CN215162833U - Magnetic rod assembly and nucleic acid extraction device - Google Patents
Magnetic rod assembly and nucleic acid extraction device Download PDFInfo
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- CN215162833U CN215162833U CN202120141943.1U CN202120141943U CN215162833U CN 215162833 U CN215162833 U CN 215162833U CN 202120141943 U CN202120141943 U CN 202120141943U CN 215162833 U CN215162833 U CN 215162833U
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Abstract
The utility model provides a magnetic rod assembly and a nucleic acid extraction device, which comprises a magnetic rod, an inner magnetic rod sleeve and an outer magnetic rod sleeve; the inner layer magnetic rod sleeve and the outer layer magnetic rod sleeve respectively comprise a hollow rod sleeve main body with two end parts; wherein: the first end of the two ends of the inner layer magnetic rod sleeve is closed, and the second end is open; the cross section size of at least part of the outer wall of the magnetic rod is smaller than or equal to that of the inner wall of the inner layer magnetic rod sleeve, and the magnetic rod can be selectively inserted into the inner layer magnetic rod sleeve or separated from the inner layer magnetic rod sleeve from the second end part of the inner layer magnetic rod sleeve; a first end and a second end of the two ends of the outer layer magnetic rod sleeve are both open; the cross section size of the inner wall of the outer layer magnetic rod sleeve is closely matched with the cross section size of at least part of the outer wall of the inner layer magnetic rod sleeve, so that the inner layer magnetic rod sleeve can be inserted into the outer layer magnetic rod sleeve from the second end part of the outer layer magnetic rod sleeve and can reciprocate along the inner wall of the outer layer magnetic rod sleeve.
Description
Technical Field
The utility model relates to an external diagnosis technical field especially relates to a bar magnet subassembly and nucleic acid extraction element.
Background
The extraction of nucleic acid by using magnetic beads is an effective technical means for gene detection and gene extraction, and is now widely applied in various fields such as disease control center, clinical disease diagnosis, blood transfusion safety, forensic identification, environmental microorganism detection, food safety detection, animal husbandry, molecular biology research and the like, and along with the continuous development of nucleic acid extraction technology, high-throughput and automatic nucleic acid extraction technology has become a development trend in the industry.
In the prior art, the automation of nucleic acid extraction mainly adopts two modes, one is to adopt an automatic nucleic acid extractor, and the other is to adopt an automatic workstation.
However, the automatic nucleic acid extraction instrument can only realize the automatic transfer of magnetic beads, and cannot perform the operations of adding, sucking and transferring the sample liquid in the sample plate; the automatic workstation can carry out operations such as adding, suction and transfer to the sample liquid, can not carry out magnetic separation to the magnetic bead.
Therefore, the prior art cannot integrally realize the operation of the magnetic beads and the sample liquid by adopting the same equipment.
SUMMERY OF THE UTILITY MODEL
The utility model provides a bar magnet subassembly and nucleic acid extraction element to solve and can't adopt same equipment to realize the problem to the operation of magnetic bead and sample liquid integratedly.
According to a first aspect of the present invention, there is provided a magnetic rod assembly, comprising a magnetic rod, an inner magnetic rod sleeve and an outer magnetic rod sleeve;
the inner magnetic rod sleeve and the outer magnetic rod sleeve respectively comprise a hollow rod sleeve main body with two end parts; wherein:
a first end of the two ends of the inner layer magnetic rod sleeve is closed, and a second end of the two ends of the inner layer magnetic rod sleeve is open; the cross section size of at least part of the outer wall of the magnetic rod is smaller than or equal to that of the inner wall of the inner layer magnetic rod sleeve, and the magnetic rod can be selectively inserted into the inner layer magnetic rod sleeve or separated from the inner layer magnetic rod sleeve from the second end of the inner layer magnetic rod sleeve;
a first end and a second end of the two ends of the outer layer magnetic rod sleeve are both open; the cross section size of the inner wall of the outer layer magnetic rod sleeve is closely matched with the cross section size of at least part of the outer wall of the inner layer magnetic rod sleeve, so that the inner layer magnetic rod sleeve can be inserted into the outer layer magnetic rod sleeve from the second end of the outer layer magnetic rod sleeve and can reciprocate along the inner wall of the outer layer magnetic rod sleeve.
