CN215843050U - Micro-channel structure and micro-fluidic chip - Google Patents
Micro-channel structure and micro-fluidic chip Download PDFInfo
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- CN215843050U CN215843050U CN202122004565.5U CN202122004565U CN215843050U CN 215843050 U CN215843050 U CN 215843050U CN 202122004565 U CN202122004565 U CN 202122004565U CN 215843050 U CN215843050 U CN 215843050U
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Abstract
The utility model discloses a micro-channel structure and a micro-fluidic chip, the micro-channel structure comprises a substrate, at least two dispersion flow channels, a continuous flow channel, a mixed flow channel, a main flow channel and a non-return structure, wherein the substrate is provided with a continuous phase inlet, at least two dispersion phase inlets and a micro-droplet outlet, the at least two dispersion flow channels are arranged on the substrate, the inlets of the two dispersion flow channels are respectively communicated with the two dispersion phase inlets, the outlets of the two dispersion flow channels are mutually communicated to form a mixed port, the inlet of the continuous flow channel is communicated with the continuous phase inlet, the outlet of the continuous flow channel forms a shear port, the mixed port is communicated with the shear port through the mixed flow channel, the shear port is communicated with the micro-droplet outlet through the main flow channel, the non-return structure is arranged on the flow channel, the flow channel is at least one of the main flow channel and the mixed flow channel, the non-return structure can be movably arranged relative to the flow channel, when the flow channel is the main flow channel, the non-return structure is provided with an overflowing hole for continuous phase backflow along the flow passage direction of the main flow passage.
Description
Technical Field
The utility model relates to the technical field of microfluidics, in particular to a micro-channel structure and a microfluidic chip.
Background
At present, micro-droplets carrying cells are generally synthesized by using a microfluidic technology. The microfluidic technology, which is a commonly used method for controlling liquid or gas, is a technology for precisely operating, processing and controlling a fluid or a sample at a scale of several nanometers, and is generally a technology for operating and controlling a sample fluid in a micro-channel within a scale range of 100 μm. Microfluidic technology is used to separate cellular fluids based on 100 μm flow channels and is used for bioanalytics without limitations and requirements on cell viability. However, in the existing microfluidic structure oil and sample, the sample is sheared by the oil to generate micro-droplets with the oil wrapping the sample, the micro-droplets and the oil enter the storage cavity together for collection, and the micro-droplets and the oil in the storage cavity need to be separated for subsequent treatment, so how to separate the oil from the micro-droplets is a problem which needs to be solved urgently.
SUMMERY OF THE UTILITY MODEL
The utility model mainly aims to provide a micro-channel structure and a micro-fluidic chip, and aims to solve the problem of how to separate oil from micro-droplets.
In order to achieve the above object, the present invention provides a micro flow channel structure, comprising:
a substrate formed with a continuous phase inlet, at least two dispersed phase inlets, and a droplet outlet;
the at least two dispersing runners are arranged on the substrate, inlets of the two dispersing runners are respectively communicated with the inlets of the two dispersed phases, and outlets of the two dispersing runners are mutually communicated to form a mixing port;
the continuous flow channel is arranged on the substrate, an inlet of the continuous flow channel is communicated with the continuous phase inlet, and an outlet of the continuous flow channel forms a shear port;
the mixing flow channel is arranged on the base plate, an inlet of the mixing flow channel is communicated with the mixing port, and an outlet of the mixing flow channel is communicated with the shearing port;
the main flow channel is arranged on the base plate, an inlet of the main flow channel is communicated with the shearing port, and an outlet of the main flow channel is communicated with the droplet outlet; and the number of the first and second groups,
a non-return structure disposed in a flow passage, wherein the flow passage is at least one of the primary flow passage and the mixing flow passage, and the non-return structure is movably disposed relative to the flow passage to open the flow passage when the droplet flows toward the droplet outlet and close the flow passage when the droplet flows toward the shear port;
when the flow channel is the main flow channel, the check structure is provided with an overflowing hole for continuous phase backflow along the flow channel direction of the main flow channel.
Optionally, the flow channel has a first side wall and a second side wall which are oppositely arranged along the width direction of the flow channel, and has a front-back direction extending along the flow direction;
the check structure includes:
a first baffle extending from the first sidewall toward the second sidewall to be spaced from the second sidewall;
the elastic plate is arranged on the rear side of the first baffle plate, the elastic plate extends from the second side wall to the first side wall, the projection of at least the free end of the elastic plate on the cross section of the flow channel falls on the first baffle plate, and the elastic plate can be bent backwards and deformed under the action of external force;
wherein, the overflowing hole is arranged on the elastic plate and/or the first baffle plate.
