DE202008002718U1 - Catheter with proanthocyanidin-containing hydrophilic coating - Google Patents

Catheter with proanthocyanidin-containing hydrophilic coating Download PDF

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Publication number
DE202008002718U1
DE202008002718U1 DE200820002718 DE202008002718U DE202008002718U1 DE 202008002718 U1 DE202008002718 U1 DE 202008002718U1 DE 200820002718 DE200820002718 DE 200820002718 DE 202008002718 U DE202008002718 U DE 202008002718U DE 202008002718 U1 DE202008002718 U1 DE 202008002718U1
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catheter
surface coating
hydrophilic surface
cranberry extract
proanthocyanidin
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Medical Service GmbH
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Medical Service GmbH
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M25/0045—Catheters; Hollow probes characterised by structural features multi-layered, e.g. coated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/442—Colorants, dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M25/0045—Catheters; Hollow probes characterised by structural features multi-layered, e.g. coated
    • A61M2025/0046—Coatings for improving slidability

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Katheter mit einer hydrophilen Oberflächenbeschichtung, die mindestens ein Proanthocyanidin enthält.Catheter having a hydrophilic surface coating containing at least one proanthocyanidin.

Description

Die vorliegende Erfindung betrifft einen Katheter, insbesondere zum Einführen in die Harnröhre, mit einer hydrophilen Oberflächenbeschichtung.The The present invention relates to a catheter, in particular for Insertion into the urethra, with a hydrophilic Surface coating.

Ein solcher Katheter mit einer hydrophilen Oberflächenbeschichtung ist z. B. aus der EP 1324785 B1 bekannt. Bei dem dort beschriebenen Katheter enthält die äußere hydrophile Oberflächenbeschichtung ein Anthrachinon, das bevorzugt ein Aloin ist, das aus den Blättern der Aloe Vera gewonnen wird. Anthrachinone weisen bakterizide und antivirale Eigenschaften auf, sie bekämpfen Pilzerkrankungen, wirken als Analgetikum und als entzündungshemmende Stoffe.Such a catheter with a hydrophilic surface coating is z. B. from the EP 1324785 B1 known. In the catheter described therein, the outer hydrophilic surface coating contains an anthraquinone, which is preferably an aloin derived from the leaves of the aloe vera. Anthraquinones have bactericidal and antiviral properties, fight fungal diseases, act as analgesics and as anti-inflammatory agents.

Derartige Katheter werden z. B. für den intermittierenden Katheritismus eingesetzt. Dieser ist eine einfache Methode, die Harnblase schonend und ohne schädlichen Druck zu entleeren. Dabei werden die Nieren bestmöglich geschützt.such Catheters are z. For intermittent Catheritism used. This is a simple method of sparing the bladder and to empty without harmful pressure. Here are the Kidneys best protected.

Moderne Katheter werden bevorzugt aus PVC, Polyamid, einem Latex- oder Silikonmaterial hergestellt. Die Verwendung einer äußeren hydrophilen Beschichtung lässt den Katheter sehr gleitend werden, wenn die Beschichtung mit Flüssigkeit aktiviert wird. Dadurch kann der Katheter einfach eingeführt und wieder entfernt werden, ohne den Verwender nachhaltig zu beeinflussen. Weitere Katheter sind z. B. aus der GB 1600963 , der EP 0093093 und EP 0093094 bekannt.Modern catheters are preferably made of PVC, polyamide, a latex or silicone material. The use of an outer hydrophilic coating allows the catheter to become very slippery when the coating is activated with liquid. This allows the catheter to be easily inserted and removed without affecting the user. Other catheters are z. B. from the GB 1600963 , of the EP 0093093 and EP 0093094 known.

Solche Katheter haben sich im Einsatz weitgehendst bewährt. Es bestehen aber auch hier Bestrebungen, Weiterentwicklungen durchzuführen und gegebenenfalls eine Kostenreduktion herbeizuführen.Such Catheters have proven themselves in use for the most part. It However, there are also efforts to carry out further developments and possibly to bring about a cost reduction.

Darüber hinaus ist es bekannt, dass Cranberry-Extrakt/Konzentrat insbesondere bei Verabreichung als Nahrungsergänzungsmittel und bei direktem Auftragen gesundheitlich positive Auswirkung im Harntrakt hat. Hierzu wird auf die US 5525341 , US 5646178 und US 5650432 verwiesen.In addition, it is known that cranberry extract / concentrate, especially when administered as a dietary supplement and when applied directly has a positive health effect in the urinary tract. This is on the US 5525341 . US 5646178 and US 5650432 directed.

