DE60227094D1 - Microwell-biochip - Google Patents
Microwell-biochipInfo
- Publication number
- DE60227094D1 DE60227094D1 DE60227094T DE60227094T DE60227094D1 DE 60227094 D1 DE60227094 D1 DE 60227094D1 DE 60227094 T DE60227094 T DE 60227094T DE 60227094 T DE60227094 T DE 60227094T DE 60227094 D1 DE60227094 D1 DE 60227094D1
- Authority
- DE
- Germany
- Prior art keywords
- undersurface
- solution
- polymerizing
- microwell
- hydrogel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/18—Apparatus therefor
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
- B01L3/50255—Multi-well filtration
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00281—Individual reactor vessels
- B01J2219/00286—Reactor vessels with top and bottom openings
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
- B01J2219/00315—Microtiter plates
- B01J2219/00317—Microwell devices, i.e. having large numbers of wells
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00385—Printing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/0054—Means for coding or tagging the apparatus or the reagents
- B01J2219/00572—Chemical means
- B01J2219/00576—Chemical means fluorophore
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00702—Processes involving means for analysing and characterising the products
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00725—Peptides
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/0074—Biological products
- B01J2219/00743—Cells
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0689—Sealing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/12—Specific details about manufacturing devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0819—Microarrays; Biochips
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
- B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0346—Capillary cells; Microcells
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Water Supply & Treatment (AREA)
- Clinical Laboratory Science (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Devices For Use In Laboratory Experiments (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Microwell biochips ( 11 ) are formed from a thin flat plate ( 13 ) of polymeric material having a plurality of regularly spaced holes ( 15 ) that extend completely therethrough and create microwells. The lower end of each hole is closed by a microporous, hydrophobic, polymeric membrane ( 17 ) laminated to the undersurface of the plate which retains an aqueous test solution in the wells until a vacuum is applied to the undersurface thereof to effect draining of the solution and of any wash solution that might be subsequently added. A spot of polymerizing isocyanate-functional hydrogel is applied generally centrally to the porous membrane surface at the bottom of each well in a manner so as to cover only a minor portion of the surface and out of contact with the well sidewalls, thus leaving substantial surface area through which drainage can be readily effected. Biological capture agents are associated with the polymerizing hydrogel so as to become immobilized as a part thereof.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32963201P | 2001-10-15 | 2001-10-15 | |
PCT/US2002/032751 WO2003034026A2 (en) | 2001-10-15 | 2002-10-15 | Microwell biochip |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60227094D1 true DE60227094D1 (en) | 2008-07-24 |
Family
ID=23286305
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60227094T Expired - Lifetime DE60227094D1 (en) | 2001-10-15 | 2002-10-15 | Microwell-biochip |
Country Status (7)
Country | Link |
---|---|
US (1) | US7217520B2 (en) |
EP (1) | EP1444500B1 (en) |
JP (1) | JP4117249B2 (en) |
AT (1) | ATE398284T1 (en) |
AU (1) | AU2002340198A1 (en) |
DE (1) | DE60227094D1 (en) |
WO (1) | WO2003034026A2 (en) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1403644A1 (en) * | 2002-09-25 | 2004-03-31 | Agilent Technologies Inc. a Delaware Corporation | Fluid analyzer |
GB0311902D0 (en) | 2003-05-22 | 2003-06-25 | Cambridge Life Sciences | Assay method and apparatus |