Optionally, the assembly state of the magnetic rod assembly comprises a first assembly state and a second assembly state;
when the magnetic rod is in the first assembly state, the magnetic rod is inserted into the inner-layer magnetic rod sleeve, and the inner-layer magnetic rod sleeve is inserted into the outer-layer magnetic rod sleeve;
when the magnetic rod is in the second assembly state, the inner layer magnetic rod sleeve is inserted into the outer layer magnetic rod sleeve, and the magnetic rod is not inserted into the inner layer magnetic rod sleeve.
Optionally, the cross-sectional shape of the magnetic rod is at least one of the following:
a circular shape;
a polygon;
an oval shape.
Optionally, the cross-sectional shape of the magnetic rod is matched with the cross-sectional shape of the inner wall of the inner-layer magnetic rod sleeve.
Optionally, the cross-sectional shapes of the inner layer magnetic rod sleeve and the outer layer magnetic rod sleeve are both circular rings; the cross section of the outer wall of the inner layer magnetic rod sleeve and the cross section of the inner wall of the outer layer magnetic rod sleeve are both circular.
Optionally, the length of the magnetic rod is greater than that of the inner-layer magnetic rod sleeve; the length of the inner layer magnetic rod sleeve is larger than that of the outer layer magnetic rod sleeve.
Optionally, one end of the magnetic rod is provided with a pull rod.
Optionally, the material of the magnetic rod includes a permanent magnet or an electromagnet.
Optionally, when the magnetic rod is made of an electromagnet, the magnetic rod assembly further comprises an electromagnetic control device, and the electromagnetic control device is electrically connected with the electromagnet.
According to a second aspect of the present invention, there is provided a nucleic acid extraction device comprising the magnetic rod assembly of the first aspect of the present invention and its alternatives.
The utility model provides a bar magnet subassembly and nucleic acid extraction element, can pass through the bar magnet, the inlayer bar magnet cover, mutually support between the outer bar magnet cover, relative motion, realize the independent operation magnetic bead (for example, the separation of magnetic bead, transfer and mixing), independent operation sample liquid (for example, the joining of liquid, the suction, mixing and transfer) and the concurrent operation of magnetic bead and sample liquid (for example, suction liquid when separating the magnetic bead, add liquid when separating the magnetic bead), enriched the function based on the bar magnet subassembly of bar magnet cover, the equipment structure that nucleic acid drawed has been simplified, help improving the operating efficiency that nucleic acid drawed, and simultaneously, provide the basis for the full automatization of various operations in the nucleic acid extraction technique.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without inventive exercise.
Fig. 1 is a first schematic structural diagram of a magnetic rod assembly according to an embodiment of the present invention;
fig. 2 is a schematic structural diagram of a magnetic rod assembly according to an embodiment of the present invention;
fig. 3 is a third schematic structural diagram of a magnetic rod assembly according to an embodiment of the present invention;
FIG. 4a is a schematic view of a magnetic rod assembly in a first assembled state according to an embodiment of the present invention;
FIG. 4b is a schematic view of the magnetic rod assembly in a second assembled state according to an embodiment of the present invention;
fig. 5a is a schematic structural diagram of a magnetic rod assembly for magnetic bead separation according to an embodiment of the present invention;
fig. 5b is a schematic structural diagram of a magnetic rod assembly for adding magnetic beads according to an embodiment of the present invention;
fig. 5c is a schematic structural diagram of a magnetic rod assembly for adding magnetic beads according to an embodiment of the present invention;
FIG. 6 is a schematic diagram of a magnetic rod assembly for separating magnetic beads and sucking out liquid according to an embodiment of the present invention;
FIG. 7 is a schematic structural diagram of a magnetic rod assembly for separating magnetic beads and adding liquid according to an embodiment of the present invention;
