DE602004022508D1 - Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen - Google Patents

Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen

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Publication number
DE602004022508D1
DE602004022508D1 DE602004022508T DE602004022508T DE602004022508D1 DE 602004022508 D1 DE602004022508 D1 DE 602004022508D1 DE 602004022508 T DE602004022508 T DE 602004022508T DE 602004022508 T DE602004022508 T DE 602004022508T DE 602004022508 D1 DE602004022508 D1 DE 602004022508D1
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manufactured
mold
test agent
dimensional
micro
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Expired - Lifetime
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DE602004022508T
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English (en)
Inventor
Joseph P M D Vacanti
Robert Rubin
Wing Cheung
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General Hospital Corp
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General Hospital Corp
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5038—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving detection of metabolites per se
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE602004022508T 2003-01-16 2004-01-16 Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen Expired - Lifetime DE602004022508D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44053903P 2003-01-16 2003-01-16
PCT/US2004/001098 WO2004065616A2 (en) 2003-01-16 2004-01-16 Use of three-dimensional microfabricated tissue engineered systems for pharmacologic applications

Publications (1)

Publication Number Publication Date
DE602004022508D1 true DE602004022508D1 (de) 2009-09-24

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DE602004022508T Expired - Lifetime DE602004022508D1 (de) 2003-01-16 2004-01-16 Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen

Country Status (5)

Country Link
US (2) US7670797B2 (de)
EP (1) EP1589814B1 (de)
AT (1) ATE439039T1 (de)
DE (1) DE602004022508D1 (de)
WO (1) WO2004065616A2 (de)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7759113B2 (en) * 1999-04-30 2010-07-20 The General Hospital Corporation Fabrication of tissue lamina using microfabricated two-dimensional molds
EP1589814B1 (de) 2003-01-16 2009-08-12 The General Hospital Corporation Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen
EP1732707B1 (de) 2004-03-19 2015-04-22 Commonwealth Scientific and Industrial Research Organisation Aktivierungsverfahren
US8741555B2 (en) * 2004-05-14 2014-06-03 Organ Recovery Systems, Inc. Apparatus and method for perfusion and determining the viability of an organ
US8075904B2 (en) * 2004-08-11 2011-12-13 California Institute Of Technology High aspect ratio template and method for producing same for central and peripheral nerve repair
US7837913B2 (en) * 2004-08-11 2010-11-23 California Institute Of Technology High aspect ratio template and method for producing same
BRPI0606574A2 (pt) 2005-01-21 2017-06-27 Commw Scient Ind Res Org métodos de ativação de um revestimento orgânico e de preparação de um tratamento de ativação, substrato revestido e tratamento de ativação para um revestimento orgânico
DK1948259T3 (en) 2005-10-26 2017-04-10 Genesis Tech Ltd ACELLULAR BIOabsorbable Tissue Regeneration Matrices Produced by Incubation of ACELLULAR BLOOD PRODUCTS
US8603806B2 (en) * 2005-11-02 2013-12-10 The Ohio State Universtiy Research Foundation Materials and methods for cell-based assays
US10176887B1 (en) 2005-11-14 2019-01-08 Organ Recovery Systems, Inc. Ex vivo methods for drug discovery, development and testing
SE0850071L (sv) * 2006-04-10 2008-12-19 Wisconsin Alumni Res Found Reagenser och förfaranden för användning av humana embryonala stamceller för att utvärdera toxicitet av farmaceutiska föreningar och andra kemikalier.
