CN209751955U - system for treating depression based on 3D printing ear mold - Google Patents
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Abstract
the utility model relates to the technical field of a system for treating depression based on a 3D printing ear mold, which comprises an ear vagus nerve stimulation system, a mobile equipment module, a hospital PC end, a maintenance end and a cloud server; the ear vagus nerve stimulation system comprises a pulse detection module, a Bluetooth module, a state display module, a power supply module, a DC-DC adjustable boosting and voltage stabilizing module, a first boosting module, a second boosting module, a third boosting module and a data processing module; the stimulation frequency is 15-30Hz, the output current is 1-10mA (250 omega load impedance), the output power is 0.1-0.3VA (250 omega load impedance), and the pulse width is 0.2ms +/-30%; the treatment course is timed to be 20-40min, the system for treating the depression provided by the utility model can well combine and analyze the data in the brain waves and the depression through the stimulation parameter setting, thereby playing the role of stimulation treatment.
Description
Technical Field
the utility model relates to an ear vagus nerve stimulation system, especially a system based on 3D prints ear mould treatment depression.
Background
At present, the population suffering from depression worldwide reaches 3.22 hundred million people, and the coming Chinese brain plan also puts depression into the focus of research. In 2005, implantable vagus nerve stimulation was approved by the FDA as an antidepressant therapy, but it was expensive, and had a serious risk of postoperative infection, and it was not yet effectively generalized. The study shows that the concha region is the only region with vagus nerve distribution on the body surface, wherein the 100% vagus nerve distribution of the concha can more accurately activate the vagus nerve compared with other parts of the external ear, and the obvious antidepressant effect is generated. Meanwhile, the vagus nerve distribution region is just the key site (such as spleen, kidney and liver) for the acupuncture and moxibustion therapy of depression in traditional Chinese medicine (as shown in figure 1), which is contrary to the traditional medical concept! Depression is not only a psychogenic disease, but also an abnormality of brain waves. Previous experiments prove that abnormal discharge occurs in the beta wave frequency band (14-30Hz) of the brain waves in a depression state, and the auricular vagus nerve stimulation at 20Hz (just within the beta wave frequency band) can produce more optimal anti-depression effect compared with other frequencies, namely, the beta wave abnormality is closely related to depression emotion. Therefore, both traditional medicine and modern medicine can be used as theoretical supports for the effectiveness of the therapy.
On one hand, the current diseases guided under the auricular vagus nerve stimulation therapy are wide in range, such as epilepsy, diabetes, insomnia, depression and the like, while the pathogenesis of various diseases is different, the same stimulation parameters are selected, and obviously, the method is unreasonable. On the other hand, the existing stimulation parameters for treating depression have a large range (1.5Hz-120Hz), and the definition of effective stimulation parameters is unclear.
In addition, the systems of the prior art for treating depression stimulate the area, which is not capable of achieving precise single-point stimulation.
SUMMERY OF THE UTILITY MODEL
The technical scheme of the utility model is that: a system for treating depression based on a 3D printed ear mold comprises an ear vagus nerve stimulation system, a mobile device module, a hospital PC (personal computer) terminal, a maintenance terminal and a cloud server; the ear vagus nerve stimulation system comprises a pulse detection module, a Bluetooth module, a state display module, a power supply module, a DC-DC adjustable boosting and voltage stabilizing module, a first boosting module, a second boosting module, a third boosting module and a data processing module; the output end of the power supply module is connected with the input end of the first boosting module, and the output end of the first boosting module is connected with the input end of the data processing module; the output end of the data processing module is connected with the input end of the display module and the input end of the second boosting module respectively, the output end of the second boosting module is connected with the input end of the DC-DC adjustable boosting and voltage stabilizing module, the output end of the DC-DC adjustable boosting and voltage stabilizing module is connected with the input ends of the ear vagus nerve stimulation system and the pulse detection module respectively, the output end of the power supply module is connected with the input end of the third boosting module, and the output end of the third boosting module is connected with the input end of the pulse detection module; the data processing module is connected with the mobile equipment module through a Bluetooth module, stimulation parameters are selected through the mobile equipment module, the mobile equipment end is connected with the cloud server through a network, and the cloud server is also connected with a hospital PC end and a maintenance end;