FIG. 8 is a schematic diagram of a partially enlarged structure of a magnetic rod assembly for separating magnetic beads and adding liquid according to an embodiment of the present invention;
fig. 9 is a schematic structural diagram of a magnetic rod assembly for sucking out a sample liquid according to an embodiment of the present invention;
fig. 10 is a schematic structural diagram of a magnetic rod assembly for sample liquid addition in an embodiment of the present invention;
fig. 11 is a fourth schematic structural view of a magnetic rod assembly according to an embodiment of the present invention;
fig. 12 is a schematic structural diagram of a magnetic rod assembly according to an embodiment of the present invention;
description of reference numerals:
1-a magnetic bar;
11-magnetic rod segment one;
12-magnetic rod section two;
13-a pull rod;
2-inner layer magnetic rod sleeve;
21-a first end portion;
22-a second end;
23-inner layer magnetic rod sleeve section one;
24-inner layer magnetic rod sleeve section II;
25-inner layer magnetic rod sleeve section III;
3-outer layer magnetic rod sleeve;
31-a first end portion;
32-a second end;
4-sample liquid;
41-magnetic beads;
5-sample liquid;
6-electromagnetic control device.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
The terms "first," "second," "third," "fourth," and the like in the description and in the claims, as well as in the drawings, if any, are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It is to be understood that the data so used is interchangeable under appropriate circumstances such that the embodiments of the invention described herein are capable of operation in sequences other than those illustrated or otherwise described herein. Furthermore, the terms "comprises," "comprising," and "having," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.
The technical solution of the present invention will be described in detail with specific examples. The following several specific embodiments may be combined with each other, and details of the same or similar concepts or processes may not be repeated in some embodiments.
Referring to fig. 1, the magnetic rod assembly includes a magnetic rod 1, an inner magnetic rod sleeve 2 and an outer magnetic rod sleeve 3;
the inner layer magnetic rod sleeve 2 and the outer layer magnetic rod sleeve 3 respectively comprise a hollow rod sleeve main body with two end parts; wherein:
the magnetic rod 1 can be understood as a rod body having a magnetic force or capable of generating a magnetic force.
A first end 21 of the two ends of the inner layer magnetic rod sleeve 2 is closed, and a second end 22 is open; the cross-sectional dimension of at least part of the outer wall of the magnetic rod 1 is smaller than or equal to the cross-sectional dimension of the inner wall of the inner layer magnetic rod sleeve 2, wherein the cross-sectional dimension of at least part of the outer wall of the magnetic rod 1 is smaller than or equal to the cross-sectional dimension of the inner wall 2 of the inner layer magnetic rod sleeve, and the following can be understood: at least part of the magnetic rod segments can be inserted into the inner layer magnetic rod sleeve 2, and the cross section size of the magnetic rod segments 11 inserted into the inner layer magnetic rod sleeve 2 is smaller than or equal to that of the inner wall of the inner layer magnetic rod sleeve 2, so that the magnetic rod 1 can be inserted into or taken out of the second end part of the inner layer magnetic rod sleeve 2. The magnet bar 1 can be selectively inserted into the inner layer magnet bar sleeve 2 or separated from the inner layer magnet bar sleeve 2 from the second end 22 of the inner layer magnet bar sleeve.
In an example, referring to fig. 2, the cross-sectional dimension of the first magnetic rod segment 11 inserted into the inner magnetic rod sleeve 2 is smaller than the cross-sectional dimension of the inner wall of the inner magnetic rod sleeve 2, and the cross-sectional dimension of the second magnetic rod segment 12 not inserted into the inner magnetic rod sleeve 2 is larger than the cross-sectional dimension of the inner wall of the inner magnetic rod sleeve 2; in other examples, the cross-sectional dimension of the first magnetic rod segment 11 may also be equal to (or close to) the cross-sectional dimension of the inner wall of the inner-layer magnetic rod sleeve 2, and the cross-sectional dimension of the second magnetic rod segment 12 may also be equal to (or close to) the cross-sectional dimension of the first magnetic rod segment 11.
