DE19522472A1 - Prepn. of natural healing prods. for treatment of prostate disorders - Google Patents

Prepn. of natural healing prods. for treatment of prostate disorders

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Publication number
DE19522472A1
DE19522472A1 DE19522472A DE19522472A DE19522472A1 DE 19522472 A1 DE19522472 A1 DE 19522472A1 DE 19522472 A DE19522472 A DE 19522472A DE 19522472 A DE19522472 A DE 19522472A DE 19522472 A1 DE19522472 A1 DE 19522472A1
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Germany
Prior art keywords
treatment
prods
natural
fermentation
wheat
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Granted
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DE19522472A
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German (de)
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DE19522472C2 (en
Inventor
Eugen Baumgaertner
Guenter Dr Kron
Wolfgang Dr Weber
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Individual
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Priority to DE19522472A priority Critical patent/DE19522472C2/en
Publication of DE19522472A1 publication Critical patent/DE19522472A1/en
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Publication of DE19522472C2 publication Critical patent/DE19522472C2/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • General Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

Prepn. (A) of a natural healing prod. for treatment of prostate disorders by microbial organisms which are found in the natural location of the vegetable starting material (wheat). Also claimed are: (1) a natural healing agent for treatment of prostate disorders, recovered from the fermentation prods. of selectively enriched microorganisms of the process as described in (A); (2) a special method for targeted enrichment of temp. resistant and spore forming microorganisms from wheat, and (3) a modification of liq. fermentation end prods. by lyophilisation, sterile filtration, boiling/sterilisation and addn. of fruit acids.

Description

Die Innovation dieser Erfindung beruht auf dem gezielten Einsatz und der Selektion, der am natürlichen Standort des pflanzlichen Ausgangsproduktes vorkommenden mikrobiellen Organismen, zur Herstellung eines Fermentationsproduktes gegen Prostatabeschwerden.The innovation of this invention is based on the targeted use and selection, the occurring at the natural location of the vegetable starting material microbial organisms, for the production of a fermentation product against Prostate trouble.

Bei den Produzenten handelt es sich um aerob und anaerob wachsende Mikroorga­ nismen. Nach Abschluß der Fermentationsphase sind nahezu ausschließlich Lactobacillen (1*10⁶ - 5*10⁷ KBE/ml) und Bakterien der Gattung Bacillus (1*10⁵-5*10⁵ KBE/ml) in hohen Konzentrationen nachweisbar, und somit als Haupt­ produzenten anzusehen.The producers are aerobic and anaerobic microorganisms. After completion of the fermentation phase are almost exclusively Lactobacilli (1 * 10⁶ - 5 * 10⁷ cfu / ml) and bacteria of the genus Bacillus (1 * 10⁵-5 * 10⁵ cfu / ml) detectable in high concentrations, and thus to be regarded as the main producer.

Herstellungsverfahrenproduction method

Bei dem Fermentationssubstrat handelt es sich um geschälte, entkeimte und gemah­ lene Weizenkörner. Die aufgeschlämmte Suspension wird im Verhältnis 1 : 20 in kochendes Wasser eingerührt. Die Inkubationstemperatur beträgt zu Beginn des mikrobiellen Selektionsprozesses 70°C und wird innerhalb einer Stunde auf 85°C erhöht. Anschließend wird die Suspension in luftdicht schließende Behältnisse verbracht, die nur zu 90% gefüllt werden dürfen.The fermentation substrate is peeled, sterilized and gemah lene wheat grains. The slurried suspension is in the ratio 1:20 in stirred in boiling water. The incubation temperature is at the beginning of the microbial selection process 70 ° C and is within one hour at 85 ° C. elevated. Subsequently, the suspension in hermetically sealed containers spent, which may be filled only 90%.

Durch dieses spezielle Verfahren werden die notwendigen bakteriellen Produzenten selektioniert. Hierbei handelt es sich um sporenbildende (Bacillus cereus var.) und nicht sporenbildende Gattungen (Leuconostoc ssp).By this special procedure become the necessary bacterial producers selected. These are spore-forming (Bacillus cereus var.) And Non-spore-forming genera (Leuconostoc ssp).

Nach der Abkühlphase und bei optimalen Lagerungsbedingungen (Raumtemperatur 18°C, Tageslicht bzw. Kunstlicht) beginnen sich die Bakterien zu vermehren. Durch das aerobe Wachstum der Mikroorganismen wird der vorhandene Sauerstoff verbraucht. Anschließend kommt es zu einer weiteren Substratumsetzung durch die fakultativ anaerob und strikt anaerob wachsenden Bakterien. Der dabei entstehende Gasdruck wird durch überdruckableitende Spezialverschlüsse ausgeglichen. Während der Fermentation verschiebt sich der pH-Bereich von neutral (pH 7) zu sauer (pH 3). Durch das spezielle Fermentationsverfahren wird eine verzögerte Milchsäuregärung erreicht, die unter anderem für die Bildung von Buttersäure verantwortlich ist. After the cooling phase and under optimal storage conditions (room temperature 18 ° C, daylight or artificial light), the bacteria begin to multiply. By the aerobic growth of the microorganisms becomes the oxygen present consumed. Subsequently, there is a further substrate conversion by the facultative anaerobic and strictly anaerobic growing bacteria. The resulting Gas pressure is compensated by overpressure-draining special closures. While In fermentation, the pH range shifts from neutral (pH 7) to acidic (pH 3). Due to the special fermentation process, a delayed lactic acid fermentation which is responsible, inter alia, for the formation of butyric acid.  