US20050019905A1 (en) * | 2003-07-23 | 2005-01-27 | The President And Fellows Of Harvard College | System for containing and processing small objects |
US20060286555A1 (en) * | 2003-08-21 | 2006-12-21 | Van Beuningen Marinus G J | Microarray support for bioprobe synthesis |
DE602005007591D1 (en) * | 2004-04-21 | 2008-07-31 | Pamgene Bv | MASKED SOLID CARRIER |
DE102004023178B4 (en) | 2004-05-07 | 2006-06-29 | Hellma Gmbh & Co. Kg | Apparatus for analysis or absorption measurement on a small amount of liquid medium by means of light |
US20050266398A1 (en) * | 2004-06-01 | 2005-12-01 | Peter Lea | Method and device for rapid detection and quantitation of macro and micro matrices |
EP1771066A2 (en) * | 2004-07-13 | 2007-04-11 | Neose Technologies, Inc. | Branched peg remodeling and glycosylation of glucagon-like peptide-1 glp-1 |
CA2475456A1 (en) | 2004-07-20 | 2006-01-20 | Biophys, Inc. | Method and device to optimize analyte and antibody substrate binding by least energy adsorption |
CA2475191A1 (en) * | 2004-07-20 | 2006-01-20 | Biophys, Inc. | System and method for rapid reading of macro and micro matrices |
CA2475240A1 (en) * | 2004-07-20 | 2006-01-20 | Biophys, Inc. | Method and device to measure dynamic internal calibration true dose response curves |
US20090136982A1 (en) | 2005-01-18 | 2009-05-28 | Biocept, Inc. | Cell separation using microchannel having patterned posts |
US8158410B2 (en) | 2005-01-18 | 2012-04-17 | Biocept, Inc. | Recovery of rare cells using a microchannel apparatus with patterned posts |
KR20070116585A (en) | 2005-01-18 | 2007-12-10 | 바이오셉트 인코포레이티드 | Cell separation using microchannel having patterned posts |
US20060252087A1 (en) * | 2005-01-18 | 2006-11-09 | Biocept, Inc. | Recovery of rare cells using a microchannel apparatus with patterned posts |
US20060188940A1 (en) * | 2005-02-22 | 2006-08-24 | Michael Cima | Combinatorial hydrogel formulation |
JP4591195B2 (en) | 2005-05-19 | 2010-12-01 | ソニー株式会社 | Substrate and apparatus for bioassay, and method for producing substrate |
US20090130384A1 (en) * | 2005-09-30 | 2009-05-21 | Toyama Prefecture | Chip Provided with film Having Hole Pattern with the Use of Thermoresponsive Polymer and Method of Producing the Same |
US7695956B2 (en) * | 2006-01-12 | 2010-04-13 | Biocept, Inc. | Device for cell separation and analysis and method of using |
GB0611701D0 (en) * | 2006-06-14 | 2006-07-26 | Biochrom Ltd | Analytical apparatus |
CA2569971A1 (en) | 2006-12-04 | 2008-06-04 | Umedik Inc. | Method for double-dip substrate spin optimization of coated micro array supports |
US20120129208A1 (en) * | 2009-03-18 | 2012-05-24 | Michelle Khine | Honeycomb shrink wells for stem cell culture |
CN107033368A (en) | 2009-11-09 | 2017-08-11 | 聚光灯技术合伙有限责任公司 | fragmentation hydrogel |
US9700650B2 (en) | 2009-11-09 | 2017-07-11 | Spotlight Technology Partners Llc | Polysaccharide based hydrogels |
JP5975220B2 (en) * | 2009-11-16 | 2016-08-23 | シリコン バイオディバイスイズ,インク. | Device for analyzing biological fluid specimens and method for analyzing |
US9174216B2 (en) | 2013-03-13 | 2015-11-03 | DeNovo Science, Inc. | System for capturing and analyzing cells |
WO2013019491A1 (en) | 2011-08-01 | 2013-02-07 | Denovo Sciences | Cell capture system and method of use |
US10466160B2 (en) | 2011-08-01 | 2019-11-05 | Celsee Diagnostics, Inc. | System and method for retrieving and analyzing particles |
US9404864B2 (en) | 2013-03-13 | 2016-08-02 | Denovo Sciences, Inc. | System for imaging captured cells |
US9606102B2 (en) | 2013-01-26 | 2017-03-28 | Denovo Sciences, Inc. | System and method for capturing and analyzing cells |
US9707562B2 (en) | 2013-03-13 | 2017-07-18 | Denovo Sciences, Inc. | System for capturing and analyzing cells |
US9856535B2 (en) | 2013-05-31 | 2018-01-02 | Denovo Sciences, Inc. | System for isolating cells |
US10391490B2 (en) | 2013-05-31 | 2019-08-27 | Celsee Diagnostics, Inc. | System and method for isolating and analyzing cells |
US9567630B2 (en) * | 2013-10-23 | 2017-02-14 | Genia Technologies, Inc. | Methods for forming lipid bilayers on biochips |