The stimulation parameters comprise stimulation frequency, pulse width, treatment course timing, output power and output current;
The stimulation frequency is 15-30Hz, and the output current is 1-10mA (250 omega load impedance);
The output power is 0.1-0.3VA (250 omega load impedance), and the pulse width is 0.2ms +/-30%; the treatment course is timed to be 20-40 min;
Preferably, the stimulation frequency is 20Hz, and the treatment course timing is 25-35 min;
preferably, the treatment course timing is 30 min;
Preferably, the ear vagus nerve stimulation system further comprises a personal ear acupoint positioning module and an ear vagus nerve stimulation instrument;
The personal auricular point positioning module scans the ears of the patients by using a 3D technology, captures 3D images of biological tissues with micron resolution and prints to form an ear canal model of a specific patient;
The ear vagus nerve stimulation system is characterized in that an ear vagus nerve stimulation instrument is fixed in an ear canal model of a patient printed by a personal auricular point positioning module;
Preferably, the auricular vagus nerve stimulation apparatus includes an array signal generator;
Preferably, the array signal generator is composed of a plurality of electrodes, and the diameter of each electrode is 1 cm;
Preferably, the first voltage boosting module boosts the voltage of the power supply module from 3V to 5V to supply power to the data processing module, the second voltage boosting module boosts the amplitude of the pulse signal output by the data processing module from 5V to 9V, and the third voltage boosting module boosts the voltage of the power supply module from 3V to 12V to supply power to the pulse detection module;
Preferably, the data processing module adopts an MCU, and the MCU adopts MK66FX1M0VLQ18 as a main control chip;
Preferably, the MCU comprises a PWM module, a timer, a FLASH data reading and writing unit, and a data reading module, wherein the PWM module generates a pulse wave with a specific pulse width and frequency and outputs the pulse wave to the second boosting module; the timer outputs a pulse signal to ensure the robustness; the read-write FLASH data unit is used for storing pulse setting parameters in real time and automatically reading the stored parameters after starting up; the data reading module reads the data of the pulse detection module, analyzes whether the output pulse width and the amplitude meet the requirements or not, and displays the result in the display module;
Preferably, the display module displays the state of the output signal of the ear vagus nerve stimulation system;
When the output waveform meets the requirement, the display module displays that the green light is on;
When the output waveform basically accords with the standard waveform but the amplitude fluctuates, the display module displays that the blue light is on;
When the output waveforms do not conform, the display module displays that the red light is on.
Preferably, the DC-DC adjustable voltage boosting and stabilizing module performs voltage boosting and stabilizing processing on the pulse signal output by the MCU to control the voltage boosting amplitude, thereby realizing control of the pulse intensity.
Compared with the prior art, the utility model discloses the beneficial effect who produces is:
(1) the utility model can determine the auricular point to be treated according to the shape of the cavum concha of the patient, and accurately output pulse stimulation to the corresponding region of the auricular point;
(2) the ear vagus nerve stimulation instrument provided by the utility model combines the traditional ear acupuncture points to provide possibility for individual treatment;
(3) The system for treating depression based on the 3D printing ear mold can effectively improve depression symptoms; the stimulation area is more accurate, and single-point stimulation can be realized;
(4) The utility model provides a system based on 3D prints ear mould treatment tristimania passes through the amazing parameter setting, can be with the data in the brain wave and the fine combination analysis of tristimania to the effect of the amazing treatment of performance.
