DE202016003139U1 - nasal applicator - Google Patents

Abstract

Nasal applicator for the nasal administration of medical active substances, in particular analgesics, with an active ingredient container (13), a dispensing mandrel (3) insertable into a nostril and a dispenser (4) for metered dispensing of the active substance from the active substance container (13) via the dispensing mandrel (3) characterized in that at least one tilt sensor (10) for detecting the inclination (αx, αy) of the nose applicator (1) and a control device (7) for locking the dispenser (4) at detected inclinations outside a predetermined allowable inclination range and / or for activating a dose detecting means (5) at detected inclinations within a predetermined allowable inclination range.

Description

The present invention relates to a nasal applicator for the nasal administration of medical agents, in particular analgesics, with a dispensing mandrel insertable into a nostril, a drug container connectable to the dispensing mandrel, and a dispenser for dispensing the active ingredient from the drug container via the dispensing mandrel.

In pain therapy sometimes strong painkillers or opioids must be administered, it is advantageous to achieve a rapid onset, it is advantageous to administer these painkillers through the nasal mucosa. Nose applicators provided for this purpose are known in various forms and can be operated by the patient himself in a simple manner. The nasal applicator is inserted with its delivery mandrel into a nostril and then actuated to deliver a predetermined dose of the analgesic, for example in atomized form of an aerosol. For example, a dispensing metering mechanism provided inside the nose applicator may include a motor-driven pump, but sometimes is also a hand-operated conveyor mechanism that may operate by, for example, compressing the applicator housing or pushing a delivery plunger.

Nose applicators are for example from the writings US 2005/0098583 . FR 2 721 521 or GB 2 408 214 known, the latter GB 2 408 214 a blocking of the drug delivery in case of improper application of the applicator provides. The FR 2 721 521 shows a nasal applicator for nasal powder application.

On the one hand, self-administration of analgesics is sensible and desirable in order to give the analgesic only when it is actually needed, on the other hand, the self-administering analgesic must be protected against unintentional overdose, especially if it is a potent opioid. Painkiller acts.

The font DE 10 2013 012 292 proposes for this purpose to provide at the nasal applicator a dose detection device by means of which the delivered amount of active substance is detected. Once the highest permissible dose is reached, the dispenser is blocked so that no further strokes or doses can be dispensed. In this case, the maximum dose can be programmed on a patient-specific basis, for example in an RFID chip which can be attached to the patient's wrist, from which the control device of the nose applicator reads out the maximum permissible dose and activates or blocks the dispensing meter accordingly.

A difficulty with such patient-autonomously operable nasal applicators, however, is whether the amount of drug actually administered to the patient does in fact correspond to the calculated amount of drug delivered, as determined by the doser-detector. On the one hand, this may be due to the fact that the dispensing mandrel was not properly inserted into the nostril, or that the quantity of active substance dispensed was sprayed next to the nostril or was not completely introduced into the nostril. On the other hand, discrepancies may also be due to inaccuracies in determining the amount of drug delivered. If, for example, the metering detection device only counts the delivery strokes, fluctuations in the delivery quantity per stroke remain unconsidered.

In order to alleviate the former problem, ie to take account of active substance discharge past the nose, it has already been proposed to provide a temperature sensor on the delivery mandrel which is intended to detect by temperature whether the delivery mandrel has been introduced into the nostril or not. For example, if the temperature sensor detects a temperature well below 37 °, for example, only room temperature, the controller assumes that the dispensing mandrel has not been inserted into the nostril and disables the dispenser. However, such a temperature detection is quite expensive and requires a responsive sensor, otherwise a premature withdrawal of the delivery mandrel temperature drop can not be detected quickly enough. Furthermore, the above second problem of fluctuating dose per stroke remains unresolved.

Proceeding from this, the present invention seeks to provide an improved nose applicator of the type mentioned, which avoids the disadvantages of the prior art and the latter further develops in an advantageous manner. In particular, a more precise self-administration of highly effective painkillers is to be made possible, which deals efficiently with the existing painkillers stocks, without having to undertake overly complex monitoring measures.

According to the invention, said object is achieved by a nose applicator according to claim 1. Preferred embodiments of the invention are the subject of the dependent claims.

