CN219455583U - Liquid sampler and sampling detection device comprising same - Google Patents

Abstract

The utility model discloses a liquid sampler and a sampling detection device comprising the same; the liquid sampler comprises a sampling tube, a sampling head, a push rod and a flow separation membrane; a conducting column is arranged on the end face of the inner cavity of the sampling tube; the sampling head and the push rod are arranged at two ends of the sampling tube; the sampling head is communicated with the inner cavity of the sampling tube; the push rod is in sliding connection with the inner cavity of the sampling tube; a storage cavity is arranged in the push rod; the opening of the storage cavity faces the conducting column and is provided with a flow separation membrane for sealing the storage cavity; the buffer solution is stored in the storage cavity; in the initial state, a gap is reserved between the flow separation membrane and the conducting column; in a state that the push rod slides inwards to a limit position, the flow separation membrane is damaged by the conducting column; the sample collecting device provided by the utility model is provided with the buffer solution, and after the liquid sample is collected, the buffer solution and the liquid sample are mixed and output into the sample adding hole of the detection reagent plate according to a specific proportion only by pushing the push rod; thereby omitting the process of manually mixing the sample liquid and the buffer liquid.

Description

Liquid sampler and sampling detection device comprising same

Technical Field

The utility model belongs to the technical field of sample detection, and particularly relates to a liquid sampler and a sampling detection device comprising the same.

Background

Liquid sample detection represented by a blood sample is widely used in the related fields such as infectious diseases; at present, liquid sample detection is mainly divided into a sample collection stage and a sample detection stage; the staff is required to transfer the sample to the mixing container through the collecting unit, then the mixed sample is dripped into the detecting device, and the immune combination reaction principle is utilized to detect whether the sample contains the analyzed substance, so that the whole testing process is completed. This operation step is loaded down with trivial details and takes time, and there may be the possibility of contacting with the buffer in the operation process, can't satisfy user's demand to safety and sanitation, leads to many people not high to the wish of self-detection. Therefore, it is necessary to design a sampling and detecting integrated device which is easy to operate and does not require a user to control the buffer solution dosage.

The patent application with publication number CN114160219A provides a liquid sample collecting device and a detecting device; the liquid sample collecting bottle comprises a liquid sample collecting bottle and a sampler, wherein the inner wall of the liquid sample collecting bottle is provided with a guide rail which inclines from top to bottom and descends spirally, and the lower end of the rod part of the sampler is provided with a guide groove. After the lower end of the rod part of the sampler is inserted into the liquid sample collecting bottle, the guide groove at the lower end of the rod part is matched with the guide rail on the inner wall of the bottle body, so that the lower end of the rod part of the sampler is guided to spirally descend in the liquid sample collecting bottle, and then the liquid drawing part of the sampler is screwed and extruded. The liquid sample squeezing and removing rate is higher, so that the minimum amount of the liquid sample required by detection is more easily met, and the success rate of detection and the accuracy of detection results are further improved. However, the solution provided by this patent does not allow for automatic mixing of the buffer with the sample liquid.

Disclosure of Invention

The utility model aims to provide a sampling detection device for a liquid sample.

In a first aspect, the present utility model provides a liquid sampler comprising a sampling tube, a sampling head, a push rod and a flow barrier membrane; a conducting column is arranged on the end face of the inner cavity of the sampling tube; the sampling head and the push rod are arranged at two ends of the sampling tube; the sampling head is communicated with the inner cavity of the sampling tube; the push rod is in sliding connection with the inner cavity of the sampling tube.

A storage cavity is arranged in the push rod; the opening of the storage cavity faces the conducting column and is provided with a flow separation membrane for sealing the storage cavity; the buffer solution is stored in the storage cavity; in the initial state, a gap is reserved between the flow separation membrane and the conducting column; in a state in which the push rod slides inward to the limit position, the flow blocking film is broken by the conduction column.

Preferably, a sealing structure is arranged between the outer side surface of the push rod and the side wall of the inner cavity of the sampling tube; the side part of the sampling tube is provided with an exhaust hole; in the initial state, the projection distance between the sealing structure and the exhaust hole on a plane parallel to the sliding direction of the push rod is a, and the distance from the flow separation film to the outer end of the conducting column is b; a is less than or equal to b.