Optionally, the flow channel has a first side wall and a second side wall which are oppositely arranged along the width direction of the flow channel, and the second side wall is provided with a mounting groove which extends along the flow direction of the flow channel;
the check structure includes:
the second baffle extends from the first side wall to the second side wall and is spaced from the second side wall; and the number of the first and second groups,
the movable plate is movably mounted on the mounting groove along the flowing direction of the main runner, and extends from the second side wall to the first side wall;
wherein, the overflowing hole is arranged on the second baffle plate and/or the movable plate.
Optionally, two check structures are provided, one of the check structures is provided in the main flow channel, and the other check structure is provided in the mixing flow channel;
wherein, the overflowing hole is arranged on the check structure of the main flow channel.
Optionally, the micro flow channel structure further includes a rectifying flow channel structure disposed in at least one of the dispersing flow channels, where an inlet of the rectifying flow channel structure includes an inlet of the dispersing flow channel, so that the dispersed phases flowing out from the inlets of the dispersing flow channels sequentially enter the dispersing flow channels.
Optionally, from the inlet of the rectifying flow passage structure to the outlet of the rectifying flow passage structure, the pipe diameter of the rectifying flow passage structure is gradually reduced.
Optionally, the dispersion flow channel is arranged in a multi-bending manner along the flow direction, and the plurality of bending flow channels form the rectification flow channel structure.
Optionally, the bending part of the bending flow channel is arranged in an arc shape.
Optionally, the continuous flow passage is provided in plurality, and a plurality of the continuous flow passages meet at the shear port.
In the technical scheme of the utility model, inlets of two dispersing flow channels are respectively communicated with two inlets of the dispersed phase, outlets of the two dispersing flow channels are communicated with each other to form a mixing port, an inlet of the continuous flow channel is communicated with an inlet of the continuous phase, an outlet of the continuous flow channel forms a shearing port, an inlet of the mixing flow channel is communicated with the mixing port, an outlet of the mixing flow channel is communicated with the shearing port, the dispersed phases entering through the two inlets of the dispersed phase are mixed and then enter the mixing flow channel through the dispersing flow channels, the mixed dispersed phase is sheared into droplets by the continuous phase flowing out of the continuous flow channel at the shearing port, the droplets enter the droplet outlet through the main flow channel and flow out, and the droplets are enabled to flow unidirectionally from the shearing port to the droplet outlet through the check structure and simultaneously pass through an overflowing hole arranged in the main flow channel, so that the continuous phase can flow back through the non-return structure and the overflow aperture to separate the droplets from the continuous phase.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the structures shown in the drawings without creative efforts.
FIG. 1 is a schematic structural view of a micro flow channel structure according to an embodiment of the present invention;
FIG. 2 is a schematic view of the micro flow channel structure (including the substrate) of FIG. 1
FIG. 3 is an enlarged schematic view of the structure at A in FIG. 1;
FIG. 4 is a schematic diagram of one embodiment of the check structure flow in FIG. 1;
FIG. 5 is a schematic view of another embodiment of the check structure of FIG. 1 in flow communication; .
The reference numbers illustrate:
| reference numerals | Name (R) | Reference numerals | Name (R) |
| 100 | |
3 | Continuous flow passage |
| 1 | |
4 | |
| 11 | |
5 | |
| 12 | Dispersed |
6 | Non-return |
| 13 | Droplet |
61 | |
| 2 | |
62 | |
| 21 | |
63 | Second baffle |
| 211 | |
64 | Movable plate |
The implementation, functional features and advantages of the objects of the present invention will be further explained with reference to the accompanying drawings.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It should be noted that, if directional indication is involved in the embodiment of the present invention, the directional indication is only used for explaining the relative positional relationship, the motion situation, and the like between the components in a certain posture, and if the certain posture is changed, the directional indication is changed accordingly.
In addition, if there is a description of "first", "second", etc. in an embodiment of the present invention, the description of "first", "second", etc. is for descriptive purposes only and is not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In addition, technical solutions between various embodiments may be combined with each other, but must be realized by a person skilled in the art, and when the technical solutions are contradictory or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope of the present invention.