Es ist daher die Aufgabe der vorliegenden Erfindung, einen Katheter mit verbesserten infektionshemmenden Eigenschaften bereitzustellen.It Therefore, the object of the present invention is a catheter with improved anti-infective properties.

Diese Aufgabe wird erfindungsgemäß bei einem Katheter dadurch gelöst, dass die hydrophile Oberflächenbeschichtung mindestens ein Proanthocyanadin enthält. Bei Pro anthocyanidinen handelt es sich um in Pflanzen natürlich auftretende Stoffe, die zur Gruppe der Flavonoide gehören und den übergeordneten Polyphenolen zuzuordnen sind. Sie werden auch als kondensierte Tannine bezeichnet. Proanthocyanidine üben eine antioxidative Schutzwirkung vor den Auswirkungen freier Radikale aus und kommen in verschiedenen Pflanzen vor z. B. in Traubenkernen, in der Schale und dem Laub roter Trauben, in den roten Häutchen von Erdnüssen, in Kokosnüssen, in Äpfeln, in der Rinde der Strandkiefer (Pinus Maritima) und in Cranberries. Die Wirkungsweise wurde bislang nur bei Verabreichung in Form von Nahrungsergänzungsmitteln untersucht. Es wurde dabei herausgefunden, dass die Proanthocyanidine zur Gesunderhaltung der Harnwegsbereichs durch das Hemmen der Adhäsion von bestimmten Bakterien an den Schleimhäuten und/oder Zellwänden beitragen. Bakterielle Adhäsion an Schleimhäuten wird allgemein als eine wichtige Grundvoraussetzung für deren Ansiedlung und dem Auslösen einer Infektion betrachtet. Die Proanthocyanidine wirken antiadhäsiv und sind somit für ein verändertes Adhärenzverhalten der E.-coli-Bakterien verantwortlich, die sich nicht mehr an den Zellwänden anlagern. Somit trägt diese Substanz zu einer Gesunderhaltung der Harntraktes bei, denn wenn diese Krankheitserreger nicht anhaften können, rufen sie auch keine Infektion hervor, sondern werden einfach aus dem Körper ausgespült. Bezüglich der bevorzugten Proanthocyanidinen und deren Strukturformeln wird auf die US 5525341 , US 5646178 und US 5650432 verwiesen.This object is achieved in a catheter in that the hydrophilic surface coating contains at least one proanthocyanadin. Pro anthocyanidins are naturally occurring substances in plants that belong to the group of flavonoids and are assigned to the parent polyphenols. They are also referred to as condensed tannins. Proanthocyanidins exert an antioxidant protective effect against the effects of free radicals and occur in various plants from z. B. in grape seeds, in the shell and the leaves of red grapes, in the red pellets of peanuts, in coconuts, in apples, in the bark of the beach pine (Pinus maritima) and in cranberries. The mode of action has so far been studied only when administered in the form of dietary supplements. It has been found that the proanthocyanidins contribute to maintaining the health of the urinary tract by inhibiting the adhesion of certain bacteria to the mucous membranes and / or cell walls. Bacterial adhesion to mucous membranes is generally considered to be an important prerequisite for their colonization and induction of infection. The proanthocyanidins have an antiadhesive effect and are thus responsible for an altered adherence behavior of the E. coli bacteria, which are no longer attached to the cell walls. Thus, this substance contributes to the health of the urinary tract, because if these pathogens can not attach, they also cause no infection, but are simply flushed out of the body. With respect to the preferred proanthocyanidins and their structural formulas is directed to the US 5525341 . US 5646178 and US 5650432 directed.

Des Weiteren kann die hydrophile Oberflächenbeschichtung mindestens ein Anthocyan enthalten. Bei Anthocyanen handelt es sich um wasserlösliche Pflanzenfarbstoffe, die zu den flavonen-ähnlichen Stoffen, den Flavonoiden, gehören. Die Stoffgruppe der Anthocyane selbst lässt sich in die zuckerffreien Anthocyanidine (Aglykone) und die Anthocyane (Glycoside) unterteilen. Die Anthocyane wirken entzündungshemmend. Die Wirkungsweise der Anthocyane wurde bislang nur bei Verabreichung in Form von Nahrungsergänzungsmitteln untersucht.Of Furthermore, the hydrophilic surface coating may be at least contain an anthocyanin. Anthocyanins are water-soluble Vegetable dyes, which are among the flavone-like substances, the flavonoids. The substance group of anthocyanins itself can be divided into the sugar-free anthocyanidins (aglycones) and subdivide the anthocyanins (glycosides). The anthocyanins are effective anti-inflammatory. The mode of action of anthocyanins was so far only when administered in the form of dietary supplements examined.

