DE502006003030D1 - USE OF INHIBITORS OF THE NA + / H + EXCHANGER, SUBTYPE 5 (NHE5) TO IMPROVE MEMBERSHIP - Google Patents

USE OF INHIBITORS OF THE NA + / H + EXCHANGER, SUBTYPE 5 (NHE5) TO IMPROVE MEMBERSHIP

Info

Publication number
DE502006003030D1
DE502006003030D1 DE502006003030T DE502006003030T DE502006003030D1 DE 502006003030 D1 DE502006003030 D1 DE 502006003030D1 DE 502006003030 T DE502006003030 T DE 502006003030T DE 502006003030 T DE502006003030 T DE 502006003030T DE 502006003030 D1 DE502006003030 D1 DE 502006003030D1
Authority
DE
Germany
Prior art keywords
nhe5
subtype
inhibitors
exchanger
membership
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE502006003030T
Other languages
German (de)
Inventor
Heinz-Werner Kleemann
Hans-Jochen Lang
Uwe Heinelt
Armin Hofmeister
Holger Gaul
Ulrich Hendrich Schroeder
Klaus Reymann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Publication of DE502006003030D1 publication Critical patent/DE502006003030D1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DE502006003030T 2005-09-20 2006-09-08 USE OF INHIBITORS OF THE NA + / H + EXCHANGER, SUBTYPE 5 (NHE5) TO IMPROVE MEMBERSHIP Active DE502006003030D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005044815A DE102005044815A1 (en) 2005-09-20 2005-09-20 Use of inhibitors of Na + / H + exchanger, subtype 5 (NHE5) for memory improvement
PCT/EP2006/008771 WO2007033774A2 (en) 2005-09-20 2006-09-08 Use of inhibitors of the na+/h+ exchanger, subtype 5 (nhe5), to improve memory retention

Publications (1)

Publication Number Publication Date
DE502006003030D1 true DE502006003030D1 (en) 2009-04-16

Family

ID=37102563

Family Applications (2)

Application Number Title Priority Date Filing Date
DE102005044815A Withdrawn DE102005044815A1 (en) 2005-09-20 2005-09-20 Use of inhibitors of Na + / H + exchanger, subtype 5 (NHE5) for memory improvement
DE502006003030T Active DE502006003030D1 (en) 2005-09-20 2006-09-08 USE OF INHIBITORS OF THE NA + / H + EXCHANGER, SUBTYPE 5 (NHE5) TO IMPROVE MEMBERSHIP

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE102005044815A Withdrawn DE102005044815A1 (en) 2005-09-20 2005-09-20 Use of inhibitors of Na + / H + exchanger, subtype 5 (NHE5) for memory improvement

Country Status (14)

Country Link
US (1) US20080234317A1 (en)
EP (1) EP1928458B1 (en)
JP (1) JP2009508890A (en)
KR (1) KR20080046676A (en)
CN (1) CN101267822A (en)
AR (1) AR056520A1 (en)
AT (1) ATE424203T1 (en)
AU (1) AU2006294137A1 (en)
BR (1) BRPI0616196A2 (en)
CA (1) CA2623472A1 (en)
DE (2) DE102005044815A1 (en)
IL (1) IL189915A0 (en)
TW (1) TW200812584A (en)
WO (1) WO2007033774A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE036405T2 (en) * 2008-12-31 2018-07-30 Ardelyx Inc Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
US10543207B2 (en) 2008-12-31 2020-01-28 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
SI2983667T1 (en) 2013-04-12 2019-09-30 Ardelyx, Inc. Nhe3-binding compounds and methods for inhibiting phosphate transport
US10647679B2 (en) 2015-03-15 2020-05-12 Emory University N-methyl-D-aspartate receptor (NMDAR) potentiators, pharmaceutical compositions, and uses related thereto
EP3565808A1 (en) 2017-01-09 2019-11-13 Ardelyx, Inc. Compounds useful for treating gastrointestinal tract disorders
US11147884B2 (en) 2017-01-09 2021-10-19 Ardelyx, Inc. Inhibitors of NHE-mediated antiport

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352688A (en) * 1991-02-14 1994-10-04 The Mount Sinai School Of Medicine Of The City University Of New York Methods for the treatment of bradyphrenia in parkinson's disease
US5466696A (en) * 1992-09-10 1995-11-14 Warner Lambert Company Tacrine and cytochrome P450 oxidase inhibitors and methods of use
JPH08217681A (en) * 1995-02-13 1996-08-27 Lion Corp Senile dementia preventing and treating agent
ZA9610738B (en) * 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
JP4907817B2 (en) * 1999-11-03 2012-04-04 エーエムアール テクノロジー インコーポレイテッド 4-Phenyl substituted tetrahydroisoquinolines and their use to block reuptake of norepinephrine, dopamine and serotonin
JP4907818B2 (en) * 1999-11-03 2012-04-04 エーエムアール テクノロジー インコーポレイテッド Aryl and heteroaryl substituted tetrahydroisoquinolines and their use to prevent reuptake of norepinephrine, dopamine and serotonin
WO2003033016A1 (en) * 2001-10-16 2003-04-24 Jenny Phipps Use of neurotrophic factors for treating neurodegenerative diseases and cancer
DE10163914A1 (en) * 2001-12-22 2003-07-03 Aventis Pharma Gmbh Substituted 4-phenyltetrahydroisoquinolinium salts, process for their preparation, their use as medicament, and medicament containing them
US20050070601A1 (en) * 2003-09-29 2005-03-31 Creative Compounds, Llc Psychostimulant Effects of Forskolin Including Anorexia
DE102005044817A1 (en) * 2005-09-20 2007-03-22 Sanofi-Aventis Deutschland Gmbh Substituted 4-phenyltetrahydroisoquinolines, process for their preparation, their use as medicament, and medicament containing them

Also Published As

Publication number Publication date
AU2006294137A1 (en) 2007-03-29
BRPI0616196A2 (en) 2011-06-14
AR056520A1 (en) 2007-10-10
CA2623472A1 (en) 2007-03-29
ATE424203T1 (en) 2009-03-15
CN101267822A (en) 2008-09-17
TW200812584A (en) 2008-03-16
EP1928458B1 (en) 2009-03-04
IL189915A0 (en) 2008-11-03
JP2009508890A (en) 2009-03-05
US20080234317A1 (en) 2008-09-25
DE102005044815A1 (en) 2007-03-22
WO2007033774A3 (en) 2007-06-28
KR20080046676A (en) 2008-05-27
EP1928458A2 (en) 2008-06-11
WO2007033774A2 (en) 2007-03-29

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Legal Events

Date Code Title Description
8372 Publication of ep patent withdrawn