The magnetic rod 1 may be a structure capable of generating a magnetic field as a whole, or may be a structure capable of generating a magnetic field partially, for example, a structure capable of generating a magnetic field only by the first magnetic rod segment 11, or a structure capable of generating a magnetic field by both the first magnetic rod segment 11 and the second magnetic rod segment 12.
Referring to fig. 1 and 3, a first end 31 and a second end 32 of the two ends of the outer layer magnetic rod sleeve 3 are both open; the cross-sectional dimension of the inner wall of the outer layer magnetic rod sleeve 3 is closely matched with the cross-sectional dimension of at least part of the outer wall of the inner layer magnetic rod sleeve 2, so that the inner layer magnetic rod sleeve 2 can be inserted into the outer layer magnetic rod sleeve 3 from the second end 32 of the outer layer magnetic rod sleeve 3 and can reciprocate along the inner wall of the outer layer magnetic rod sleeve 3.
Wherein, the cross-sectional dimension of the inner wall of the outer layer magnetic rod sleeve 3 is closely matched with the cross-sectional dimension of at least part of the outer wall of the inner layer magnetic rod sleeve 2, which can be understood as follows: at least part of the inner-layer magnetic rod sleeve section can be inserted into the outer-layer magnetic rod sleeve 3 and inserted into the inner-layer magnetic rod sleeve section in the outer-layer magnetic rod sleeve 3, and the cross section size of the outer wall of the part of the inner-layer magnetic rod sleeve section I23 is equal to (or close to) the cross section size of the inner wall of the outer-layer magnetic rod sleeve 3.
In an example, referring to fig. 3, the outer wall cross-sectional dimension of the inner bar sleeve segment one 23 inserted into the outer bar sleeve 3 is equal to (or close to) the inner wall cross-sectional dimension of the outer bar sleeve 3, the outer cross-sectional dimension of the inner bar sleeve segment two 24 inserted into the outer bar sleeve 3 is smaller than the inner wall cross-sectional dimension of the outer bar sleeve 3, and the outer wall cross-sectional dimension of the inner bar sleeve segment three 25 not inserted into the outer bar sleeve is larger than the inner wall cross-sectional dimension of the outer bar sleeve 3; in other examples, the cross-sectional dimensions of the outer walls of the first inner-layer magnetic rod sleeve section 23, the second inner-layer magnetic rod sleeve section 24 and the third inner-layer magnetic rod sleeve section 25 may be equal to (or close to) the cross-sectional dimensions of the inner walls of the outer-layer magnetic rod sleeve 3.
Further, referring to fig. 4a and 4b, the assembly states of the magnetic rod assembly include a first assembly state and a second assembly state;
in the first assembly state, please refer to fig. 4a, the magnetic rod 1 is inserted into the inner magnetic rod sleeve 2, and the inner magnetic rod sleeve 2 is inserted into the outer magnetic rod sleeve 3;
in the second assembly state, please refer to fig. 4b, the inner magnetic rod sleeve 2 is inserted into the outer magnetic rod sleeve 3, and the magnetic rod 1 is not inserted into the inner magnetic rod sleeve 2.
In an application scenario, referring to fig. 5a, in the first assembly state, the bar magnet assembly is configured to:
when the magnetic rod 1 is inserted into contact with the first end 21 of the inner layer magnetic rod sleeve, the first end 21 of the inner layer magnetic rod sleeve is inserted into the outer layer magnetic rod sleeve 3, and the first end 31 of the outer layer magnetic rod sleeve 3 is inserted into the sample liquid 4 containing magnetic beads, the magnetic beads 41 in the sample liquid are adsorbed to the outer side of the inner layer magnetic rod sleeve 2 and/or the outer layer magnetic rod sleeve 3, wherein the outer side of the inner layer magnetic rod sleeve 2 can be understood as: the outer wall of inner layer bar cover 2, perhaps the inner wall of outer bar cover 3, magnetic bead 41 can adsorb in the outer wall of inner layer bar cover 2 promptly, also can adsorb in the inner wall of outer bar cover 3, can also adsorb in the outer wall of outer bar cover 3.
