DE60130771D1 - Substituierte heterocyclische amide - Google Patents
Substituierte heterocyclische amideInfo
- Publication number
- DE60130771D1 DE60130771D1 DE60130771T DE60130771T DE60130771D1 DE 60130771 D1 DE60130771 D1 DE 60130771D1 DE 60130771 T DE60130771 T DE 60130771T DE 60130771 T DE60130771 T DE 60130771T DE 60130771 D1 DE60130771 D1 DE 60130771D1
- Authority
- DE
- Germany
- Prior art keywords
- amids
- substituted heterocyclic
- inhibitor
- factor
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22109200P | 2000-07-27 | 2000-07-27 | |
US221092P | 2000-07-27 | ||
PCT/US2001/016528 WO2002010154A2 (en) | 2000-07-27 | 2001-07-18 | Substituted heterocyclic amides |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60130771D1 true DE60130771D1 (de) | 2007-11-15 |
DE60130771T2 DE60130771T2 (de) | 2008-07-17 |
Family
ID=22826311
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60130771T Expired - Fee Related DE60130771T2 (de) | 2000-07-27 | 2001-07-18 | Substituierte heterocyclische amide |
Country Status (7)
Country | Link |
---|---|
US (1) | US7160878B2 (de) |
EP (1) | EP1307444B1 (de) |
AT (1) | ATE374765T1 (de) |
AU (1) | AU2001280438A1 (de) |
DE (1) | DE60130771T2 (de) |
ES (1) | ES2292607T3 (de) |
WO (1) | WO2002010154A2 (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU776053B2 (en) | 2000-03-31 | 2004-08-26 | Astellas Pharma Inc. | Diazepan derivatives or salts thereof |
EP1311501B1 (de) | 2000-08-17 | 2005-11-02 | Eli Lilly And Company | Antithrombosemittel |
RU2276137C2 (ru) * | 2000-11-22 | 2006-05-10 | Астеллас Фарма Инк. | Замещенные производные бензола или их соли, фармацевтическая композиция на их основе |
AU2001297648A1 (en) | 2000-11-28 | 2002-08-28 | Eli Lilly And Company | Substituted carboxamides as inhibitors of factor xa |
DK1395289T3 (da) * | 2001-06-07 | 2011-03-28 | Christine Dr Sang | Behandling af neuropatisk smerte med en N-methyl-D-aspartat- (NMDA-)receptorantagonist |
WO2003050088A1 (en) * | 2001-12-07 | 2003-06-19 | Eli Lilly And Company | Substituted heterocyclic carboxamides with antithrombotic activity |
US20050119251A1 (en) * | 2001-12-21 | 2005-06-02 | Jian-Min Fu | Nicotinamide derivatives and their use as therapeutic agents |
US7390813B1 (en) | 2001-12-21 | 2008-06-24 | Xenon Pharmaceuticals Inc. | Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents |
US7262194B2 (en) * | 2002-07-26 | 2007-08-28 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
ES2297489T3 (es) | 2003-05-30 | 2008-05-01 | Eli Lilly And Company | Eteres antitromboticos. |
ATE556056T1 (de) * | 2003-07-29 | 2012-05-15 | Xenon Pharmaceuticals Inc | Pyridylderivate und deren verwendung als therapeutische mittel |
US7759348B2 (en) | 2003-07-30 | 2010-07-20 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives and their use as therapeutic agents |
NZ545265A (en) * | 2003-07-30 | 2009-11-27 | Xenon Pharmaceuticals Inc | Pyridazine derivatives and their use for treating diseases mediated by stearoyl-CoA desaturase (SCD) enzymes |
US7754711B2 (en) | 2003-07-30 | 2010-07-13 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives and their use as therapeutic agents |
EP2316826A1 (de) * | 2003-07-30 | 2011-05-04 | Xenon Pharmaceuticals Inc. | Pyridazine Derivate und deren Verwendung als therapeutische Wirkstoffe |