It is therefore proposed, immediately before and / or during and / or shortly after a delivery stroke or pulse or the actuation of the Dosage dispenser to determine the orientation of the nose applicator in space in terms of its inclination to the vertical and / or horizontal and from this infer whether it is a regular, purpose-designed discharge process. According to the invention, the nose applicator has a tilt sensor for detecting the inclination of the nose applicator and a control device for locking the dispenser at detected inclinations outside a predetermined allowable tilt range and / or activating a doser detecting means at detected inclinations within a predetermined allowable tilt range. If the inclination of the nose applicator deviates too much from a predetermined target orientation, the controller assumes that there is an irregular dispensing operation so that the controller may disable the dispenser to inhibit a dispensing operation and / or deactivate the dispenser detector not to count the irregular delivery stroke for monitoring the drug dose delivered to the user. If the sensed tilt is within a predetermined allowable tilt range about the intended target orientation, the controller will depart from a regular dispensing stroke so that the controller may unlock the dispenser and / or activate the dispenser detector to detect the dose of drug dispensed in the dispensing process ,

The said allowable tilt ranges outside of which the dispenser is blocked and the dispenser detector is activated may be identical, but may also have different limits for disabling the dispenser and activating the dispenser detector. For example, the allowable tilt range within which the dispenser is unlocked may be narrower than the range of inclination within which the dispensed dose is detected, for example, to detect dispensed drug doses even if the incline changes during dispensing and even more so from the target Orientation deviates.

By the above-mentioned consideration of the inclination of the nose applicator can be prevented that a Dosierhub or a dispensing operation is carried out at too inclined drug container and the dispenser drafts air instead of active ingredient or a drug mixture with too little active ingredient. This can occur, for example, if a cannula or a discharge line is provided in the active substance container, which sucks or absorbs the active substance in a specific region of the container and this region no longer lies completely in the region of the container filled by the active ingredient or active ingredient mixture. On the other hand, by taking into account the inclination and the release of the drug can be prevented or not taken into account when due to excessive misalignment of the nose applicator, for example, with the delivery mandrel downside down, no longer be expected with a proper administration of the drug into the nasal cavity can.

As an alternative or in addition to the explained prohibition of a dispensing operation or a non-counting of a dispensing operation, the control device may also be configured to lock the dispenser in response to a detected tilt position after a successful drug delivery and / or to keep in an open refill position to a regular To refill the dispenser. In particular, after a successful release of active ingredient, the control device can hold the dispensing meter in its triggering state and / or delay or block a pumping operation at least until an allowable tilting range detected by the tilting sensor is present and suitable for refilling.

Advantageously, the control device can hold a pumping device of the delivery metering device in an open refilling position, especially when an active ingredient delivery has been made in the overhead position, until the nose applicator reaches an angle position suitable for refilling.

If, for example, the nasal applicator is triggered overhead, it may indeed come to a regular discharge stroke with a sufficiently filled dispenser. Remains of the nose applicator after the drug delivery, however, in the above-mentioned position, a riser over which the dispenser or its pumping device is filled, so to speak, look into the air and protrude above the drug level in the storage container, so that due to lack of filling the riser re-filling the dispenser or its pumping device is not working properly. This would then take place at the next delivery stroke - even if this takes place in a suitable angle range - no regular drug delivery.

In this respect, the triggering position can advantageously be maintained with the aid of the aforementioned inclination sensor until the nose applicator is again held in a suitable inclination range for the refilling operation. In particular, closing of the pump can be prevented in overhead positions or generally for certain tilting ranges and / or the pump can be kept open for such a long time or the refilling pumping process can be delayed until it is again suitable angular range is present, in particular the said riser is again in the liquid.

The control device can in this case use different inclination or angle ranges for different locking tasks. Specifically, the illustrated tilting range for preventing erroneous refilling may differ from the tilting range by not counting a discharge stroke or disabling the dispensing stroke delivery metering device.

To account for the aforementioned problem of air extraction or insufficient supply of active ingredient from the drug container in the dispenser as precisely as possible, the fill level of the drug container can be considered in the development of the invention and the limits of the permissible inclination range, outside of which or within which the dispenser dispensed and / or the dose detection is activated, depending on the level changed. This is based on the consideration that at different fill levels different inclinations can lead to no longer proper Dosierhüben. Advantageously, a fill level determining device may be provided for determining the fill level of the active ingredient container, wherein the control device may have a limit determination device for determining the limits of the permissible tilt range as a function of the fill level of the active ingredient container.

In particular, the limits of the permissible inclination range can be set closer and / or the permissible inclination range can be reduced if the level of the active substance container decreases. With increasingly low level, the tendency of air extraction or not more complete feeding of active ingredient increases, so that it can be assumed even with minor deviations from the desired orientation of the nose applicator from a no longer proper Dosierhub. Accordingly, the controller may disable the dispenser and / or deactivate the dispenser detector if the sensed slopes also differ only slightly from the desired orientation.

