CN208770520U - Combination type biological Artificial Liver Support System - Google Patents
Combination type biological Artificial Liver Support System Download PDFInfo
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- CN208770520U CN208770520U CN201820190166.8U CN201820190166U CN208770520U CN 208770520 U CN208770520 U CN 208770520U CN 201820190166 U CN201820190166 U CN 201820190166U CN 208770520 U CN208770520 U CN 208770520U
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- branch pipeline
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Landscapes
- External Artificial Organs (AREA)
Abstract
A kind of combination type biological Artificial Liver Support System, support system includes at least sequentially connected branch pipeline: upstream termination is set as the blood input branch pipeline of blood input terminal, including at least first point of slurry branch pipeline of the first plasma separator, including at least plasma perfusion device, the abiotic purification branch pipeline of bilirubin adsorption device, including at least the biological cleaning branch pipeline of hepatocyte cultures canister assembly, what downstream end was set as blood output end returns slurry branch pipeline, first point of slurry branch pipeline and biological cleaning branch pipeline, between the arrival end of abiotic purification branch pipeline, between the outlet end and biological cleaning branch pipeline of abiotic purification branch pipeline, it is abiotic purification branch pipeline outlet end and return slurry branch pipeline between by three-way device connection, three-way device includes three-way connection and the branch that connect respectively with three-way connection, at least two branches are respectively equipped with Constriction and connecting parts.
Description
Technical field
The utility model relates generally to biological field and medical instruments field, has complex function more particularly to one kind
Artificial liver support system.
Background technique
China is the high-incidence country of liver diseases, and liver diseases can finally develop as liver distribution, due to liver function
Energy failure, mortality is higher, treats also relatively difficult.Clinically, liver transplant is as current most effective liver disease
Means the problems such as expense is high and human autoimmune's system repels, limit answering for liver transplant since donor is rare
With.Simultaneously during waiting liver transplant, patient still endures the influence of liver distribution, the constitution and body of patient to the fullest extent
Body situation is possible to be affected to being not suitable for being applicable in hepatic transplantation.
Artificial liver will extend part or long period patient's service life and the promotion of not applicable hepatic transplantation at present
Quality of life also can provide the control state of an illness for the patient for waiting donor, preparation to receive hepatic transplantation, the journey for delaying liver to deteriorate
Degree promotes successful surgery probability.In the prior art, the function that artificial liver is realized is relatively simple, mainly catharsis, to
It excludes in patient's body blood because of metabolic function missing caused by compromised liver function or detraction bring toxin buildup.Existing people
Work liver can not achieve the processing of the comprehensive condition of the serious patient of hepatic failure, patient needs replacing more machines due to having a single function
Device leads to the increased costs of patient, also making patients' body burden and psychological pressure.Switching between a variety of machines can also be led
Technical staff's learning cost is caused to increase, operation difficulty rises, shallow storage space increase in demand.
The utility model is intended to provide a kind of new combination type biological Artificial Liver Support System, can be realized multiple functions
Switching.
Utility model content
The utility model provides a kind of combination type biological Artificial Liver Support System, and the support system includes at least successively
The branch pipeline of connection: upstream termination is set as the blood input branch pipeline of blood input terminal, includes at least the first plasma separator
First point slurry branch pipeline, including at least plasma perfusion device, bilirubin adsorption device abiotic purification branch pipeline, include at least liver
What the biological cleaning branch pipeline of cell culture canister assembly, downstream end were set as blood output end returns slurry branch pipeline, and described first
Divide between slurry branch pipeline and the biological cleaning branch pipeline, the abiotic arrival end for purifying branch pipeline, the abiotic purification point
Between the outlet end of pipeline and the biological cleaning branch pipeline, it is described it is abiotic purification branch pipeline outlet end and return slurry branch pipeline
Between connected by three-way device, the three-way device includes three-way connection and the branch that connect respectively with the three-way connection,
At least two branches are respectively equipped with constriction and connecting parts.
Preferably, first point of slurry branch pipeline includes: first exported equipped with blood entry port, plasma outlet port, haemocyte
Plasma separator and by conduit connect with the plasma outlet port divide stock pump, from it is described divide stock pump extend to downstream point slurry
Branch and it is connected to first three-way device for dividing slurry branch end, wherein described point of slurry branch and first threeway
First three-way connection of device is directly connected to, remaining branch extended from first three-way connection is equipped with the constriction and connects
Refute part.