WO2007123535A1 (en) * 2006-04-24 2007-11-01 The Ex One Company Ultrasonic machining fabrication of guided tissue generation surfaces and tissue scaffolds
EP2029766A4 (de) * 2006-06-08 2010-02-10 Univ North Carolina Pulsung von gallenkammern bei hepatozyten aus sandwich-kulturen
ES2614436T3 (es) 2007-04-12 2017-05-31 The General Hospital Corporation Red bascular biomimética y dispositivos que la usan
US8771930B2 (en) * 2007-05-18 2014-07-08 Lifeline Scientific, Inc. Ex vivo methods for testing toxicity of substances using donated human organs or tissues
US8765364B2 (en) * 2007-05-18 2014-07-01 Lifeline Scientific, Inc. Ex vivo methods for validating substance testing with human organs and/or tissues
CA2696339C (en) 2007-08-22 2017-12-19 Probiogen Ag Culture system and method for immunogenicity and immunofunction testing in vitro
EP2200931B1 (de) * 2007-09-19 2017-06-07 The Charles Stark Draper Laboratory, Inc. Mikrofluidstrukturen mit kreisförmigem querschnitt
US20110033887A1 (en) * 2007-09-24 2011-02-10 Fang Nicholas X Three-Dimensional Microfabricated Bioreactors with Embedded Capillary Network
US20090234332A1 (en) * 2008-03-17 2009-09-17 The Charles Stark Draper Laboratory, Inc Artificial microvascular device and methods for manufacturing and using the same
US8685432B2 (en) * 2008-03-25 2014-04-01 University Of Utah Research Foundation Controlled release tissue graft combination biomaterials
WO2010009307A2 (en) 2008-07-16 2010-01-21 Children's Medical Center Corporation Organ mimic device with microchannels and methods of use and manufacturing thereof
WO2011002926A2 (en) 2009-07-01 2011-01-06 The General Hospital Corporation Isolated adult cells, artificial organs,rehabilitated organs, research rools, organ encasements, organ perfusion systems, and methods for preparing and utilizing the same
US20110082563A1 (en) * 2009-10-05 2011-04-07 The Charles Stark Draper Laboratory, Inc. Microscale multiple-fluid-stream bioreactor for cell culture
US20110186165A1 (en) * 2009-10-05 2011-08-04 Borenstein Jeffrey T Three-dimensional microfluidic platforms and methods of use and manufacture thereof
HUE039900T2 (hu) 2010-03-22 2019-02-28 Stemina Biomarker Discovery Inc Gyógyszerek humán fejlõdésre gyakorolt toxicitásának elõrejelzése humán õssejtszerû sejtek és metabolomika alkalmazásával
EP2404672A1 (de) * 2010-07-06 2012-01-11 Universiteit Twente Multiwell-System mit hohem Durchsatz zum Kultivieren von in-vitro oder in-vivo 3D-Gewebekonstrukten, Verfahren zum Herstellen des Multiwell-Systems und Verfahren zur Herstellung von 3D-Gewebekonstrukten aus Zellen, die das Multiwell-System verwenden
WO2012048276A2 (en) 2010-10-08 2012-04-12 Caridianbct, Inc. Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
US20140038275A1 (en) * 2010-11-24 2014-02-06 Paul Gatenholm Pharmacology Bioassays for Drug Discovery, Toxicity Evaluation and in vitro Cancer Research Using a 3D Nanocellulose Scaffold and Living Tissue
SG192931A1 (en) 2011-02-28 2013-09-30 Harvard College Cell culture system
EP2773955B1 (de) * 2011-11-04 2018-07-18 inRegen Wirkstoffprüfung und potenztests
US20130143230A1 (en) * 2011-12-02 2013-06-06 The Trustees Of The Stevens Institute Of Technology Microfluidic-based cell-culturing platform and method
EP2788119A1 (de) 2011-12-05 2014-10-15 Research Triangle Institute Modell für den menschlichen atemweg mit mehreren fluidischen pfaden
US20140308688A1 (en) 2011-12-08 2014-10-16 Research Triangle Institute Human emulated response with microfluidic enhanced systems
US9725687B2 (en) 2011-12-09 2017-08-08 President And Fellows Of Harvard College Integrated human organ-on-chip microphysiological systems
US9861663B2 (en) * 2012-02-23 2018-01-09 Technion Research & Development Foundation Ltd. Ex-vivo vascularized implant composition comprising poly-l-lactic acid, polylactic-co-glycolic-acid and olfactory bulb cells