drawings
FIG. 1 is a schematic diagram of key parts of acupoint selection in the treatment of depression by traditional Chinese medicine acupuncture and moxibustion in the prior art;
Fig. 2 is a schematic structural diagram of a system for treating depression based on a 3D printing ear mold provided by the present invention;
fig. 3 is a schematic structural diagram of an ear vagus nerve stimulation system provided by the present invention;
Detailed Description
the following description of the embodiments of the present invention will be made with reference to the accompanying drawings:
referring to fig. 2, fig. 2 is a schematic structural diagram of a system for treating depression based on a 3D printing ear mold provided by the present invention; a system for treating depression based on a 3D printed ear mold comprises an ear vagus nerve stimulation system, a mobile device module, a hospital PC (personal computer) terminal, a maintenance terminal and a cloud server; the ear vagus nerve stimulation system comprises a pulse detection module, a Bluetooth module, a display module, a power supply module, a DC-DC adjustable boosting and voltage stabilizing module, a first boosting module, a second boosting module, a third boosting module and a data processing module; the output end of the power supply module is connected with the input end of a first boosting module, the output end of the first boosting module is connected with the input end of the data processing module, and the first boosting module boosts the voltage of the power supply module from 3V to 5V so as to supply power to the data processing module; the output end of the data processing module is respectively connected with the input end of the display module and the input end of the second boosting module, the output end of the second boosting module is connected with the input end of the DC-DC adjustable boosting and voltage stabilizing module, the amplitude of a pulse signal output by the data processing module is increased from 5V to 9V by the second boosting module, the output end of the DC-DC adjustable boosting and voltage stabilizing module is respectively connected with the input ends of the ear vagus nerve stimulation system and the pulse detection module, the output end of the power supply module is connected with the input end of the third boosting module, and the output end of the third boosting module is connected with the input end of the pulse detection module; the third boosting module boosts the voltage of the power supply module from 3V to 12V so as to supply power to the pulse detection module, the data processing module is connected with the mobile equipment module through the Bluetooth module and selects stimulation parameters through the mobile equipment module, the mobile equipment end is connected with the cloud server through a network, and the cloud server is also connected with a hospital PC end and a maintenance end;
the DC-DC adjustable voltage boosting and stabilizing module performs voltage boosting and stabilizing treatment on the pulse signal output by the MCU, and controls the voltage boosting amplitude, thereby realizing the control of the pulse intensity.
Wherein, the stimulation parameters provided by the utility model comprise stimulation frequency, pulse width, treatment course timing, output power and output current;
the stimulation frequency is 15-30Hz, preferably 20Hz, the output current is 1-10mA (250 omega load impedance),
The output power is 0.1-0.3VA (250 omega load impedance), and the pulse width is 0.2ms +/-30%; the treatment course is timed to be 20-40min, preferably 25-35min, more preferably 30 min;
wherein, the ear vagus nerve stimulation system also comprises a personal ear acupoint positioning module and an ear vagus nerve stimulation instrument;
The individual auricular point positioning module scans the ears of the patients by using a 3D technology, captures 3D images of biological tissues with micron resolution, and then prints and forms an ear canal model of a specific patient;
The ear vagus nerve stimulation system is characterized in that an ear vagus nerve stimulation instrument is fixed in an ear canal model of a patient formed by printing of a personal ear acupoint positioning module, wherein the ear vagus nerve stimulation instrument comprises an array signal generator; the utility model provides an array signal generator comprises a plurality of electrode, and the diameter of electrode is 1 cm.
the data processing module adopts an MCU (microprogrammed control unit), and the MCU adopts MK66FX1M0VLQ18 as a main control chip;
Referring to fig. 3, fig. 3 is a schematic structural diagram of an ear vagus nerve stimulation system provided by the present invention; the MCU comprises a PWM module, a timer, a FLASH data reading and writing unit and a data reading module, wherein the PWM module generates pulse waves with specific pulse width and frequency and outputs the pulse waves to the second boosting module; the timer outputs a pulse signal to ensure the robustness; the read-write FLASH data unit is used for storing pulse setting parameters in real time and automatically reading the stored parameters after starting up; the data reading module reads the data of the pulse detection module, analyzes whether the output pulse width and the amplitude meet the requirements or not, and displays the result in the display module.
Wherein, the MCU: and a core processor on the hardware side. The functions are as follows:
the driving Bluetooth module receives a data instruction from a user mobile device end, changes a pulse mode and intensity, and simultaneously sends detected pulse data to the user mobile end;
A PWM module: controlling a PWM module in the MCU to generate pulse waves with specific pulse width and frequency and outputting the pulse waves to the boosting module;
A data reading module: reading data of the pulse detection module, analyzing whether the output pulse width and amplitude meet requirements or not, and displaying the result in the display module;
reading and writing the FLASH data unit: storing pulse setting parameters in real time, and automatically reading the stored parameters after starting up;
configuring an MCU internal timer: and a pulse signal is output at fixed time, so that the robustness is ensured.
