CN208928183U - Trace metal detects paper substrate micro-fluidic chip system in a kind of atmosphere pollution - Google Patents
Trace metal detects paper substrate micro-fluidic chip system in a kind of atmosphere pollution Download PDFInfo
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- CN208928183U CN208928183U CN201820625579.4U CN201820625579U CN208928183U CN 208928183 U CN208928183 U CN 208928183U CN 201820625579 U CN201820625579 U CN 201820625579U CN 208928183 U CN208928183 U CN 208928183U
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- fluidic chip
- paper substrate
- substrate micro
- photosensitive resin
- filter paper
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Abstract
The utility model relates to trace metals in a kind of atmosphere pollution to detect paper substrate micro-fluidic chip system.Scanning element including paper substrate micro-fluidic chip, for acquiring paper substrate micro-fluidic chip testing result and the processing unit being connect with scanning element；The paper substrate micro-fluidic chip includes the filter paper layer positioned at bottom, the hollow out circle photosensitive resin layer above filter paper layer, the hollow out circle photosensitive resin layer includes the analysis channel being separately connected positioned at the sample injection port in the center of circle, the N number of and sample injection port of equidistantly distributed, each analysis channel is disposed with pretreating zone, detection zone along away from sample injection port direction, the hollow out circle photosensitive resin layer further includes N number of colorimetric reference corresponding with detection zone area, wherein, N is positive integer.The utility model structure is simple, at low cost, can be improved PM2.5Trace metal analysis efficiency and precision.
Description
Technical field
The utility model relates to trace metals in a kind of atmosphere pollution to detect paper substrate micro-fluidic chip system.
Background technique
Along with the fast development of China's economy and continuing to increase for energy consumption, the extreme weathers such as haze take place frequently, shadow
Ring national physically and mentally healthy and the economic development potentialities.The extreme weathers such as haze take place frequently, and affect national physically and mentally healthy and economic hair
Open up potentiality.Fine particle PM2.5It is to form one of principal element of haze.Meanwhile the PM to suspend in air2.5Particle has larger
Specific surface area, it is extremely strong to the adsorption capacity of the organic matters such as cycloaromatics, trace metal and virus, this will increase healthy life body it is thin
Generation gene mutation intracellular and canceration risk.Wherein, trace metal can be with PM2.5Entered in human body by respiratory tract, skin etc.,
Vivo protein and various enzymes are inactivated across cell membrane and a variety of organs are affine, and then damages brain, liver, bone and nerve
System.Accurate and efficient analysis PM2.5Trace metal element component and study its to the toxic effect mechanism of healthy cell be wound
New method for governing pollution promotes the horizontal important scientific premise of prevention and control.In conventional methods where, fine particle PM2.5Sample preparation is adopted
Collection and detection need to be completed in different experiments room by distinct device.Typical trace metal element detecting instrument is inductive coupling
Plasma spectrometer, Atomic Absorption Spectrometer etc., average test cost are hundreds of dollars, and need to be grasped by Specialty Experiment personnel
Vertical, detection cycle is usually 5 ~ 10 days.Therefore, there is testing cost height, period length, specialized requirement height and samples for tradition research
Equal limitation easy to pollute in this transport process.Traditional detection method and development of new detection instrument are improved, PM is improved2.5Trace metal
Analysis efficiency and precision have most important theories researching value and practical meaning in engineering.
Summary of the invention
The purpose of this utility model is to provide trace metals in a kind of atmosphere pollution to detect paper substrate micro-fluidic chip system
System, the system structure is simple, at low cost, can be improved PM2.5Trace metal analysis efficiency and precision.
To achieve the above object, the technical solution of the utility model is: trace metal detects paper in a kind of atmosphere pollution
Base micro-fluidic chip system, scanning element including paper substrate micro-fluidic chip, for acquiring paper substrate micro-fluidic chip testing result,
And the processing unit being connect with scanning element；The paper substrate micro-fluidic chip includes positioned at the filter paper layer of bottom, positioned at filter paper
Layer top hollow out circle photosensitive resin layer, the hollow out circle photosensitive resin layer include positioned at the center of circle sample injection port, etc.
The analysis channel that the N number of and sample injection port of spacing distribution is separately connected, each analysis channel is along away from sample injection port direction
It is disposed with pretreating zone, detection zone, the hollow out circle photosensitive resin layer further includes N number of colorimetric corresponding with detection zone
Reference area, wherein N is positive integer.
In an embodiment of the utility model, the filter paper layer uses chemical analysis filter paper.
In an embodiment of the utility model, the size of the round photosensitive resin layer is less than filter paper layer, so that circular light
Quick resin layer is integrally covered in filter paper layer surface.