The level of the drug container can be determined in different ways. In an advantageous embodiment of the invention, a level sensor for measuring the level in the drug container may be provided, said level sensor, for example, can work optically, for example, can be configured as a light barrier, which can detect a arranged in the drug container float and / or granular or liquid active ingredient, which is opaque or lichtabschwächend, the drug level detected directly. However, said fill level sensor can also be designed to operate capacitively or inductively, for example to detect the conductivity of the active substance container or the active substance contained therein. A mechanically trained level sensor is conceivable.

As an alternative or in addition to such a fill level sensor, the fill level of the drug reservoir can also be calculated from the already dispensed drug amount that has been detected by the dose detection device. In particular, in the light of the fact that the Dosierfassungseinrichtung then, if at too large inclinations dispensing is only regular Dosierhübe recorded, it can be assumed that the difference between the original total active ingredient in the container and the successively delivered drug amount of still in the drug container corresponds residual amount of the active ingredient. The control device may comprise a corresponding computing module which successively subtracts the dispensed active ingredient quantity detected by the dosing detection device from the original total quantity. The original total amount can be stored, for example, in a storage device connected to the control device and / or removed from a memory module provided on the active substance container and / or a marking attached thereto.

The aforementioned inclination sensor for detecting the inclination of the nose applicator can basically also be designed differently. For example, a mechanical angle or inclination sensor can be provided. Such a mechanical inclination sensor may, for example, be designed in the manner of a pendulum or comprise a ball arranged in a cup-shaped cage, as is known per se for mechanical inclination sensors. For example, the inclination sensor may also include a spring mass system in which the deflection of a small test mass is detected as a function of the position.

Alternatively or in addition to such a mechanical tilt sensor, however, an electronic tilt sensor may also be provided. For example, a sensor may be provided which contains a dielectric fluid whose position or level can be detected capacitively or inductively in a receptacle.

In an advantageous development of the invention, the at least one inclination sensor may be multi-axially working and / or multiple inclination sensors may be provided for multi-axis inclination detection in order to determine the inclination of the nose applicator in space To capture axes. This may be important, for example, if a dispensing cannula in the active substance container is not centrally positioned centrally, but towards an edge side of the active substance container in order to be able to remove the active substance from the container as completely as possible. For example, by means of the at least one inclination sensor, tilting of the nose applicator to the right and left and forward and backward relative to a vertical can be detected.

The at least one inclination sensor can in principle be attached to different locations of the nose applicator, advantageously accommodated inside a housing part of the nose applicator.

The at least one inclination sensor can in this case be arranged such that an orientation of the active substance container relative to the vertical is detected. In this case, the predetermined, permissible inclination range can be predetermined, for example, such that a vertical orientation of the longitudinal axis of the active substance container is a desired desired position and the permissible inclination range inclines the longitudinal axis of the active substance container by, for example, +/- 45 ° relative to the vertical, the abovementioned +/- - deviation range or its limits may vary, in particular can be set variable depending on the level.

If in the aforementioned manner by means of a Dosiererfassungseinrichtung detected the amount of active ingredient detected, the nose applicator can ensure that the patient tolerable maximum dose is respected or not exceeded, for example by the fact that the control device locks the dispenser then when the maximum allowable dose is reached ,

In this case, the nasal applicator can be configured individually with regard to the deliverable maximum amount of active substance, on the one hand a maximum amount per time, for example in the form of micrograms / hour, and / or on the other hand, absolute maximum levels, for example, not readily degradable agents, can be specified when they reach the blocking device for blocking the dispensing meter is activated in each case, so that the dispensing device can deliver only the individually predetermined maximum amount of active substance. The stated permissible maximum amounts of active substance can be variably specified by inputting corresponding control data into said patient data memory. In a development of the invention, the application quantities or maximum amounts dispensed by the dispenser can be controlled, for example, as a function of the patient's weight or its opioid habits.

The patient-specific configuration can in principle be done in various ways. For example, the nose applicator or its control device and / or its patient data memory can be connected via a data transmission interface to a higher-level, external computer from which the necessary control data for the respective patient or user can be imported.

As an alternative or in addition to the configurability via an external data transmission interface, the nose applicator itself may also be provided with suitable input means which enable the input of the patient-specific control data into the control device or its patient data memory, for example in the form of a keyboard and / or a touchscreen, either directly on the Housing or in attachable form, for example, in the manner of an external PC keyboard.

