CN209137753U - A kind of intracorporal electrode plate of implantable mouse - Google Patents
A kind of intracorporal electrode plate of implantable mouse Download PDFInfo
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- CN209137753U CN209137753U CN201820073934.1U CN201820073934U CN209137753U CN 209137753 U CN209137753 U CN 209137753U CN 201820073934 U CN201820073934 U CN 201820073934U CN 209137753 U CN209137753 U CN 209137753U
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Abstract
The utility model discloses a kind of implantable intracorporal electrode plates of mouse, substrate, the contact point unit being disposed on the substrate and interface unit including being implanted into mouse Epidural cavity or lower limb muscles surface, the contact point unit includes that electrical stimulating contacts and signal receive contact, the interface unit includes anode interface, cathode interface and interface of the ground wire, and two electrical stimulating contacts are electrically connected anode interface by conducting wire and the cathode interface forms stimulation circuit；Signal described in two of them receives contact and is electrically connected the anode interface and cathode interface formation feedback loop by conducting wire, one of them described signal receives contact and is electrically connected the interface of the ground wire by conducting wire, and the goldleaf for covering its surface is provided on the substrate.The utility model at least has the following advantages: having preferable resistance to corrosion and bio-compatibility, electrode plate can not only send stimulus signal but also can carry out collection and the feedback of signal, and positive and negative electrode and ground wire are integrated in one.
Description
Technical field
The utility model relates to animal experiment device technical field more particularly to a kind of intracorporal electrodes of implantable mouse
Plate.
Background technique
The research of mouse electro photoluminescence is concentrated mainly on to the Epidural cavity spinal cord stimulation trial of mouse and the lower limb of mouse at present
Muscle electric stimulation.Epidural cavity spinal cord stimulation trial is to be implanted into one group of stimulating electrode in epidural space by operation, by electric stimulation pulse
It is transferred in spinal cord, directly stimulation central nervous tissue.Commonly used approach is directly fixed using stainless steel electrode at present
To spinal cord Epidural cavity, or use FPC electrode plate.In the prior art, stainless steel electrode is coated with insulating layer using polytetrafluoroethylene (PTFE),
Disadvantages mentioned above is that the part of wire exposure is easy to the internal formation oxide layer in mouse, and implantation that cannot be long-term is to guarantee
The effect of stimulation.For currently used FPC plate, which are mainly applied to rats, and it equally exists problem easy to oxidize.
Patch electrode and needle electrode are mainly used for mouse lower limb muscles electro photoluminescence at present, the patch electrode exists
The shortcomings that be, in Study Mouse lower limb nerve loop, patch electrode is to paste on the skin, first without suitable for mouse
Gauge size, there is no specificity for next signal received.The needle electrode has the disadvantage that needle electrode is insertion
Into the muscle of mouse, the long-term myoelectricity for nondestructively detecting specific muscle can not be met.
Above two mode there is also the shortcomings that be, be merely able to mouse carry out electro photoluminescence, can not be to small after stimulation
The state of mouse carries out signal collection feedback, and needs additionally to draw ground wire all the way during experiment, and the device is complicated and to experiment
It is big to influence error.
Utility model content
The technical problem to be solved by the present invention is to provide a kind of implantable intracorporal electrode plates of mouse, have preferable
Resistance to corrosion and bio-compatibility, electrode plate can not only send stimulus signal but also can carry out collection and the feedback of signal,
And positive and negative electrode and ground wire are integrated in one.
In order to solve the above-mentioned technical problem, the utility model provides a kind of intracorporal electrode plate of implantable mouse, including
It is implanted into the substrate on mouse Epidural cavity or lower limb muscles surface, setting contact point unit on the substrate and interface unit respectively,
The contact point unit includes that multiple electrical stimulating contacts and signal receive contact, and the interface unit includes that anode interface, cathode connect
Mouthful and interface of the ground wire, electrical stimulating contacts described in wherein at least one the anode interface, at least one institute are electrically connected by conducting wire
It states electrical stimulating contacts and the cathode interface formation stimulation circuit is electrically connected by conducting wire；Signal described in wherein at least one receives touching
Point is electrically connected the anode interface by conducting wire, at least one described signal receives contact and is electrically connected cathode interface shape by conducting wire
At feedback loop, one of them described signal receives contact and is electrically connected the interface of the ground wire by conducting wire, is arranged on the substrate
There is the goldleaf for covering its surface.
Further, setting includes that 2 electrical stimulating contacts and 3 signals receive in the peridural contact point unit of mouse
Contact, each electrical stimulating contacts receive contact with a signal respectively and share a tip side.
Further, the contact point unit that mouse lower limb muscles surface is arranged in includes 2 electrical stimulating contacts and 3 letters
Number receive contact.
Further, the substrate stacking is provided with multilayer, and the overall thickness of substrate described in multilayer is between 58-62 μm.
Further, the anode interface, cathode interface and interface of the ground wire include cover film, and the cover film interval is set
It sets.
