CO6160311A2 - Nuevos derivados de fluoreno composiciones que los contienen y utilizacion como inhibidores de la proteina chaperona hsp90 - Google Patents

Nuevos derivados de fluoreno composiciones que los contienen y utilizacion como inhibidores de la proteina chaperona hsp90

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Publication number
CO6160311A2
CO6160311A2 CO09041714A CO09041714A CO6160311A2 CO 6160311 A2 CO6160311 A2 CO 6160311A2 CO 09041714 A CO09041714 A CO 09041714A CO 09041714 A CO09041714 A CO 09041714A CO 6160311 A2 CO6160311 A2 CO 6160311A2
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Colombia
Prior art keywords
alkyl
alkoxy
alkylthio
different
conh2
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CO09041714A
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English (en)
Inventor
Fabienne Thompson
Patrick Mailliet
Jean-Marie Ruxer
Helene Goulaouic
Francois Vallee
Herve Minoux
Fabienne Pilorge
Luc Bertin
Stephane Hourcade
Maria Mendez-Perez
Peter Hamley
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Sanofi Aventis
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Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of CO6160311A2 publication Critical patent/CO6160311A2/es

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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1.- Productos de fórmula (I):en los que: Het representa un heterociclo aromático o parcialmente insaturado - de tipo dihidro o tetrahidro - mono o bicíclico, de 5 a 11 eslabones, que contiene de 1 a 4 heteroátomos, elegidos entre N O o S, sustituido opcionalmente con uno o varios radicales R idénticos o diferentes tales como los descritos más adelante, R está en el grupo constituido por H, halógeno, CF3, nitro, ciano, alquilo, hidroxi, mercapto, amino, alquilamino, dialquilamino, alcoxi, alquiltio, carboxi libre o esterificado por un radical alquilo, carboxamida, CO-NH(alquilo) y CON(alquilo)2, NH-CO-alquilo, NH-SO2-alquilo y heterocicloalquilo, estando todos los radicales alquilo, alcoxi, alquiltio y heterocicloalquilo sustituidos opcionalmente, R1 se elige del grupo constituido por X-(A-B)n-CONH2, X-(A-B)n-O-CONH2, X-(A-B)n-NH-CONH2, X-(CH2)m-heterocicloalquilo, X-(CH2)m-arilo y X-(CH2)m-heteroarilo con X que representa -O-C(O), -NH-C(O), NH-CS, -NH-CO-CH2-O-; -NH-CO-CH2-S-CH2-CO-NH-; -NH-CO-(CH2)2-SO2-; -NH-CO-CH2-N(CH3)-CO-; A y B idénticos o diferentes representan independientemente un enlace sencillo, CH2, CH-alquilo, CH-aralquilo, n = 1,2 y m = 0, 1, R2 y R´2, idénticos o diferentes, se seleccionan independientemente del grupo constituido por H, halógeno, CF3, nitro, ciano, alquilo, hidroxi, mercapto, amino, alquilamino, dialquilamino, alcoxi, alquiltio (metiltio), carboxi libre o esterificado por un radical alquilo, carboxamida, CO-NH(alquilo) y NH-CO-alquilo, estando todos los radicales alquilo, alcoxi y alquiltio sustituidos opcionalmente, p y p' idénticos o diferentes representan respectivamente los números enteros 1 a 4 y 1 a 3; L se elige entre enlace sencillo, CH2, C(O), O, S o NH, estando dichos productos de fórmula (I) en todas las formas tautómeras e isómeras posibles racémicas, enantiómeras y diastereoisómeras, así como las sales de adición con los ácidos minerales y orgánicos o con las bases minerales y orgánicas de dichos productos de fórmula (I).
CO09041714A 2006-10-24 2009-04-24 Nuevos derivados de fluoreno composiciones que los contienen y utilizacion como inhibidores de la proteina chaperona hsp90 CO6160311A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0609331A FR2907453B1 (fr) 2006-10-24 2006-10-24 Nouveaux derives du fluorene,compositions les contenant et utilisation

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Publication Number Publication Date
CO6160311A2 true CO6160311A2 (es) 2010-05-20

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US (1) US8163750B2 (es)
EP (1) EP2078009B1 (es)
JP (1) JP5431944B2 (es)
KR (1) KR20090080948A (es)
CN (1) CN101528735A (es)
AR (1) AR063507A1 (es)
AU (1) AU2007310767A1 (es)
BR (1) BRPI0718202A2 (es)
CA (1) CA2664115A1 (es)
CL (1) CL2007003046A1 (es)
CO (1) CO6160311A2 (es)
CR (1) CR10690A (es)
EA (1) EA200970400A1 (es)
FR (1) FR2907453B1 (es)
IL (1) IL197887A0 (es)
MA (1) MA30904B1 (es)
MX (1) MX2009004049A (es)
NO (1) NO20091972L (es)
PE (1) PE20081261A1 (es)
TN (1) TN2009000086A1 (es)
TW (1) TW200825083A (es)
UY (1) UY30667A1 (es)
WO (1) WO2008049994A1 (es)

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BRPI0609509A2 (pt) 2005-03-30 2010-04-13 Conforma Therapeutics Corp composto ou um polimorfo, solvato, tautÈmero, enanciÈmero, pró-droga ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso do composto, polimorfo, solvato, tautÈmero, enanciÈmero, pró-droga ou sal farmaceuticamente aceitável
GB2423328B (en) 2005-04-09 2007-02-28 Louver Lite Ltd Window blind system
WO2006108707A1 (en) 2005-04-11 2006-10-19 Crucell Holland B.V. Virus purification using ultrafiltration
FR2885904B1 (fr) * 2005-05-19 2007-07-06 Aventis Pharma Sa Nouveaux derives du fluorene, compositions les contenant et utilisation

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US8163750B2 (en) 2012-04-24
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CN101528735A (zh) 2009-09-09
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