DE2521003C2 - Cream, ointment or the like - Google Patents

Cream, ointment or the like

Info

Publication number
DE2521003C2
DE2521003C2 DE19752521003 DE2521003A DE2521003C2 DE 2521003 C2 DE2521003 C2 DE 2521003C2 DE 19752521003 DE19752521003 DE 19752521003 DE 2521003 A DE2521003 A DE 2521003A DE 2521003 C2 DE2521003 C2 DE 2521003C2
Authority
DE
Germany
Prior art keywords
cream
hollow
foam
micro
skin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE19752521003
Other languages
German (de)
Other versions
DE2521003B1 (en
Inventor
Philipp; Picker Carsten; 3000 Hannover Schaefer
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Individual
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Individual
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to DE19752521003 priority Critical patent/DE2521003C2/en
Publication of DE2521003B1 publication Critical patent/DE2521003B1/en
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Publication of DE2521003C2 publication Critical patent/DE2521003C2/en
Expired legal-status Critical Current

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Description

Zum Verbinden, bzw. zum Einbetten der Mikrohohlperlen eignen sich alle bekannten sogenannten »Salbengrundlagen«, insbesondere pflanzliche und tierische Fette und öle, Stearin, Wollfett, Fettalkohole, Lanolin, Wachse, mineralische Öle, Vaseline^ Gelatine, Glyzerin, niedrige Alkohole, Lösungsmittel usw.For connecting or embedding the hollow microbeads, all known so-called ones are suitable "Ointment bases", in particular vegetable and animal fats and oils, stearin, wool fat, fatty alcohols, lanolin, waxes, mineral oils, petrolatum ^ Gelatin, glycerin, lower alcohols, solvents, etc.

Erfindungsgemäß besteht die Creme od. dgl, volumenmäßig zu 5 bis 96%, vorzugsweise zu 18 bis 72°/o, aus Mikrohohlperlen.According to the invention, the cream or the like consists of 5 to 96% by volume, preferably 18 to 72%, made of hollow microbeads.

Die erfindungsgemäße Creme od. dgl. hat eine Dichte von 0,05 bis 0,91, vorzugsweise von 0,16 bis 0,48, und besitzt eine schaumartige Konsistenz.The cream or the like according to the invention has a density of 0.05 to 0.91, preferably from 0.16 to 0.48, and has a foam-like consistency.

Sie läßt sich bei allen Temperaturen besonders leicht auf dis Haut auftragen und gleichmäßig auf ihr verteilen.It is particularly easy to apply and evenly to the skin at all temperatures distribute.

Die schaumartige Konsistenz der erfindungsgemäßen Creme wird durch Drude, Wärme, bewegte Luft, sowie durch bewegtes Wasser nicht zerstört.The foam-like consistency of the cream according to the invention is achieved by pressure, heat, moving air, as well as not destroyed by moving water.

Die Creme od. dgL ist atmungsaktiv und stört in Schichten unter 1 mm die Hautatmung nicht oderThe cream or dgL is breathable and does not or does not interfere with skin breathing in layers under 1 mm kaum. Sie ist deshalb mit entsprechenden Wirksubstanzen als Creme für Gesichtsmasken und als Salbe bei Brandverletzungen besonders gut geeignetbarely. It is therefore with appropriate active ingredients as a cream for face masks and as an ointment particularly suitable for burn injuries

In Folge der in den Mikrohohlperlen eingekapsel-S ten Luft, die auch unter Druck nicht entweichen kann, besitzt die erfindungsgemäße Creme ausgezeichnete kälte- und wärmeisolierende Eigenschaften. Sie ist deshalb als Schutzcreme gegen kaltes Wasser, wie sie von Schwimmern und Tauchern verwendet wird, beAs a result of the air encapsulated in the hollow microbeads, which cannot escape even under pressure, the cream according to the invention has excellent cold and heat insulating properties. she is therefore be used as a protective cream against cold water, as used by swimmers and divers sonders geeignetespecially suitable

Die vorzugsweise verwendeten hochpolymeren Mikrohohlperlen aus Polyvinylidenchlorid-Copolymerisat sind unbrennbar. In Verbindung mit unbrennbaren flüssigen oder pastösen Substanzen, wie z. B. ChlorThe high-polymer hollow microbeads made of polyvinylidene chloride copolymer are preferably used and are non-flammable. In connection with incombustible liquid or pasty substances, such as. B. Chlorine paraffin, sind s»e besonders geeignet als Schutzcremeparaffin, they are particularly suitable as protective creams

bei Brandkatastrophen, bei Arbeiten an Hochöfen usw.in the event of fire disasters, when working on blast furnaces, etc.

