DE50308083D1 - PREPARATION OF SOLID DOSAGE FORMS USING A NETWORKED NON-THERMOPLASTIC TRANS - Google Patents

PREPARATION OF SOLID DOSAGE FORMS USING A NETWORKED NON-THERMOPLASTIC TRANS

Info

Publication number
DE50308083D1
DE50308083D1 DE50308083T DE50308083T DE50308083D1 DE 50308083 D1 DE50308083 D1 DE 50308083D1 DE 50308083 T DE50308083 T DE 50308083T DE 50308083 T DE50308083 T DE 50308083T DE 50308083 D1 DE50308083 D1 DE 50308083D1
Authority
DE
Germany
Prior art keywords
solid dosage
preparation
dosage forms
thermoplastic
trans
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE50308083T
Other languages
German (de)
Inventor
Joerg Rosenberg
Gunther Berndl
Markus Maegerlein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott GmbH and Co KG
Original Assignee
Abbott GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott GmbH and Co KG filed Critical Abbott GmbH and Co KG
Application granted granted Critical
Publication of DE50308083D1 publication Critical patent/DE50308083D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Abstract

Production of a solid dosage form (A) involves: (1) forming a shapable mass comprising (by weight) 50-99.4% crosslinked, non-thermoplastic carrier (I), 0.5-30 wt. % adjuvant(s) (II) selected from thermoplastic polymers, lipids, sugar alcohols (or derivatives) and solubilizers and 0.1-49.5% active agent(s) (III) at or above the softening point of (II) (but at 70 degrees C or more); and (2) cooling.
DE50308083T 2002-10-09 2003-10-09 PREPARATION OF SOLID DOSAGE FORMS USING A NETWORKED NON-THERMOPLASTIC TRANS Expired - Lifetime DE50308083D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10247037A DE10247037A1 (en) 2002-10-09 2002-10-09 Solid, rapid release dosage form, especially for sparingly soluble drugs, obtained by forming and cooling softened, shapable mixture of crosslinked non-thermoplastic carrier, adjuvant and active agent
PCT/EP2003/011205 WO2004032903A2 (en) 2002-10-09 2003-10-09 Method for producing solid galenic formulations using a crosslinked non-thermoplastic carrier

Publications (1)

Publication Number Publication Date
DE50308083D1 true DE50308083D1 (en) 2007-10-11

Family

ID=32038379

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10247037A Withdrawn DE10247037A1 (en) 2002-10-09 2002-10-09 Solid, rapid release dosage form, especially for sparingly soluble drugs, obtained by forming and cooling softened, shapable mixture of crosslinked non-thermoplastic carrier, adjuvant and active agent
DE50308083T Expired - Lifetime DE50308083D1 (en) 2002-10-09 2003-10-09 PREPARATION OF SOLID DOSAGE FORMS USING A NETWORKED NON-THERMOPLASTIC TRANS

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE10247037A Withdrawn DE10247037A1 (en) 2002-10-09 2002-10-09 Solid, rapid release dosage form, especially for sparingly soluble drugs, obtained by forming and cooling softened, shapable mixture of crosslinked non-thermoplastic carrier, adjuvant and active agent

Country Status (13)

Country Link
US (1) US7846477B2 (en)
EP (1) EP1556012B1 (en)
JP (1) JP4443415B2 (en)
CN (1) CN1703202B (en)
AT (1) ATE371443T1 (en)
AU (1) AU2003283261B2 (en)
BR (2) BRPI0314984B1 (en)
CA (1) CA2501245C (en)
DE (2) DE10247037A1 (en)
ES (1) ES2290513T3 (en)
RU (1) RU2344809C2 (en)
WO (1) WO2004032903A2 (en)
ZA (1) ZA200503636B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001034119A2 (en) 1999-11-12 2001-05-17 Abbott Laboratories Inhibitors of crystallization in a solid dispersion
DE10026698A1 (en) 2000-05-30 2001-12-06 Basf Ag Self-emulsifying active ingredient formulation and use of this formulation
AU2013201423B2 (en) * 2003-08-28 2015-11-05 Abbvie Inc. Solid pharmaceutical dosage form
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US20050048112A1 (en) * 2003-08-28 2005-03-03 Jorg Breitenbach Solid pharmaceutical dosage form
US8377952B2 (en) * 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
TW200815033A (en) * 2006-08-10 2008-04-01 Cipla Ltd Antiretroviral solid oral composition
US7915247B1 (en) 2006-08-21 2011-03-29 Mutual Pharmaceutical Company, Inc. Methods of use of fenofibric acid
WO2008067164A2 (en) * 2006-11-15 2008-06-05 Abbott Laboratories Solid pharmaceutical dosage formulations
SG189403A1 (en) * 2010-10-14 2013-05-31 Abbott Gmbh & Co Kg Curcuminoid solid dispersion formulation
US9096556B2 (en) 2011-05-27 2015-08-04 Hetero Research Foundation Amorphous ritonavir co-precipitated
EP2964679B1 (en) * 2013-03-07 2018-04-04 Dow Global Technologies LLC Novel esterified cellulose ethers of low viscosity and high molecular weight