It is highly preferred that the abiotic purification branch pipeline includes: the plasma perfusion device exported equipped with perfusion entrance, perfusion,
The bilirubin adsorption device that perfusion outlet is connected by conduit extends to the first purification branch in downstream from the bilirubin adsorption device
And it is connected to the second three-way device of first purification branch end；Wherein, the first purification branch and described second
Second three-way connection of three-way device is directly connected to, remaining branch extended from second three-way connection is equipped with the constriction
And connecting parts.
Further, the biological cleaning branch pipeline includes: to close the oxygenator of outlet equipped with oxygen, close the company of outlet with the oxygen
The circulating pump that connects, the hepatocyte cultures canister assembly being connect with the circulating pump by circulation branch road and with hepatocyte cultures tank group
Stock pump is returned in part connection, from it is described return that stock pump extends to downstream return slurry branch.
Further, the slurry branch pipeline of returning includes at least: connecting the haemocyte and exports and be equipped with whole blood outlet
The bubble monitor of haemocyte mixer, the connection whole blood outlet, the bubble monitor are also connected with the blood output end,
The upstream termination for returning slurry branch pipeline is connected to third three-way device, and the third three-way connection of the third three-way device is described
The upstream of third three-way connection extends branch and respectively by the constriction and connecting parts, and connection first purifies branch and returns slurry
Branch.
Still further, the biological cleaning branch pipeline and return slurry branch pipeline between be additionally provided with second point of slurry branch pipeline, institute
It states second point of slurry branch pipeline and includes at least the second blood plasma separation equipped with the second plasma inlet, the second plasma outlet port, cell outlet
Device, second plasma inlet connect hepatocyte cultures canister assembly, return slurry branch pipeline described in the second plasma outlet port connection.
It is further preferred that the cell outlet is connected with to deposition of cells or cell fragment and adjustment flow velocity difference
Liquid storage bottle, the liquid storage bottle be also connected with oxygen close outlet and circulating pump entrance.
It is further preferred that the second chamber of the cell outlet connection liquid storage bottle, the first chamber and the second chamber
Cell fragment or cell of the partition sedimentation is isolated are equipped between room.
Further, hepatocyte cultures canister assembly described in hepatocyte cultures canister assembly include hepatocyte cultures tank body and
The entrance of the circulation line connected by conduit with valve member, the circulation line connects the circulating pump, the circulation pipe
Slurry branch pipeline is returned described in the outlet connection on road.
It is further preferred that the valve member includes the first valve, the second valve, third valve, the 4th valve, it is described
Circulation line includes the first circulation pipeline connecting with the first valve, the second circulation pipeline connecting with the second valve and third
The third circulation line of valve connection, the 4th circulation line connecting with the 4th valve, the first circulation pipeline are followed with second
Endless tube road is connected by first interface, and the first interface connects the circulation branch road, and the third circulation line is followed with the 4th
Endless tube road is connected by second interface, and stock pump is returned described in the second interface connection, and the first circulation pipeline and third recycle
Pipeline is connected by third interface, one end of third interface access hepatocyte cultures tank body, the second circulation pipeline with
4th circulation line is connected by the 4th interface, the other end of the 4th interface access hepatocyte cultures tank body.
It is further preferred that the fluid flow direction of the third interface and the 4th interface is incorgruous.
Preferably, the branch of the three-way device connect with the conduit for the branch pipeline being connected by screw member, casing
At least one connection type of component connection.
It is highly preferred that the structure of screw member connection include the branch being externally threaded and one end be tapped with
The conduit of the branch pipeline for the internal screw thread that external screw thread matches.
Further, the conduit and branch junction are additionally provided with to screw branch pipeline and branch and providing resistance and enhancing
The casing of leakproofness.
The utility model, which provides a kind of combination type biological Artificial Liver Support System, can preferably solve partial technical problems,
And it has an advantage that
(1) a kind of combination type biological Artificial Liver Support System involved in the utility model, not by three-way device control
With the on-off of branch pipeline, enter the support system in different modes, convenient for pointedly carrying out at differentiation to blood
Reason；
(2) a kind of combination type biological Artificial Liver Support System involved in the utility model, by adjusting threeway dress
The quantity set and position can also increase or delete the branch pipeline with different function, further adjust the support system
Integrated function；
(3) a kind of combination type biological Artificial Liver Support System involved in the utility model, passes through Reasonable Arrangement liver cell
The circulation line of canister assembly and the on-off of reasonable control valve component are cultivated, may be implemented a variety of in hepatocyte cultures canister assembly
The mode of fluid flowing；
(4) a kind of combination type biological Artificial Liver Support System involved in the utility model, by being arranged in different pipelines
Thermoregulator, be able to maintain that in the support system and system that fluid, hepatocyte cultures canister assembly etc. are in body temperature model
In enclosing, the control in different temperatures section is provided for the branch pipeline of different function.