At present, micro-droplets carrying cells are generally synthesized by using a microfluidic technology. The microfluidic technology, which is a commonly used method for controlling liquid or gas, is a technology for precisely operating, processing and controlling a fluid or a sample at a scale of several nanometers, and is generally a technology for operating and controlling a sample fluid in a micro-channel within a scale range of 100 μm. Microfluidic technology is used to separate cellular fluids based on 100 μm flow channels and is used for bioanalytics without limitations and requirements on cell viability. However, in the existing microfluidic structure oil and sample, the sample is sheared by the oil to generate micro-droplets with the oil wrapping the sample, the micro-droplets and the oil enter the storage cavity together for collection, and the micro-droplets and the oil in the storage cavity need to be separated for subsequent treatment.
In view of this, the present invention provides a microfluidic chip including a micro channel structure, and any microfluidic chip including the micro channel structure is within the protection scope of the present invention, wherein fig. 1 to 5 are schematic structural diagrams of an embodiment of the micro channel structure provided by the present invention.
Referring to fig. 1 to 3, the micro flow channel structure 100 includes a substrate 1, at least two dispersion flow channels 2, a continuous flow channel 3, a mixing flow channel 3, a main flow channel 5, and a check structure 6, wherein the substrate 1 is formed with a continuous phase inlet 11, at least two dispersed phase inlets 12, and a droplet outlet 13; the at least two dispersing flow channels 2 are arranged on the substrate 1, inlets of the two dispersing flow channels 2 are respectively communicated with the two dispersed phase inlets 12, and outlets of the two dispersing flow channels 2 are mutually communicated to form a mixing port; the continuous flow channel 3 is arranged on the substrate 1, an inlet of the continuous flow channel 3 is communicated with the continuous phase inlet 11, and an outlet of the continuous flow channel 3 forms a shear port; the mixing flow channel 3 is arranged on the substrate 1, an inlet of the mixing flow channel 3 is communicated with the mixing port, and an outlet of the mixing flow channel 3 is communicated with the shearing port; the primary flow channel 5 is disposed on the substrate 1, an inlet of the primary flow channel 5 is communicated with the shear port, an outlet of the primary flow channel 5 is communicated with the droplet outlet 13, the check structure 6 is disposed on a flow channel, the flow channel is at least one of the primary flow channel 5 and the mixing flow channel 3, and the check structure 6 is movably disposed relative to the flow channel so as to open the flow channel when droplets flow toward the droplet outlet 13 and close the flow channel when droplets flow toward the shear port; when the flow channel is the main flow channel 5, the check structure 6 is provided with an overflowing hole for continuous phase backflow along the flow channel direction of the main flow channel 5.
In the technical solution of the present invention, inlets of the two dispersing flow channels 2 are respectively communicated with the two dispersed phase inlets 12, outlets of the two dispersing flow channels 2 are communicated with each other to form a mixing port, an inlet of the continuous flow channel 3 is communicated with the continuous phase inlet 11, an outlet of the continuous flow channel 3 forms a shear port, an inlet of the mixing flow channel 3 is communicated with the mixing port, an outlet of the mixing flow channel 3 is communicated with the shear port, the dispersed phases entering through the two dispersed phase inlets 12 are mixed by the dispersing flow channel 2 and then enter the mixing flow channel 3, the mixed dispersed phases are sheared into droplets by the continuous phase flowing out from the continuous flow channel 3 at the shear port, the droplets enter the droplet outlet 13 through the main flow channel 5 and flow out from the shear port to the droplet outlet 13 through the check structure 6, so that the droplets flow unidirectionally from the shear port to the droplet outlet 13, at the same time, the continuous phase can flow back through the overflowing hole arranged in the main flow channel 5, and the droplets are separated from the continuous phase through the non-return structure 6 and the overflowing hole.
It should be noted that the continuous phase may be oil or water, the disperse phase is the sample to be detected, and further, the samples entering the disperse flow channel 2 through the two disperse phase inlets 12 may be the same or different, for example, one sample is a cell, and the other sample is an enzyme; or both cells, etc., as the present invention is not limited in this regard.
It should be noted that, in the present invention, the driving manner of the micro flow channel structure 100 is provided with a plurality of ways, in one embodiment, the micro flow channel structure 100 includes a forward driving device, and the forward driving device is communicated with the continuous phase inlet 11 and the dispersion inlet to generate micro droplets; meanwhile, the micro flow channel structure 100 further includes a back-driving device, which is communicated with the droplet outlet 13 to drive the continuous phase to flow back.