Example 1:
1. A hardware end:
1) The ear vagus nerve stimulation system also comprises a personal ear acupoint positioning module and an ear vagus nerve stimulation instrument;
personal auricular point positioning module: scanning the ear of a patient by using a 3D technology, capturing a 3D image of biological tissues with micron resolution, and printing to form an ear canal model of the specific patient;
The ear vagus nerve stimulation system is characterized in that an ear vagus nerve stimulation instrument is fixed in an ear canal model of a patient formed by printing of a personal ear acupoint positioning module, wherein the ear vagus nerve stimulation instrument comprises an array signal generator; the utility model provides an array signal generator comprises a plurality of electrode, and the diameter of electrode is 1 cm.
2) MCU: and a core processor on the hardware side. The functions are as follows:
A. The drive Bluetooth module receives a data instruction from the user mobile equipment terminal, changes the pulse mode and the intensity, and simultaneously sends the detected pulse data to the user mobile terminal
a PWM module for controlling the PWM module in the MCU to generate pulse wave with specific pulse width and frequency and outputting the pulse wave to the voltage boosting module
C. Reading the data unit, reading the data of the pulse detection module, analyzing whether the output pulse width and amplitude meet the requirements, and displaying the result in the display module
D. Reading and writing FLASH data unit, storing pulse setting parameters in real time, and automatically reading stored parameters after starting
E. the timer is configured with the MCU internal timer and outputs pulse signals at fixed time to ensure the robustness
3) A Bluetooth module: and receiving data from a mobile equipment end of a user, and sending pulse information extracted by a hardware end to the mobile end.
4) a boosting module: respectively 5V to 9V and 3V to 5V
A first boost module: the 3V to 5V boosting module boosts the 3V power supply of the system to 5V to supply the MCU for normal work
A second boost module: the 5V to 9V boosting module boosts the amplitude of the pulse signal output by the MCU to 9V
5) The pulse detection module: measuring the width and amplitude of the output pulse of the system, and sending the measured data to the MCU
6) a display module: displaying the state of the output signal of the system
A. the output waveform meets the requirement and turns on green light
B. the output waveform basically conforms to the standard but has fluctuation in amplitude, and the lamp is bright and blue
C. The output waveform of the system is not accordant and the system lights up a red light
7) A power supply module: the requirement is 3VDC, and the power supply is provided for the hardware system.
2. A software end:
1) a mobile device end: connect to the ear acupuncture point appearance through the bluetooth, specific function is as follows:
A. Receiving data from hardware end and displaying in waveform form
B. parameter instructions such as pulse mode, pulse intensity and the like can be sent to the hardware end
C. the APP account number of the user mobile terminal can only be connected to a designated hardware terminal in a matching manner
D. Uploading the user data to the cloud (server) in real time and storing the user data into a corresponding account database
E. The user history data can be acquired and displayed at the mobile terminal
F. user information authentication, modification, and modification of login password
G. The key selects a pulse parameter acquisition mode: mobile terminal/server terminal
2) the hospital PC end:
A. after logging in, the cloud can be accessed to acquire equipment information and account information of a specified user; user information can be added or deleted; can look over account password, help to find back the password
B. The parameters of the pulse output of the hardware end can be controlled through the cloud end, and remote medical treatment is realized
C. The pulse waveform output by the user equipment in real time can be observed, and historical data can also be read
3) A maintenance end:
A. Providing engineer or manager maintenance servers and databases
4) Cloud: establishing a special server and a database, and storing information and treatment data of a plurality of patients; allowing mobile devices, PC terminals, etc. to access historical data
1. MCU: MK66FX1M0VLQ18(32bit) is selected as a main control chip
the system requires that the frequency of output pulses is 1-120Hz, and the pulse width is 0.2ms +/-30%, so the higher the clock of the controller is, the better the clock is, the lower the clock frequency of the 8-bit MCU is checked, for example, STC89C51 is 8MHZ, PIC16 is 32MHZ, the limitation of the clock frequency can reduce the efficiency of the whole system, therefore, the system selects an MK66FX1M0VLQ18(32bit) singlechip with a clock main frequency of 180MHZ as the controller, the K66 singlechip is a 32-bit ARM core, and other parameters are as follows:
