14 | 2002-08-30 | Warner Lambert Co | Pirimidinas biciclicas como inhibidores de metaloproteinasas de matriz |
US6924276B2 (en) | 2001-09-10 | 2005-08-02 | Warner-Lambert Company | Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors |
US6962922B2 (en) | 2001-10-12 | 2005-11-08 | Warner-Lambert Company Llc | Alkynylated quinazoline compounds |
CA2462442A1 (en) | 2001-10-12 | 2003-04-24 | Warner-Lambert Company Llc | Alkyne matrix metalloproteinase inhibitors |
WO2003033478A1 (en) | 2001-10-12 | 2003-04-24 | Warner-Lambert Company Llc | Alkynylated fused ring pyrimidine compounds as matrix metalloprotease-13 inhibitors |
US6933298B2 (en) | 2001-12-08 | 2005-08-23 | Aventis Pharma Deutschland Gmbh | Pyridine-2,4-dicarboxylic acid diamides and pyrimidine-4,6-dicarboxylic acid diamides and the use thereof for selectively inhibiting collagenases |
US6894057B2 (en) | 2002-03-08 | 2005-05-17 | Warner-Lambert Company | Oxo-azabicyclic compounds |
US6747147B2 (en) | 2002-03-08 | 2004-06-08 | Warner-Lambert Company | Oxo-azabicyclic compounds |
WO2003076416A1 (en) | 2002-03-08 | 2003-09-18 | Warner-Lambert Company Llc | Oxo azabicyclic compounds |
WO2004000321A1 (en) | 2002-06-25 | 2003-12-31 | Warner-Lambert Company Llc | Thiazine and oxazine derivatives as mmp-13 inhibitors for treating arthritis |
US20040006077A1 (en) | 2002-06-25 | 2004-01-08 | Bernard Gaudilliere | Thiazine and oxazine derivatives as MMP-13 inhibitors |
-
2003
- 2003-08-04 JP JP2004527212A patent/JP2006500351A/ja not_active Ceased
- 2003-08-04 EP EP03784400A patent/EP1553949B1/de not_active Expired - Lifetime
- 2003-08-04 AT AT03784400T patent/ATE359791T1/de not_active IP Right Cessation
- 2003-08-04 DE DE60313350T patent/DE60313350T2/de not_active Expired - Fee Related
- 2003-08-04 ES ES03784400T patent/ES2283851T3/es not_active Expired - Lifetime
- 2003-08-04 CA CA002497656A patent/CA2497656A1/en not_active Abandoned
- 2003-08-04 MX MXPA05001783A patent/MXPA05001783A/es active IP Right Grant
- 2003-08-04 AU AU2003250471A patent/AU2003250471A1/en not_active Abandoned
- 2003-08-04 WO PCT/IB2003/003525 patent/WO2004014868A2/en active IP Right Grant
- 2003-08-04 BR BR0313385-0A patent/BR0313385A/pt not_active IP Right Cessation
- 2003-08-05 US US10/634,419 patent/US7160893B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1553949B1 (de) | 2007-04-18 |
WO2004014868A2 (en) | 2004-02-19 |
US20040053952A1 (en) | 2004-03-18 |
AU2003250471A8 (en) | 2004-02-25 |
EP1553949A2 (de) | 2005-07-20 |
WO2004014868A3 (en) | 2004-06-03 |
AU2003250471A1 (en) | 2004-02-25 |
DE60313350T2 (de) | 2008-01-03 |
ATE359791T1 (de) | 2007-05-15 |
ES2283851T3 (es) | 2007-11-01 |
BR0313385A (pt) | 2005-06-14 |
US7160893B2 (en) | 2007-01-09 |
WO2004014868A8 (en) | 2004-07-29 |
JP2006500351A (ja) | 2006-01-05 |
MXPA05001783A (es) | 2005-04-25 |
CA2497656A1 (en) | 2004-02-19 |
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