Das Fermentationsende ist erreicht, wenn keine Gasentwicklung mehr festzustellen ist, und die Bakteriensuspension sich als weißes Sediment am Boden absetzt. Während der Fermentation darf es zu keiner Farbbildung kommen. Dies würde auf eine Fehlgärung hinweisen.The fermentation end is reached when no more gas evolution and the bacterial suspension settles to the ground as a white sediment. During the fermentation it must come to no color formation. This would be up to indicate a fermentation failure.

Das so erhaltene Endprodukt ist verbrauchsfertig und kann mindestens 2 Jahre ohne Zugabe von Konservierungsmitteln aufbewahrt werden. Es kann ebenso in lyophili­ sierter, sterilfiltrierter oder abgekochter Form eingesetzt werden. Der strenge Buttersäuregeruch kann durch Zusatz von Fruchtsäuren und Aromastoffen beseitigt werden.The resulting end product is ready for consumption and can be at least 2 years without Preservation of preservatives are kept. It may as well be in lyophili siert, sterilized filtered or boiled form. The strict one Buttersäuregruch can be eliminated by adding fruit acids and flavorings become.

Chemische Analyse des FermentationsendproduktsChemical analysis of the final fermentation product pH-Wert|∼3,5pH | ~3,5 Proteinprotein ∼5,0 g/l~5.0 g / l Ethanolethanol ∼0,1 g/l~0.1 g / l Essigsäureacetic acid ∼1,0 g/l~ 1.0 g / l Milchsäurelactic acid ∼70 g/l~70g / l Buttersäurebutyric ∼4,5 g/l~4.5 g / l

Wirkungeffect

Das Fermentationsprodukt lindert in hohem Maße die Beschwerden speziell bei Prostataerkrankungen. Besonders wichtig ist die Reduzierung des nächtlichen Harn­ drangs und damit verbunden ein erholsamer revitalisierender Schlaf. Außerdem wirkt die Substanz entzündungshemmend bei Harnweg-, Nieren- und Blaseninfek­ tionen.The fermentation product greatly alleviates the discomfort especially Prostate diseases. Especially important is the reduction of nocturnal urine Urgent and associated a restful revitalizing sleep. also The substance has an anti-inflammatory effect on urinary tract, kidney and bladder infections tions.

Der Vorteil dieses Mittels liegt folglich in der deutlichen Verbesserung der Lebens­ qualität, da die unangenehmsten Folgeerscheinungen des Prostataleidens wirksam bekämpft werden.The advantage of this remedy lies in the significant improvement of life quality, since the most unpleasant sequelae of prostate, effective be fought.

Claims (4)

1. Verfahren zum Herstellen eines Naturheilmittels zur Behandlung von Prostata­ leiden durch mikrobielle Organismen, die an dem natürlichen Standort des pflanzlichen Ausgangsprodukts (Weizen) vorkommen.1. A method of producing a natural remedy for the treatment of prostate suffer from microbial organisms that live in the natural site of the vegetable starting material (wheat) occur. 2. Naturheilmittel zur Behandlung von Prostatabeschwerden, gewonnen aus dem Fermentationsprodukt selektiv angereicherter Mikroorganismen nach dem unter Punkt 1) genannten Verfahren.2. Natural Remedies for the treatment of prostate problems, obtained from the fermentation product of selectively enriched microorganisms after the procedure referred to in point 1). 3. Spezielle Methode zur gezielten Anreicherung temperaturresistenter und sporenbildender Mikroorganismen aus Weizen.3. Special method for targeted enrichment temperature-resistant and spore-forming microorganisms from wheat. 4. Modifikation des flüssigen Fermentationsendproduktes durch Lyophilisieren, Sterilfiltration, Abkochen sowie durch Zugabe von Fruchtsäuren.4. modification of the liquid fermentation end product by lyophilization, Sterile filtration, decoction and addition of fruit acids.
DE19522472A 1995-06-21 1995-06-21 Manufacturing process of a fermentation product for the treatment of prostate disorders Expired - Fee Related DE19522472C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19522472A DE19522472C2 (en) 1995-06-21 1995-06-21 Manufacturing process of a fermentation product for the treatment of prostate disorders

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19522472A DE19522472C2 (en) 1995-06-21 1995-06-21 Manufacturing process of a fermentation product for the treatment of prostate disorders

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DE19522472A1 true DE19522472A1 (en) 1997-01-02
DE19522472C2 DE19522472C2 (en) 1998-07-02