In order to facilitate the self-administration of the active ingredient or to simplify the use of the nose applicator even weaker or affected by the already existing pain patients, in development of the invention, the nose applicator may comprise an energy-fed Förderaktor who takes over the conveying and dispensing of the active ingredient energy-driven or at least supported wherein said Förderaktor can operate electrically, magnetically, pneumatically or hydraulically or with other forms of energy. In particular, the delivery actuator may be designed in the form of a pressure accumulator and / or a spring accumulator in order to use the stored energy to drive a suitable active ingredient delivery element such as a pump or a piston. Accordingly, the user only has to trigger the activation of the conveyor actuator or the conveyor element driven by it. As a result, the user, for example, the compression of the nose applicator or the impressions of a delivery piston is spared.

If the nasal applicator operates in the above-mentioned manner with an energetically driven delivery actuator, said blocking device can easily block or deactivate the delivery actuator, for example by interrupting the energy supply or blocking the pressure or spring accumulator. Alternatively or additionally, a mechanical blocking, for example, the dispenser or its delivery element may be provided, for example by engaging a pawl or similar elements, what Advantageously, in turn, can be carried out externally energized.

The present invention will be explained in more detail below with reference to a preferred embodiment and associated drawings. In the drawings show:

1 a schematic representation of a nose applicator according to an advantageous embodiment of the invention, and

2 : A schematic representation to illustrate the tilt detection and control of the nose applicator in the application.

As 1 shows, the nose applicator 1 a substantially cylindrical housing 2 comprise, from which front side a delivery mandrel 3 for insertion into a nasal cavity. The housing 2 may be a handpiece for grasping the nose applicator 1 form and / or in its interior a receiving chamber 12 form and therein a drug container 13 interchangeable, which is to the dispenser 4 of the nose applicator 1 is connectable. To the drug container 13 To be able to change, the housing 2 for example, by a lid 28 opened, the drug container 13 inserted and then the lid 28 be closed again.

The promotion of the active ingredient from the drug container used 13 is advantageously carried out by a third party actuated Förderaktor 26 which may comprise, for example, a compressed gas cartridge or a spring device, by means of which the active substance from the active substance container 13 is expelled. The active ingredient can be via a cannula 16 that are in the drug container 13 extends to the metering valve 29 be promoted, from which the active ingredient with an open metering valve 29 through a pipe 17 through the nose-thorn 3 further conveyed through and at the frontal opening of the delivery mandrel 3 is delivered.

For dosing the amount of active ingredient comprises said dispensing meter 4 according to 1 a metering valve 29 that from a control device 7 can be controlled and operated when, for example, an operating switch 9 on the housing 2 is pressed. The electronic control device 7 can advantageously also inside the housing 2 be housed and includes a patient data memory 8th , from the electronic control device 7 for a particular patient individually definable control data such as maximum dose, single dose or daily dose may include. The named control device 7 and said patient data store 8th may for example be formed by a microcontroller and associated circuit components such as a memory element, wherein the patient data memory 8th for example, on the exchangeable drug container 13 attached or with an attached memory module 15 can be connectable.

The control device 7 can through a locking device 6 the said dispensing meter 4 lock, for example, when a maximum dose is reached or an unlock code is not present. To detect the actual delivery amount, the nose applicator comprises 1 a dose detection device 5 For example, in the control device 7 can be integrated and the valve actuation of the metering valve 29 counts and / or the length of the operations determined.

Alternatively or additionally, this can 2 clarifies, the nose applicator 1 or its control device 7 also with an RFID element 20 communicate which the patient, for example, by means of a bracelet or other body fastener 25 on the body. In said RFID element 20 On the one hand, patient-specific control data, for example regarding the maximum permissible dose, can be stored, and / or one unlock code, which is the nose applicator 1 in the first case unlocks or said locking device 6 unlocked. For this purpose, the control device 7 by means of an RFID transceiver 21 with the mentioned RFID element 20 communicate when the nasal applicator is close enough to the patient.