In an embodiment of the utility model, the scanning lens of the scanning element be set to paper substrate micro-fluidic chip just on
Side.
In an embodiment of the utility model, the N takes 12.
In an embodiment of the utility model, the scanning element is mobile phone.
Compared to the prior art, the utility model has the following beneficial effects: the utility model structure is simple, at low cost,
It can be improved PM2.5Trace metal analysis efficiency and precision.
Detailed description of the invention
Fig. 1 is the utility model paper substrate micro-fluidic chip schematic layout pattern.
Fig. 2 is the top view of Fig. 1.
Fig. 3 is paper substrate micro-fluidic chip process flow.
Specific embodiment
With reference to the accompanying drawing, the technical solution of the utility model is specifically described.
As shown in Figure 1, trace metal detects paper substrate micro-fluidic chip system in a kind of atmosphere pollution of the utility model,
Including paper substrate micro-fluidic chip, for acquiring paper substrate micro-fluidic chip testing result scanning element (can be used mobile phone etc. other
Scanning device with shooting function) and the processing unit that is connect with scanning element；The paper substrate micro-fluidic chip includes position
In the filter paper layer 1 of bottom, the hollow out circle photosensitive resin layer 2 above filter paper layer, the hollow out circle photosensitive resin layer 2 is wrapped
Include the sample injection port 3 positioned at the center of circle, N number of (N takes 12 in this example) of equidistantly distributed is separately connected with sample injection port 3
Analysis channel 4, each analysis channel 4 is disposed with pretreating zone 5, detection zone 6 along away from 3 direction of sample injection port, described
Hollow out circle photosensitive resin layer 2 further includes N number of colorimetric reference corresponding with detection zone 6 area 7, wherein N is positive integer.It is described
Filter paper layer uses chemical analysis filter paper.The size of the circle photosensitive resin layer is less than filter paper layer, so that round photosensitive resin layer
Entirety is covered in filter paper layer surface.The scanning lens of the scanning element is set to the surface of paper substrate micro-fluidic chip.
The following are the specific implementation processes of the utility model.
The utility model is directed to current PM2.5The problem of trace metal detects is based on micro manufacturing, microflow control technique,
Provide the environment-friendly type paper base micro-fluidic chip system that a kind of structure is simple, at low cost.Chip is with ordinary chemical analysis filter paper
Basis material is processed on filter paper close/hydrophobic logical with high hydrophobicity photosensitive resin even spread filter paper using ultraviolet photolithographic technology
Road and functional unit.Metal detection is based on chromatography colorimetric method, by complex reaction of different metal under the conditions of specific pH value,
Obtain the product of specific color.For quantitative analysis reaction product, chip measuring system model machine is processed using 3D printing technique, is
System captures and reads product pattern by smart phone camera lens, can make numerical value processing to pattern by corresponding image software for calculation
With analysis, feedback obtains tenor information in final sample to be detected.
The paper substrate micro-fluidic chip of the utility model designs: chip design uses two-dimension plane structure, reagent pre-coating, into
The fluids such as the sample driving capillary force effect intrinsic based on fiber filter paper, i.e., unmodified region (or developer solution etched area) retain filter paper
Hydrophily, and photosensitive resin curing area is then modified to hydrophobicity.In the circular work region central design sample introduction zone of 20 mm of diameter
(5.0 mm of φ)；12 detection zones of circumference uniform distribution (2.0 mm of φ), between detection zone and sample introduction zone by microchannel (20.0 ×
1.0 mm) connection；The oval pretreating zone (a:3.5 mm, b:1.5 mm) of microchannel central design, it is molten for balance sample
Liquid pH-value or the anti-interference reagent of pre-coating；In each detection zone adjacent 15 on circumferenceoDesign control group reaction zone (φ 2.0
Mm), to assess the environmental background signal strength in experiment, control group is not connected with any structure.Chip overall dimensions are
25.0×25.0 mm.As shown in Figure 1, 2, wherein Fig. 1 marks chip three-dimensional structure and each functional unit layout；Fig. 2 is chip
It is laid out top view.The design can at most measure 12 kinds of metal element contents simultaneously.Chip design is described as follows: outside chip
Profile is designed as circle, to guarantee inside different analytical units that flow resistance is consistent and sample diffusion process indifference, sample sample introduction zone
Uniquely and it is located at the center of circle, the channel of 12 analytical units equidistantly dissipates around.In addition, chip Shanghai devises 12 colorimetric ginsengs
Examination district, to remove background signal in subsequent image analysis.
The paper substrate micro-fluidic chip of the utility model is processed: filter paper is cut into regular square by laser cutting machine by step 1.
