CN212213762U - Container for collecting and preserving biopsy samples - Google Patents
Container for collecting and preserving biopsy samples Download PDFInfo
- Publication number
- CN212213762U CN212213762U CN201921856693.9U CN201921856693U CN212213762U CN 212213762 U CN212213762 U CN 212213762U CN 201921856693 U CN201921856693 U CN 201921856693U CN 212213762 U CN212213762 U CN 212213762U
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- container
- cup
- shaped body
- perforating
- needle
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0096—Casings for storing test samples
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/025—Align devices or objects to ensure defined positions relative to each other
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0672—Integrated piercing tool
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
- B01L2300/123—Flexible; Elastomeric
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
A container (10) for collecting and preserving a biopsy sample (S), comprising: a cup-shaped body (16) for containing a biopsy sample (S) to be preserved; a cap (18) of elastomeric material releasably mounted on the mouth of the cup-shaped body (16); a container (22) manufactured as a bellows element and filled with a preservation solution; a needle (26) adapted to perforate the cap (18), the needle (26) having a passage (28) in fluid communication with the container (22) to allow an operator to introduce the preservation solution contained in the container (22) into the cup-shaped body (16) by squeezing the container (22); and a safety cap member (34) adapted to seal the passage (28) so as to prevent the preservation solution contained in the container (22) from flowing out until the needle (26) has pierced the cap (18), so as to put the container (22) in fluid communication with the cup-shaped body (16) via the passage (28).
Description
Technical Field
The utility model relates to a container for collecting and preserving biopsy sample.
Background
The biopsy sample is usually collected in a dedicated container after removal from the patient, containing a preservative, usually formalin (aqueous formaldehyde solution). The container with the biopsy sample immersed in formalin can then be closed and sent to the laboratory for analysis. Formalin and other preserving agents are toxic substances, particularly carcinogenic substances, by inhalation. Therefore, there is a need to prevent the operator from coming into direct contact with formalin, which is used as a preservative for preserving the biopsy samples, or in any case from being exposed to the vapors of formalin.
To meet this need, specific containers for collecting and preserving biopsy samples have been conceived.
A container for collecting and storing biopsy samples is known, for example, from WO 2012/171529. According to this known solution, the container comprises a body adapted to contain the biopsy sample to be preserved and a lid adapted to be engaged by screwing the body to tightly close the body. The cap comprises a container containing a preservation solution (e.g. formalin) and sealed by a septum, and a piercing member arranged to push against the septum to tear the septum, thereby allowing the preservation solution contained in the container to flow out of the container and fill the body of the container to submerge the biopsy sample. Such known containers are rather complex and expensive to manufacture.
SUMMERY OF THE UTILITY MODEL
The object of the present invention is to provide a container for collecting and preserving biopsy samples, the safety level of which is unchanged, simpler than the above-mentioned prior art and cheaper to manufacture.
According to the present invention, this and other objects are achieved in full by a container comprising:
a cup-shaped body for receiving a biopsy sample to be preserved,
a cap of resilient material releasably mounted over the mouth of the cup-shaped body,
a container filled with a preservation solution, said container being made as a bellows element,
a perforating device for perforating the lid, said perforating device having at least one passage in fluid communication with the container to allow an operator to introduce the preservation solution contained in the container into the cup-shaped body by squeezing the container, and
sealing means for sealingly closing said at least one passage, thereby preventing preservation solution contained in the container from flowing out of the container until said perforating means has perforated the lid, thereby placing the container in fluid communication with the cup-shaped body via said at least one passage.
The container according to the invention is simple and cheap to manufacture, since the number of parts is reduced, and since such parts can easily be manufactured by plastic moulding or similar manufacturing processes.
Drawings
Other features and advantages of the invention will become apparent from the following detailed description, given by way of non-limiting example only, with reference to the accompanying drawings, in which:
fig. 1 is a partial cross-sectional view schematically illustrating two main components of a container for collecting and preserving biopsy samples according to the present invention;
FIG. 2 is an exploded perspective view of the container of FIG. 1; and is
Fig. 3 to 5 are partial cross-sectional views showing the container of fig. 1 in three different positions during use by an operator after the operator has placed a biopsy sample to be preserved in the cup of the container.
Detailed Description
Referring initially to fig. 1 and 2, a container for collecting and storing biopsy samples in accordance with one embodiment of the present invention is generally designated 10.
The container 10 basically comprises two parts 12 and 14, hereinafter referred to as first and second parts, respectively, which are separated from each other in an initial use condition of the container (as shown in fig. 1) and which are mounted one on the other in a final use condition of the container (as shown in fig. 3 to 5).