Further, strengthening course is provided with above the cover film.
Further, the thickness of the strengthening course is between 0.27-0.33 ㎜.
Further, the substrate is in " I " fonts, and each vertex of the substrate is connected using arc transition.
By above-mentioned technical proposal, the utility model at least has the following advantages:
1, by being provided with contact point unit and interface unit, by electrical stimulating contacts and signal receive contact respectively with anode
Interface and the electrical connection of cathode interface, on the basis of realizing to mouse electro photoluminescence, while may be implemented either synchronously or asynchronously to stimulation
The signal that mouse generates afterwards is collected, and observes the state of mouse effectively in real time；
2, contact is received by being provided with multiple electrical stimulating contacts and signal, can effectively avoids part touching occur in implantation
When point contact is bad, the shortcomings that being implanted into again is needed, flexibility and more adaptable；By the way that interface of the ground wire and positive and negative electrode are connect
Mouth is integrated in one, design compared with the existing technology, with preferable balanced impedance, reduces stimulus artifact and moves dry
The advantages of disturbing, reducing influence of noise；
3, by being provided with goldleaf, there is preferable resistance to corrosion and bio-compatibility, can effectively guarantee long-term
The stability and safety of implantation, simultaneously effective ensure that the accuracy of experimental data.
Detailed description of the invention
Fig. 1 is an angle overall structure diagram of the utility model；
Fig. 2 is another angle overall structure diagram of the utility model.
In the figures above: 1, substrate；2, electrical stimulating contacts；3, signal receives contact；4, anode interface；5, cathode interface；
6, interface of the ground wire；7, goldleaf；8, strengthening course.
Specific embodiment
The utility model is described in further detail in the following with reference to the drawings and specific embodiments, so that those skilled in the art
The utility model may be better understood and can be practiced, but illustrated embodiment is not as the restriction to the utility model.
Referring to figs. 1 and 2, the utility model discloses a kind of implantable intracorporal electrode plates of mouse, including respectively
It is implanted into substrate 1, the contact point unit being arranged on the substrate 1 and the interface unit of mouse Epidural cavity or lower limb muscles surface.Institute
It states substrate 1 and has been stacked multilayer, the overall thickness of substrate described in multilayer passes through above-mentioned set-up mode, energy between 58-62 μm
Enough rigidity for effectively guaranteeing substrate 1.The substrate 1 is in " I " fonts, and each vertex of the substrate 1 is connected using arc transition
It connects, the damage to mouse can be reduced smaller, while the corrosivity of substrate can be slowed down.
The contact point unit includes that multiple electrical stimulating contacts 2 and signal receive contact 3, and the interface unit connects including anode
Mouthfuls 4, cathode interface 5 and interface of the ground wire 6, electrical stimulating contacts 2 described in wherein at least one are electrically connected the anode by conducting wire and connect
Mouthfuls 4, electrical stimulating contacts 2 described in wherein at least one, which by conducting wire are electrically connected the cathode interface 5 and are formed, stimulates circuit；Wherein extremely
A few signal receives contact 3 and is electrically connected the anode interface 4, at least one signal reception contact 3 by conducting wire
Cathode interface 5, which is electrically connected, by conducting wire forms feedback loop.By above-mentioned set-up mode, electrical stimulating contacts 2 and signal are received
Contact 3 is electrically connected with anode interface 4 and cathode interface 5 respectively, on the basis of realizing to mouse electro photoluminescence, may be implemented simultaneously
The signal either synchronously or asynchronously generated to mouse after stimulation is collected, and observes the state of mouse effectively in real time.The utility model
In, signal, which is set gradually, along the direction close to the substrate middle line receives contact 3, electrical stimulating contacts 2.
In the utility model, setting includes 2 electrical stimulating contacts 2 and 3 letters in the peridural contact point unit of mouse
Number contact 3 is received, each electrical stimulating contacts 2 receive contact 3 with the signal respectively and share a tip side.By upper
The set-up mode stated can reduce the size of the implantation intracorporal substrate 1 of mouse as much as possible, and the normal physiological for not influencing mouse is living
It is dynamic；And the signal that can either synchronously or asynchronously generate to mouse after stimulation is collected, and observes the state of mouse effectively in real time.This
In utility model, the contact point unit that mouse lower limb muscles surface is arranged in includes that 2 electrical stimulating contacts 2 and 3 signals connect
Receive contact 3.By above-mentioned set-up mode, can effectively avoid needing again when part contact poor contact occurs in implantation
The shortcomings that implantation, flexibility and more adaptable.Setting receives contact 3 in the peridural signal of mouse and is arranged in mouse
The signal on lower limb muscles surface receives contact 3, wherein any one of signal, which receives contact 3, is electrically connected institute by conducting wire
It states interface of the ground wire 6, in the present invention, is preferably provided in the intermediate signal and receives contact 3 and be electrically connected the interface of the ground wire 6.It is logical
It crosses and interface of the ground wire 6, anode interface 4 and cathode interface 5 is integrated in one, design compared with the existing technology has preferable
Balanced impedance, the advantages of reducing stimulus artifact and motion artifacts, reducing influence of noise.