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001037862A2 (en) * 1999-11-25 2001-05-31 Vakcina Kft A vaccine comprising lactobacilli for treating prostate inflammation and benign prostate hyperplasias
DE102009039191A1 (en) 2009-08-28 2011-03-03 Baumgärtner, Eugen Preparing substance, useful e.g. for treating physical illness, preferably prostate illness, comprises stirring peeled, sterilized and ground wheat grains in boiling water, incubating with microorganisms, and fermenting obtained suspension

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2934552A1 (en) * 1979-08-13 1981-02-19 Gotthard Ihle Plant-derived dietetic enzyme and vitamin compsn. prepn. - by steeping, dry-germinating and comminuting cereal grain and or legumes
DE3046773A1 (en) * 1980-12-12 1982-07-15 Wilhelm 4670 Lünen Kanne sen. METHOD FOR PRODUCING A DIETETARY BEVERAGE AND A PARTICULAR BEVERAGE PRODUCED BY THIS METHOD
DE3246186A1 (en) * 1982-12-14 1984-06-14 Wilhelm 4670 Lünen Kanne sen. METHOD FOR PRODUCING A FLOUR CONTAINING IN PARTICULAR LACTIC ACID BACTERIA, AND A FLOUR PRODUCED BY THIS METHOD
EP0281458A2 (en) * 1987-02-19 1988-09-07 Laboratoires Standa Food additive supplement made from seeds, almost without parasite micro-organisms, its manufacture and its use
DE3802840A1 (en) * 1988-02-01 1989-08-10 Kanne Brottrunk Gmbh & Co Kg Process for the production of a fermented product containing viable lactic acid bacteria
DE3905055A1 (en) * 1989-02-18 1990-08-23 Eckes Fa Peter Whole-grain cereal products and process for the production thereof
WO1991017672A1 (en) * 1990-05-18 1991-11-28 Hannu Salovaara Food product containing dietary fiber and method of making said product

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2934552A1 (en) * 1979-08-13 1981-02-19 Gotthard Ihle Plant-derived dietetic enzyme and vitamin compsn. prepn. - by steeping, dry-germinating and comminuting cereal grain and or legumes
DE3046773A1 (en) * 1980-12-12 1982-07-15 Wilhelm 4670 Lünen Kanne sen. METHOD FOR PRODUCING A DIETETARY BEVERAGE AND A PARTICULAR BEVERAGE PRODUCED BY THIS METHOD
DE3246186A1 (en) * 1982-12-14 1984-06-14 Wilhelm 4670 Lünen Kanne sen. METHOD FOR PRODUCING A FLOUR CONTAINING IN PARTICULAR LACTIC ACID BACTERIA, AND A FLOUR PRODUCED BY THIS METHOD
EP0281458A2 (en) * 1987-02-19 1988-09-07 Laboratoires Standa Food additive supplement made from seeds, almost without parasite micro-organisms, its manufacture and its use
DE3802840A1 (en) * 1988-02-01 1989-08-10 Kanne Brottrunk Gmbh & Co Kg Process for the production of a fermented product containing viable lactic acid bacteria
DE3905055A1 (en) * 1989-02-18 1990-08-23 Eckes Fa Peter Whole-grain cereal products and process for the production thereof
WO1991017672A1 (en) * 1990-05-18 1991-11-28 Hannu Salovaara Food product containing dietary fiber and method of making said product

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Derwent Abstract, Ref. JP 06-007415 A *
Encyclopaedia of Food Science Food Technology and Nutrition, Academic Press, London 1992, Vol.4, S.2651-2655 *
FIEDLER,Herbert P.: Lexikon der Hilfsstoffe für Pharmazie, Kosmetik und angrenzende Gebiete, Editio Cantor, Aulendorf, 1981, S.618 *
Food Science & Technology Abstracts, 93(11):G0005 *
LOZAS, E.S. et.al.: Plant Foods for Humon Nutrition 44(1993) 45-62 *
Ullmanns Encyklopädie der technischen Chemie, Verlag Chemie, Weinheim 1979, 4.Aufl., Bd.17, S.1-7 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001037862A2 (en) * 1999-11-25 2001-05-31 Vakcina Kft A vaccine comprising lactobacilli for treating prostate inflammation and benign prostate hyperplasias
WO2001037862A3 (en) * 1999-11-25 2001-11-22 Ujhelyi Ottilia Hf A vaccine comprising lactobacilli for treating prostate inflammation and benign prostate hyperplasias
US9056073B2 (en) 1999-11-25 2015-06-16 Vakcina Kft Vaccine comprising lactobacilli for treating prostate inflammation and benign prostate hyperplasias
DE102009039191A1 (en) 2009-08-28 2011-03-03 Baumgärtner, Eugen Preparing substance, useful e.g. for treating physical illness, preferably prostate illness, comprises stirring peeled, sterilized and ground wheat grains in boiling water, incubating with microorganisms, and fermenting obtained suspension

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