The bar magnet assembly described above can be understood as: for separating magnetic beads, for example, the magnetic beads 41 are separated from the sample liquid 4 containing the magnetic beads 41.
By way of further example, referring to fig. 5b, the bar magnet assembly is further configured to:
when the magnetic rod assembly in the first assembly state adsorbs the magnetic beads 41 and the magnetic rod 1 is pulled out from the inner-layer magnetic rod sleeve 2 or loses the magnetic force, the magnetic beads 41 are separated from the magnetic rod assembly.
Referring to fig. 5c, the magnetic bar 1 loses its magnetic force when the magnetic bar 1 is an electromagnet and the electromagnet is powered off.
The above described bar magnet assembly may be understood as the addition of magnetic beads, for example beads 41 to the sample liquid 5.
If the operation of separating the magnetic beads 41 and the operation of adding the magnetic beads 41 are combined, for example, the magnetic beads are separated first and then the magnetic beads are added, the magnetic rod assembly can be understood as being used for transferring the magnetic beads 41, for example, transferring the magnetic beads 41 in the sample liquid 4 to the sample liquid 5.
By way of further example, referring to fig. 6, in the first assembly state, the bar magnet assembly is further configured to:
when the sample liquid 4 containing the magnetic beads 41 is inserted into the first end 31 of the outer-layer sheath and the inner-layer sheath 2 moves along the inner wall of the outer-layer sheath 3 away from the first end 31 of the outer-layer sheath, the sample liquid 4 is drawn into the outer-layer sheath 3, and the magnetic beads 41 in the sample liquid 4 are adsorbed to the outside of the inner-layer sheath 2. At this time, the magnetic beads 41 in the sample liquid 4 are adsorbed to the outside of the inner layer sheath 2, and the liquid in the sample liquid 4 is located in a space formed by the inner wall of the outer layer sheath 3 and the first end 21 of the inner layer sheath 2. The outer side of the inner layer rod sleeve 2 can be understood with reference to the position described above.
Wherein the inner layer magnetic rod sleeve 2 moves along the inner wall of the outer layer magnetic rod sleeve 3 away from the first end 31 of the outer layer magnetic rod sleeve, which can be understood as follows: the inner layer magnetic rod sleeve 2 and the magnetic rod 1 are drawn out from the first end 31 of the outer layer magnetic rod sleeve 3 together.
The magnetic bar assembly described above may be understood as: for aspirating liquid simultaneously with the separation of the magnetic beads, for example in the sample liquid 4 simultaneously with the separation of the magnetic beads 41.
Correspondingly, referring to fig. 7 and 8, in the first assembly state, the magnetic rod assembly is further configured to:
the magnetic beads 41 are adsorbed outside the inner layer magnetic rod sleeve 2, the sample liquid 4 is contained in the outer layer magnetic rod sleeve 3, and the inner layer magnetic rod sleeve 2 carries the magnetic rods 1 along the inner wall of the outer layer magnetic rod sleeve 3 to be close to the first end portion 31 of the outer layer magnetic rod sleeve, so that the sample liquid without the magnetic beads 41 is released outside the outer layer magnetic rod sleeve 3. At this time, the magnetic beads 41 in the sample liquid 4 are adsorbed to the outside of the inner-layer magnetic rod sleeve 2, and the liquid in the sample liquid 4 is released to the outside of the magnetic rod assembly. The outer side of the inner layer rod sleeve 2 can be understood with reference to the position described above.
Wherein, the inner layer magnetic rod sleeve 2 moves along the inner wall of the outer layer magnetic rod sleeve 3 near the first end 31 of the outer layer magnetic rod sleeve, which can be understood as follows: the inner layer magnetic rod sleeve 2 and the magnetic rod 1 are jointly inserted inwards from the first end 31 of the outer layer magnetic rod sleeve 3.
The magnetic bar assembly described above may be understood as: for separating the magnetic beads, a liquid is added at the same time, for example, a liquid is added to the sample liquid 4 at the same time as the magnetic beads 41 are separated.