The anode interface 4, cathode interface 5 and interface of the ground wire 6 include cover film, the cover film interval setting.Institute
It states and is provided with strengthening course 7 above cover film, the thickness of the strengthening course 7 is between 0.27-0.33 ㎜.
It is provided with the goldleaf 8 for covering its surface on the substrate 1, by being provided with goldleaf 8, there is preferable anti-corruption
Erosion ability and bio-compatibility can effectively guarantee stability and safety that overall electrode plate is chronically implanted, while effectively
Ground ensure that the accuracy of experimental data.
Embodiment described above is only preferred embodiments for fully illustrating the utility model, the utility model
Protection scope it is without being limited thereto.Those skilled in the art made equivalent substitute or change on the basis of the utility model
It changes, both is within the protection scope of the present invention.The protection scope of the utility model is subject to claims.
Claims (8)
1. a kind of intracorporal electrode plate of implantable mouse, which is characterized in that including being implanted into mouse Epidural cavity or lower limb muscles respectively
The substrate on surface, setting contact point unit on the substrate and interface unit, the contact point unit include multiple electro photoluminescence touchings
Point and signal receive contact, and the interface unit includes anode interface, cathode interface and interface of the ground wire, described in wherein at least one
Electrical stimulating contacts are electrically connected the anode interface by conducting wire, at least one described electrical stimulating contacts passes through described in conducting wire electrical connection
Cathode interface forms stimulation circuit；Signal described in wherein at least one receive contact by conducting wire be electrically connected the anode interface,
At least one described signal receives contact and is electrically connected cathode interface formation feedback loop by conducting wire, one of them described signal connects
It receives contact and the interface of the ground wire is electrically connected by conducting wire, the goldleaf for covering its surface is provided on the substrate.
2. the implantable intracorporal electrode plate of mouse as described in claim 1, which is characterized in that be arranged in the peridural institute of mouse
Stating contact point unit includes that 2 electrical stimulating contacts and 3 signals receive contact, and each electrical stimulating contacts are respectively and described in one
Signal receives contact and shares a tip side.
3. the implantable intracorporal electrode plate of mouse as described in claim 1, which is characterized in that be arranged in mouse lower limb muscles table
The contact point unit in face includes that 2 electrical stimulating contacts and 3 signals receive contact.
4. the implantable intracorporal electrode plate of mouse as described in claim 1, which is characterized in that the substrate stacking is provided with more
Layer, the overall thickness of substrate described in multilayer is between 58-62 μm.
5. the implantable intracorporal electrode plate of mouse as described in claim 1, which is characterized in that the anode interface, cathode connect
Mouth and interface of the ground wire include cover film, the cover film interval setting.
6. the implantable intracorporal electrode plate of mouse as claimed in claim 5, which is characterized in that be provided with above the cover film
Strengthening course.
7. the implantable intracorporal electrode plate of mouse as claimed in claim 6, which is characterized in that the thickness of the strengthening course exists
Between 0.27-0.33 ㎜.
8. the implantable intracorporal electrode plate of mouse as described in claim 1, which is characterized in that the substrate is in " work " word
Each vertex of type, the substrate is connected using arc transition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820073934.1U CN209137753U (en) | 2018-01-17 | 2018-01-17 | A kind of intracorporal electrode plate of implantable mouse |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820073934.1U CN209137753U (en) | 2018-01-17 | 2018-01-17 | A kind of intracorporal electrode plate of implantable mouse |
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| CN209137753U true CN209137753U (en) | 2019-07-23 |
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| CN201820073934.1U Active CN209137753U (en) | 2018-01-17 | 2018-01-17 | A kind of intracorporal electrode plate of implantable mouse |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110404164A (en) * | 2019-08-29 | 2019-11-05 | 苏州大学 | Spinal cord closed loop electric stimulation |
| WO2023040509A1 (en) * | 2021-09-17 | 2023-03-23 | 苏州景昱医疗器械有限公司 | Stimulating electrode |
-
2018
- 2018-01-17 CN CN201820073934.1U patent/CN209137753U/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110404164A (en) * | 2019-08-29 | 2019-11-05 | 苏州大学 | Spinal cord closed loop electric stimulation |
| CN110404164B (en) * | 2019-08-29 | 2020-12-22 | 苏州大学 | Spinal cord closed loop electrical stimulation system |
| WO2021036165A1 (en) * | 2019-08-29 | 2021-03-04 | 苏州大学 | Closed-loop electrical spinal cord stimulation system |
| WO2023040509A1 (en) * | 2021-09-17 | 2023-03-23 | 苏州景昱医疗器械有限公司 | Stimulating electrode |
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