The first part 12 comprises an open-topped cup-shaped body 16 for receiving a biopsy sample (denoted S in figures 3 to 5) to be preserved. The cup-shaped body 16 comprises a base 16a and a side wall 16b (for example cylindrical) and is preferably made of a transparent plastic material. The first part 12 further comprises a cover 18 of elastic material releasably mounted on the mouth (top side) of the cup-shaped body 16 to allow an operator to insert a biopsy sample S into the cup-shaped body 16. Preferably, the lid 18 has a reduced thickness in a central section to allow easy perforation of the lid when the operator introduces the preservation solution into the cup-shaped body, as will be explained in more detail below.
The second component 14 basically includes a perforated member 20, a container 22 filled with a preservation solution (e.g., formalin) and a protective cap 24.
The perforating member 20 comprises a central needle element 26, hereinafter simply referred to as needle, which is arranged to perforate the cover 18, preferably at the centre (section of reduced thickness) of the cover 18. The needle 26 has an internal passage 28 that passes completely through the needle and allows the preservation solution to flow to the cup-shaped body 16 once the needle 26 pierces the cap 18.
The perforating member 20 further comprises a plurality of guides 30 arranged around the needle 26, preferably evenly angularly spaced (for example, three guides arranged at 120 ° to each other, or four guides arranged at 90 ° to each other). The guide means 30 are configured to cooperate with the side walls 16b of the cup-shaped body 16 to allow the guide perforated member 20 to slide along the longitudinal axis (indicated with z) of the cup-shaped body 16, i.e. in a vertical direction, when the operator pushes the perforated member 20 towards the bottom of the cup-shaped body 16 to perforate the lid 18.
The piercing member 20 also includes a connecting element 32 in fluid communication with the internal passage 28 of the needle 26.
Preferably, the different elements of the perforating member 20 described above, i.e. the needle 26, the guide means 30 and the connecting element 32, are made of one piece of plastic material.
In the initial delivery state of the container, the needle 26 is covered by a safety cap member 34, which safety cap member 34 is made of a plastic material softer than the material of the needle 26, so that it can be easily pierced by the needle itself. A safety cap member 34 is mounted on needle 26 to attach to needle 26 and close off interior passage 28.
The container 22 is made as a bellows element and is connected to the connection element 32 of the perforating member 20 so that, when the operator presses it, the preservation solution contained therein is pumped into the cup-shaped body 16, the preservation solution flowing through the internal channel 28 of the needle 26.
The protective cover 24 is shaped to releasably couple with the perforated member 30 and to surround the container 22 in a state of coupling with the perforated member 30. In this way, the protective cover 24 not only acts as a protective element for the container 22, but also as an actuating member that can be acted on by the operator to push the perforating member 30 towards the bottom of the cup-shaped body 16, so as to perforate the cover 18.
The operation of the container 10 is as follows.
In the initial transport state of the container 10, the first component 12 and the second component 14 are separated from each other.
As for the first part 12, the cup-shaped body 16 is sealed by a lid 18. With respect to the second component 14, the container 22 is protected by the protective cap 24, while the interior passage 28 of the needle 26 is closed by the safety cap member 34. Therefore, the preservation solution contained in the container 22 does not have a chance to flow out.
Once the biopsy sample S is removed from the patient, the operator removes the cover 18 from the cup-shaped body 16, places the biopsy sample S within the cup-shaped body 16, thereby closing the cup-shaped body 16 with the cover 18.
In this regard, the operator mounts the second component 14 on the first component 12 with the needle 26 of the piercing member 20 protected by the safety cover member 34 abutting the cover 18 and the guide 30 of the piercing member 20 disposed about the cover 18, as shown in fig. 3.
In this regard, as shown in fig. 4, the operator pierces the cap 18 by pushing the protective cap 24 and the piercing member 20 with the needle 26 as they are pushed towards the bottom of the cup-shaped body 16. Since safety cap member 34 is made of a plastic material that is softer than the material of needle 26, needle 26 can easily pierce safety cap member 34 and thus underlying cap 18, as described above, cap 18 advantageously having a reduced thickness cross-section corresponding to needle 26 to facilitate piercing. In this step, the piercing member 20 is guided in movement with respect to the cup-shaped body 16 by the guiding means 30. In this way, easy movement and correct centering of the perforating member 20 and of the needle 26 together with the perforating member 20 with respect to the cup-shaped body 16 are ensured.