If the operation of sucking out the liquid while separating the magnetic beads 41 and the operation of adding the liquid while separating the magnetic beads 41 are combined, for example, the operation of sucking the magnetic beads 41 is performed first, the inner-layer magnetic rod sleeve 2 and the magnetic rod 1 are driven to move outward from the first end 31 of the outer-layer magnetic rod sleeve 3 together, and then the operation of sucking the magnetic beads 41 is performed, the inner-layer magnetic rod sleeve 2 and the magnetic rod 1 are driven to move inward from the first end 31 of the outer-layer magnetic rod sleeve 3 together, the magnetic rod assembly can be understood as being used for operating (adding, separating, and transferring) only the liquid with respect to the sample liquid containing the magnetic beads.
In other application scenarios, referring to fig. 9, in the second assembly state, the magnetic bar assembly is configured to: when the sample liquid 6 is inserted into the first end 31 of the outer layer magnetic rod sleeve and the inner layer magnetic rod sleeve 2 moves along the inner wall of the outer layer magnetic rod sleeve 3 away from the first end 31 of the outer layer magnetic rod sleeve, the sample liquid 5 is extracted into the outer layer magnetic rod sleeve, and at the moment, the extracted sample liquid 5 is in a space formed by the inner wall of the outer layer magnetic rod sleeve 3 and the first end 21 of the inner layer magnetic rod sleeve 2.
The sample liquid 5 may be a sample liquid containing no magnetic beads or a sample liquid containing magnetic beads, and the movement of the inner rod sleeve 2 along the inner wall of the outer rod sleeve 3 away from the first end 31 of the outer rod sleeve can be understood as: the inner layer magnetic rod sleeve 2 does the motion of drawing out the outer layer magnetic rod sleeve 3.
The magnetic bar assembly described above may be understood as: the term "sample liquid" used in the present specification means a liquid used in aspirating a sample liquid without magnetic beads, and means a sample liquid and magnetic beads simultaneously aspirated in aspirating a sample liquid with magnetic beads.
By way of further example, referring to fig. 10, in the second assembly state, the bar magnet assembly is further configured to:
the sample liquid 5 is contained in the outer layer magnetic rod sleeve 3, and when the inner layer magnetic rod sleeve 2 moves along the inner wall of the outer layer magnetic rod sleeve 3 close to the first end 31 of the outer layer magnetic rod sleeve, the sample liquid 5 is released out of the outer layer magnetic rod sleeve 3.
The sample liquid 5 may be a sample liquid containing no magnetic beads or a sample liquid containing magnetic beads, and the movement of the inner rod sleeve 2 along the inner wall of the outer rod sleeve 3 near the first end 31 of the outer rod sleeve can be understood as: the inner layer magnetic rod sleeve 2 is inserted into the outer layer magnetic rod sleeve 3.
The magnetic bar assembly described above may be understood as: the method is used for adding the sample liquid, wherein if the sample liquid does not contain the magnetic beads, the method can be understood as being used for adding the liquid, and if the sample liquid contains the magnetic beads, the method can be understood as being used for adding the sample liquid and the magnetic beads simultaneously.
If the operation of sucking out the sample liquid and the operation of adding the sample liquid are combined, for example, the sample liquid 5 is sucked out first and then the sample liquid 5 is added, the magnetic rod assembly can be understood as being used for transferring the sample liquid, wherein the sample liquid may or may not include magnetic beads.
In a further example, in the second assembly state, the magnetic bar assembly is further configured to:
a sample liquid is inserted into the first end of the outer layer magnetic rod sleeve 3, and the sample liquid is mixed while being operated to perform stirring motion in the sample liquid.
The stirring motion can be understood as that the inner layer magnetic rod sleeve 2 and the outer layer magnetic rod sleeve 3 are driven to do at least one of reciprocating motion, mixing motion, oscillating motion, rotating motion and the like in the sample liquid at the same time, so that the sample liquid is fully mixed. The sample solution may or may not contain magnetic beads.