Ein weitere? Vorteil der Erfindung besteht darin,Another one? The advantage of the invention is that

daß sich die Mikrohohiperlen als solche physiologischthat the micro hollow pearls as such are physiologically absolut unbedenklich gegenüber dem menschlichenabsolutely harmless to the human

ao bzw. tierischen Körper und den Wirksubstanzen verhalten.ao or animal body and the active substances behave.

Claims (1)

od. dgL eingebauten, meist niedermolekularen Sub-or dgL built-in, mostly low-molecular sub- -. Patentanspruch: stanzen, wie z. B. das Treibmittel, die Emulgatoren-. Claim: punch, such as B. the propellant, the emulsifiers und die Schaumstabilisatoren mit vielen medizini-and the foam stabilizers with many medicinal Crerae, Salbe, Paste mit medizinischen und/ sehen und/oder kosmetischen Wirksubstanzen unver-K oder kosmetischen Wirksubstanzen, mit reinigen- 5 träglich sind, bzw. mit ihnen reagieren und ihre Wir-Crerae, ointment, paste with medicinal and / see and / or cosmetic active ingredients un-K or cosmetic active substances that are harmful to cleansing 5, or react with them and their effects den und/oder schützenden Eigenschaften, da- kung vermindern oder unerwünscht steigern.
4 durch gekennzeichnet, daß die Creme Ein Nachteil besteht auch darin, daß insbesondere
reduce or undesirably increase the and / or protective properties.
4 characterized in that the cream A disadvantage is also that in particular
flüssig, pastös oder wachsähnlich ist, und minde- Treibmittel und Emulgatoren physiologisch nicht instens teilweise aus Mikrohohlperlen besteht, 4e- different sind und besonders unangenehm auf die ren dünne Hülle aus einem thermoplastischen io Schleimhäute wirken und oft Allergien verursachen. Kunststoff gebildet ist,, und daß diese Mikrohohl- Ein wesentlicher Nachteil jeder Creme od. dgl. beperlen verschiedene Durchmesser besitzen^ steht darin, daß ihre Viskosität in hohem Maße vonis liquid, pasty or wax-like, and minor propellants and emulsifiers physiologically not instens partially consists of hollow microbeads, 4e are different and particularly uncomfortable on the ren thin shell made of a thermoplastic io affect mucous membranes and often cause allergies. Plastic is formed, and that these micro-hollow A major disadvantage of every cream or the like. Bead have different diameters ^ it says that their viscosity is to a large extent of ··■""■ ' der Temperatur der Creme, der Luft und der des·· ■ "" ■ 'the temperature of the cream, the air and that of the Körpers abhängt, was eine gleichmäßige Verteilung 15 erschwert bzw. unmöglich machtBody depends, which makes a uniform distribution 15 difficult or impossible Die Viskositäten aller Cremen od. dgl., insbesondre solcher auf fettiger CremeVSalbengrundlage mit relativ niedriger Dichte, sind im Gebrauchsbereich von —25° C (UV-Sdiutzcreme für den Wintersport)The viscosities of all creams or the like, especially those based on a greasy cream / ointment base relatively low density, are in the use range of -25 ° C (UV protection cream for winter sports) ao bis + 55° C (UV-Schutzcreme für den Badeurlaub)ao to + 55 ° C (UV protection cream for beach holidays) sehr verschieden und liegen zwischen flüssig bis wachsähnlich.very different and range from liquid to waxy. Die Erfindung hat sich die Aufgabe gestellt, diese Nachteile zu beheben und eine Creme zu schaffen, a5 die eine niedrige Dichte besitzt und die in einem weiten Temperaturbereich annähernd die ursprünglicheThe invention has the task of eliminating these disadvantages and creating a cream a5 which has a low density and which is wide Temperature range approximately the original Die Erfindung betrifft eine Creme mit niedriger Viskosität beibehält. Die in schaumartiger Konsistenz Dichte, insbesondere eine Creme, Salbe, Paste od. dgl. keine oder kaum Feuchtigkeit an die Atmosphäre