Sheet；Step 2. takes 0.5 ml photosensitive resin (such as 2000.5 type photoresist of SU-8) to drop to monolithic filter paper (25.0 × 25.0
Mm), the positive and negative surface of chip is wiped with common print paper after photoresist complete wetting filter paper；Step 3. shifts filter paper to 45oC
Horizontal hot plate carries out drying glue, is completely dried photoresist inside filter paper；Step 4. transfer filter paper to ultraviolet exposure machine is contacted
Formula exposure, exposure parameter specifically refer to SU-8 official workshop manual depending on different shaped photoresist；Step 5. will filter after exposure
Paper submerges in developer solution, takes out drying after chip design is high-visible；Step 6. cuts pressure membrane and is sealed on chip unilateral side,
To ensure micro fluid dynamcis stabilization and ne-leakage.Based on same process process, changing filter paper size can expand the chip manufacture
It opens up more extensive.For example, taking A4 size (210mm × 297mm) filter paper that 48 comparable size design chips can be processed.Fig. 3
It is the chip manufacture flow diagram of the utility model, hydrophobicity photoresist can be formed after uv-exposure on chip stablizes knot
Filter paper matrix is divided parent/hydrophobic region by structure.
The system design and model machine of the utility model manufacture: conventional paper substrate micro-fluidic colorimetric analysis is set by means of scanner etc.
Standby, chip colorimetric analysis in the utility model substitutes scanner using smart phone, have it is more portable, more rapidly with it is more environmentally friendly
The advantages that.To guarantee to have in different chip weld colorimetry image collection process good consistency, system uses enclosed construction；It is more
A framework uses modularized design, convenient for saving parking space and disassembly；Design mobile phone holding tank, it is ensured that camera lens to collected core
Piece constant distance (or being adjustable to constant).Design work is mainly completed in commercialization computer-aided three-dimensional design software.It borrows
Increases material manufacturing technology, the disparate modules of print system model machine framework are helped, intermodule can be spliced by corresponding connection structure.Printed material
Recyclable organism degradable material polylactic acid is selected, to guarantee system lock and light-proofness, material color selects black.By software
Each module three dimensional design completed imports 3D printer and controls software, completes printing precision and support construction etc. in control software
Setting, and complete last molding.
It is the preferred embodiment of the utility model above, it is all to change according to made by technical solutions of the utility model, it is produced
Function without departing from technical solutions of the utility model range when, belong to the protection scope of the utility model.
Claims (3)
1. trace metal detects paper substrate micro-fluidic chip system in a kind of atmosphere pollution, which is characterized in that including paper base miniflow
Control chip, the scanning element for acquiring paper substrate micro-fluidic chip testing result and the processing unit connecting with scanning element；
The paper substrate micro-fluidic chip includes the filter paper layer positioned at bottom, the hollow out circle photosensitive resin layer above filter paper layer, institute
Stating hollow out circle photosensitive resin layer includes distinguishing positioned at the sample injection port in the center of circle, the N number of and sample injection port of equidistantly distributed
The analysis channel of connection, each analysis channel is disposed with pretreating zone, detection zone along away from sample injection port direction, described
Hollow out circle photosensitive resin layer further includes N number of colorimetric reference corresponding with detection zone area, wherein N is positive integer；The scanning
The scanning lens of unit is set to the surface of paper substrate micro-fluidic chip；The N takes 12.
2. trace metal detects paper substrate micro-fluidic chip system in a kind of atmosphere pollution according to claim 1, special
Sign is that the filter paper layer uses chemical analysis filter paper.
3. trace metal detects paper substrate micro-fluidic chip system in a kind of atmosphere pollution according to claim 1, special
Sign is that the scanning element is mobile phone.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820625579.4U CN208928183U (en) | 2018-04-28 | 2018-04-28 | Trace metal detects paper substrate micro-fluidic chip system in a kind of atmosphere pollution |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201820625579.4U CN208928183U (en) | 2018-04-28 | 2018-04-28 | Trace metal detects paper substrate micro-fluidic chip system in a kind of atmosphere pollution |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114345430A (en) * | 2022-01-14 | 2022-04-15 | 北京工商大学 | Portable device for simultaneously detecting multiple antibiotic residues through paper-based micro-fluidic chip |
-
2018
- 2018-04-28 CN CN201820625579.4U patent/CN208928183U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114345430A (en) * | 2022-01-14 | 2022-04-15 | 北京工商大学 | Portable device for simultaneously detecting multiple antibiotic residues through paper-based micro-fluidic chip |
| CN114345430B (en) * | 2022-01-14 | 2022-10-28 | 北京工商大学 | Portable device for simultaneously detecting multiple antibiotic residues through paper-based micro-fluidic chip |
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