Further, the cross-sectional shape of the magnetic rod 1 may be any one of a circle, a polygon, or an ellipse, and may be other shapes as long as the magnetic rod can be inserted into the inner-layer magnetic rod sleeve 2 and can reciprocate in the outer-layer magnetic rod sleeve 3 along with the inner-layer magnetic rod sleeve 2, without departing from the scope of the present embodiment.
Still further, for convenience of processing, the cross-sectional shape of the magnetic rod 1 may be matched with the cross-sectional shape of the inner wall of the inner-layer magnetic rod sleeve 2, which may also be understood as follows: the cross section of the magnetic rod 1 is the same as that of the inner wall of the inner magnetic rod sleeve 2, for example, the cross section of the inner magnetic rod sleeve 2 and that of the outer magnetic rod sleeve 3 may be both circular rings, and the cross section of the outer wall of the inner magnetic rod sleeve 2 and that of the inner wall of the outer magnetic rod sleeve 3 may be both circular.
Further, in order to facilitate the operation of relative movement between the magnetic rod assemblies, the length of the magnetic rod 1 is greater than that of the inner-layer magnetic rod sleeve 2, and the length of the inner-layer magnetic rod sleeve 2 is greater than that of the outer-layer magnetic rod sleeve 3.
Still further, referring to fig. 11, in order to facilitate manual operation of the magnetic rod 1, for example, to extract or insert the magnetic rod 1, a pull rod 13 may be further disposed at one end of the magnetic rod, wherein the shape and material of the pull rod 13 are not limited, and as long as the shape and material are capable of facilitating extraction and insertion, the scope of the present embodiment is not deviated.
Further, the magnetic rod 1 may be made of a permanent magnet or an electromagnet, and when the magnetic rod 1 is an electromagnet, referring to fig. 12, the magnetic rod assembly further includes an electromagnetic control device 6, the electromagnetic control device 6 is electrically connected to the electromagnet, and when the electromagnet is powered on, the electromagnet generates a magnetic force, which is shown in the foregoing, if the magnetic rod 1 is made of an electromagnet, the process of inserting the magnetic rod 1 into the inner magnetic rod sleeve 2 specifically includes: the process of inserting the electromagnet into the magnet sleeve 2 and energizing the electromagnet, when the electromagnet is de-energized, the electromagnet loses its magnetic force, which is equivalent to withdrawing the magnet bar 1 from the inner magnet sleeve 2 as described above.
In a specific scheme, at least one of the movements of the magnetic rod 1, the inner-layer magnetic rod sleeve 2 and the outer-layer magnetic rod sleeve 3 can be realized through automatic control, for example: the magnetic rod 1, the inner layer magnetic rod sleeve 2 and the outer layer magnetic rod sleeve 3 can be respectively connected with corresponding driving parts, and then the magnetic rod 1, the inner layer magnetic rod sleeve 2 and the outer layer magnetic rod sleeve 3 can be driven by the driving parts. No matter whether adopt automated control, how to realize the drive again, do not break away from the scope of the embodiment of the utility model.
It can be seen, the embodiment of the utility model provides an among the bar magnet subassembly, can be through bar magnet 1, inlayer bar magnet cover 2, mutually support between the outer bar magnet cover 3, relative motion, realize the independent operation magnetic bead (for example, the separation of magnetic bead, shift and mixing), independent operation sample liquid (for example, the joining of liquid, the suction with, mixing and shifting) and magnetic bead and sample liquid simultaneous operation (for example, suction liquid when separating the magnetic bead, join liquid when separating the magnetic bead), enriched the function based on the bar magnet of bar magnet cover, the equipment structure of nucleic acid extraction has been simplified, help improving the operating efficiency of nucleic acid extraction, and simultaneously, provide the basis for the full automatization of various operations in the nucleic acid extraction technique.
The utility model also provides a nucleic acid extraction element, including the bar magnet subassembly that above alternative involved.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; although the present invention has been described in detail with reference to the foregoing embodiments, it should be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the present invention.