mit medizinischen und/oder kosmetischen Wirksub- abgibt und die in diesem schaumartigen Zustand unStanzen, bzw. reinigenden und/oder schützenden Ei- 30 ter Druck und/oder Wärme nicht kollabiert, sich genschaften. leicht und gleichmäßig verteilen läßt, isolierende undThe invention relates to a cream that retains low viscosity. The foam-like consistency Dense, in particular a cream, ointment, paste or the like. No or hardly any moisture to the atmosphere with medicinal and / or cosmetic active substances and which are unStanzen in this foam-like state, or cleansing and / or protective egg pressure and / or heat does not collapse, itself properties. Can be easily and evenly distributed, insulating and Eine Creme od. dgl., wie sie beispielsweise zum atmungsaktive Eigenschaften besitzt, physiologisch Heinigen und Pflegen von Zähnen und Zahnfleisch, indifferent ist und sich den Wirksubstanzen gegensowie zum Schützen der Haut und zum Heilen von über neutral verhält. Ferner gehört es zur Aufgabe Wunden, sowie zum Behandeln von Allergien, ferner 35 der Erfindung, teure Wirksubstanzen und teure SaI-AIs Gesichtsmasken, zum Entfernen von Körperhaa- bengrundlagen zu sparen.A cream or the like, as it has, for example, breathable properties, physiologically Cleaning and care of teeth and gums, is indifferent and the active substances against each other as well as behaves to protect the skin and to heal excessively neutral. It is also part of the task Wounds, as well as for treating allergies, also 35 of the invention, expensive active ingredients and expensive SaI-AIs Face masks to save for removing body skin bases. ten und Hornhaut, sowie zum Rasieren benutzt wird, Die Lösung dieser Aufgabe besteht nach der Erfin-th and calluses, as well as is used for shaving, the solution to this problem is according to the invention ist in der Regel eine bei Zimmertemperatur flüssige dung in den Merkmalen des Kennzeichen des Anbis hatbfeste oder pastöse tixotrope Substanz mit ei- Spruchs und lautet: Creme, Salbe, Paste mit medizitier hohen Dichte. Physikalisch gesehen sind es Dis- 4» nischen und/oder kosmetisdien Wirksubstanzen, mit persionen, Emulsionen, Pasten, öle, Gele, Lösungen reinigenden und/oder schützenden Eigenschaften, da- oder Mischungen der genannten. Meistens enthalten durch gekennzeichnet, daß die Creme flüssig, pastös sie für die jeweiligen Anwendungsgebiete neben an- oder wachsähnlich ist, und mindestens teilweise aus derem medizinische und/oder kosmetische Wirksub- Mikrohohlperlen besteht, deren dünne Hülle aus eistanzen. 45 nem thermoplastisdien Kunststoff gebildet ist, und £s ist bekannt eine Creme od. dgl. zu Schäumen. daß diese Mikrohohlperlen verschiedene Durdimes-Dazu verwendet man ein Treibmittel, daß durch seine ser besitzen.is usually a liquid at room temperature in the characteristics of the mark of the ancestor has solid or pasty thixotropic substance with egg saying and reads: cream, ointment, paste with medizitier high density. From a physical point of view, there are disparate and / or cosmetic active substances persions, emulsions, pastes, oils, gels, solutions with cleaning and / or protective properties, or mixtures of the above. Mostly contain characterized by the fact that the cream is liquid, pasty it is for the respective application areas in addition to or similar to wax, and at least partially off whose medical and / or cosmetic active substance is made of hollow microbeads, the thin shell of which is punched from ice. 45 nem thermoplastisdien plastic is formed, and It is known to foam a cream or the like. that these hollow microbeads have different durdimes if you use a propellant that own through his water. Expansion (Verdampfung) die Creme beim Verlas- In besonders bevorzugter Weise sind die Mikro-Expansion (evaporation) the cream when leaving In a particularly preferred