ES2663903T3 (es) * 2012-04-26 2018-04-17 Tissuse Gmbh Métodos para determinar y/o vigilar estados de un sistema de cultivo celular tridimensional y dispositivo de sensor óptico para llevar a cabo dichos métodos
WO2014123978A2 (en) 2013-02-05 2014-08-14 University Of Utah Research Foundation Implantable devices for bone or joint defects
CN105518121A (zh) * 2013-07-12 2016-04-20 中南创发生物科技有限公司 肝脏感染
CN104278008B (zh) 2013-07-12 2020-08-21 北京宏冠再生医学科技有限公司 一种通过小分子化合物处理来制备多潜能干细胞的方法、试剂盒和用途
US9855554B2 (en) 2013-07-22 2018-01-02 President And Fellows Of Harvard College Microfluidic cartridge assembly
US10041045B2 (en) 2013-09-20 2018-08-07 Hackensack University Medical Center Microfluidic three-dimensional osteocyte network reconstructed with microbeads as scaffold
WO2015073918A1 (en) 2013-11-16 2015-05-21 Terumo Bct, Inc. Expanding cells in a bioreactor
EP3083940A4 (de) 2013-12-20 2017-08-23 President and Fellows of Harvard College Scherkraftarme mikrofluidische vorrichtungen und verfahren zur verwendung und herstellung davon
WO2015125736A1 (ja) * 2014-02-19 2015-08-27 株式会社モリタ製作所 医療用機器要素、医療用機器、医療用機器構成部品、医療用ハンドピース、医療用機器要素の製造方法、及び医療用切削装置
CN106232800B (zh) 2014-03-25 2020-07-03 泰尔茂比司特公司 介质的被动替代
EP3169626A4 (de) 2014-07-14 2018-04-04 President and Fellows of Harvard College Systeme und verfahren zur verbesserten leistung fluidischer und mikrofluidischer systeme
CN106715676A (zh) 2014-09-26 2017-05-24 泰尔茂比司特公司 按计划供养
WO2016065004A1 (en) * 2014-10-22 2016-04-28 The General Hospital Corporation Methods and devices to study metabolism
CA2968655C (en) * 2014-11-25 2021-11-16 President And Fellows Of Harvard College Methods for generation of podocytes from pluripotent stem cells and cells produced by the same
JP6517031B2 (ja) * 2015-02-05 2019-05-22 キヤノンメディカルシステムズ株式会社 医用画像処理装置および磁気共鳴イメージング装置
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
EP3115766A1 (de) 2015-07-10 2017-01-11 3Scan Inc. Räumliches multiplexen von histologischen flecken
WO2017019542A1 (en) 2015-07-24 2017-02-02 President And Fellows Of Harvard College Radial microfluidic devices and methods of use
KR102142364B1 (ko) 2015-08-13 2020-08-07 베이하오 스템 셀 앤 리제너레이티브 메디슨 리서치 인스티 튜트 씨오.,엘티디. 유도 연장 만능 줄기 세포, 이의 제조방법 및 사용 방법
EP3334821A4 (de) 2015-08-14 2019-07-17 The General Hospital Corporation Systeme und verfahren zur verwendung biomimetischer strukturen für kommunikation in lebendem gewebe
JP6608043B2 (ja) 2015-08-26 2019-11-20 エミュレイト， インコーポレイテッド 灌流マニホールドアセンブリ
CN108934168B (zh) 2015-11-30 2022-05-03 北昊干细胞与再生医学研究院有限公司 用于将非多能细胞重编程为多能干细胞的改进方法
EP3181700A1 (de) * 2015-12-18 2017-06-21 Safeguard Biosystems Holdings Ltd. Dreidimensionales polymer netzwerk mit darin befindlichen kanälen
WO2017184222A1 (en) * 2016-04-22 2017-10-26 Curators Of The University Of Missouri Chemical library diversity enhancement through in vitro library pre-metabolism
WO2017205667A1 (en) 2016-05-25 2017-11-30 Terumo Bct, Inc. Cell expansion
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
WO2018052953A1 (en) 2016-09-13 2018-03-22 President And Fellows Of Harvard College Methods relating to intestinal organ-on-a-chip
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
CN110612344B (zh) 2017-03-31 2023-09-12 泰尔茂比司特公司 细胞扩增
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US20200277567A1 (en) 2017-05-31 2020-09-03 BeiHao Stem Cell and Regenerative Medicine Research Institute Co., Ltd Methods for chemically induced lineage reprogramming
KR102062465B1 (ko) 2017-09-25 2020-01-03 아주대학교산학협력단 나노섬유 기반 장기간 초대 간세포 3차원 배양시스템 및 배양방법
WO2019059702A2 (ko) * 2017-09-25 2019-03-28 아주대학교산학협력단 나노섬유 기반 장기간 초대 간세포 3차원 배양시스템 및 배양방법