In einer besonders vorteilhaften Ausführungsform ist vorgesehen, dass die hydrophile Oberflächenbeschichtung Cranberry-Extrakt/Konzentrat enthält. In Cranberry-Extrakt/Konzentrat sind sowohl Proantocyanidine als auch Anthocyane enthalten. Der zumeist pulverförmige Cranberry-Extrakt/Konzentrat ist wasserlöslich und zumeist durch Sprühtrocknen aus einem Cranberry-Presskuchen extrahiert. Denkbar ist auch die Verwendung von flüssigem oder breiigem Cranberry-Konzentrat. In dieser Form lässt sich der Cranberry-Extrakt/Konzentrat sehr leicht der Beschichtungsmenge beimengen, die dann auf die Katheteroberfläche aufgetragen wird. Dies geschieht nach heutigem Stand der Technik mittels UV-Vernetzung. Wei terentwicklungen zum Auftragen der Beschichtungslösung sind denkbar. Es kann sowohl weißer als auch roter Cranberry-Extrakt/Konzentrat Anwendung finden. Cranberry-Extrakt/Konzentrat ist bislang hautpsächlich als Bestandteil von Nahrungsergänzungsmitteln und funktionellen Lebensmitteln bekannt. Die Verwendung als Beschichtungsstoff für eine hydrophile Oberflächenbeschichtung dahingegen ist jedoch neu.In a particularly advantageous embodiment, it is provided that the hydrophilic surface coating contains cranberry extract / concentrate. Cranberry extract / concentrate contains both proanthocyanidins and anthocyanins. The mostly powdered cranberry extract / concentrate is water soluble and mostly extracted by spray drying from a cranberry press cake. Also conceivable is the use of liquid or mushy cranberry concentrate. In this form, the cranberry extract / concentrate can very easily add to the amount of coating that is then applied to the catheter surface. This happens according to the current state of the art by means of UV crosslinking. Wei ter developments for applying the coating solution are conceivable. It can find both white and red cranberry extract / concentrate application. Cranberry Extract / Concentrate has been largely known as a component of nutritional supplements and functional foods. The use as In contrast, coating material for a hydrophilic surface coating, however, is new.

Als Trägerstoff kann der zumeist pulverförmige Cranberry-Extrakt Magnesiumhydroxid enthalten. Magnesiumhydroxid ist ein amorphes weißes Pulver, das als Trennmittel zugesetzt wird.When Carrier can be the mostly powdered cranberry extract Magnesium hydroxide included. Magnesium hydroxide is an amorphous white powder added as a release agent.

Des Weiteren kann der Cranberry-Extrakt Kalziumtriphosphat enthalten. Bei Kalziumtriphosphat handelt es sich um ein Rieselmittel, durch welches das Auftragen eines pulverförmigen Cranberry-Extraktes erleichtert wird.Of Further, the cranberry extract may contain calcium triphosphate. Calcium triphosphate is a pouring agent, by which is the application of a powdered cranberry extract is relieved.

Gemäß einer weiteren Ausführungsform kann der Cranberry-Extrakt/Konzentrat mindestens 80%, bevorzugt 85%, Fruchtfeststoffe enthalten. Hierdurch ergibt sich eine recht hohe Konzentration an Proanthocyanidinen und Anthocyanen.According to one In another embodiment, the cranberry extract / concentrate at least 80%, preferably 85%, fruit solids. hereby results in a fairly high concentration of proanthocyanidins and anthocyanins.

Des Weiteren ist auch die Verwendung von Proanthocyanidinen als Bestandteil einer hydrophilen Oberflächenbeschichtung von Magensonden, Endoskopen und ähnlichen medizinischen Geräten zum Einführen in Körperöffnungen möglich.Of Another is the use of proanthocyanidins as an ingredient a hydrophilic surface coating of stomach tubes, endoscopes and similar medical devices for insertion in body openings possible.

Die hydrophile Oberflächenbeschichtung kann weitere entzündungshemmende Mittel enthalten, wie z. B. Fettsäuren. Auch können Antioxidationsmittel in der hydrophilen Oberflächenbeschichtung enthalten sein. Als Antioxidationsmittel kommen u. a. Vitamin C, Vitamin E, Betacarotin und Selen oder eine Kombination dieser Stoffe zur Anwendung.The hydrophilic surface coating may be more anti-inflammatory Contain means such. B. fatty acids. Also can Antioxidant in the hydrophilic surface coating be included. As antioxidant u. a. Vitamin C, Vitamin E, beta carotene and selenium or a combination of these substances for use.