A. Standard frequency: 180 MHZ; 256K SRAM; 1024K +256K FLASH
B. Hardware floating point operations are supported; 3.3V 5V all can supply power
C.6 UART modules, 2 groups of IIC modules and 3 groups of SPI modules
d.2 way ADC module (optional 8Bit \10Bit \12Bit \16 Bit)
E.8 paths of PWM channels, the PWM precision can be modified to realize high-precision configuration
F. The chip is provided with a low-lock easy-to-release scheme, is not limited by locking caused by over-frequency or run-off, and has high reliability
G. has strong ROM API function, realizes rapid development and rapid debugging downloading, and can be debugged on line
2. a Bluetooth module: HC-05 master-slave integrated Bluetooth module
The bluetooth module mainly realizes the construction of a data transmission channel with a user mobile terminal, and the parameters of the module are as follows:
A. input voltage: 3.6V-6V, therefore the MCU can supply power directly
B. A 3.3V voltage stabilizing chip is loaded on the board; the power supply is prevented from reverse connection, and the module does not work when reverse connection is carried out, so that the safety is high
C.6 Pin: EN/VCC/GND/RXD/TXD/STATE with connection status indicator lamp
D. After the pairing is successful, the serial port can be used as a full-duplex serial port, and only supports the communication formats of 8-bit data bits, 1-bit stop bits and no parity bits
3. DC-DC adjustable boosting and voltage stabilizing module
Carry out the steady voltage processing that steps up with the pulse signal of MCU output, by the single chip microcomputer control amplitude that steps up to realize the control of pulse strength, the parameter of this module is as follows:
A. precision: 1 percent; conversion efficiency: can reach 95 percent
B. input voltage: 6V-30V; output voltage: 7V-32V is continuously adjustable, and can automatically store the last set voltage
C. Output current: 3A; output power: maximum 65W
D. Input reverse connection prevention protection measures are included; with short-circuit protection measures
4. pulse detection module
The system requires the frequency of output pulse to be 1-120Hz and the pulse width to be 0.2ms +/-30%, so that a high-precision measurement module is required to measure the output pulse, pulse parameters mainly comprise pulse width and pulse amplitude, the module mainly measures the pulse width, and the module parameters are as follows:
A. The pulse width measurement precision is ms level, and the measurement range is as follows: 0.01-62.5 ms; frequency range: 8Hz-50KHz
B. The minimum precision is 1 us; measuring rate: 2-3 times per second
C. The power supply voltage is: 12V or 24V (customizable)
5. Boost module (first boost module, second boost module, third boost module)
the system requires a 3V power supply to supply power, but the working voltage of the MCU is 5V, so that the voltage needs to be boosted from 3V to 5V; meanwhile, the input signal voltage of the DC-DC adjustable boosting and voltage stabilizing module needs to be larger than 6V, and the amplitude of the pulse voltage generated by the MCU is 5V, so that 5V needs to be boosted to 9V; the supply voltage of the pulse detection module is 12V at the lowest, so that the voltage of 3V needs to be boosted to 12V.
6. Display module
After the MCU reads the data of the pulse detection module, whether the output pulse parameters meet the requirements is judged, and meanwhile, the display module is driven to carry out corresponding display, and a three-color lamp is used for displaying in the design. The display requirements are as follows:
A. The output waveform meets the requirement and turns on green light
B. The output waveform basically conforms to the standard but has fluctuation in amplitude, and the lamp is bright and blue
C. The output waveform of the system is not accordant and the system lights up a red light
the utility model provides an amazing parameter does respectively: the stimulation frequency is 20Hz, the output current is 1-10mA (250 omega load impedance), the output power is 0.1-0.3VA (250 omega load impedance), and the pulse width is 0.2ms +/-30%; when the treatment course is timed to be 30min, the efficiency of curing the depression is higher, and the curative effect on patients is better.
the foregoing embodiments and description have been provided to illustrate the principles and preferred embodiments of the present invention, and various changes and modifications may be made without departing from the spirit and scope of the invention, which fall within the scope of the invention as claimed.