Detailed description of the invention
The utility model is above-mentioned and/or additional aspect and advantage from the following description of the accompanying drawings of embodiments will
Become obvious and be readily appreciated that, in which:
Fig. 1 is the overall structure figure of combination type biological Artificial Liver Support System described in the utility model；
Fig. 2 is that blood described in the utility model inputs branch pipeline structure chart；
Fig. 3 is first point of slurry branch pipeline structure chart described in the utility model；
Fig. 4 is abiotic purification branch pipeline structure chart described in the utility model；
Fig. 5 is biological cleaning branch pipeline structure chart described in the utility model；
Fig. 6 is that described in the utility model return starches branch pipeline structure chart；
Fig. 7 is three-way device structure chart described in the utility model；
Fig. 8 is second point of slurry branch pipeline structure chart described in the utility model；
Fig. 9 is liquid storage bottle structure chart described in the utility model；
Figure 10 is the abiotic purification pattern schematic diagram of the utility model combination type biological Artificial Liver Support System；
Figure 11 is the biological cleaning pattern diagram of the utility model combination type biological Artificial Liver Support System；
Figure 12 is the composite mode schematic diagram of the utility model combination type biological Artificial Liver Support System.
Specific embodiment
The embodiments of the present invention are described below in detail, examples of the embodiments are shown in the accompanying drawings.Below by
The embodiment being described with reference to the drawings is exemplary, and is only used for explaining the utility model, and cannot be construed to the utility model
Limitation.For the ease of showing that the practical application of the combination type biological Artificial Liver Support System, following embodiments will introduce institute
The specific component part of support system is stated, shows the component connection relationship of the support systematic difference and the support system
It more sufficiently and is easy to understand, it is notable that the protection scope of the utility model is not by being limited.
It (is called in the following text referring to FIG. 1, Fig. 1 illustrates a kind of combination type biological Artificial Liver Support System 1 provided by the present embodiment
" support system 1 ") overall structure.The branch pipeline that the support system 1 is included at least and connected, the branch pipeline include:
Upstream termination is set as the blood input branch pipeline 11 of blood input terminal 111, including at least the first of the first plasma separator 121
Point slurry branch pipeline 12, including at least plasma perfusion device 131, the abiotic purification branch pipeline 13 of bilirubin adsorption device 132, at least wrap
Include the biological cleaning branch pipeline 14 of hepatocyte cultures canister assembly 141, downstream end is set as the slurry that returns of blood output end 151 and is in charge of
Road 15.It is described first point slurry branch pipeline 12 and the biological cleaning branch pipeline 14, it is abiotic purification branch pipeline 13 arrival end it
Between, it is described it is abiotic purification branch pipeline 13 outlet end and the biological cleaning branch pipeline 14 between, it is described it is abiotic purification point
The outlet end of pipeline 13 and returning is connected between slurry branch pipeline 15 by three-way device 16.It please be attached to and refer to Fig. 7, the three-way device
16 include three-way connection 161 and the first branch 162-1 connecting respectively with the three-way connection 161, remaining two branch ---
Pinch valve 163 and screwed assembly 164 are respectively equipped on second branch 162-2, third branch 162-3.Other possible
In embodiment, the pinch valve 163 can be using the coutroi velocities such as non-return valve, idler wheel valve and the valve of conduit on-off substitution
Or it is used in mixed way.The three-way connection 161 connects second, the branch of the first branch 162-1 and first branch 162-1
Road 162-2, third branch 162-3, fluid is generated in three-way connection 161 and is shunted or interflow, and flows into the from first branch 162-1
Two branch 162-2, third branch 162-3, or first branch 162-1 is imported from second branch 162-2, third branch 162-3.?