Darüber hinaus kann die hydrophile Oberflächenbeschichtung ein Mucopolysaccharid enthalten, welches als Barriere gegen mikrobiellen Befall des Epithels dient. Bewährt hat sich in diesem Zusammenhang insbesondere als Mucopolysaccharid Azemanan.About that In addition, the hydrophilic surface coating can Mucopolysaccharide which acts as a barrier against microbial Infestation of the epithelium is used. Has proven in this context especially as mucopolysaccharide Azemanan.

Als weiterer Bestandteil der hydrophilen Oberflächenbeschichtung kommt Lignine bei einer weiteren Ausführungsform zur Anwendung, durch die andere Inhaltsstoffe der Oberflächenbeschichtung besser aufgenommen werden können.When further component of the hydrophilic surface coating Lignine is used in a further embodiment, better by the other ingredients of the surface coating can be included.

Die Beschichtung kann bekannte hydrophile Beschichtungspolymere aufweisen, wie z. B. Polyvinylpyrrolidon, welches auf die Oberfläche des Katheters zusammen mit dem mindes tens einen Proanthocyanidin bzw. eines Cranberry-Extrakts und evtl. anderer Inhaltsstoffe in einer bekannten Weise aufgebracht werden.The Coating may comprise known hydrophilic coating polymers, such as As polyvinylpyrrolidone, which on the surface of the catheter together with the at least one proanthocyanidin or a cranberry extract and possibly other ingredients in be applied in a known manner.

Zur Anwendung kommen bekannte Katheterformen, die insbesondere zur Einführung in eine Harnröhre geeignet sind und eine abgerundete Spitze zur besseren Applikation aufweisen. Mindestes eine seitliche Öffnung angrenzend der Spitze des Katheters ermöglicht dem Urin, in das Innere des Katheters zu gelangen, wenn die Spitze des Katheters die Blase erreicht. Der Katheter selbst kann aus einer Reihe von Polymeren geformt sein, welche z. B. Vinylpolymere (z. B. PVC), Latex oder Silikonmaterialien, Polyester oder Polyacrylate sind.to Application are known catheter forms, in particular for the introduction are suitable in a urethra and a rounded tip for better application. At least one side opening adjacent the tip of the catheter allows the urine, to get into the interior of the catheter when the tip of the catheter reached the bubble. The catheter itself can be made up of a number of Be formed polymer, which z. Vinyl polymers (eg PVC), Latex or silicone materials, polyesters or polyacrylates.

Die hydrophile Beschichtung wird bevorzugt auf der Außenfläche des Katheters aufgebracht, aber auch ein Beschichten der Innenseite ist möglich.The hydrophilic coating is preferred on the outer surface applied to the catheter, but also a coating of the inside is possible.

ZITATE ENTHALTEN IN DER BESCHREIBUNGQUOTES INCLUDE IN THE DESCRIPTION

Diese Liste der vom Anmelder aufgeführten Dokumente wurde automatisiert erzeugt und ist ausschließlich zur besseren Information des Lesers aufgenommen. Die Liste ist nicht Bestandteil der deutschen Patent- bzw. Gebrauchsmusteranmeldung. Das DPMA übernimmt keinerlei Haftung für etwaige Fehler oder Auslassungen.This list The documents listed by the applicant have been automated generated and is solely for better information recorded by the reader. The list is not part of the German Patent or utility model application. The DPMA takes over no liability for any errors or omissions.

Zitierte PatentliteraturCited patent literature

  • - EP 1324785 B1 [0002] - EP 1324785 B1 [0002]
  • - GB 1600963 [0004] - GB 1600963 [0004]
  • - EP 0093093 [0004] - EP 0093093 [0004]
  • - EP 0093094 [0004] - EP 0093094 [0004]
  • - US 5525341 [0006, 0008] US 5525341 [0006, 0008]
  • - US 5646178 [0006, 0008] US 5646178 [0006, 0008]
  • - US 5650432 [0006, 0008] US 5650432 [0006, 0008]

Claims (6)