Claims (8)
1. a system for treating depression based on a 3D printed ear model is characterized by comprising an ear vagus nerve stimulation system, a mobile device module, a hospital PC (personal computer) terminal, a maintenance terminal and a cloud server; the ear vagus nerve stimulation system comprises a pulse detection module, a Bluetooth module, a state display module, a power supply module, a DC-DC adjustable boosting and voltage stabilizing module, a first boosting module, a second boosting module, a third boosting module and a data processing module; the output end of the power supply module is connected with the input end of the first boosting module, and the output end of the first boosting module is connected with the input end of the data processing module; the output end of the data processing module is connected with the input end of the display module and the input end of the second boosting module respectively, the output end of the second boosting module is connected with the input end of the DC-DC adjustable boosting and voltage stabilizing module, the output end of the DC-DC adjustable boosting and voltage stabilizing module is connected with the input ends of the ear vagus nerve stimulation system and the pulse detection module respectively, the output end of the power supply module is connected with the input end of the third boosting module, and the output end of the third boosting module is connected with the input end of the pulse detection module; the data processing module is connected with the mobile device module through a Bluetooth module, stimulation parameters are selected through the mobile device module, the mobile device end is connected with the cloud server through a network, and the cloud server is further connected with a hospital PC end and a maintenance end.
2. The system for treating depression according to claim 1, wherein the auricular vagus nerve stimulation system further comprises a personal auricular point location module, an auricular vagus nerve stimulation apparatus;
the personal auricular point positioning module scans the ears of the patients by using a 3D technology, captures 3D images of biological tissues with micron resolution and prints to form an ear canal model of a specific patient;
the ear vagus nerve stimulation system is characterized in that an ear vagus nerve stimulation instrument is fixed in an ear canal model of a patient printed by an individual auricular point positioning module.
3. The system for treating depression according to claim 2, wherein the ear vagus nerve stimulation device comprises an array signal generator.
4. The system for treating depression according to claim 3, wherein the arrayed signal generator is comprised of a plurality of electrodes, the electrodes being 1cm in diameter.
5. The system for treating depression according to claim 1, wherein the first voltage boosting module boosts the voltage of the power supply module from 3V to 5V to supply power to the data processing module, the second voltage boosting module boosts the amplitude of the pulse signal output by the data processing module from 5V to 9V, and the third voltage boosting module boosts the voltage of the power supply module from 3V to 12V to supply power to the pulse detection module.
6. The system for treating depression according to claim 1, wherein the data processing module employs an MCU, and the MCU employs MK66FX1M0VLQ18 as a master control chip.
7. the system for treating depression according to claim 6, wherein the MCU comprises a PWM module, a timer, a FLASH data reading and writing unit and a data reading module, wherein the PWM module generates pulse waves with specific pulse width and frequency and outputs the pulse waves to the second boosting module; the timer outputs a pulse signal to ensure the robustness; the read-write FLASH data unit is used for storing pulse setting parameters in real time and automatically reading the stored parameters after starting up; the data reading module reads the data of the pulse detection module, analyzes whether the output pulse width and the amplitude meet the requirements or not, and displays the result in the display module.
8. The system for treating depression according to claim 1, wherein the DC-DC adjustable voltage boosting and stabilizing module performs voltage boosting and stabilizing processing on the pulse signal output by the MCU to control the voltage boosting amplitude, thereby realizing the control of the pulse intensity.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109603003A (en) * | 2018-10-25 | 2019-04-12 | 中国中医科学院针灸研究所 | A kind of system based on 3D printing ear mold treatment depression |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109603003A (en) * | 2018-10-25 | 2019-04-12 | 中国中医科学院针灸研究所 | A kind of system based on 3D printing ear mold treatment depression |
| CN109603003B (en) * | 2018-10-25 | 2024-03-19 | 中国中医科学院针灸研究所 | Ear mold treatment system based on 3D printing |
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