Preferably, the inner side wall of the sampling tube is provided with a positioning bulge; the outer side surface of the push rod is provided with a positioning groove; the positioning groove is positioned at one side of each sealing ring far away from the inner end of the push rod; in the initial state, the positioning protrusion and the positioning groove form a buckling position fit.

Preferably, the part of the push rod, which is positioned at one side of the positioning groove far away from the flow separation membrane, is a diameter-reducing section; the outline of the diameter-reducing section is separated from or tangent to the projection of the outer outline of the positioning bulge on a plane perpendicular to the sliding direction of the push rod.

Preferably, the sampling end of the sampling tube is detachably connected with an outer cover; the outer cover is sleeved outside the sampling head.

Preferably, the sampling end of the sampling tube is provided with a convex and hollow mounting part; the inner space of the mounting part is communicated with the inner cavity of the sampling tube; the sampling head is embedded in the mounting part, and the outer end extends out of the mounting part.

Preferably, the outer ends of the conducting columns are sharp.

Preferably, a flow passage is arranged in the conducting column; the sampling head is communicated with the inner cavity of the sampling tube through a flow passage. The shape of the conducting column is the same as the shape of the storage cavity.

Preferably, the outer side surface of the sampling tube is provided with a plurality of anti-slip stripes.

Preferably, a sealing ring is arranged between the outer side surface of the push rod and the side wall of the inner cavity of the sampling tube.

Preferably, the sampling head is a tubular structure made of hydrophilic materials.

In a second aspect, the utility model provides a sampling detection device comprising a detector and a liquid sampler as described above. The detector comprises a shell and a detection reagent strip; the detection reagent strip is arranged in the shell; the shell is provided with a sample adding hole and an observation window; the sampling head on the liquid sampler can be inserted into the sample application hole and contacted with the detection reagent strip.

Preferably, in the non-use state, the liquid sampler and the detector are connected together by means of a detachable connection.

Preferably, the side part of the sampling tube is provided with an exhaust hole; the liquid sampler and the detector form buckling position matching through a buckling structure in a non-use state; the exhaust hole on the sampling tube is arranged at the position of the clamping structure. Thereby the buckle structure can play the role of protecting the exhaust hole.

Preferably, the sample adding hole is in a stepped hole shape and comprises a large-diameter section positioned at the outer side and a small-diameter section positioned at the inner side; the detection end of the sampling tube can be inserted into the large-diameter section and is limited by the step surface between the large-diameter section and the small-diameter section; under the state that the detection end of the sampling tube is limited by the step surface, the sampling head passes through the small-diameter section and contacts with the detection reagent strip.

Preferably, a plurality of inner buckling bulges are symmetrically arranged on the side wall of the large-diameter section; an inner buckling groove is formed in the side face of the detection end of the sampling tube; under the state that the detection end of the sampling tube is inserted into the large-diameter section of the sampling hole, the inner buckling protrusion and the inner buckling groove form buckling position matching.

The utility model has the beneficial effects that:

1. the sample collecting device provided by the utility model is provided with the buffer solution, and after the liquid sample is collected, the buffer solution and the liquid sample are mixed and output into the sample adding hole of the detection reagent plate according to a specific proportion only by pushing the push rod; therefore, the process of manually mixing the sample liquid and the buffer liquid is omitted, and the operation of the liquid sample is simplified.

2. The side part of the sampling tube is provided with the vent hole, the vent hole is opened before the buffer solution is released through structural constraint, and the vent hole is closed when the buffer solution is released; the exhaust hole can avoid the inner cavity of the sampling tube from forming a closed space during sampling, so that the sample liquid can be sucked into the sampling head in a sufficient amount; the automatic sealing vent hole can avoid buffer solution overflowing from the vent hole when the buffer solution is released, so that pollution problem is caused and the mixing ratio accuracy of sample liquid and buffer solution is affected.

