CN2798936Y - Disposable blood virus deactivation blood filtering bag - Google Patents
Disposable blood virus deactivation blood filtering bag Download PDFInfo
- Publication number
- CN2798936Y CN2798936Y CN 200520082933 CN200520082933U CN2798936Y CN 2798936 Y CN2798936 Y CN 2798936Y CN 200520082933 CN200520082933 CN 200520082933 CN 200520082933 U CN200520082933 U CN 200520082933U CN 2798936 Y CN2798936 Y CN 2798936Y
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- CN
- China
- Prior art keywords
- blood
- bag
- filter
- film
- virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000004369 blood Anatomy 0.000 title claims abstract description 53
- 239000008280 blood Substances 0.000 title claims abstract description 53
- 241000700605 Viruses Species 0.000 title claims abstract description 46
- 230000009849 deactivation Effects 0.000 title claims description 12
- 238000001914 filtration Methods 0.000 title abstract description 9
- 230000000415 inactivating effect Effects 0.000 claims abstract description 26
- 238000005286 illumination Methods 0.000 claims abstract description 22
- 238000001179 sorption measurement Methods 0.000 claims abstract description 9
- 239000000463 material Substances 0.000 claims abstract description 4
- 239000012528 membrane Substances 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 abstract description 19
- 230000002779 inactivation Effects 0.000 abstract description 18
- 239000003814 drug Substances 0.000 abstract description 8
- 239000000470 constituent Substances 0.000 abstract description 7
- 230000002349 favourable effect Effects 0.000 abstract 1
- 239000003504 photosensitizing agent Substances 0.000 description 5
- 239000007788 liquid Substances 0.000 description 4
- 210000002381 plasma Anatomy 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 208000019838 Blood disease Diseases 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 208000014951 hematologic disease Diseases 0.000 description 2
- 208000018706 hematopoietic system disease Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 description 1
- 241001391944 Commicarpus scandens Species 0.000 description 1
- 208000003441 Transfusion reaction Diseases 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002615 hemofiltration Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 229960000907 methylthioninium chloride Drugs 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Images
Landscapes
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
The utility model relates to a disposable blood virus inactivation and filtering blood bag. The utility model comprises a transferring needle, a guide pipe, a clamp of a guide pipe, a medicine feed filter, an illumination transferring bag, an adsorption filter and an inactivation storing bag, wherein the medicine feed filter which is arranged between the transferring needle and the illumination transferring bag in the manner of tandem connection is composed of an upper cover, a lower cover, a medicine feed film and a filtering film, the medicine feed film is a fibrous diaphragm which is made of macromolecular materials, virus inactivating agents are adsorbed on the medicine feed film beforehand and the medicine feed film and the filtering film are fixed together between the upper cover and the lower cover. When the utility model is used, blood passes through the medicine feed film, the virus inactivating agents are dissolved in blood quickly, the addition of the virus inactivating agents is automatically completed and then illumination inactivation of viruses is carried out. The utility model has the advantages of simple structure, long storing time, favorable effects of virus inactivation and convenient operation and utilization. The utility model is suitable for collecting separated blood, inactivating viruses in blood constituents and filtering white cells.
Description
Technical field
This utility model relates to a kind of medical blood bag, and the hemofiltration bag is crossed in the deactivation of specifically a kind of disposable use blood disease.
