DE2521003C2 - Cream, ointment or the like - Google Patents
Cream, ointment or the likeInfo
- Publication number
- DE2521003C2 DE2521003C2 DE19752521003 DE2521003A DE2521003C2 DE 2521003 C2 DE2521003 C2 DE 2521003C2 DE 19752521003 DE19752521003 DE 19752521003 DE 2521003 A DE2521003 A DE 2521003A DE 2521003 C2 DE2521003 C2 DE 2521003C2
- Authority
- DE
- Germany
- Prior art keywords
- cream
- hollow
- foam
- micro
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000006071 cream Substances 0.000 title claims description 28
- 239000002674 ointment Substances 0.000 title claims description 5
- 239000000126 substance Substances 0.000 claims description 10
- 239000011325 microbead Substances 0.000 claims description 9
- 210000003491 Skin Anatomy 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 235000011837 pasties Nutrition 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 3
- 239000003921 oil Substances 0.000 claims description 2
- 239000003883 ointment base Substances 0.000 claims description 2
- 239000011049 pearl Substances 0.000 claims description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 claims description 2
- 239000006260 foam Substances 0.000 claims 6
- 239000002537 cosmetic Substances 0.000 claims 5
- 230000001681 protective Effects 0.000 claims 4
- 239000011324 bead Substances 0.000 claims 3
- 239000003995 emulsifying agent Substances 0.000 claims 3
- 239000006072 paste Substances 0.000 claims 3
- 239000004033 plastic Substances 0.000 claims 3
- 229920003023 plastic Polymers 0.000 claims 3
- 239000003380 propellant Substances 0.000 claims 3
- 206010020751 Hypersensitivity Diseases 0.000 claims 2
- 230000006750 UV protection Effects 0.000 claims 2
- 238000004140 cleaning Methods 0.000 claims 2
- 235000013601 eggs Nutrition 0.000 claims 2
- 239000004872 foam stabilizing agent Substances 0.000 claims 2
- 229920001169 thermoplastic Polymers 0.000 claims 2
- 239000004416 thermosoftening plastic Substances 0.000 claims 2
- 206010020649 Hyperkeratosis Diseases 0.000 claims 1
- 210000004400 Mucous Membrane Anatomy 0.000 claims 1
- 241000282941 Rangifer tarandus Species 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 238000001704 evaporation Methods 0.000 claims 1
- 230000035611 feeding Effects 0.000 claims 1
- 230000003031 feeding effect Effects 0.000 claims 1
- 238000005187 foaming Methods 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 230000035876 healing Effects 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000001264 neutralization Effects 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 238000009827 uniform distribution Methods 0.000 claims 1
- 200000000019 wound Diseases 0.000 claims 1
- 239000003925 fat Substances 0.000 description 2
- 239000011252 protective cream Substances 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 229940039717 Lanolin Drugs 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 229940066842 Petrolatum Drugs 0.000 description 1
- 229920001328 Polyvinylidene chloride Polymers 0.000 description 1
- DCXXMTOCNZCJGO-UHFFFAOYSA-N Stearin Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 1
- 210000002268 Wool Anatomy 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000005033 polyvinylidene chloride Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Description
Zum Verbinden, bzw. zum Einbetten der Mikrohohlperlen eignen sich alle bekannten sogenannten »Salbengrundlagen«, insbesondere pflanzliche und tierische Fette und öle, Stearin, Wollfett, Fettalkohole, Lanolin, Wachse, mineralische Öle, Vaseline^ Gelatine, Glyzerin, niedrige Alkohole, Lösungsmittel usw.For connecting or embedding the hollow microbeads, all known so-called ones are suitable "Ointment bases", in particular vegetable and animal fats and oils, stearin, wool fat, fatty alcohols, lanolin, waxes, mineral oils, petrolatum ^ Gelatin, glycerin, lower alcohols, solvents, etc.