3. The utility model adopts an integrated design of sample collection and detection, and in the transportation process, the liquid sampler is matched with the buckling position of the detector; when the liquid sampler is required to be detected, after the liquid sampler is taken down for sampling, the liquid sampler is inserted into a sample adding hole of the detector and pressed, so that detection can be realized, the operation process is quite simpler, an operator is not required to mix and add a liquid sample and a buffer solution according to a certain proportion, the process of mixing the sample and the buffer solution and the detection process are completed in the device, the operation steps are simplified, and the cross contamination risk is reduced.

Drawings

FIG. 1 is an exploded view of a liquid sampler according to embodiment 1 of the present utility model;

FIG. 2 is a schematic cross-sectional view of a liquid sampler according to embodiment 1 of the present utility model;

FIG. 3 is a schematic perspective view of a sampling tube according to example 1 of the present utility model;

fig. 4 is a schematic diagram of the overall structure of a sampling detection device according to embodiment 2 of the present utility model;

FIG. 5 is an exploded view of the detector in example 2 of the present utility model;

FIG. 6 is a schematic perspective view of a detector in embodiment 2 of the present utility model;

fig. 7 is a schematic flow chart of sample detection in embodiment 2 of the present utility model.

Detailed Description

The utility model is further described below with reference to the accompanying drawings.

Example 1

As shown in fig. 1, 2 and 3, a liquid sampler comprises a push rod 1, a flow separation membrane 2, a sealing ring 3, a sampling tube 4, a sampling head 5 and a housing 6; the two ends of the sampling tube 4 are a sampling end and a push rod mounting end respectively. The push rod mounting end of the sampling tube 4 is arranged in an open mode. A conducting column 8 is arranged on the end face of the inner cavity of the sampling tube 4. The outer end of the conducting post 8 is sharp. A flow passage 9 is arranged in the conducting column 8. The sampling end of the sampling tube 4 is provided with an outwardly convex and hollow mounting portion. The inner space of the mounting part is communicated with the inner cavity of the sampling tube 4 through a flow passage 9; the sampling head 5 is embedded in the mounting portion, and the outer end extends beyond the mounting portion. When the buffer solution exists in the sampling tube 4, the sampling head 5 can be infiltrated through the flow channel 9. The outer cover 6 is sleeved on the outer side of the mounting part and is used for protecting the sampling head 5 and avoiding the sampling head 5 from being polluted in transportation and storage. The outer side of the sampling tube 4 is provided with a number of anti-slip stripes 14 for the user to grip.

The sampling head 5 can collect a liquid sample, and can specifically adopt a sponge, a hydrophilic polymer material collecting head or other elements capable of sucking liquid. The hydrophilic high polymer material collecting head can collect quantitative liquid samples through capillary action, and the sampling angle and the sampling position of an operator have small influence on the collection amount of the liquid samples.

The push rod 1 extends into the push rod mounting end of the sampling tube 4 and is in sliding connection with the inner cavity of the sampling tube 4. The inner end of the outer side surface of the push rod 1 is embedded with two sealing rings which are arranged at intervals; the sealing ring 3 is embedded into an annular groove arranged on the outer side surface of the push rod 1. The push rod 1 and the inner side wall of the sampling tube 4 are sealed by a sealing ring. A storage cavity 7 is arranged in the push rod 1; the opening of the reservoir 7 communicates with the inner end edge of the push rod 1. The inner end opening of the push rod 1 is provided with a flow separation membrane 2. The barrier film 2 encloses a reservoir chamber 7. The storage chamber 7 stores a buffer solution. The flow barrier 2 is aligned with the outer ends of the conducting posts 8. The shape of the storage cavity 7 corresponds to the shape of the via post 8, and the via post 8 can be completely inserted into the storage cavity 7.

A positioning bulge 10 is arranged at the position, close to the installation end of the push rod, of the inner cavity of the sampling tube 4; the outer side surface of the push rod 1 is provided with a positioning groove 11. The positioning groove 11 is positioned at one side of each sealing ring far away from the inner end of the push rod 1. The positioning groove 11 is an annular groove. In the initial state, the positioning protrusion 10 and the positioning groove 11 form buckling position matching, and one end interval is reserved between the flow isolation film 2 and the outer end of the conducting column 8. When the push rod 1 is pushed inwards, so that the positioning groove 11 of the push rod 1 passes over the positioning groove 11, the flow separation membrane 2 punctures the outer end of the conducting column 8, and the buffer solution stored in the storage cavity 7 flows to the sampling head 5 through the flow channel 9.