Background technology
We know, the blood of present clinical infusion or blood constituent are by various cells and have the different activities molecular composition, and the blood transfusion of the leukocyte in the blood constituent that the blood donor contributes is deleterious, it not only carries the histocompatibility antigen that causes the transfusion reaction of patient's immunity, also carries the leukocytic virus of a large amount of parents.So must carry out viral inactivation treatment to blood, for can be with inactivation of virus, pass through light-struck photochemical method again and kill virus after can adopting an amount of photosensitizer of in blood adding, its principle has been made detailed door screen and has been stated in the ZL98121328.6 patent, but what use in this patent is the liquid photosensitizer, facts have proved, this liquid photosensitizer unstable properties, storage period is short, and adapted is unfavorable for large-scale popularization temporarily.The device that patent ZL98121328.6 comprised is that a cover adds the device that assembly, fluorescence irradiation bag, leucocyte-removing absorption photosensitizer transfusion filter spare and blood plasma storage bag are formed by blood taking needle, blood taking bag, conduit, first transfering bag, general formula photosensitizer easy to break, because blood taking needle is the device that is directly used in from the human blood collection, so the blood after this device is not suitable for collection and separates and the inactivation of virus of blood constituent.The structure of the virus inactivating agent adder that patent ZL200320110490.8 comprised comprises the glass tubing that solid-state virus inactivating agent is housed and is encapsulated in the plug and the built-in needle for inserting bottle at glass tubing two.Built-in needle for inserting bottle need be pushed during use, puncture the solid-state virus inactivating agent conducting that makes blood or blood constituent and built-in methylene blue liquid behind the plug or added excipient, reach the purpose of blood disease deactivation, manipulate inconvenience.
Summary of the invention
Technical problem to be solved in the utility model is the deficiency that overcomes above-mentioned blood-plasma virus killing apparatus, and a kind of simple in structure, period of storage is long, inactivation of virus is effective, easy for operation disposable blood virus inactivating filter blood bag is provided.
The technical scheme in the invention for solving the above technical problem is: disposable blood virus inactivating filter blood bag, comprise and shift pin, conduit, vessel clamp, dosing filter, illumination transfering bag, adsorption filter, deactivation reservoir bag, it is characterized in that: the dosing filter is serially connected in and shifts between pin and the illumination transfering bag, it is made up of loam cake, lower cover, dosing film, filter membrane, the dosing film is the fibrous diaphragm that macromolecular material is made, be adsorbed with virus inactivating agent on it in advance, the dosing film is fixed between loam cake and the lower cover with filter membrane.
This utility model is because the dosing film in the dosing filter adsorbs a certain amount of various dose virus inactivating agent in advance, but through long term store after the cold drying, blood during use (can be whole blood, red cell suspension, blood plasma, platelet) is by the dosing film, virus inactivating agent can be dissolved in the blood that needs deactivation rapidly, automatically finish the interpolation of virus inactivating agent, go in the illumination transfering bag through the medical filtration membrane filtration is laggard then.Illumination transfering bag and coupling part are put into medical inactivation of virus cabinet according to operation sequence and are carried out the illumination inactivation of viruses.The illumination inactivation of virus finishes, and illumination transfering bag height is put, and opens flow-stopping clip, makes the blood that contains virus inactivating agent through adsorption filter, finish the filtration of virus inactivating agent absorption and blood after, enter the deactivation reservoir bag, standby.This utility model is simple in structure, period of storage is long, inactivation of virus is effective, easy for operation, be applicable to the blood after gather separating and the inactivation of virus and the leukoreduction filter of blood constituent.Package unit can carry out the ethylene oxide sterilizing sterilization together during production, and safety saves time.
Description of drawings
Below in conjunction with accompanying drawing this utility model is described further.
Fig. 1 is this utility model structural representation;
Fig. 2 is this utility model dosing structure of filter sketch map.
1. shift pins among the figure, 2. vessel clamp, 3. dosing filter, 4. vessel clamp, 5. adsorption filter, 6. deactivation reservoir bag, 7. vessel clamp, 8. illumination transfering bag, 9. conduit, 10. loam cake, 11. lower covers, 12. dosing films, 13. filter membranes.