Erfindungsgemäß besteht die Creme od. dgl, volumenmäßig zu 5 bis 96%, vorzugsweise zu 18 bis 72°/o, aus Mikrohohlperlen.According to the invention, the cream or the like consists of 5 to 96% by volume, preferably 18 to 72%, made of hollow microbeads.
Die erfindungsgemäße Creme od. dgl. hat eine Dichte von 0,05 bis 0,91, vorzugsweise von 0,16 bis 0,48, und besitzt eine schaumartige Konsistenz.The cream or the like according to the invention has a density of 0.05 to 0.91, preferably from 0.16 to 0.48, and has a foam-like consistency.
Sie läßt sich bei allen Temperaturen besonders leicht auf dis Haut auftragen und gleichmäßig auf ihr verteilen.It is particularly easy to apply and evenly to the skin at all temperatures distribute.
Die schaumartige Konsistenz der erfindungsgemäßen Creme wird durch Drude, Wärme, bewegte Luft, sowie durch bewegtes Wasser nicht zerstört.The foam-like consistency of the cream according to the invention is achieved by pressure, heat, moving air, as well as not destroyed by moving water.
Die Creme od. dgL ist atmungsaktiv und stört in Schichten unter 1 mm die Hautatmung nicht oderThe cream or dgL is breathable and does not or does not interfere with skin breathing in layers under 1 mm kaum. Sie ist deshalb mit entsprechenden Wirksubstanzen als Creme für Gesichtsmasken und als Salbe bei Brandverletzungen besonders gut geeignetbarely. It is therefore with appropriate active ingredients as a cream for face masks and as an ointment particularly suitable for burn injuries
In Folge der in den Mikrohohlperlen eingekapsel-S ten Luft, die auch unter Druck nicht entweichen kann, besitzt die erfindungsgemäße Creme ausgezeichnete kälte- und wärmeisolierende Eigenschaften. Sie ist deshalb als Schutzcreme gegen kaltes Wasser, wie sie von Schwimmern und Tauchern verwendet wird, beAs a result of the air encapsulated in the hollow microbeads, which cannot escape even under pressure, the cream according to the invention has excellent cold and heat insulating properties. she is therefore be used as a protective cream against cold water, as used by swimmers and divers sonders geeignetespecially suitable
Die vorzugsweise verwendeten hochpolymeren Mikrohohlperlen aus Polyvinylidenchlorid-Copolymerisat sind unbrennbar. In Verbindung mit unbrennbaren flüssigen oder pastösen Substanzen, wie z. B. ChlorThe high-polymer hollow microbeads made of polyvinylidene chloride copolymer are preferably used and are non-flammable. In connection with incombustible liquid or pasty substances, such as. B. Chlorine paraffin, sind s»e besonders geeignet als Schutzcremeparaffin, they are particularly suitable as protective creams
bei Brandkatastrophen, bei Arbeiten an Hochöfen usw.in the event of fire disasters, when working on blast furnaces, etc.
daß sich die Mikrohohiperlen als solche physiologischthat the micro hollow pearls as such are physiologically absolut unbedenklich gegenüber dem menschlichenabsolutely harmless to the human
ao bzw. tierischen Körper und den Wirksubstanzen verhalten.ao or animal body and the active substances behave.
Claims (1)
4 durch gekennzeichnet, daß die Creme Ein Nachteil besteht auch darin, daß insbesonderereduce or undesirably increase the and / or protective properties.
4 characterized in that the cream A disadvantage is also that in particular
nach kurzer Zeit durch Feuchtigkeitsabgabe an die Unter Mikrohohlperlen werden hier auch MikroHaut und/oder die Atmosphäre oder spontan bei hohlkugeln verstanden, deren dünne Hülle aus einem Druck. Besonders instabil ist der Schaum bei Wärme thermoplastischen Kunststoff besteht, und die innen und bewegter Luft und bei bewegtem Wasser. Der 60 hohl sind, bzw. in ihrem Kern ein Gas enthalten, welvon einer geschäumten Creme od. dgl. erwünschte iso- dies vorzugsweise Luft ist. Die zur Anwendung komlierende, schützende, heilende, eine Wirksubstanz menden Mikrohohlperlen weisen, wie bereits erhähnt, speidiernde Effekt wird daher nur unvollkommen er- unterschiedliche Durchmesser auf, und zwar von reicht. Außerdem ist die Creme, insbesondere wenn 0,005 bis 0,65 mm, vorzugsweise von 0,01 bis sie in stärkerer Schicht aufgetragen wird, nicht at- 65 0,09 mm.In all cases, the fringed cream or the like is extremely unstable and sensitive. The foam collapses vinylidene chloride copolymer.