Further, in an embodiment, referring to fig. 4, the flow channel has a first side wall and a second side wall oppositely disposed along a width direction thereof, and has a front-back direction extending along a flow direction; the check structure 6 comprises a first baffle 61 and an elastic plate 62, wherein the first baffle 61 extends from the first side wall to the second side wall and is spaced from the second side wall; the elastic plate 62 is arranged at the rear side of the first baffle 61, the elastic plate 62 extends from the second side wall to the first side wall, the projection of at least the free end of the elastic plate 62 on the cross section of the flow passage falls on the first baffle 61, and the elastic plate 62 can be bent and deformed backwards under the action of external force; wherein the flow hole is provided in the elastic plate 62 and/or the first baffle 61, so that when a droplet flows from the shear port to the droplet outlet 13, the elastic plate 62 deforms to allow the droplet to pass through; when the droplets flow from the droplet outlet 13 to the shear port, the elastic plate 62 is attached to the first baffle 61 to prevent the droplets from flowing back, and simultaneously passes through the flow-through hole to allow the continuous phase to flow back.
In another embodiment, referring to fig. 5, the flow channel has a first side wall and a second side wall oppositely disposed along the width direction thereof, and the second side wall is provided with an installation groove extending along the flow direction of the flow channel; the check structure 6 includes a second baffle 63 and a movable plate 64, the second baffle 63 extends from the first sidewall toward the second sidewall to be spaced apart from the second sidewall, the movable plate 64 is movably mounted to the mounting groove along the flow direction of the primary runner 5, and the movable plate 64 extends from the second sidewall toward the first sidewall; wherein the overflowing hole is provided in the second baffle 63 and/or the movable plate 64, so that when the droplet flows from the shearing opening to the droplet outlet 13, the movable plate 64 moves backward to separate from the second baffle 63, thereby opening the flow channel for the droplet to pass through; when droplets flow from the droplet outlet 13 towards the shear port, the movable plate 64 engages the second baffle 63, thereby preventing backflow of droplets, while passing through the flow-through hole, to enable backflow of the continuous phase.
In order to avoid the continuous phase from flowing back to the dispersion flow channel 2, in one embodiment, two check structures 6 are provided, one check structure 6 is provided in the main flow channel 5, and the other check structure 6 is provided in the mixing flow channel 3; wherein, the discharge orifice is located on the non return structure 6 of sprue 5, so set up, through locating the non return structure 6 of sprue 5 to make the continuous phase can pass through non return structure 6 backward flow, simultaneously through locating the non return structure 6 of mixing flow channel 3, totally enclosed mixing flow channel 3, in order to avoid the continuous phase to get into disperse flow channel 2.
Since the dispersion phase may be a cell or an enzyme, too much dispersion phase entering the dispersion flow channel 2 may cause uneven mixing of the dispersion phase, in order to enable the dispersion phase to uniformly enter the dispersion flow channel 2, please refer to fig. 1 and 2, the micro flow channel structure 100 further includes a rectification flow channel structure 21 disposed on at least one dispersion flow channel 2, an inlet of the rectification flow channel structure 21 includes an inlet of the dispersion flow channel 2, so as to enable the dispersion phase flowing out from the dispersion phase inlet 12 to sequentially enter the dispersion flow channel 2, and thus, the arrangement is such that the dispersion phase can sequentially and uniformly enter the dispersion flow channel 2 through the rectification flow channel structure 21, thereby facilitating uniform mixing of the dispersion phase.
In an embodiment, referring to fig. 2, from the inlet of the rectifying flow channel structure 21 to the outlet of the rectifying flow channel structure 21, the pipe diameter of the rectifying flow channel structure 21 is gradually reduced, so that the speed of the dispersed phase entering the dispersing flow channel 2 is controlled by reducing the pipe diameter, so that the dispersed phase sequentially enters the dispersing flow channel 2.
In another embodiment, referring to fig. 1, the dispersion channel 2 is bent for multiple times along the flow direction, and the plurality of bent channels 211 form the rectification channel structure 21, so that a dean drag force is applied to the dispersion phase by a secondary vortex generated by a centrifugal force generated when the dispersion phase flows through the bent channels 211, and an inertial lift force of an inertial flow is also applied to the dispersion phase, and the two forces are balanced to balance the dispersion phase in the micro channel, so that the dispersion phase can sequentially enter the dispersion channel 2 through the bent channels 211, and further, the bent portions of the bent channels 211 are arranged in an arc shape to allow the dispersion phase to smoothly pass through the bent portions.
In order to improve the efficiency of droplet generation, in an embodiment, the continuous flow path 3 is provided in plurality, and a plurality of continuous flow paths 3 meet at the shearing port, and the arrangement is such that the mixed dispersed phase can be sheared by the continuous phase faster by arranging a plurality of continuous flow paths 3 to increase the number of continuous phases, so as to improve the droplet generation efficiency.