The part of the push rod 1 on the side of the positioning groove 11 away from the flow separation membrane 2 is called a diameter reduction section. The diameter of the diameter-reducing section is smaller than or equal to the circular diameter formed by connecting the bottoms of the positioning grooves 11; so that the reduced diameter section does not squeeze and rub against the positioning boss 10 to form resistance when the push rod 1 is pushed inward.

The side part of the sampling tube is provided with an exhaust hole 12; the vent hole 12 enables the lumen of the sampling tube 4 to communicate with the external environment so that the sampling head can draw the liquid sample by utilizing the capillary effect. The distance from the vent hole 12 to the sampling head 5 is greater than the distance from the outer end of the conducting post 8 to the sampling head 5. In the initial state, the distance between the sealing ring 3 close to the conducting column 8 and the exhaust hole 12 in the axial direction of the sampling tube is a, and the distance between the flow separation film and the outer end of the conducting column 8 is b; a is less than or equal to b; thus, during the pushing of the push rod 1 inwards, the time point at which the barrier membrane is pierced by the conducting post 8 is later than or simultaneously with the time point at which the sealing ring 3 passes the vent hole 12; therefore, when the flow separation membrane is punctured, the exhaust hole 12 is blocked, the inner cavity of the sampling tube 4 is only provided with the only outlet of the sampling head 5, and the buffer liquid can be pushed into the sampling head by the pressure generated after the containing cavity in the sampling tube 4 is contracted, so that the buffer liquid and the sample liquid in the sampling head are mixed and output.

In this embodiment, a preferred, unnecessary technical solution is provided: at the moment when the vent hole 12 just passes over the sealing ring 3, so that the sampling tube has only the only outlet of the sampling head, the flow separation membrane is in contact with the conducting column 8, i.e. a=b. The unnecessary technical scheme can avoid that the positive pressure in the sampling tube can output the sample liquid in the sampling head 5 before the buffer solution is released; thereby, the mixing effect of the sample liquid and the buffer liquid can be improved.

In this embodiment, a preferred, unnecessary technical solution is provided: the sampling head 5 adopts a tubular structure, and can quantitatively absorb samples by utilizing the capillary effect and the self hydrophilic characteristic; the quantitative buffer liquid output by the push rod 1 is matched, so that the accurate mixing of the liquid sample and the buffer liquid according to a specific proportion can be realized.

The working principle of the utility model is as follows:

first, when sampling is required, the liquid sampler is taken and the housing is pulled out. The liquid sample is contacted with the sampling head 5, and the sampling head 5 absorbs the liquid sample.

Then, a detection reagent plate or a detection reagent kit with a sample adding hole is taken, and a sampling head 5 of the liquid sampler is aligned with the sample adding hole of the detection reagent plate or the detection reagent kit.

Finally, pushing the push rod inwards to enable the positioning groove 11 to pass through the positioning protrusion 10, enabling the sharp tip of the conducting column to puncture the flow isolation film, enabling the conducting column to be inserted into the push rod storage cavity, compressing the space of the storage cavity, enabling buffer solution to pass through the flow channel 9 on the conducting column, and enabling the buffer solution to flow into the sample adding hole of the detection reagent plate or the detection reagent box together through the sampling head; the detection reagent plate or the detection kit automatically detects whether the liquid sample contains the target substance.

Example 2

As shown in fig. 4, a sampling detection device includes a detector 100 and a liquid sampler 200 as described in embodiment 1; the liquid sampler 200 is used for collecting a liquid sample, and by pushing the push rod on the liquid sampler 200, the collected liquid sample and the buffer solution can be mixed and fed into the detector 100. The detector 100 is used to detect whether a target substance is contained in a liquid sample.