US10850278B2 (en) | 2014-01-29 | 2020-12-01 | Arizona Board Of Regents On Behalf Of Arizona State University | Microreactor array platform |
WO2016022930A1 (en) | 2014-08-07 | 2016-02-11 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Reversible stencils for fabricating micro-tissues |
US10036739B2 (en) | 2015-01-27 | 2018-07-31 | Genia Technologies, Inc. | Adjustable bilayer capacitance structure for biomedical devices |
US10809243B2 (en) | 2015-08-31 | 2020-10-20 | Roche Sequencing Solutions, Inc. | Small aperture large electrode cell |
WO2017040989A1 (en) * | 2015-09-04 | 2017-03-09 | Saint Louis University | Custom multiwell plate design for rapid preparation and assembly of photo-patterned hydrogels |
EP3651903A4 (en) | 2017-08-29 | 2021-06-16 | Bio-Rad Laboratories, Inc. | System and method for isolating and analyzing cells |
JP1619171S (en) | 2018-01-19 | 2018-11-26 | ||
USD894421S1 (en) | 2018-01-19 | 2020-08-25 | Hamamatsu Photonics K.K. | Sample holder for ionized sample analysis |
JP1619173S (en) | 2018-01-19 | 2018-11-26 | ||
USD898940S1 (en) | 2018-01-19 | 2020-10-13 | Hamamatsu Photonics K.K. | Sample holder for ionized sample analysis |
JP1614535S (en) | 2018-01-19 | 2018-09-25 | ||
USD895142S1 (en) | 2018-01-19 | 2020-09-01 | Hamamatsu Photonics K.K. | Sample holder for ionized sample analysis |
USD891635S1 (en) | 2018-01-19 | 2020-07-28 | Hamamatsu Photonics K.K. | Sample holder for ionized sample analysis |
JP1614365S (en) | 2018-01-19 | 2018-09-25 | ||
JP1614541S (en) * | 2018-01-19 | 2018-09-25 | ||
USD895835S1 (en) | 2018-01-19 | 2020-09-08 | Hamamatsu Photonics K.K. | Sample holder for ionized sample analysis |
JP1614538S (en) | 2018-01-19 | 2018-09-25 | ||
USD895832S1 (en) | 2018-01-19 | 2020-09-08 | Hamamatsu Photonics K.K. | Sample holder for ionized sample analysis |
USD901715S1 (en) | 2018-01-19 | 2020-11-10 | Hamamatsu Photonics K.K. | Sample holder for ionized sample analysis |
JP1614369S (en) | 2018-01-19 | 2018-09-25 | ||
JP1614364S (en) * | 2018-01-19 | 2018-09-25 | ||
JP1614536S (en) | 2018-01-19 | 2018-09-25 | ||
JP1614542S (en) | 2018-01-19 | 2018-09-25 | ||
TWI672502B (en) * | 2018-10-05 | 2019-09-21 | 長庚大學 | Platelet antibody screening and simultaneous immunoassay method and detection device for platelet cross-matching |
US10633693B1 (en) | 2019-04-16 | 2020-04-28 | Celsee Diagnostics, Inc. | System and method for leakage control in a particle capture system |
AU2020267743B2 (en) | 2019-05-07 | 2023-04-06 | Bio-Rad Laboratories, Inc. | System and method for automated single cell processing |
US11273439B2 (en) | 2019-05-07 | 2022-03-15 | Bio-Rad Laboratories, Inc. | System and method for target material retrieval from microwells |
EP3982716A4 (en) | 2019-06-14 | 2023-09-06 | Bio-Rad Laboratories, Inc. | System and method for automated single cell processing and analyses |
KR20220041854A (en) * | 2019-08-07 | 2022-04-01 | 가부시키가이샤 파트너 펌 | Solid-phase reaction vessel and measurement method using the same |
US11504719B2 (en) | 2020-03-12 | 2022-11-22 | Bio-Rad Laboratories, Inc. | System and method for receiving and delivering a fluid for sample processing |
WO2022114079A1 (en) * | 2020-11-26 | 2022-06-02 | 国立大学法人埼玉大学 | Immunochromatographic kit for fluorescent immunochromatography and housing case comprising immunochromatographic kit |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3939105A (en) * | 1974-06-18 | 1976-02-17 | Union Carbide Corporation | Microporous polyurethane hydrogels, method and composites with natural and other synthetic fibers or films |
US4734192A (en) * | 1982-07-01 | 1988-03-29 | Millipore Corporation | Multiwell membrane filtration apparatus |
US4526690A (en) | 1983-02-04 | 1985-07-02 | Millipore Corporation | Apparatus for nucleic acid quantification |
US4493815A (en) * | 1983-07-28 | 1985-01-15 | Bio-Rad Laboratories, Inc. | Supporting and filtering biochemical test plate assembly |