Referring now to fig. 5, once the needle 26 has passed completely through the cap 18, and therefore the channel 28 of the needle 26 is in communication with the interior of the cup-shaped body 16, the operator removes the protective cap 24 by squeezing the container 22 and injects the preservation solution into the cup-shaped body 16 until the biopsy sample S is completely immersed in the preservation solution. The operator then places the protective cap 24 back over the piercing member 20 to close the container 22. The container 10 is now ready to be transferred to an analysis laboratory for analysis of the biopsy sample S collected therein.
As is apparent from the above description, the container for collecting and preserving biopsy samples according to the present invention has a simple structure, which is made of parts that can be manufactured by a low-cost plastic molding process. The container is therefore cheap to manufacture, yet ensures the required safety features against the risk of contact with the preservation solution or exposure to vapour generated by the preservation solution.
Naturally, the principle of the invention remaining the same, the embodiments and the constructional details may be widely different from those described and illustrated purely by way of non-limiting example, without thereby departing from the scope of the invention.
For example, the container may also include a safety ring mounted to seal the top body to further enhance the safety level of the container.
Claims (8)
1. A container (10) for collecting and preserving a biopsy sample (S), characterized in that it comprises:
a cup-shaped body (16) for receiving a biopsy sample (S) to be preserved,
a cap (18) of elastic material releasably mounted on the mouth of the cup-shaped body (16),
a container (22) manufactured as a bellows element and filled with a preservation solution,
a perforating device for perforating the lid (18), the perforating device having at least one passage (28) in fluid communication with the container (22) to allow an operator to introduce the preservation solution contained in the container (22) into the cup-shaped body (16) by squeezing the container (22), and
-sealing means (34) for sealingly closing said at least one passage (28) so as to prevent preservation solution contained in said container (22) from flowing out of said container (22) until said perforating means have perforated said lid (18) so as to place said container (22) in fluid communication with said cup-shaped body (16) via said at least one passage (28).
2. The container according to claim 1, further comprising a connecting element (32), the container (22) being connected to the perforation means by the connecting element (32) to allow a preservation solution contained in the container (22) to flow through the at least one channel (28).
3. Container according to claim 2, characterized in that it further comprises guide means (30) for guiding said perforating means in cooperation with said cup-shaped body (16) when perforating said lid (18).
4. The container of claim 1, further comprising: a connection element (32), by means of which the container (22) is connected to the perforation means, to allow the preservation solution contained in the container (22) to flow through the at least one channel (28); and a guide device (30) for guiding the perforating device in cooperation with the cup-shaped body (16) when perforating the lid (18).
5. Container according to claim 3, wherein the perforation means are made in one piece with the connecting element (32) and/or the guide means (30).
6. Container according to claim 3, wherein the perforating means are made in one piece with the connecting element (32) and/or with the guide means (30), and further comprising guide means (30) for guiding the perforating means in cooperation with the cup-shaped body (16) when perforating the lid (18).
7. The container according to claim 1, wherein the perforation means comprise a needle (26) and wherein the sealing means (34) comprise a cover member made of a material softer than the needle (26) and mounted on the needle (26) to adhere to the needle (26) and close the at least one passage (28).
8. A container according to any of claims 1 to 7, further comprising a protective cover (24) arranged to fit around the container (22) to completely enclose the container (22) and prevent access to the container (22).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT201800010354 | 2018-11-15 | ||
| IT102018000010354 | 2018-11-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN212213762U true CN212213762U (en) | 2020-12-25 |
Family
ID=65767088
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201921856693.9U Active CN212213762U (en) | 2018-11-15 | 2019-10-30 | Container for collecting and preserving biopsy samples |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN212213762U (en) |
| WO (1) | WO2020100083A1 (en) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3369708A (en) * | 1965-09-07 | 1968-02-20 | Lincoln Lab Inc | Means for reconstituting a dry biological and for controlled dispensing thereof |
| ATE57612T1 (en) * | 1983-05-20 | 1990-11-15 | Bengt Gustavsson | ARRANGEMENT FOR THE TRANSFER OF A SUBSTANCE. |
| US20030053938A1 (en) * | 2001-09-19 | 2003-03-20 | Becton, Dickinson And Company. | Liquid specimen collection container |
| US10576468B2 (en) * | 2014-01-20 | 2020-03-03 | Abogen, Inc. | Devices, solutions and methods for sample collection |
| US10729617B2 (en) * | 2016-03-29 | 2020-08-04 | Phipps Innovations, Llc | System, apparatus, and method for extending the useful life of medicine |
-
2019
- 2019-10-30 CN CN201921856693.9U patent/CN212213762U/en active Active
- 2019-11-14 WO PCT/IB2019/059794 patent/WO2020100083A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020100083A1 (en) | 2020-05-22 |
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| GR01 | Patent grant | ||
| GR01 | Patent grant |