manner, the micro- sen des Druckbehälters aufschäumt. hohlperlen von der flüssigen oder pastösen Substanzthe pressure vessel foams. hollow pearls from the liquid or pasty substance Es ist auch bekannt eine Creme od. dgl. zusammen 50 völlig umgeben, also in sie eingebettet. Gemäß der mit Emulgatoren und Schaumstabilisatoren media- Erfindung besitzen die Mikrohohlperlen eine glatte nisch mittels eines Schnellrührers zu Schäumen. Oberfläche und kommen immer in unterschiedlicherIt is also known to completely surround a cream or the like together 50, that is to say embedded in it. According to the With emulsifiers and foam stabilizers media invention, the hollow microbeads have a smooth foaming using a high-speed stirrer. Surface and always come in different Ferner ist es bekannt eine Creme od. dgl. direkt Größe, also mit verschiedenen Durchmessern zur Verauf der Haut zu Schäumen (Rasierschaum). wendung. In bevorzugter Weise besteht die geschlos-It is also known a cream or the like. Direct size, that is, with different diameters for sale to lather the skin (shaving foam). turn. In a preferred manner, the closed In allen Fällen ist die gesdiäumte Creme od. dgl. 55 sene elastisdie Hülle der Mikrohohlperlen aus Polyäußerst instabil und sensibel. Der Schaum kollabiert vinylidenchlorid-Copolymerisat.
nach kurzer Zeit durch Feuchtigkeitsabgabe an die Unter Mikrohohlperlen werden hier auch MikroHaut und/oder die Atmosphäre oder spontan bei hohlkugeln verstanden, deren dünne Hülle aus einem Druck. Besonders instabil ist der Schaum bei Wärme thermoplastischen Kunststoff besteht, und die innen und bewegter Luft und bei bewegtem Wasser. Der 60 hohl sind, bzw. in ihrem Kern ein Gas enthalten, welvon einer geschäumten Creme od. dgl. erwünschte iso- dies vorzugsweise Luft ist. Die zur Anwendung komlierende, schützende, heilende, eine Wirksubstanz menden Mikrohohlperlen weisen, wie bereits erhähnt, speidiernde Effekt wird daher nur unvollkommen er- unterschiedliche Durchmesser auf, und zwar von reicht. Außerdem ist die Creme, insbesondere wenn 0,005 bis 0,65 mm, vorzugsweise von 0,01 bis sie in stärkerer Schicht aufgetragen wird, nicht at- 65 0,09 mm.
In all cases, the fringed cream or the like is extremely unstable and sensitive. The foam collapses vinylidene chloride copolymer.
after a short time due to the release of moisture to the micro-hollow beads are also understood here as micro-skin and / or the atmosphere or, spontaneously, in the case of hollow spheres, their thin shell from a pressure. The foam is particularly unstable when there is heat made of thermoplastic material, and the inside and moving air and when moving water. The 60 are hollow, or contain a gas in their core, the desired iso- this is preferably air from a foamed cream or the like. The protective, healing, active substance-containing microbeads that are required for use have, as already mentioned, the feeding effect, therefore, only imperfectly have different diameters, namely from ranges. In addition, the cream, especially if 0.005 to 0.65 mm, preferably from 0.01 to it is applied in a thicker layer, is not at-65 0.09 mm.
mungsaktiv und verhindert die Hautatmung. Eine Besdireibung soldier Mikrohohlperlen findetactive and prevents skin breathing. A description of the micro-hollow beads can be found Ein weiterer Naditeil besteht darin, daß die zur sich in der USA.-Patentschrift 36 15 972 und in der Schaumerzeugung notwendigen, in eine Creme Zeitschrift »Modem Plastics« 1969, August, S. 55.Another Naditeil is that the to be in the USA. Patent 36 15 972 and in the Foam generation necessary, in a cream magazine "Modem Plastics" 1969, August, p. 55.
DE19752521003 1975-05-12 Cream, ointment or the like Expired DE2521003C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19752521003 DE2521003C2 (en) 1975-05-12 Cream, ointment or the like