SG145701A1 (en) | 2003-07-30 | 2008-09-29 | Xenon Pharmaceuticals Inc | Piperazine derivatives and their use as therapeutic agents |
EP1670783A2 (de) * | 2003-09-30 | 2006-06-21 | Eli Lilly And Company | Aromatische ether mit antithrombotischer wirkung |
US7371743B2 (en) | 2004-02-28 | 2008-05-13 | Boehringer Ingelheim International Gmbh | Carboxylic acid amides, the preparation thereof and their use as medicaments |
SE0401342D0 (sv) * | 2004-05-25 | 2004-05-25 | Astrazeneca Ab | Therapeutic compounds |
BRPI0418939A (pt) * | 2004-07-06 | 2008-04-08 | Xenon Pharmaceuticals Inc | derivados de nicotinamida e sua utilização como agentes terapêuticos |
US7592343B2 (en) * | 2004-09-20 | 2009-09-22 | Xenon Pharmaceuticals Inc. | Pyridazine-piperazine compounds and their use as stearoyl-CoA desaturase inhibitors |
MX2007003321A (es) * | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como agentes terapeuticos. |
US20080167321A1 (en) * | 2004-09-20 | 2008-07-10 | Xenon Pharmaceuticals Inc. | Pyridine Derivatives For Inhibiting Human Stearoyl-Coa-Desaturase |
EP2289510A1 (de) | 2004-09-20 | 2011-03-02 | Xenon Pharmaceuticals Inc. | Heterozyklische Derivate zur Behandlung von durch Stearoyl-Coa-Desaturase-Enzyme verursachten Krankheiten |
CN101084212A (zh) * | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为硬脂酰CoA去饱和酶介导剂的用途 |
WO2006034440A2 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
BRPI0515477A (pt) * | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos bicìclicos e o uso dos mesmos como inibidores de estaroil-coa-desaturase (scd) |
CN101084207A (zh) * | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途 |
EP2316458A1 (de) * | 2004-09-20 | 2011-05-04 | Xenon Pharmaceuticals Inc. | Pyridazin-Derivate zur Verhinderung menschlicher Stearoyl-coa-desaturas |
DE602005019316D1 (en) | 2004-11-24 | 2010-03-25 | Lilly Co Eli | Aromatische etherderivate als thrombin-hemmer |
DE602005016297D1 (de) * | 2004-11-29 | 2009-10-08 | Lilly Co Eli | Antithrombotische diamide |
US7264402B2 (en) * | 2005-03-10 | 2007-09-04 | Corning Cable Systems Llc | Multi-fiber optic receptacle and plug assembly |
CN101208089A (zh) * | 2005-06-03 | 2008-06-25 | 泽农医药公司 | 氨基噻唑衍生物作为人硬酯酰-CoA去饱和酶抑制剂 |
BRPI0817211A2 (pt) | 2007-09-20 | 2017-05-16 | Irm Llc | composto composições como moduladores da atividade de gpr119 |
US20130261130A1 (en) * | 2010-11-01 | 2013-10-03 | Shaheen Ahmed | Neurotrypsin inhibitors |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4994456A (en) * | 1989-03-01 | 1991-02-19 | Nisshin Flour Milling Co., Ltd. | Pyridinecarboxylic acid amide derivatives and pharmaceutical compositions comprising same |
JP2664238B2 (ja) | 1989-03-01 | 1997-10-15 | 日清製粉株式会社 | ニコチン酸またはそのエステル誘導体 |
GB9816837D0 (en) | 1998-08-04 | 1998-09-30 | Zeneca Ltd | Amide derivatives |
IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
HUP9601331A3 (en) | 1996-05-17 | 2000-06-28 | Egyt Gyogyszervegyeszeti Gyar | Piperazine- and homopiperazine-derivatives, process for producing them and pharmaceutical compositions containing them |
ATE334975T1 (de) | 1997-05-30 | 2006-08-15 | Takeda Pharmaceutical | Sulfonamidderivate, ihre herstellung und verwendung |
CA2294042A1 (en) | 1997-06-26 | 1999-01-07 | David Kent Herron | Antithrombotic agents |