WO2019191299A1 (en) 2018-03-27 2019-10-03 San Diego State University In situ partially degradable separation interface for fabrication of complex near net shape objects by pressure assisted sintering
AU2019273040A1 (en) * 2018-05-25 2020-12-10 The General Hospital Corporation Additive manufacture of complex implantable living devices
JP7453961B2 (ja) * 2018-09-05 2024-03-21 ザイムトロニクス キャタリティック システムズ インコーポレイテッド 磁気骨格上の固定化酸素及びミクロソーム
WO2020172337A1 (en) * 2019-02-19 2020-08-27 Iontox, Llc Methods to predict repeated dose toxicity using an integrated organ platform
US10945034B2 (en) 2019-07-11 2021-03-09 International Business Machines Corporation Video fractal cross correlated action bubble transition
CA3155890A1 (en) * 2019-10-16 2021-04-22 Wisconsin Alumni Research Foundation MECHANICALLY STABLE HIGH CELL DENSITY HONEYCOMB RETINAL SCAFFOLD DESIGN FOR PHOTORECEPTOR CELL TRANSPLANTATION AND RETINAL PIGMENT HELIUM EPIT THERAPY
CA3174121A1 (en) 2020-03-30 2021-10-07 Pierre Julius Magistretti Compositions and methods for controlling cellular identity
WO2023018634A1 (en) * 2021-08-12 2023-02-16 Merck Sharp & Dohme Llc Dosage regimen for administration of belzutifan
WO2023056408A1 (en) * 2021-09-30 2023-04-06 University Of Southern California Human hepatocyte culture medium and conditioned medium of in vitro cultured human hepatocytes and uses thereof
WO2023076285A1 (en) * 2021-10-25 2023-05-04 Satellite Biosciences, Inc. Engineered tissue constructs for the treatment of hyperammonemia

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3907687A (en) 1968-12-07 1975-09-23 Baxter Laboratories Inc Plate dialyzer
US3684097A (en) 1970-07-02 1972-08-15 Gen Electric Blood component exchange device
US3839204A (en) 1972-04-27 1974-10-01 Gen Electric Integral blood heat and component exchange device and two flow path membrane blood gas exchanger
FR2197565B1 (de) 1972-08-30 1975-03-07 Rhone Poulenc Ind
US3892533A (en) 1973-03-02 1975-07-01 Sci Med Oxygenator gas distribution header
NL7310808A (nl) 1973-08-06 1975-02-10 Josef Augustinus Elizabeth Spa Inrichting voor het uitwisselen van stoffen tussen twee zich aan weerszijden van een membraan bevindende
US4008047A (en) 1974-12-26 1977-02-15 North Star Research Institute Blood compatible polymers for blood oxygenation devices
DE2622684B2 (de) 1976-05-21 1979-03-15 Licentia Patent-Verwaltungs-Gmbh, 6000 Frankfurt Membranaustauscher
US4191182A (en) * 1977-09-23 1980-03-04 Hemotherapy Inc. Method and apparatus for continuous plasmaphersis
US4229290A (en) * 1978-03-14 1980-10-21 Raj Ghen M G Compact low surface area dialyzer method and apparatus
JPS6244961B2 (de) 1979-08-21 1987-09-24 Nikorai Sutepanobitsuchi Ridorenko
ATE28797T1 (de) 1982-12-07 1987-08-15 Brian John Bellhouse Vorrichtung zur uebertragung mit einer membran.
US5266480A (en) 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
JPH0342927Y2 (de) 1987-02-09 1991-09-09
IT1202689B (it) 1987-03-25 1989-02-09 Franco Maria Montevecchi Procedimento e dispositivo per la circolazione extracorporea del sangue e per assistenza cardiovascolare
US5225161A (en) 1988-10-20 1993-07-06 Baxter International Inc. Integrated membrane blood oxygenator/heat exchanger
US5316724A (en) 1989-03-31 1994-05-31 Baxter International Inc. Multiple blood path membrane oxygenator
US5204055A (en) 1989-12-08 1993-04-20 Massachusetts Institute Of Technology Three-dimensional printing techniques
US5061620A (en) 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5222982A (en) 1991-02-11 1993-06-29 Ommaya Ayub K Spinal fluid driven artificial organ
US5263924A (en) 1991-09-25 1993-11-23 Baxter International Inc. Integrated low priming volume centrifugal pump and membrane oxygenator
CA2074671A1 (en) * 1991-11-04 1993-05-05 Thomas Bormann Device and method for separating plasma from a biological fluid