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19752521003 DE2521003C2 (en) 1975-05-12 Cream, ointment or the like

Publications (2)

Publication Number Publication Date
DE2521003B1 DE2521003B1 (en) 1976-08-12
DE2521003C2 true DE2521003C2 (en) 1977-03-24

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Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5935553A (en) 1989-12-22 1999-08-10 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5985246A (en) 1989-12-22 1999-11-16 Imarx Pharmaceutical Corp. Contrast agents for ultrasonic imaging and methods for preparing the same
US5997898A (en) 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US6028066A (en) 1997-05-06 2000-02-22 Imarx Pharmaceutical Corp. Prodrugs comprising fluorinated amphiphiles
US6033645A (en) 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US6033646A (en) 1989-12-22 2000-03-07 Imarx Pharmaceutical Corp. Method of preparing fluorinated gas microspheres
US6056938A (en) 1995-02-21 2000-05-02 Imarx Pharaceutical Corp. Cationic lipids and the use thereof
US6071495A (en) 1989-12-22 2000-06-06 Imarx Pharmaceutical Corp. Targeted gas and gaseous precursor-filled liposomes
US6071494A (en) 1996-09-11 2000-06-06 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a contrast agent and a renal vasodilator
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US6117414A (en) 1991-04-05 2000-09-12 Imarx Pharmaceutical Corp. Method of computed tomography using fluorinated gas-filled lipid microspheres as contract agents
US6123923A (en) 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6146657A (en) 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US6315981B1 (en) 1989-12-22 2001-11-13 Imarx Therapeutics, Inc. Gas filled microspheres as magnetic resonance imaging contrast agents
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6443898B1 (en) 1989-12-22 2002-09-03 Imarx Pharmaceutical Corp. Therapeutic delivery systems
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US6528039B2 (en) 1991-04-05 2003-03-04 Bristol-Myers Squibb Medical Imaging, Inc. Low density microspheres and their use as contrast agents for computed tomography and in other applications
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US6638767B2 (en) 1996-05-01 2003-10-28 Imarx Pharmaceutical Corporation Methods for delivering compounds into a cell
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US8084056B2 (en) 1998-01-14 2011-12-27 Lantheus Medical Imaging, Inc. Preparation of a lipid blend and a phospholipid suspension containing the lipid blend

Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6315981B1 (en) 1989-12-22 2001-11-13 Imarx Therapeutics, Inc. Gas filled microspheres as magnetic resonance imaging contrast agents
US5935553A (en) 1989-12-22 1999-08-10 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US6443898B1 (en) 1989-12-22 2002-09-03 Imarx Pharmaceutical Corp. Therapeutic delivery systems
US6001335A (en) 1989-12-22 1999-12-14 Imarx Pharmaceutical Corp. Contrasting agents for ultrasonic imaging and methods for preparing the same
US6479034B1 (en) 1989-12-22 2002-11-12 Bristol-Myers Squibb Medical Imaging, Inc. Method of preparing gas and gaseous precursor-filled microspheres
US6461586B1 (en) 1989-12-22 2002-10-08 Imarx Therapeutics, Inc. Method of magnetic resonance focused surgical and therapeutic ultrasound
US6033646A (en) 1989-12-22 2000-03-07 Imarx Pharmaceutical Corp. Method of preparing fluorinated gas microspheres
US5985246A (en) 1989-12-22 1999-11-16 Imarx Pharmaceutical Corp. Contrast agents for ultrasonic imaging and methods for preparing the same
US6071495A (en) 1989-12-22 2000-06-06 Imarx Pharmaceutical Corp. Targeted gas and gaseous precursor-filled liposomes
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US6146657A (en) 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US6773696B2 (en) 1991-04-05 2004-08-10 Bristol-Myers Squibb Medical Imaging, Inc. Contrast agent comprising low density microspheres
US6117414A (en) 1991-04-05 2000-09-12 Imarx Pharmaceutical Corp. Method of computed tomography using fluorinated gas-filled lipid microspheres as contract agents
US6528039B2 (en) 1991-04-05 2003-03-04 Bristol-Myers Squibb Medical Imaging, Inc. Low density microspheres and their use as contrast agents for computed tomography and in other applications
US6576220B2 (en) 1994-03-11 2003-06-10 Imarx Therapeutics, Inc. Non-invasive methods for surgery in the vasculature
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US6056938A (en) 1995-02-21 2000-05-02 Imarx Pharaceutical Corp. Cationic lipids and the use thereof
US5997898A (en) 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US6638767B2 (en) 1996-05-01 2003-10-28 Imarx Pharmaceutical Corporation Methods for delivering compounds into a cell
US6033645A (en) 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
US6071494A (en) 1996-09-11 2000-06-06 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a contrast agent and a renal vasodilator
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6444660B1 (en) 1997-05-06 2002-09-03 Imarx Therapeutics, Inc. Lipid soluble steroid prodrugs
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6028066A (en) 1997-05-06 2000-02-22 Imarx Pharmaceutical Corp. Prodrugs comprising fluorinated amphiphiles
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US6716412B2 (en) 1997-09-15 2004-04-06 Imarx Therapeutics, Inc. Methods of ultrasound treatment using gas or gaseous precursor-filled compositions
US6123923A (en) 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US8084056B2 (en) 1998-01-14 2011-12-27 Lantheus Medical Imaging, Inc. Preparation of a lipid blend and a phospholipid suspension containing the lipid blend

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