The above description is only a preferred embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications and equivalents made by the contents of the present specification and drawings, or directly/indirectly applied to other related technical fields, are included in the scope of the present invention.
Claims (10)
1. A micro flow channel structure for a micro flow chip, the micro flow channel structure comprising:
a substrate formed with a continuous phase inlet, at least two dispersed phase inlets, and a droplet outlet;
the at least two dispersing runners are arranged on the substrate, inlets of the two dispersing runners are respectively communicated with the inlets of the two dispersed phases, and outlets of the two dispersing runners are mutually communicated to form a mixing port;
the continuous flow channel is arranged on the substrate, an inlet of the continuous flow channel is communicated with the continuous phase inlet, and an outlet of the continuous flow channel forms a shear port;
the mixing flow channel is arranged on the base plate, an inlet of the mixing flow channel is communicated with the mixing port, and an outlet of the mixing flow channel is communicated with the shearing port;
the main flow channel is arranged on the base plate, an inlet of the main flow channel is communicated with the shearing port, and an outlet of the main flow channel is communicated with the droplet outlet; and the number of the first and second groups,
a non-return structure disposed in a flow passage, wherein the flow passage is at least one of the primary flow passage and the mixing flow passage, and the non-return structure is movably disposed relative to the flow passage to open the flow passage when the droplet flows toward the droplet outlet and close the flow passage when the droplet flows toward the shear port;
when the flow channel is the main flow channel, the check structure is provided with an overflowing hole for continuous phase backflow along the flow channel direction of the main flow channel.
2. The micro flow channel structure of claim 1 wherein the flow channel has a first side wall and a second side wall which are oppositely disposed in a width direction thereof, and has a front-back direction extending in a flow direction;
the check structure includes:
a first baffle extending from the first sidewall toward the second sidewall to be spaced from the second sidewall;
the elastic plate is arranged on the rear side of the first baffle plate, the elastic plate extends from the second side wall to the first side wall, the projection of at least the free end of the elastic plate on the cross section of the flow channel falls on the first baffle plate, and the elastic plate can be bent backwards and deformed under the action of external force;
wherein, the overflowing hole is arranged on the elastic plate and/or the first baffle plate.
3. The micro flow channel structure of claim 1, wherein the flow channel has a first side wall and a second side wall which are oppositely disposed in a width direction thereof, the second side wall being provided with a mounting groove extending in a flow direction of the flow channel;
the check structure includes:
the second baffle extends from the first side wall to the second side wall and is spaced from the second side wall; and the number of the first and second groups,
the movable plate is movably mounted on the mounting groove along the flowing direction of the main runner, and extends from the second side wall to the first side wall;
wherein, the overflowing hole is arranged on the second baffle plate and/or the movable plate.
4. The micro flow channel structure of claim 1 wherein two check structures are provided, one of the check structures being provided in the primary flow channel and the other check structure being provided in the mixing flow channel;
wherein, the overflowing hole is arranged on the check structure of the main flow channel.
5. The micro flow channel structure of claim 1 further comprising a rectifying flow channel structure disposed in at least one of the dispersion flow channels, wherein the inlet of the rectifying flow channel structure comprises the inlet of the dispersion flow channel, so that the dispersion phases flowing out corresponding to the inlet of the dispersion phase sequentially enter the dispersion flow channel.
6. The microfluidic channel structure of claim 5 wherein the diameter of the tube of the rectifying channel structure decreases from the inlet of the rectifying channel structure to the outlet of the rectifying channel structure.
7. The micro flow channel structure of claim 5, wherein the discrete flow channels are arranged in a plurality of bends in the flow direction, the plurality of bends forming the rectifying flow channel structure.
8. The micro flow channel structure of claim 7 wherein the bends of the curved flow channels are arcuate.
9. The micro flow channel structure of claim 1 wherein there are a plurality of the continuous flow channels, the plurality of continuous flow channels meeting at the cutout.
10. A microfluidic chip comprising the micro flow channel structure according to any one of claims 1 to 9.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202122004565.5U CN215843050U (en) | 2021-08-24 | 2021-08-24 | Micro-channel structure and micro-fluidic chip |
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| CN202122004565.5U CN215843050U (en) | 2021-08-24 | 2021-08-24 | Micro-channel structure and micro-fluidic chip |
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| CN215843050U true CN215843050U (en) | 2022-02-18 |
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