As 1 further shows, comprises the nose applicator 1 at least one tilt sensor 10 inside the applicator housing 2 be arranged and with the control device 7 can communicate. The named tilt sensor 10 can, as explained above, work according to different principles of action and advantageously the inclination of the nose applicator 1 capture biaxially with respect to the vertical. As 2 shows, by means of the at least one tilt sensor 10 the inclination of the nose applicator 1 relative to the vertical Z-axis, in the direction of the X-axis and in the direction of the Y-axis, so that the inclination is detected biaxially. The tilt sensor 10 sets the inclination angle α _y , cf. 2 , in the direction of the Y-axis and the inclination angle α _x in the direction of the X-axis, so that the control device 7 Knows how strong the nose applicator 1 inclined to the upright Z-axis.

The tilt sensor 10 can thereby the inclination of the longitudinal axis 19 of the drug container 13 and / or the housing 2 and / or the entire nose applicator body relative to the upright Z-axis.

Advantageously, the tilt sensor 10 and / or another orientation or inclination sensor also indicate which peripheral portion of the nose applicator is arranged up or down, that is, the rotational orientation of the nose applicator 1 with respect to its longitudinal axis 19 can be specified so that the control device 7 informed about which rotational position of the nose applicator 1 occupies in the above tilt position. For example, it can be specified whether the actuation switch 9 above or below or in which intermediate position of the operating switch 9 lies. This may be significant if the drug container 13 not rotationally symmetric with respect to the longitudinal axis 19 is formed and / or the cannula 16 , through which the active ingredient is delivered, is not positioned exactly in the center.

If the angle of inclination with respect to the vertical in the form of the two abovementioned angles α _x and α _y deviates more than predetermined limit values, so that the inclination is no longer within a permissible inclination range of +/- 45 ° or +/- 35 ° or +/- 25 ° relative to the vertical, the control device 7 over the locking device 6 the dispenser 4 lock and prevent the release of active ingredient. Alternatively or additionally, the control device 7 the dose detecting device 5 disable, so that a possibly still dispensed Dosierhub is not counted.

Alternatively or additionally, the control device 7 after a successful drug delivery the dispenser 4 hold in the release position or prevent a pumping operation at least until the tilt sensor indicates a suitable for refilling angle range of the nose applicator. This can be helpful, in particular, if a delivery stroke has taken place in an overhead position, as was explained in the introduction.

As 1 shows, the nose applicator 1 Furthermore, a level determining device 18 have, by means of which the level of the drug container 13 can be determined with active ingredient, said level determining means 18 For example, a level sensor 14 may have the level of the active ingredient in the drug container 13 detected by sensors.

The level signal of the level sensor 14 can the control device 7 be supplied, for example, if the level is too low, the dispenser 4 to lock and / or the Dosierfassungseinrichtung 5 to deactivate and / or hold the triggering position after the delivery stroke. In particular, the determined level in the drug container 13 but also be used to change the limits of the aforementioned allowable slope range, in particular such that the lower the level is set, the lower the allowable inclination relative to the vertical. This can take place in steps or else continuously, for example, such that a maximum angle of inclination of, for example, +/- 45 ° is permitted up to a level of 50% or more, and an angle of +/- 35 at a level between 25% and 50% ° is permitted and at a level of less than 25% only an inclination angle of +/- 25 ° is allowed. The above-mentioned filling level ranges and inclination angles are only to be understood as examples; other stages or also a stepless, for example linear or exponential dependency between inclination angle and filling level can be provided.

Similarly, the limits of the allowable inclination range also in dependence of the aforementioned rotational orientation of the nose applicator with respect to its longitudinal axis 19 be set variably, in particular narrowed, to take into account whether inclination of the drug container 13 the cannula provided therein 16 its inlet opening in an upper or lower portion of the drug container 13 Has. In particular, the allowable tilt range can be narrowed when the cannula opening is up.

The nasal applicator described can be used in particular for the administration of highly effective opioid analgesics, but the nasal applicator can in principle also be used for the delivery of other medicaments which are administered under the control of the patient himself. These may in particular be substances which are usefully administered under at least one of the following boundary conditions: a) The illness or complaints / symptoms to be treated suddenly set in and can not be predicted with sufficient accuracy (for example migraine attacks, nausea / vomiting, blood sugar fluctuations , epileptic seizures, extreme blood pressure fluctuations). b) The drugs used to treat the above symptoms are absorbed quickly through the nasal mucosa and cause a rapid improvement of the symptoms. c) The medicines used for the treatment of the symptoms mentioned under a) have a certain risk potential or have strong side effects, ie their application must be regulated within certain limits (for example, the so-called "triptans" can act quickly and reliably in migraine attacks, but in an overdose lead to severe circulatory disorders). d) The drugs used to treat the symptoms mentioned under a) can lead to dependence / addiction (examples: opioids, antiepileptics), so that in Within the framework of a patient-controlled application, access control or patient identification must take place.