GB2176601B (en) * | 1985-06-10 | 1989-02-01 | Bio Rad Laboratories | Test plate assembly defining discrete regions on a microporous membrane with low boundary distortion |
US5047215A (en) | 1985-06-18 | 1991-09-10 | Polyfiltronics, Inc. | Multiwell test plate |
US4777021A (en) | 1986-04-25 | 1988-10-11 | Richard K. Wertz | Manifold vacuum device for biochemical and immunological uses |
US4895706A (en) * | 1986-10-28 | 1990-01-23 | Costar Corporation | Multi-well filter strip and composite assemblies |
US4797259A (en) | 1986-12-15 | 1989-01-10 | Pall Corporation | Well-type diagnostic plate device |
US4921809A (en) * | 1987-09-29 | 1990-05-01 | Findley Adhesives, Inc. | Polymer coated solid matrices and use in immunoassays |
US5009780A (en) | 1989-07-20 | 1991-04-23 | Millipore Corporation | Multi-well filtration apparatus |
US5667976A (en) | 1990-05-11 | 1997-09-16 | Becton Dickinson And Company | Solid supports for nucleic acid hybridization assays |
US5141719A (en) * | 1990-07-18 | 1992-08-25 | Bio-Rad Laboratories, Inc. | Multi-sample filtration plate assembly |
US5116496A (en) | 1991-03-19 | 1992-05-26 | Minnesota Mining And Manufacturing Company | Membrane-containing wells for microtitration and microfiltration |
US5264184A (en) * | 1991-03-19 | 1993-11-23 | Minnesota Mining And Manufacturing Company | Device and a method for separating liquid samples |
US5326533A (en) | 1992-11-04 | 1994-07-05 | Millipore Corporation | Multiwell test apparatus |
AU700315B2 (en) * | 1993-10-28 | 1998-12-24 | Houston Advanced Research Center | Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions |
US5554536A (en) | 1995-01-05 | 1996-09-10 | Millipore Investment Holdings Limited | Biological analysis device having improved contamination prevention |
US5674395A (en) | 1995-06-05 | 1997-10-07 | Millipore Corporation | Multiple sample separator |
US5679310A (en) | 1995-07-11 | 1997-10-21 | Polyfiltronics, Inc. | High surface area multiwell test plate |
US6146854A (en) | 1995-08-31 | 2000-11-14 | Sequenom, Inc. | Filtration processes, kits and devices for isolating plasmids |
WO1997049987A1 (en) | 1996-06-27 | 1997-12-31 | Cellstat Technologies, Inc. | High-throughput screening method and apparatus |
EP0929361A4 (en) * | 1996-10-04 | 2000-07-19 | Whatman Inc | Device and method for simultaneous multiple chemical syntheses |
US6083761A (en) * | 1996-12-02 | 2000-07-04 | Glaxo Wellcome Inc. | Method and apparatus for transferring and combining reagents |
US5906796A (en) * | 1997-08-04 | 1999-05-25 | Ansys, Inc. | Solid phase extraction plate |
US6027695A (en) | 1998-04-01 | 2000-02-22 | Dupont Pharmaceuticals Company | Apparatus for holding small volumes of liquids |
US6159368A (en) | 1998-10-29 | 2000-12-12 | The Perkin-Elmer Corporation | Multi-well microfiltration apparatus |
CA2369002A1 (en) * | 1999-02-26 | 2000-08-31 | Mosaic Technologies | Methods for purifying dna using immobilized capture probes |
US6372813B1 (en) * | 1999-06-25 | 2002-04-16 | Motorola | Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays |
-
2002
- 2002-10-15 AT AT02778545T patent/ATE398284T1/en not_active IP Right Cessation
- 2002-10-15 DE DE60227094T patent/DE60227094D1/en not_active Expired - Lifetime
- 2002-10-15 JP JP2003536713A patent/JP4117249B2/en not_active Expired - Fee Related
- 2002-10-15 EP EP02778545A patent/EP1444500B1/en not_active Expired - Lifetime
- 2002-10-15 AU AU2002340198A patent/AU2002340198A1/en not_active Abandoned
- 2002-10-15 WO PCT/US2002/032751 patent/WO2003034026A2/en active Application Filing
-
2004
- 2004-04-12 US US10/823,021 patent/US7217520B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
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WO2003034026A2 (en) | 2003-04-24 |
EP1444500A2 (en) | 2004-08-11 |
EP1444500B1 (en) | 2008-06-11 |
JP4117249B2 (en) | 2008-07-16 |
JP2005506530A (en) | 2005-03-03 |
US7217520B2 (en) | 2007-05-15 |
US20040191891A1 (en) | 2004-09-30 |
WO2003034026A3 (en) | 2003-11-27 |
AU2002340198A1 (en) | 2003-04-28 |
ATE398284T1 (en) | 2008-07-15 |
EP1444500A4 (en) | 2006-02-08 |
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