DE50307638D1 - Method and device for transferring medically active substances into cells - Google Patents

Method and device for transferring medically active substances into cells

Info

Publication number
DE50307638D1
DE50307638D1 DE50307638T DE50307638T DE50307638D1 DE 50307638 D1 DE50307638 D1 DE 50307638D1 DE 50307638 T DE50307638 T DE 50307638T DE 50307638 T DE50307638 T DE 50307638T DE 50307638 D1 DE50307638 D1 DE 50307638D1
Authority
DE
Germany
Prior art keywords
cells
medically active
active substances
transferring
sensors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE50307638T
Other languages
German (de)
Inventor
Friedrich Dr Ueberle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dornier Medtech Systems GmbH
Original Assignee
Dornier Medtech Systems GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dornier Medtech Systems GmbH filed Critical Dornier Medtech Systems GmbH
Application granted granted Critical
Publication of DE50307638D1 publication Critical patent/DE50307638D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli

Abstract

Method for transferring medically active molecules into human, animal or vegetable cells uses acoustic energy to produce cavitation. The life of the cavitation bubbles is measured using sensors and used to control the intensity of the sound. An Independent claim is included for apparatus for carrying out the method comprising an acoustic converter (1a), e.g. an array of piezoelectric components, connected to sensors (4) by a control circuit (5)
DE50307638T 2002-05-24 2003-05-19 Method and device for transferring medically active substances into cells Expired - Lifetime DE50307638D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10223196A DE10223196B4 (en) 2002-05-24 2002-05-24 Method and device for transferring molecules into cells

Publications (1)

Publication Number Publication Date
DE50307638D1 true DE50307638D1 (en) 2007-08-23

Family

ID=29285678

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10223196A Expired - Fee Related DE10223196B4 (en) 2002-05-24 2002-05-24 Method and device for transferring molecules into cells
DE50307638T Expired - Lifetime DE50307638D1 (en) 2002-05-24 2003-05-19 Method and device for transferring medically active substances into cells

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE10223196A Expired - Fee Related DE10223196B4 (en) 2002-05-24 2002-05-24 Method and device for transferring molecules into cells

Country Status (5)

Country Link
US (1) US7267659B2 (en)
EP (1) EP1365016B1 (en)
AT (1) ATE366796T1 (en)
DE (2) DE10223196B4 (en)
ES (1) ES2289209T3 (en)

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Also Published As

Publication number Publication date
DE10223196B4 (en) 2004-05-13
US7267659B2 (en) 2007-09-11
EP1365016A2 (en) 2003-11-26
ATE366796T1 (en) 2007-08-15
EP1365016B1 (en) 2007-07-11
US20040039329A1 (en) 2004-02-26
DE10223196A1 (en) 2003-12-11
EP1365016A3 (en) 2004-01-21
ES2289209T3 (en) 2008-02-01

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