QUOTES INCLUDE IN THE DESCRIPTION

This list of the documents listed by the applicant has been generated automatically and is included solely for the better information of the reader. The list is not part of the German patent or utility model application. The DPMA assumes no liability for any errors or omissions.

Cited patent literature

• US 2005/0098583 [0003]
• FR 2721521 [0003, 0003]
• GB 2408214 [0003, 0003]
• DE 102013012292 [0005]

Claims (13)

Nasal applicator for the nasal administration of medical active substances, in particular analgesics, with a drug container ( 13 ), a delivery mandrel insertable into a nostril ( 3 ) and a dispenser ( 4 ) for the metered dispensing of the active substance from the active substance container ( 13 ) over the delivery mandrel ( 3 ), characterized in that at least one inclination sensor ( 10 ) for detecting the inclination (α _x , α _y ) of the nose applicator ( 1 ) and a control device ( 7 ) for blocking the dispensing meter ( 4 ) at detected inclinations outside a predetermined allowable inclination range and / or for activating a dose detection device ( 5 ) are provided at detected inclinations within a predetermined allowable inclination range. A nose applicator according to the preceding claim, wherein a filling level determining device ( 18 ) for determining the level of the active substance container ( 13 ) is provided and the control device ( 7 ) a limit determination device for determining the limits of the permissible inclination range as a function of the level of the active substance container ( 13 ) having. Nose applicator according to the preceding claim, wherein the boundary determination means narrows the allowable inclination range with decreasing filling level. Nose applicator according to one of the two preceding claims, wherein the filling level determining device ( 18 ) a level sensor ( 14 ) for measuring an active ingredient level in the active substance container ( 13 ) having. Nose applicator according to one of claims 2 to 4, wherein the filling level determining device ( 18 ) a computing module for calculating the level of the from the Dosierfassungsvorrichtung ( 5 ) has detected, delivered drug amounts. Nose applicator according to one of the preceding claims, wherein the at least one inclination sensor ( 10 ) is designed to work biaxially and / or to determine the inclination relative to the vertical in the direction of two mutually perpendicular axes (X, Y). Nose applicator according to one of the preceding claims, wherein the at least one inclination sensor ( 10 ) and / or a further sensor is formed such that in a respective tilt position can be detected, which peripheral portion of the nose applicator ( 1 ) and / or the drug container ( 13 ) above and which peripheral portion comes to lie down and / or through which peripheral portions of the nose applicator ( 1 ) and / or the drug container ( 13 ) a vertical, the longitudinal axis ( 19 ) of the nose applicator ( 1 ) and / or what inclination a through a certain peripheral portion of the nose applicator ( 1 ) and / or the drug container ( 13 ), the longitudinal axis ( 19 ) occupies a level with respect to the vertical. Nose applicator according to the preamble of claim 1 or any one of the preceding claims, wherein the / a control device ( 7 ) is adapted, after a successful drug delivery, the dispenser ( 4 ) and / or a pumping operation for refilling the dispenser ( 4 ) at least as long to delay and / or block until one of the tilt sensor ( 10 ), the permissible inclination range is present. Nose applicator according to the preceding claim, wherein the control device ( 7 ) is designed to hold a pumping device in its open and / or filling position after an active ingredient delivery has been made in the overhead position of the nose applicator, until it is more suitable for refilling the pumping device by the inclination sensor ( 10 ) detected inclination range is present. Nose applicator according to one of the preceding claims, wherein the at least one inclination sensor ( 10 ) is mechanically working and / or electronically working. Nose applicator according to one of the preceding claims, wherein the at least one inclination sensor ( 10 ) inside a Nasenapplikatorgehäuses ( 2 ) is received, in particular in an interior of said Nasenapplikatorgehäuses ( 2 ), in which the active substance container ( 13 ) and / or the one hand part of the nose applicator ( 1 ). Nose applicator according to one of the preceding claims, wherein the dispenser ( 4 ) from the control device ( 7 ) as a function of patient-specific control data for the patient-individual blocking of the dispensing meter, which control data in a patient data memory ( 8th ) can be entered individually for each patient, can be blocked. Nose applicator according to the preceding claim, wherein a maximum amount of active substance, preferably a maximum amount per time and / or an absolute amount, upon reaching the dispenser ( 4 ) is locked, by importing various control data in the patient data memory ( 8th ) of the control device ( 7 ) is changeable.

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