In the present embodiment, in order to preferably control the blood input terminal 111 and blood output end 151, close to blood input terminal
111 catheter downstream is provided with the input terminal valve 111-1 of control blood input 11 on-off of branch pipeline, exports close to blood
The catheter downstream at end 151 is provided with the output end valve 151-1 that slurry 15 on-off of branch pipeline is returned in control.When encountering emergency case,
Operator can close the input terminal valve 111-1 and output end valve 151-1 in time, can protect the support system
And the safety of patient.The input terminal valve 111-1 and output end valve 151-1 in the present embodiment, can be using folders
Pipe valve.
With continued reference to FIG. 7, specifically, the screwed assembly 164 include be externally threaded second branch 162-2 or
The line end 164-1 of third branch 162-3 further includes that the other end attacks internal thread branch pipeline conduit 164-2.The outer spiral shell
Line is mutually matched with the internal screw thread.More specifically, the screwed assembly 164 further includes casing 164-3, described sleeve pipe
164-3 provides resistance appropriate to screw the line end 164-1 and branch pipeline conduit 164-2, and user is helped to make
Used time rapidly screws pipeline, and avoiding user because both hands are wet, pipeline is smooth etc., reasons cause to skid.Described sleeve pipe 164-3
Auxiliary connection and sealing are played in the junction that line end 164-1 and branch pipeline conduit 164-2 can also be coated after screwing
The effect of leakproof.Described sleeve pipe 164-3 can be made of soft, flexible material, such as rubber, silica gel, plastics.?
In other possible embodiments, the line end 164-1 and branch pipeline conduit 164-2 at least one at be equipped with the prominent of wing
It rises, applies active force convenient for user.The similar structure of subsequent three-way device 16, such as the first three-way device 16A, the second threeway fill
Set 16B, third three-way device 16C please refers to above structure.
Specifically, Fig. 1 and Fig. 3 is please referred to, first point of slurry branch pipeline 12 includes: equipped with blood entry port 121-1, blood
Slurry outlet 121-2, haemocyte export the first plasma separator 121 of 121-3 and by conduit and the plasma outlet port 121-2
Connection divides stock pump 122, divides stock pump 122 to extend to dividing slurry branch 123 and be connected to and described dividing slurry branch for downstream from described
First three-way device 16A of 123 ends, wherein the first threeway of described point of slurry branch 123 and the first three-way device 16A
Connector is directly connected to, and the branch road extended from first three-way connection is equipped with pinch valve 163 and the (figure of screwed assembly 164
In do not show).Please auxiliary reference Fig. 7, the specific structure of the first three-way device 16A please refers to three-way device 16, described
The specific structure of one three-way connection please refers to three-way connection 161, and the branch that first three-way connection extends please refers to second
Road 162-2, third branch 162-3.In the pinch valve 164 that first point is starched branch pipeline 12, pinch valve 163-1A, pinch valve 163-
2A controls different branch on-off respectively.
More specifically, please referring to Fig. 1 and Fig. 4, the abiotic purification branch pipeline 13 includes: equipped with perfusion entrance 131-
1, the plasma perfusion device 131 of perfusion outlet 131-2 connects the bilirubin adsorption device 132 that perfusion exports 131-2 by conduit, from
The bilirubin adsorption device 132 extends to the first purification branch 133 in downstream and is connected to 133 end of the first purification branch
The second three-way device 16B at end.Wherein, the first purification branch 133 is connected with the 2nd 3 of the second three-way device 16B
Head is directly connected to, and the branch road extended from second three-way connection is equipped with pinch valve 163 and screwed assembly 164 (in figure
Do not show).Please auxiliary reference Fig. 7, the specific structure of the second three-way device 16B please refers to three-way device 16, described second
The specific structure of three-way connection please refers to three-way connection 161, and the branch that second three-way connection extends please refers to second branch
162-2, third branch 162-3.In the pinch valve 164 of abiotic purification branch pipeline 13, pinch valve 163-1B, pinch valve 163-
2B controls different branch on-off respectively.
Further specifically, Fig. 1 and Fig. 5 is please referred to, the biological cleaning branch pipeline 14 includes: to close to export equipped with oxygen
The oxygenator 142 of 142-1 closes the circulating pump 143 for exporting 142-1 and connecting with the oxygen, passes through circulation branch with the circulating pump 143
The hepatocyte cultures canister assembly 141 of road 143-1 connection and what is connect with hepatocyte cultures canister assembly 141 return stock pump 144, from institute
State return stock pump 144 extend to downstream return slurry branch 144-1.