As shown in fig. 5 and 6, the detector 100 includes an upper plate 21, a detection reagent strip 22, and a lower plate 23. The upper plate 21 and the lower plate 23 are fixed together. The detection reagent strip 22 is disposed between the upper plate 21 and the lower plate 23. The upper plate 21 is provided with a sample adding hole 24 and an observation window 25; the positions of the loading hole 24 and the observation window 25 correspond to the positions of the loading region and the detection region of the detection reagent strip 22, respectively.

The sampling head 5 on the sampling tube 4 can be inserted into the sample application hole 24 so that the sampling head 5 contacts the sample application area of the detection reagent strip 22, and the mixed liquid of the liquid sample on the sampling head 5 and the buffer solution is transferred to the detection reagent strip 22.

The sample well 24 has a stepped hole shape including a large diameter section located on the outer side and a small diameter section located on the inner side. The diameter of the large-diameter section is larger than or equal to the diameter of the detection end of the sampling tube 4, so that the detection end of the sampling tube 4 can be inserted into the large-diameter section and limited by the step surface between the large-diameter section and the small-diameter section. The diameter of the small-diameter section is larger than or equal to the diameter of the mounting part on the sampling tube 4, so that the mounting part on the sampling tube 4 is inserted into the small-diameter section; thereby ensuring accurate contact of the sampling head 5 with the test reagent strip 22

Two inner buckling bulges 26 are symmetrically arranged on the side wall of the large-diameter section; an inner buckling groove 13 is formed in the side face of the detection end of the sampling tube 4; under the state that the detection end of the sampling tube 4 is inserted into the large-diameter section of the sample adding hole 24, the inner buckling protrusion 26 and the inner buckling groove 13 form buckling position matching, so that the sampling tube 4 is stably fixed on the upper plate 21 and is not easy to fall off.

In this embodiment, a preferred, unnecessary technical solution is provided: the liquid sampler 200 and the detector 100 in the non-use state form a buckling position fit through a buckling structure; the clamping structure on the sampling tube comprises two clamping plates which are arranged at intervals; the outer edges of the opposite sides of the two clamping plates are provided with clamping blocks for connecting the detector 100; the clamping block is arc-shaped; the vent hole is provided between the opposite sides of the two clip plates, so that the clip structure can also play a role in protecting the vent hole while realizing the integration of the liquid sampler 200 and the detector 100.

The working principle of the utility model is as follows:

first, when sampling is required, the liquid sampler is removed from the side of the detector and the housing is pulled out. After the liquid sample is contacted by the sampling head 5 and absorbed by the sampling head 5, the sampling end of the sampling tube 4 is inserted into the sample application hole of the detector 100.

Then, as shown in fig. 7, the push rod is pushed inwards, so that the positioning groove 11 passes over the positioning protrusion 10, the sharp tip on the conducting column pierces the flow isolation membrane, the conducting column is inserted into the storage cavity of the push rod, the space of the storage cavity is compressed, the buffer solution passes through the flow channel 9 on the conducting column, passes through the sampling head, carries the liquid sample to flow into the sample of the reagent strip together, and triggers the running plate of the detection reagent strip 22.

And finally, waiting for a detection result.

Claims (13)

1. A liquid sampler comprising a sampling tube (4) and a sampling head (5); the method is characterized in that: the device also comprises a push rod (1) and a flow separation membrane (2); a conducting column (8) is arranged on the end face of the inner cavity of the sampling tube (4); the sampling head (5) and the push rod (1) are arranged at two ends of the sampling tube (4); the sampling head (5) is communicated with the inner cavity of the sampling tube (4); the push rod (1) is in sliding connection with the inner cavity of the sampling tube (4);

a storage cavity (7) is arranged in the push rod (1); the opening of the storage cavity (7) faces the conducting column (8), and is provided with a flow separation membrane (2) for sealing the storage cavity (7); the storage cavity (7) stores buffer solution; in the initial state, a gap is reserved between the flow separation membrane (2) and the conducting column (8); in a state that the push rod (1) slides inwards to a limit position, the flow separation membrane (2) is damaged by the conducting column (8).