US5549674A (en) 1992-03-02 1996-08-27 The Regents Of The University Of Michigan Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo
US5849553A (en) 1992-07-27 1998-12-15 California Institute Of Technology Mammalian multipotent neural stem cells
CA2119064A1 (en) * 1993-03-17 1994-09-18 Richard A. Berg Dermal-epidermal in vitro test system
DE4320198C1 (de) 1993-06-18 1994-07-14 Fresenius Ag Vorrichtung zum Gasaustausch, insbesondere zum Oxygenieren von Blut
US6200802B1 (en) 1993-10-08 2001-03-13 Arch Development Corporation Human peroxisome proliferator activated receptor gamma: compositions and methods
US6176874B1 (en) 1993-10-18 2001-01-23 Masschusetts Institute Of Technology Vascularized tissue regeneration matrices formed by solid free form fabrication techniques
US5518680A (en) 1993-10-18 1996-05-21 Massachusetts Institute Of Technology Tissue regeneration matrices by solid free form fabrication techniques
US5626759A (en) 1994-08-01 1997-05-06 Regents Of The University Of Colorado Blood treatment device with moving membrane
DE4433376C1 (de) 1994-09-20 1996-04-04 Peter M Prof Dr Kunz Verfahren zum Entrosten von Oberflächen auf organischer Basis und Verfahren zur Herstellung des eingesetzten Mittels
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US7008634B2 (en) 1995-03-03 2006-03-07 Massachusetts Institute Of Technology Cell growth substrates with tethered cell growth effector molecules
BE1009306A5 (fr) 1995-04-28 1997-02-04 Baxter Int Bioreacteur.
US5665596A (en) 1995-07-31 1997-09-09 Becton, Dickinson And Company Device for cell co-culture and method for its use in culturing cells
US6573063B2 (en) 1995-10-04 2003-06-03 Cytoscan Sciences, Llc Methods and systems for assessing biological materials using optical and spectroscopic detection techniques
US5869243A (en) * 1996-03-05 1999-02-09 Rhode Island Hospital Immortalized hepatocytes
US5817343A (en) 1996-05-14 1998-10-06 Alkermes, Inc. Method for fabricating polymer-based controlled-release devices
US5885829A (en) 1996-05-28 1999-03-23 The Regents Of The University Of Michigan Engineering oral tissues
US6136212A (en) 1996-08-12 2000-10-24 The Regents Of The University Of Michigan Polymer-based micromachining for microfluidic devices
EP0929271B1 (de) 1996-09-05 2004-02-25 Children's Medical Center Corporation Nierenprothese
CA2279996A1 (en) 1997-01-16 1998-07-16 Yissum Research Development Company Of The Hebrew University In Jerusale M A device and method for performing a biological modification of a fluid
US6331406B1 (en) 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
US6287558B1 (en) 1997-08-01 2001-09-11 Biohybrio Technologies Llc Devices containing cells or tissue and an agent that inhibits damage by a host cell molecule
CA2227827A1 (en) 1998-01-23 1999-07-23 Unknown In vitro artificial cornea and sclera
US6197575B1 (en) * 1998-03-18 2001-03-06 Massachusetts Institute Of Technology Vascularized perfused microtissue/micro-organ arrays
US6143293A (en) 1998-03-26 2000-11-07 Carnegie Mellon Assembled scaffolds for three dimensional cell culturing and tissue generation
EP1069822A1 (de) 1998-04-09 2001-01-24 Charlotte-Mecklenberg Hospital Authority Erzeugung von dreidimensionalem gewebe
CA2330628A1 (en) * 1998-05-01 1999-11-11 Queen's University At Kingston Method for diagnosing a vascular condition
US20010041964A1 (en) 1998-09-14 2001-11-15 George M. Grass Pharmacokinetic-based drug design tool and method
US6547994B1 (en) 1998-11-13 2003-04-15 Therics, Inc. Rapid prototyping and manufacturing process
US6165486A (en) 1998-11-19 2000-12-26 Carnegie Mellon University Biocompatible compositions and methods of using same
IT1304503B1 (it) 1998-12-24 2001-03-19 In Te C S R L Uso di una membrana selettiva in un dispositivo biomedicale per iltrattamento extracorporeo di sangue e di altri liquidi organici.