after a short time due to the release of moisture to the micro-hollow beads are also understood here as micro-skin and / or the atmosphere or, spontaneously, in the case of hollow spheres, their thin shell from a pressure. The foam is particularly unstable when there is heat made of thermoplastic material, and the inside and moving air and when moving water. The 60 are hollow, or contain a gas in their core, the desired iso- this is preferably air from a foamed cream or the like. The protective, healing, active substance-containing microbeads that are required for use have, as already mentioned, the feeding effect, therefore, only imperfectly have different diameters, namely from ranges. In addition, the cream, especially if 0.005 to 0.65 mm, preferably from 0.01 to it is applied in a thicker layer, is not at-65 0.09 mm.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19752521003 DE2521003C2 (en) | 1975-05-12 | Cream, ointment or the like |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19752521003 DE2521003C2 (en) | 1975-05-12 | Cream, ointment or the like |
Publications (2)
Publication Number | Publication Date |
---|---|
DE2521003B1 DE2521003B1 (en) | 1976-08-12 |
DE2521003C2 true DE2521003C2 (en) | 1977-03-24 |
Family
ID=
Cited By (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5935553A (en) | 1989-12-22 | 1999-08-10 | Imarx Pharmaceutical Corp. | Methods of preparing gas-filled liposomes |
US5985246A (en) | 1989-12-22 | 1999-11-16 | Imarx Pharmaceutical Corp. | Contrast agents for ultrasonic imaging and methods for preparing the same |
US5997898A (en) | 1995-06-06 | 1999-12-07 | Imarx Pharmaceutical Corp. | Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery |
US6028066A (en) | 1997-05-06 | 2000-02-22 | Imarx Pharmaceutical Corp. | Prodrugs comprising fluorinated amphiphiles |
US6033645A (en) | 1996-06-19 | 2000-03-07 | Unger; Evan C. | Methods for diagnostic imaging by regulating the administration rate of a contrast agent |
US6033646A (en) | 1989-12-22 | 2000-03-07 | Imarx Pharmaceutical Corp. | Method of preparing fluorinated gas microspheres |
US6056938A (en) | 1995-02-21 | 2000-05-02 | Imarx Pharaceutical Corp. | Cationic lipids and the use thereof |
US6071495A (en) | 1989-12-22 | 2000-06-06 | Imarx Pharmaceutical Corp. | Targeted gas and gaseous precursor-filled liposomes |
US6071494A (en) | 1996-09-11 | 2000-06-06 | Imarx Pharmaceutical Corp. | Methods for diagnostic imaging using a contrast agent and a renal vasodilator |
US6088613A (en) | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
US6117414A (en) | 1991-04-05 | 2000-09-12 | Imarx Pharmaceutical Corp. | Method of computed tomography using fluorinated gas-filled lipid microspheres as contract agents |
US6123923A (en) | 1997-12-18 | 2000-09-26 | Imarx Pharmaceutical Corp. | Optoacoustic contrast agents and methods for their use |
US6139819A (en) | 1995-06-07 | 2000-10-31 | Imarx Pharmaceutical Corp. | Targeted contrast agents for diagnostic and therapeutic use |
US6143276A (en) | 1997-03-21 | 2000-11-07 | Imarx Pharmaceutical Corp. | Methods for delivering bioactive agents to regions of elevated temperatures |
US6146657A (en) | 1989-12-22 | 2000-11-14 | Imarx Pharmaceutical Corp. | Gas-filled lipid spheres for use in diagnostic and therapeutic applications |
US6231834B1 (en) | 1995-06-07 | 2001-05-15 | Imarx Pharmaceutical Corp. | Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same |