Katheter mit einer hydrophilen Oberflächenbeschichtung, die mindestens ein Proanthocyanidin enthält.Catheter with a hydrophilic surface coating, which contains at least one proanthocyanidin. Katheter nach Anspruch 1, dadurch gekennzeichnet, dass die hydrophile Oberflächenbeschichtung mindestens ein Anthocyan enthält.Catheter according to claim 1, characterized in that that the hydrophilic surface coating at least contains an anthocyanin. Katheter nach Anspruch 1 oder 2, dadurch gekennzeichnet, dass die hydrophile Oberflächenbeschichtung Cranberry-Extrakt/Konzentrat enthält.Catheter according to claim 1 or 2, characterized that the hydrophilic surface coating cranberry extract / concentrate contains. Katheter nach einem der vorangegangenen Ansprüche, dadurch gekennzeichnet, dass der Cranberry-Extrakt Magnesiumhydroxid enthält.Catheter according to one of the preceding claims, characterized in that the cranberry extract is magnesium hydroxide contains. Katheter nach einem der vorangegangenen Ansprüche, dadurch gekennzeichnet, dass der Cranberry-Extrakt Kalziumtriphosphat enthält.Catheter according to one of the preceding claims, characterized in that the cranberry extract calcium triphosphate contains. Katheter nach Anspruch 5, dadurch gekennzeichnet, dass der Cranberry-Extrakt/Konzentrat mindestens 80%, bevorzugt 85%, Fruchtfeststoffe enthält.Catheter according to claim 5, characterized in that that the cranberry extract / concentrate is at least 80%, preferably 85%, contains fruit solids.
DE200820002718 2008-02-26 2008-02-26 Catheter with proanthocyanidin-containing hydrophilic coating Expired - Lifetime DE202008002718U1 (en)

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Cited By (7)

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Publication number Priority date Publication date Assignee Title
US20140178447A1 (en) * 2011-08-31 2014-06-26 The Trustees Of Columbia University In The City Of New York Reduction of biofilms on medical devices
US9497975B2 (en) 2011-12-06 2016-11-22 The Trustees Of Columbia University In The City Of New York Broad spectrum natural preservative composition
US9511040B2 (en) 2007-06-20 2016-12-06 The Trustees Of Columbia University In The City Of New York Skin and surface disinfectant compositions containing botanicals
US9687429B2 (en) 2007-06-20 2017-06-27 The Trustees Of Columbia University In The City Of New York Antimicrobial compositions containing low concentrations of botanicals
US9968101B2 (en) 2011-11-03 2018-05-15 The Trustees Of Columbia University In The City Of New York Botanical antimicrobial compositions
US9981069B2 (en) 2007-06-20 2018-05-29 The Trustees Of Columbia University In The City Of New York Bio-film resistant surfaces
US10806144B2 (en) 2011-11-03 2020-10-20 The Trustees Of Columbia University In The City Of New York Composition with sustained antimicrobial activity

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EP1324785B1 (en) 2000-09-21 2004-04-28 Hunter Urology Limited Catheter with hydrophilic coating comprising an anthraquinone
FR2874826A1 (en) * 2004-09-08 2006-03-10 Pharmatoka Soc Par Actions Sim Aqueous gel, used to apply on or impregnate in the depths of probes or catheters, comprises vaccinium macrocarpon extract and/or other active ingredients in a gelified or viscous excipient
CA2582333A1 (en) * 2004-09-30 2006-04-13 Boston Scientific Limited Implantable medical devices containing phenolic compound
EP1834636A1 (en) * 2006-03-08 2007-09-19 Sahajanand Medical Technologies PVT. ltd Compositions comprising porous articles and uses in implantable medical devices

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GB1600963A (en) 1977-08-08 1981-10-21 Biosearch Medical Prod Article having a low coefficient of friction hydrophilic coating and a method of providing the coating
EP0093093A1 (en) 1982-04-22 1983-11-02 Astra Meditec AB Preparation of a hydrophilic coating
EP0093094A1 (en) 1982-04-22 1983-11-02 Astra Meditec AB Process for the preparation of a hydrophilic coating
US5525341A (en) 1992-10-09 1996-06-11 Jlb, Inc. Partially purified cranberry anti-adhesion activity
US5646178A (en) 1992-10-09 1997-07-08 Jlb, Inc. Cranberry extract and biologically active compounds derived therefrom
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US9687429B2 (en) 2007-06-20 2017-06-27 The Trustees Of Columbia University In The City Of New York Antimicrobial compositions containing low concentrations of botanicals
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US10542760B2 (en) 2007-06-20 2020-01-28 The Trustees Of Columbia University In The City Of New York Skin and surface disinfectant compositions containing botanicals
US20140178447A1 (en) * 2011-08-31 2014-06-26 The Trustees Of Columbia University In The City Of New York Reduction of biofilms on medical devices
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