Claims (10)
1. A magnetic rod assembly is characterized by comprising a magnetic rod, an inner-layer magnetic rod sleeve and an outer-layer magnetic rod sleeve;
the inner magnetic rod sleeve and the outer magnetic rod sleeve respectively comprise a hollow rod sleeve main body with two end parts; wherein:
a first end of the two ends of the inner layer magnetic rod sleeve is closed, and a second end of the two ends of the inner layer magnetic rod sleeve is open; the cross section size of at least part of the outer wall of the magnetic rod is smaller than or equal to that of the inner wall of the inner layer magnetic rod sleeve, and the magnetic rod can be selectively inserted into the inner layer magnetic rod sleeve or separated from the inner layer magnetic rod sleeve from the second end of the inner layer magnetic rod sleeve;
a first end and a second end of the two ends of the outer layer magnetic rod sleeve are both open; the cross section size of the inner wall of the outer layer magnetic rod sleeve is closely matched with the cross section size of at least part of the outer wall of the inner layer magnetic rod sleeve, so that the inner layer magnetic rod sleeve can be inserted into the outer layer magnetic rod sleeve from the second end of the outer layer magnetic rod sleeve and can reciprocate along the inner wall of the outer layer magnetic rod sleeve.
2. The magnetic bar assembly of claim 1,
the assembly state of the magnetic bar component comprises a first assembly state and a second assembly state;
when the magnetic rod is in the first assembly state, the magnetic rod is inserted into the inner-layer magnetic rod sleeve, and the inner-layer magnetic rod sleeve is inserted into the outer-layer magnetic rod sleeve;
when the magnetic rod is in the second assembly state, the inner layer magnetic rod sleeve is inserted into the outer layer magnetic rod sleeve, and the magnetic rod is not inserted into the inner layer magnetic rod sleeve.
3. The magnet bar assembly of claim 1 wherein the magnet bar has a cross-sectional shape of at least one of:
a circular shape;
a polygon;
an oval shape.
4. The magnet bar assembly of claim 1 wherein the cross-sectional shape of the magnet bars matches the cross-sectional shape of the inner wall of the inner layer magnet bar sleeve.
5. The rod magnet assembly of claim 1 wherein the cross-sectional shape of the inner layer of rod jackets is circular in shape as compared to the cross-sectional shape of the outer layer of rod jackets; the cross section of the outer wall of the inner layer magnetic rod sleeve and the cross section of the inner wall of the outer layer magnetic rod sleeve are both circular.
6. The magnet bar assembly of claim 1 wherein the magnet bar has a length greater than a length of the inner layer magnet bar sleeve; the length of the inner layer magnetic rod sleeve is larger than that of the outer layer magnetic rod sleeve.
7. The magnet bar assembly of claim 1 wherein one end of the magnet bar is provided with a pull rod.
8. The assembly of claim 1, wherein the material of the magnetic rod comprises a permanent magnet or an electromagnet.
9. The assembly of claim 8, wherein when the magnetic rod is made of an electromagnet, the assembly further comprises an electromagnetic control device electrically connected to the electromagnet.
10. A nucleic acid extraction apparatus comprising the magnetic rod assembly according to any one of claims 1 to 9.
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| CN202120141943.1U CN215162833U (en) | 2021-01-19 | 2021-01-19 | Magnetic rod assembly and nucleic acid extraction device |
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| CN202120141943.1U CN215162833U (en) | 2021-01-19 | 2021-01-19 | Magnetic rod assembly and nucleic acid extraction device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113960313A (en) * | 2021-12-22 | 2022-01-21 | 上海思路迪医学检验所有限公司 | Exosome ALK fusion protein magnetic immunochemiluminescence detection kit |
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2021
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113960313A (en) * | 2021-12-22 | 2022-01-21 | 上海思路迪医学检验所有限公司 | Exosome ALK fusion protein magnetic immunochemiluminescence detection kit |
| CN113960313B (en) * | 2021-12-22 | 2022-04-12 | 上海思路迪医学检验所有限公司 | Exosome ALK fusion protein magnetic immunochemiluminescence detection kit |
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