2. A liquid sampler as claimed in claim 1, wherein: a sealing structure is arranged between the outer side surface of the push rod (1) and the side wall of the inner cavity of the sampling tube (4); the side part of the sampling tube is provided with an exhaust hole; in the initial state, the projection distance between the sealing structure and the exhaust hole on a plane parallel to the sliding direction of the push rod (1) is a, and the distance from the flow separation film to the outer end of the conducting column is b; a is less than or equal to b.

3. A liquid sampler as claimed in claim 1, wherein: the inner side wall of the sampling tube (4) is provided with a positioning bulge (10); a positioning groove (11) is formed in the outer side surface of the push rod (1); the positioning groove (11) is positioned at one side of each sealing ring far away from the inner end of the push rod (1); in the initial state, the positioning protrusion (10) and the positioning groove (11) form buckling position matching.

4. A liquid sampler according to claim 3 wherein: the part of the push rod (1) at one side of the positioning groove (11) far away from the flow separation membrane (2) is a diameter-reducing section; the outline of the diameter-reducing section is separated or tangent with the projection of the outer outline of the positioning bulge (10) on a plane perpendicular to the sliding direction of the push rod (1).

5. A liquid sampler as claimed in claim 1, wherein: the outer side surface of the sampling tube is provided with a plurality of anti-skid stripes; the sampling end of the sampling tube (4) is provided with an outwards convex and hollow installation part; the inner space of the mounting part is communicated with the inner cavity of the sampling tube (4); the sampling head (5) is embedded into the mounting part, and the outer end of the sampling head extends out of the mounting part; the sampling end of the sampling tube (4) is detachably connected with an outer cover (6); the outer cover (6) is sleeved outside the sampling head (5).

6. A liquid sampler as claimed in claim 1, wherein: the outer end of the conducting column (8) is sharp; a flow passage (9) is arranged in the conducting column (8); the sampling head (5) is communicated with the inner cavity of the sampling tube (4) through a flow passage (9); the shape of the conducting column (8) is the same as the shape of the storage cavity (7).

7. A liquid sampler as claimed in claim 1, wherein: the sampling head (5) is of a tubular structure made of hydrophilic materials.

8. A liquid sampler as claimed in claim 1, wherein: a plurality of sealing rings (3) are arranged between the outer side surface of the push rod (1) and the side wall of the inner cavity of the sampling tube (4); the sealing ring (3) is embedded into an annular groove arranged on the outer side face of the push rod (1).

9. A sampling detection device comprising a detector (100); the method is characterized in that: further comprising a liquid sampler as claimed in any one of claims 1 to 8; the detector (100) includes a housing and a detection reagent strip (22); a test reagent strip (22) is disposed within the housing; the shell is provided with a sample adding hole (24) and an observation window (25); a sampling head (5) on the liquid sampler (200) can be inserted into the sample application hole (24) and contacted with the detection reagent strip (22).

10. A sampling test device according to claim 9, wherein: in the non-use state, the liquid sampler and the detector are connected together in a detachable connection mode.

11. A sampling test device according to claim 10, wherein: the side part of the sampling tube is provided with an exhaust hole; in the non-use state, the exhaust hole on the sampling tube faces to the detector.

12. A sampling test device according to claim 9, wherein: the sample adding hole (24) is in a stepped hole shape and comprises a large-diameter section positioned at the outer side and a small-diameter section positioned at the inner side; the detection end of the sampling tube (4) can be inserted into the large-diameter section and is limited by a step surface between the large-diameter section and the small-diameter section; under the state that the detection end of the sampling tube (4) is limited by the stepped surface, the sampling head (5) passes through the small-diameter section and contacts with the detection reagent strip (22).

13. A sampling test device according to claim 12, wherein: a plurality of inner buckling bulges (26) are symmetrically arranged on the side wall of the large-diameter section; an inner buckling groove is formed in the side face of the detection end of the sampling tube (4); in the state that the detection end of the sampling tube (4) is inserted into the large-diameter section of the sampling hole (24), the inner buckling protrusion (26) and the inner buckling groove form buckling position matching.