WO2000047129A2 (en) 1999-02-11 2000-08-17 The General Hospital Corporation Microfabricated membranes and matrices
US20020090725A1 (en) 2000-11-17 2002-07-11 Simpson David G. Electroprocessed collagen
DE60017900T2 (de) 1999-04-30 2006-04-06 Massachusetts General Hospital, Boston Herstellung von dreidimensionalem vaskularisierten gewebe mittels der verwendung von zweidimensionalen mikrohergestellten formen
US20030129736A1 (en) 1999-07-15 2003-07-10 Eduardo Mitrani Device and method for performing a biological modification of a fluid
WO2001011011A2 (en) 1999-08-05 2001-02-15 Mcl Llc Multipotent adult stem cells and methods for isolation
US6525242B1 (en) 1999-11-02 2003-02-25 The University Of Connecticut Propagation of human hepatocytes in non-human mammals
US6479064B1 (en) 1999-12-29 2002-11-12 Children's Medical Center Corporation Culturing different cell populations on a decellularized natural biostructure for organ reconstruction
US20030125252A1 (en) 2000-03-14 2003-07-03 Underhill T. Michael Compositions and methods for affecting osteogenesis
US7776021B2 (en) 2000-04-28 2010-08-17 The Charles Stark Draper Laboratory Micromachined bilayer unit for filtration of small molecules
US6458275B1 (en) 2000-06-05 2002-10-01 Harvard Apparatus, Inc. Multi-well equilibrium dialysis system
WO2002026939A2 (en) 2000-09-25 2002-04-04 The Board Of Trustees Of The University Of Illinois Microfabrication of membranes for the growth of cells
US6607910B1 (en) * 2000-11-13 2003-08-19 Synthecon, Inc. Two chamber cell culture vessel
PL362932A1 (en) 2000-11-28 2004-11-02 Art Of Xen Limited Gas exchange
AU2002239810A1 (en) 2001-01-02 2002-07-16 The Charles Stark Draper Laboratory, Inc. Tissue engineering of three-dimensional vascularized using microfabricated polymer assembly technology
US7449180B2 (en) * 2001-02-06 2008-11-11 John Kisiday Macroscopic scaffold containing amphiphilic peptides encapsulating cells
NL1017570C2 (nl) 2001-03-12 2002-09-13 Stichting Hogeschool Van Utrec Bloedbehandelingsinrichting.
WO2002092778A2 (en) * 2001-05-17 2002-11-21 The Board Of Trustees Of The Leland Stanford Junior University Device and method for three-dimensional spatial localization and functional interconnection of different types of cells
JP2005511093A (ja) * 2001-10-31 2005-04-28 ブリストル−マイヤーズ　スクイブ　カンパニー 被験化合物の毒性についてのスクリーニング方法
AU2002340463A1 (en) 2001-11-16 2003-06-10 Children's Medical Center Corporation Augmentation of organ function
US20030121594A1 (en) * 2001-12-28 2003-07-03 Brill Russell P. Method for manufacture of tubular multilayer structure from fiber-resin material
WO2003061585A2 (en) * 2002-01-22 2003-07-31 The Penn State Research Foundation Drug candidate screening systems based on micropatterned hydrogels and microfluidic systems
DE10203237B4 (de) 2002-01-28 2006-08-17 Siemens Ag Verfahren zur Magnetresonanz-Bildgebung mit automatischer Anpassung des Messfeldes
WO2003104439A2 (en) 2002-03-12 2003-12-18 Surface Logix, Inc. Assay device that analyzes the absorption, metabolism, permeability and/or toxicity of a candidate compound
WO2004006840A2 (en) * 2002-07-12 2004-01-22 The Regents Of The University Of California Three dimensional cell patterned bioploymer scaffolds and method of making the same
WO2004026115A2 (en) 2002-09-23 2004-04-01 The General Hospital Corporation Theree-dimensional construct for the design and fabrication of physiological fluidic networks
US20040147016A1 (en) * 2002-09-30 2004-07-29 Rowley Jonathan A. Programmable scaffold and methods for making and using the same
US7264723B2 (en) 2002-11-01 2007-09-04 Sandia Corporation Dialysis on microchips using thin porous polymer membranes
EP1589814B1 (de) 2003-01-16 2009-08-12 The General Hospital Corporation Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen
US20050136545A1 (en) * 2003-09-15 2005-06-23 Tecan Trading Ag Microfluidics devices and methods for performing based assays
CN101061213B (zh) * 2004-05-19 2012-12-19 麻省理工学院 灌注的三维细胞/组织疾病模型
US20100240086A1 (en) * 2009-03-20 2010-09-23 Dmitry Kashanin Biochip assembly and assay method thereof

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US20060019326A1 (en) 2006-01-26
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US7670797B2 (en) 2010-03-02
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