The specific embodiment
As can be seen from Figure 1, this utility model disposable blood virus inactivating filter blood bag comprises and shifts pin 1, conduit 9, vessel clamp 2,4,7, dosing filter 3, illumination transfering bag 8, adsorption filter 5, deactivation reservoir bag 6.Dosing filter 3 is serially connected on the conduit 9 that shifts between pin 1 and the illumination transfering bag 8.Be provided with adsorption filter 5 by conduit 9 between illumination transfering bag 8 and the deactivation reservoir bag 6, adsorption filter 5 exhaust manifolds also in parallel and vessel clamp 7.During use, close all vessel clamps, remove the protective cap that shifts pin 1, syringe needle is inserted blood (can be whole blood, red cell suspension, blood plasma, platelet) bag blood transfusion socket.The bags of blood height is put, opened vessel clamp 2, make blood flow into illumination transfering bag 8 through dosing filter 3.
As can be seen from Figure 2, this utility model dosing filter 3 is made up of loam cake 10, lower cover 11, dosing film 12, filter membrane 13, the fibrous diaphragm that dosing film 12 is made for macromolecular material, be adsorbed with virus inactivating agent on it in advance, dosing film 12 is fixed between loam cake 10 and the lower cover 11 with filter membrane 13.Can be bonding by binding agent, also can adopt the ultrasonic bonding mount.
This utility model is because the dosing film 12 in the dosing filter 5 adsorbs a certain amount of various dose virus inactivating agent in advance, and required concentration is controlled by the amount of the adsorbed virus inactivating agent of diaphragm, need not add the excipient composition that potential hazard may be arranged human body.Blood is by dosing film 12 during use, and the virus inactivating agent on it can be dissolved in rapidly in the blood, finishes the interpolation of virus inactivating agent automatically, filters laggardly to go in the illumination transfering bag 8 through liquid medicine filtering membrane 13 then.Illumination transfering bag 8 and coupling part are put into medical inactivation of virus cabinet according to operation sequence and are carried out the illumination inactivation of viruses.The illumination inactivation of virus finishes, and illumination transfering bag 8 height are put, and opens flow-stopping clip 4, makes the blood that contains virus inactivating agent through adsorption filter 5, finish the filtration of virus inactivating agent absorption and blood after, enter deactivation reservoir bag 6.Open the vessel clamp 7 of exhaustor, discharge the pure air in the blood, the conduit of heat seal deactivation reservoir bag 6 is preserved blood according to a conventional method then, and is standby.
This utility model is simple in structure, period of storage is long, inactivation of virus is effective, easy for operation, be applicable to the blood after gather separating and the inactivation of virus and the leukoreduction filter of blood constituent.A whole set of products can adopt method sterilizations such as cobalt 60-gamma-rays, damp and hot high temperature, oxirane during production, and safety saves time.
Claims (1)
1. disposable blood virus inactivating filter blood bag, comprise and shift pin, conduit, vessel clamp, dosing filter, illumination transfering bag, adsorption filter, deactivation reservoir bag, it is characterized in that: the dosing filter is serially connected in and shifts between pin and the illumination transfering bag, it is made up of loam cake, lower cover, dosing film, filter membrane, the dosing film is the fibrous diaphragm that macromolecular material is made, be adsorbed with virus inactivating agent on it in advance, the dosing film is fixed between loam cake and the lower cover with filter membrane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200520082933 CN2798936Y (en) | 2005-04-29 | 2005-04-29 | Disposable blood virus deactivation blood filtering bag |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200520082933 CN2798936Y (en) | 2005-04-29 | 2005-04-29 | Disposable blood virus deactivation blood filtering bag |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2798936Y true CN2798936Y (en) | 2006-07-26 |
Family
ID=36841434
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200520082933 Expired - Lifetime CN2798936Y (en) | 2005-04-29 | 2005-04-29 | Disposable blood virus deactivation blood filtering bag |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2798936Y (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104399135A (en) * | 2014-11-20 | 2015-03-11 | 上海市血液中心 | Processing device for plasma virus inactivation |
-
2005
- 2005-04-29 CN CN 200520082933 patent/CN2798936Y/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104399135A (en) * | 2014-11-20 | 2015-03-11 | 上海市血液中心 | Processing device for plasma virus inactivation |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CX01 | Expiry of patent term |
Expiration termination date: 20150429 Granted publication date: 20060726 |