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3087860A (en) * 1958-12-19 1963-04-30 Abbott Lab Method of prolonging release of drug from a precompressed solid carrier
DE2357503A1 (en) * 1973-11-17 1975-05-28 Cassella Farbwerke Mainkur Ag PROCESS FOR THE PREPARATION OF SOLID PREPARATIONS CONTAINING CARBOCROME HYDROCHLORIDE
EP0078430B2 (en) * 1981-10-29 1993-02-10 Bayer Ag Process for preparing solid fast-releasing drug formulations of dihydropyridines
USRE33963E (en) * 1981-10-29 1992-06-16 Bayer Aktiengesellschaft Solid rapidly released medicament preparations containing dihydropyridines, and processes for their preparation
GB8403360D0 (en) * 1984-02-08 1984-03-14 Erba Farmitalia Pharmaceutical compositions
GB8403361D0 (en) 1984-02-08 1984-03-14 Erba Farmitalia Pharmaceutical composition
DE3612211A1 (en) * 1986-04-11 1987-10-15 Basf Ag CONTINUOUS TABLET METHOD
DE3612212A1 (en) * 1986-04-11 1987-10-15 Basf Ag METHOD FOR PRODUCING SOLID PHARMACEUTICAL FORMS
DE3812567A1 (en) * 1988-04-15 1989-10-26 Basf Ag METHOD FOR PRODUCING PHARMACEUTICAL MIXTURES
DE3830353A1 (en) * 1988-09-07 1990-03-15 Basf Ag METHOD FOR THE CONTINUOUS PRODUCTION OF SOLID PHARMACEUTICAL FORMS
IT1241417B (en) 1990-03-06 1994-01-14 Vectorpharma Int THERAPEUTIC COMPOSITIONS WITH CONTROLLED RELEASE OF DRUGS SUPPORTED ON CROSS-LINKED POLYMERS AND COATED WITH POLYMER FILM, AND THEIR PREPARATION PROCESS
DE4413350A1 (en) * 1994-04-18 1995-10-19 Basf Ag Retard matrix pellets and process for their production
ZA9810765B (en) * 1998-05-28 1999-08-06 Ranbaxy Lab Ltd Stable oral pharmaceutical composition containing a substituted pyridylsulfinyl benzimidazole.
IL145140A0 (en) * 1999-03-24 2002-06-30 Fmc Corp Improved aqueous solubility pharmaceutical formulations
WO2001078716A1 (en) * 2000-04-19 2001-10-25 Fujisawa Pharmaceutical Co., Ltd. Solid dispersion with improved absorbability

Also Published As

Publication number Publication date
ES2290513T3 (en) 2008-02-16
RU2005114390A (en) 2005-10-10
CN1703202B (en) 2010-05-26
US20060257470A1 (en) 2006-11-16
CA2501245A1 (en) 2004-04-22
BR0314984A (en) 2005-08-09
DE10247037A1 (en) 2004-04-22
BRPI0314984B1 (en) 2018-09-11
EP1556012A2 (en) 2005-07-27
JP4443415B2 (en) 2010-03-31
AU2003283261B2 (en) 2008-05-15
WO2004032903A2 (en) 2004-04-22
ATE371443T1 (en) 2007-09-15
US7846477B2 (en) 2010-12-07
EP1556012B1 (en) 2007-08-29
WO2004032903A3 (en) 2004-11-11
AU2003283261A1 (en) 2004-05-04
CN1703202A (en) 2005-11-30
CA2501245C (en) 2011-07-12
JP2006505547A (en) 2006-02-16
RU2344809C2 (en) 2009-01-27
ZA200503636B (en) 2006-08-30

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Legal Events

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