US6315981B1 (en) | 1989-12-22 | 2001-11-13 | Imarx Therapeutics, Inc. | Gas filled microspheres as magnetic resonance imaging contrast agents |
US6414139B1 (en) | 1996-09-03 | 2002-07-02 | Imarx Therapeutics, Inc. | Silicon amphiphilic compounds and the use thereof |
US6416740B1 (en) | 1997-05-13 | 2002-07-09 | Bristol-Myers Squibb Medical Imaging, Inc. | Acoustically active drug delivery systems |
US6443898B1 (en) | 1989-12-22 | 2002-09-03 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems |
US6521211B1 (en) | 1995-06-07 | 2003-02-18 | Bristol-Myers Squibb Medical Imaging, Inc. | Methods of imaging and treatment with targeted compositions |
US6528039B2 (en) | 1991-04-05 | 2003-03-04 | Bristol-Myers Squibb Medical Imaging, Inc. | Low density microspheres and their use as contrast agents for computed tomography and in other applications |
US6537246B1 (en) | 1997-06-18 | 2003-03-25 | Imarx Therapeutics, Inc. | Oxygen delivery agents and uses for the same |
US6548047B1 (en) | 1997-09-15 | 2003-04-15 | Bristol-Myers Squibb Medical Imaging, Inc. | Thermal preactivation of gaseous precursor filled compositions |
US6551576B1 (en) | 1989-12-22 | 2003-04-22 | Bristol-Myers Squibb Medical Imaging, Inc. | Container with multi-phase composition for use in diagnostic and therapeutic applications |
US6638767B2 (en) | 1996-05-01 | 2003-10-28 | Imarx Pharmaceutical Corporation | Methods for delivering compounds into a cell |
US6743779B1 (en) | 1994-11-29 | 2004-06-01 | Imarx Pharmaceutical Corp. | Methods for delivering compounds into a cell |
US8084056B2 (en) | 1998-01-14 | 2011-12-27 | Lantheus Medical Imaging, Inc. | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
Cited By (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6315981B1 (en) | 1989-12-22 | 2001-11-13 | Imarx Therapeutics, Inc. | Gas filled microspheres as magnetic resonance imaging contrast agents |
US5935553A (en) | 1989-12-22 | 1999-08-10 | Imarx Pharmaceutical Corp. | Methods of preparing gas-filled liposomes |
US6443898B1 (en) | 1989-12-22 | 2002-09-03 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems |
US6001335A (en) | 1989-12-22 | 1999-12-14 | Imarx Pharmaceutical Corp. | Contrasting agents for ultrasonic imaging and methods for preparing the same |
US6479034B1 (en) | 1989-12-22 | 2002-11-12 | Bristol-Myers Squibb Medical Imaging, Inc. | Method of preparing gas and gaseous precursor-filled microspheres |
US6461586B1 (en) | 1989-12-22 | 2002-10-08 | Imarx Therapeutics, Inc. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
US6033646A (en) | 1989-12-22 | 2000-03-07 | Imarx Pharmaceutical Corp. | Method of preparing fluorinated gas microspheres |
US5985246A (en) | 1989-12-22 | 1999-11-16 | Imarx Pharmaceutical Corp. | Contrast agents for ultrasonic imaging and methods for preparing the same |
US6071495A (en) | 1989-12-22 | 2000-06-06 | Imarx Pharmaceutical Corp. | Targeted gas and gaseous precursor-filled liposomes |
US6551576B1 (en) | 1989-12-22 | 2003-04-22 | Bristol-Myers Squibb Medical Imaging, Inc. | Container with multi-phase composition for use in diagnostic and therapeutic applications |
US6088613A (en) | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
US6146657A (en) | 1989-12-22 | 2000-11-14 | Imarx Pharmaceutical Corp. | Gas-filled lipid spheres for use in diagnostic and therapeutic applications |
