CY1113340T1 - Ενωσεις - Google Patents

Ενωσεις

Info

Publication number
CY1113340T1
CY1113340T1 CY20121101091T CY121101091T CY1113340T1 CY 1113340 T1 CY1113340 T1 CY 1113340T1 CY 20121101091 T CY20121101091 T CY 20121101091T CY 121101091 T CY121101091 T CY 121101091T CY 1113340 T1 CY1113340 T1 CY 1113340T1
Authority
CY
Cyprus
Prior art keywords
atherosclerosis
formula
heteroaryl group
ecm
copd
Prior art date
Application number
CY20121101091T
Other languages
English (en)
Inventor
Martin Quibell
John Paul Watts
Nicholas Sean Flinn
Original Assignee
Amura Therapeutics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amura Therapeutics Limited filed Critical Amura Therapeutics Limited
Publication of CY1113340T1 publication Critical patent/CY1113340T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

Μια πρώτη άποψη της παρούσας εφεύρεσης αφορά μια ένωση του τύπου (I), ή ένα φαρμακευτικώς αποδεκτό άλας, υδρίτη, σύμπλοκο ή προφάρμακο αυτής, όπου: το R3 επιλέγεται από κυκλοπεντυλ και κυκλοεξυλ, το R9 είναι μια υποκατεστημένη 5 ή 6-μελής αρυλ ή ετεροαρυλ ομάδα ή μια 6,5- ή 6,6-συντηγμένη διαρυλ ή ετεροδιαρυλ ομάδα. Οι ενώσεις του τύπου (I) παρουσιάζουν απροσδόκητα υψηλές διπλές αποτελεσματικότητες για την ανθρώπινη καθεψίνη S και Κ και είναι χρήσιμες για τη θεραπευτική αγωγή ρευματοειδούς αρθρίτιδας, οστεοαρθρίτιδας, χρόνιας αποφρακτικής πνευμονοπάθειας (ΧΑΠ), αθηροσκλήρωσης, καρδιαγγειακών ασθενειών που παρουσιάζουν σημαντική βλάβη και ανακατασκευή της εξωκυτταρικής μήτρας (ECM) και χρόνιου πόνου.
CY20121101091T 2008-03-13 2012-11-14 Ενωσεις CY1113340T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0804702.9A GB0804702D0 (en) 2008-03-13 2008-03-13 Compounds
EP09719113A EP2297162B1 (en) 2008-03-13 2009-03-11 Compounds

Publications (1)

Publication Number Publication Date
CY1113340T1 true CY1113340T1 (el) 2016-06-22

Family

ID=39328081

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121101091T CY1113340T1 (el) 2008-03-13 2012-11-14 Ενωσεις

Country Status (12)

Country Link
US (1) US8008290B2 (el)
EP (1) EP2297162B1 (el)
JP (1) JP2011518120A (el)
CY (1) CY1113340T1 (el)
DK (1) DK2297162T3 (el)
ES (1) ES2393050T3 (el)
GB (1) GB0804702D0 (el)
HR (1) HRP20120898T1 (el)
PL (1) PL2297162T3 (el)
PT (1) PT2297162E (el)
SI (1) SI2297162T1 (el)
WO (1) WO2009112839A1 (el)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7893067B2 (en) * 2007-06-27 2011-02-22 Medivir Ab Cysteine protease inhibitors
RS59007B1 (sr) 2014-02-03 2019-08-30 Vitae Pharmaceuticals Llc Dihidropirolopiridinski inhibitori ror-gama
CA2946618A1 (en) * 2014-04-23 2015-10-29 Grunenthal Gmbh 3-oxo-tetrahydro-furo[3,2-b]pyrrol-4(5h)-yl) derivatives ii
CA2946620A1 (en) 2014-04-23 2015-10-29 Grunenthal Gmbh 3-oxo-tetrahydro-furo[3,2-b]pyrrol-4(5h)-yl) derivatives i
SI3207043T1 (sl) 2014-10-14 2019-04-30 Vitae Pharmaceuticals, Inc. Dihidropirolopiridinovi inhibitorji za ROR-gama
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
US10301261B2 (en) 2015-08-05 2019-05-28 Vitae Pharmaceuticals, Llc Substituted indoles as modulators of ROR-gamma
EP3868750A1 (en) 2015-11-20 2021-08-25 Vitae Pharmaceuticals, LLC Modulators of ror-gamma
TWI757266B (zh) 2016-01-29 2022-03-11 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
US9481674B1 (en) 2016-06-10 2016-11-01 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
EP3658555A1 (en) 2017-07-24 2020-06-03 Vitae Pharmaceuticals, LLC Inhibitors of ror
MX2020009228A (es) 2018-03-08 2021-01-08 Incyte Corp Compuestos diolicos de aminopirazina como inhibidores de fosfoinositida 3-cinasas-gamma.
WO2020010003A1 (en) 2018-07-02 2020-01-09 Incyte Corporation AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS
AU2020250933A1 (en) 2019-04-05 2021-10-28 Centre Hospitalier Régional Et Universitaire De Brest Protease-activated receptor-2 inhibitors for the treatment of sensory neuropathy induced by a marine neurotoxic poisoning

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
PT1362052E (pt) 2001-01-17 2007-04-30 Amura Therapeutics Ltd Inibidores de cruzipaína e de outras proteases de cisteína
GB0614037D0 (en) 2006-07-14 2006-08-23 Amura Therapeutics Ltd Compounds
GB0614044D0 (en) 2006-07-14 2006-08-23 Amura Therapeutics Ltd Compounds
GB0614073D0 (en) 2006-07-14 2006-08-23 Amura Therapeutics Ltd Compounds
GB0614052D0 (en) 2006-07-14 2006-08-23 Amura Therapeutics Ltd Compounds
GB0614046D0 (en) 2006-07-14 2006-08-23 Amura Therapeutics Ltd Compounds
GB0614053D0 (en) 2006-07-14 2006-08-23 Amura Therapeutics Ltd Compounds
GB0614042D0 (en) 2006-07-14 2006-08-23 Amura Therapeutics Ltd Compounds

Also Published As

Publication number Publication date
PL2297162T3 (pl) 2013-01-31
DK2297162T3 (da) 2012-11-26
EP2297162B1 (en) 2012-08-15
ES2393050T3 (es) 2012-12-18
GB0804702D0 (en) 2008-04-16
US20110009385A1 (en) 2011-01-13
EP2297162A1 (en) 2011-03-23
JP2011518120A (ja) 2011-06-23
SI2297162T1 (sl) 2013-01-31
US8008290B2 (en) 2011-08-30
WO2009112839A1 (en) 2009-09-17
HRP20120898T1 (hr) 2012-11-30
PT2297162E (pt) 2012-11-27

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