Further specifically, Fig. 1 and Fig. 6 is please referred to, the slurry branch pipeline 15 of returning includes at least in the present embodiment:
Connect the haemocyte outlet 121-3 and haemocyte mixer 152, the connection whole blood outlet equipped with whole blood outlet 152-1
The bubble monitor 153 of 152-1, the bubble monitor 153 is also connected with the blood output end 151, described to return slurry branch pipeline
15 upstream termination is connected to third three-way device 16C.Wherein, described to return slurry branch pipeline 15 and the third three-way device 16C's
Third three-way connection is directly connected to, and the branch road extended from the third three-way connection is equipped with pinch valve 163 and threaded connection group
Part 164 (does not show) in figure.Please auxiliary reference Fig. 7, the specific structure of the third three-way device 16C please refers to three-way device
16, the specific structure of the third three-way connection please refers to three-way connection 161, and the branch that the third three-way connection extends please join
Examine second branch 162-2, third branch 162-3.In the pinch valve 164 for returning slurry branch pipeline 15, pinch valve 163-1C, pinch valve
163-2C controls different branch on-off respectively.In the present embodiment, the slurry branch pipeline 15 of returning is connected by pinch valve 163-1C
The abiotic purification branch pipeline 13 is connect, the slurry branch pipeline 15 of returning is in charge of by the pinch valve 163-2C connection biological cleaning
Road 14.In the present embodiment, for the pinch valve 163-1C and pinch valve 163-2B due to being closer, the branch of control is identical,
Pinch valve 163-1C is merged with pinch valve 163-2B in the present embodiment, only with a pinch valve.
Further specifically, please refer to Fig. 1 and Fig. 8, the biological cleaning branch pipeline 14 with return slurry branch pipeline 15 it
Between be additionally provided with second point of slurry branch pipeline 17, second point of slurry branch pipeline 17 includes at least be equipped with the second blood plasma in the present embodiment
The second plasma separator 171 of entrance 171-1, the second plasma outlet port 171-2, cell outlet 171-3, second plasma inlet
171-1 connection hepatocyte cultures canister assembly 141 returns slurry branch pipeline 15 described in the second plasma outlet port 171-2 connection.In this reality
It applies in example, the second plasma outlet port 171-2 is by returning stock pump 144 and further being accessed by returning slurry branch 144 described in connection
It is described to return slurry branch pipeline 15.It is worth noting that, the cell outlet 171-3 is in the present embodiment, input is possible mixing
There are the plasma mixtures of the impurity such as cell, cell fragment, bubble, and is not merely limited to cell.
Further specifically, please refer to Fig. 1 and Fig. 9, the cell outlet 171-3 be connected with to deposition of cells or
Cell fragment and the liquid storage bottle 18 for adjusting flow velocity difference, the liquid storage bottle 18 are also connected with oxygen and close outlet 142-1 and circulating pump
143 entrance.The cell outlet 171-3 connects the second chamber 182 of the liquid storage bottle 18, first chamber 181 and the second chamber
Partition 183 is equipped between room 182 for the cell and cell fragment to settle down to be isolated.
After the plasma mixtures enter the first chamber 181 of liquid storage bottle 18, under the action of gravity or other external force, blood
The impurity of pulp mixture starts to settle, and supernatant is more pure blood plasma, after the accumulation of certain time, the position of blood plasma
By the highest point of the excessively not described partition 183, second chamber 182 is flowed into, and hepatocyte cultures canister assembly is entered by circulating pump 143
141.Second plasma separator 171 is connected to the cooperation of liquid storage bottle 18, is able to ascend the utilization rate of blood plasma, is avoided in separation blood
After slurry, excessive blood plasma is discarded, causes to waste, cell fragment obstruction conduit or branch pipeline is also avoided, local pressure is caused to rise sharply.Institute
Strainer or filter membrane can also be substituted in other possible embodiments by stating partition 183, in order in real time, rapidly filter
Pure blood plasma out, into circulating pump 143.In addition to this, the liquid storage bottle 18 can also balance the flow velocity in support system 1.
More specifically, Fig. 1 and Fig. 5 is please referred to, hepatocyte cultures canister assembly 141 described in hepatocyte cultures canister assembly 141
The circulation line 141-3 connected including hepatocyte cultures tank body 141-1 and by conduit with valve member 141-2, it is described to follow
The entrance of endless tube road 141-3 connects the circulating pump 143, and the outlet of the circulation line 141-3 is by returning stock pump 144 and institute
Return slurry branch 144-1 connection described in return starch branch pipeline 15.