US6773696B2 (en) | 1991-04-05 | 2004-08-10 | Bristol-Myers Squibb Medical Imaging, Inc. | Contrast agent comprising low density microspheres |
US6117414A (en) | 1991-04-05 | 2000-09-12 | Imarx Pharmaceutical Corp. | Method of computed tomography using fluorinated gas-filled lipid microspheres as contract agents |
US6528039B2 (en) | 1991-04-05 | 2003-03-04 | Bristol-Myers Squibb Medical Imaging, Inc. | Low density microspheres and their use as contrast agents for computed tomography and in other applications |
US6576220B2 (en) | 1994-03-11 | 2003-06-10 | Imarx Therapeutics, Inc. | Non-invasive methods for surgery in the vasculature |
US6743779B1 (en) | 1994-11-29 | 2004-06-01 | Imarx Pharmaceutical Corp. | Methods for delivering compounds into a cell |
US6056938A (en) | 1995-02-21 | 2000-05-02 | Imarx Pharaceutical Corp. | Cationic lipids and the use thereof |
US5997898A (en) | 1995-06-06 | 1999-12-07 | Imarx Pharmaceutical Corp. | Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery |
US6139819A (en) | 1995-06-07 | 2000-10-31 | Imarx Pharmaceutical Corp. | Targeted contrast agents for diagnostic and therapeutic use |
US6521211B1 (en) | 1995-06-07 | 2003-02-18 | Bristol-Myers Squibb Medical Imaging, Inc. | Methods of imaging and treatment with targeted compositions |
US6231834B1 (en) | 1995-06-07 | 2001-05-15 | Imarx Pharmaceutical Corp. | Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same |
US6638767B2 (en) | 1996-05-01 | 2003-10-28 | Imarx Pharmaceutical Corporation | Methods for delivering compounds into a cell |
US6033645A (en) | 1996-06-19 | 2000-03-07 | Unger; Evan C. | Methods for diagnostic imaging by regulating the administration rate of a contrast agent |
US6414139B1 (en) | 1996-09-03 | 2002-07-02 | Imarx Therapeutics, Inc. | Silicon amphiphilic compounds and the use thereof |
US6071494A (en) | 1996-09-11 | 2000-06-06 | Imarx Pharmaceutical Corp. | Methods for diagnostic imaging using a contrast agent and a renal vasodilator |
US6143276A (en) | 1997-03-21 | 2000-11-07 | Imarx Pharmaceutical Corp. | Methods for delivering bioactive agents to regions of elevated temperatures |
US6444660B1 (en) | 1997-05-06 | 2002-09-03 | Imarx Therapeutics, Inc. | Lipid soluble steroid prodrugs |
US6090800A (en) | 1997-05-06 | 2000-07-18 | Imarx Pharmaceutical Corp. | Lipid soluble steroid prodrugs |
US6028066A (en) | 1997-05-06 | 2000-02-22 | Imarx Pharmaceutical Corp. | Prodrugs comprising fluorinated amphiphiles |
US6416740B1 (en) | 1997-05-13 | 2002-07-09 | Bristol-Myers Squibb Medical Imaging, Inc. | Acoustically active drug delivery systems |
US6537246B1 (en) | 1997-06-18 | 2003-03-25 | Imarx Therapeutics, Inc. | Oxygen delivery agents and uses for the same |
US6548047B1 (en) | 1997-09-15 | 2003-04-15 | Bristol-Myers Squibb Medical Imaging, Inc. | Thermal preactivation of gaseous precursor filled compositions |
US6716412B2 (en) | 1997-09-15 | 2004-04-06 | Imarx Therapeutics, Inc. | Methods of ultrasound treatment using gas or gaseous precursor-filled compositions |
US6123923A (en) | 1997-12-18 | 2000-09-26 | Imarx Pharmaceutical Corp. | Optoacoustic contrast agents and methods for their use |
US8084056B2 (en) | 1998-01-14 | 2011-12-27 | Lantheus Medical Imaging, Inc. | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
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