DE69830504T2 (de) | 1997-06-26 | 2006-03-16 | Eli Lilly And Co., Indianapolis | Antithrombotische mitteln |
JP2002510313A (ja) | 1997-06-26 | 2002-04-02 | イーライ・リリー・アンド・カンパニー | 抗血栓物質 |
EP0999834B1 (de) | 1997-06-26 | 2005-10-12 | Eli Lilly And Company | Antithrombosemittel |
AU735144B2 (en) | 1997-07-23 | 2001-07-05 | Yamanouchi Pharmaceutical Co., Ltd. | Novel hexahydro-1,4-diazepine derivatives or their salts |
DE69833036T2 (de) | 1997-09-30 | 2006-06-22 | Daiichi Pharmaceutical Co., Ltd. | Sulfonylderivate |
WO1999032447A2 (en) | 1997-12-11 | 1999-07-01 | American Home Products Corporation | 2,4,6-trisubstituted pyridines with estrogenic activity and methods for the solid phase synthesis thereof |
US6140351A (en) | 1997-12-19 | 2000-10-31 | Berlex Laboratories, Inc. | Ortho-anthranilamide derivatives as anti-coagulants |
IL135536A0 (en) | 1997-12-19 | 2001-05-20 | Schering Ag | Ortho-anthranilamide derivatives and pharmaceutical compositions containing the same |
CA2319824A1 (en) * | 1998-01-30 | 1999-08-05 | Shuichi Gomi | Phenylpiperazine derivatives as integrin .alpha.v.beta.3 antagonists |
RU2216541C2 (ru) * | 1998-08-04 | 2003-11-20 | Астразенека Аб | Производные бензамида, способ их получения и фармацевтическая композиция на их основе |
US6610704B1 (en) | 1998-12-23 | 2003-08-26 | Eli Lilly And Company | Antithrombotic amides |
EP1140905B1 (de) | 1998-12-23 | 2003-05-14 | Eli Lilly And Company | Heteroaromatische amide als inhibitoren von faktor xa |
WO2000039118A1 (en) | 1998-12-23 | 2000-07-06 | Eli Lilly And Company | Aromatic amides |
ES2217879T3 (es) | 1998-12-24 | 2004-11-01 | Eli Lilly And Company | Amidas heterociclicas. |
JP4390024B2 (ja) | 1999-04-23 | 2009-12-24 | アステラス製薬株式会社 | 新規なジアゼパン誘導体又はその塩 |
US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
RU2002110295A (ru) | 1999-09-17 | 2003-12-10 | Милленниум Фармасьютикалс, Инк. (Us) | Ингибиторы фактора Ха |
NZ517829A (en) | 1999-09-17 | 2004-12-24 | Millennium Pharm Inc | Benzamides and related inhibitors of factor Xa |
WO2001064642A2 (en) | 2000-02-29 | 2001-09-07 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor xa |
AU776053B2 (en) | 2000-03-31 | 2004-08-26 | Astellas Pharma Inc. | Diazepan derivatives or salts thereof |
-
2001
- 2001-07-18 AT AT01958825T patent/ATE374765T1/de not_active IP Right Cessation
- 2001-07-18 EP EP01958825A patent/EP1307444B1/de not_active Expired - Lifetime
- 2001-07-18 WO PCT/US2001/016528 patent/WO2002010154A2/en active IP Right Grant
- 2001-07-18 ES ES01958825T patent/ES2292607T3/es not_active Expired - Lifetime
- 2001-07-18 DE DE60130771T patent/DE60130771T2/de not_active Expired - Fee Related
- 2001-07-18 AU AU2001280438A patent/AU2001280438A1/en not_active Abandoned
- 2001-07-18 US US10/332,120 patent/US7160878B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE374765T1 (de) | 2007-10-15 |
AU2001280438A1 (en) | 2002-02-13 |
US7160878B2 (en) | 2007-01-09 |
EP1307444B1 (de) | 2007-10-03 |
WO2002010154A3 (en) | 2002-06-27 |
EP1307444A2 (de) | 2003-05-07 |
DE60130771T2 (de) | 2008-07-17 |
WO2002010154A2 (en) | 2002-02-07 |
US20040097491A1 (en) | 2004-05-20 |
ES2292607T3 (es) | 2008-03-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336 |
|
8339 | Ceased/non-payment of the annual fee |