Further specifically, with continued reference to FIG. 5, the valve member 141-2 includes the first valve 141-2A, the second valve
Door 141-2B, third valve 141-2C, the 4th valve 141-2D, the circulation line 141-3 includes and the first valve 141-2A
The first circulation pipeline 141-3A of connection, the second circulation pipeline 141-3B being connect with the second valve 141-2B and third valve
141-2C connection third circulation line 141-3C, the 4th circulation line 141-3D that is connect with the 4th valve 141-2D, it is described
First circulation pipeline 141-3A is connect with second circulation pipeline 141-3B by first interface 141-4A, the first interface 141-
4A connection the circulation branch road 143-1, the third circulation line 141-3C and the 4th circulation line 141-3D connect by second
Mouthful 141-4B connection returns stock pump 144, the first circulation pipeline 141-2A and third described in the second interface 141-4B connection
Circulation line 141-2C accesses hepatocyte cultures tank body 141- by third interface 141-4C connection, the third interface 141-4C
1 one end, the second circulation pipeline 141-2B is connect with the 4th circulation line 141-2D by the 4th interface 141-4D, described
The other end of 4th interface 141-4D access hepatocyte cultures tank body 141-1.Further specifically, the third interface 141-
The fluid flow direction of 4C and the 4th interface 141-4D are incorgruous.
In the present embodiment, blood input branch pipeline 11 is in addition to including blood input terminal 111, further include blood pump 112,
The drug loader 113 of parallel connection access blood input branch pipeline 11, the blood mixer being connected in blood input branch pipeline 11
114 and prevent liquid flow backwards check-valves 115.The drug loader 113 can select in other possible embodiments
It selects syringe etc. quantitatively or the equipment of timing enters drug injection in blood input branch pipeline 11.In the present embodiment, described
The drug that drug loader 113 inputs is the anticoagulant for preventing blood clotting.More specifically, described in the present embodiment anticoagulant
Drug uses heparin, and in other possible embodiments, anticoagulant can also be using natural anticoagulants heparin such as hirudins
Or at least one using calcium ions intercalating agents such as the sylvite such as sodium citrate, potassium fluoride and EDTA.
In other possible embodiments, the support system 1 is additionally provided with thermoregulator.Specific to the present embodiment
In, the pinch valve 163-2A and oxygen close and are equipped with the first thermoregulator 145 between outlet 142-1, described to return slurry branch pipeline
In 15, it is close to be provided with second temperature adjuster 154 at third three-way device 16C.First thermoregulator 145, second
Thermoregulator 154 not merely has heating function, it may have refrigerating function, tube fluid will be led by, which being mainly responsible for, is adjusted to suitable
Reaction, human body temperature optimum range perhaps keeps fluid stable and be conducive to flowing state avoid temperature variation or extremely
The variation of physical property of fluid caused by temperature and chemical property.The thermoregulator can be by laying quantity and position
The variation set realizes that the fining to all or part of region of the support system 1, compartmentalization temperature are adjusted.In addition to this,
It can also assist realizing the adjusting to temperature using means such as incubator, constant temperature water baths when conditions permit.It is described to return
It starches in branch pipeline 15, blood plasma homogenizer 155, blood plasma is additionally provided between second temperature adjuster 154 and mixing with cells device 152
The physical properties such as layering, muddiness, precipitating are easy to happen after second temperature adjuster 154 adjusts temperature, chemical property changes
The case where change, homogeneous can be carried out to blood plasma in advance before carrying out whole blood mixing by adding blood plasma homogenizer 155, and it is mixed to improve whole blood
The quality of conjunction.
In the present embodiment, the support system 1 (includes the first threeway by control three-way device 16 in the present embodiment
Device 16A, the second three-way device 16B, third three-way device 16C), the on-off of the branch pipeline is further controlled, and then described
Support system 1 can at least possess following mode: abiotic purification pattern, biological cleaning mode, composite mode.Below in conjunction with
Different modes elaborates the running of the support system 1.
1. please referring to Fig. 1, Fig. 3, Fig. 4, Fig. 6 and Figure 10, described Figure 10 illustrates the abiotic net of the support system 1
Change mode.The pinch valve 163-2A of first three-way device 16A of the support system 1 is closed, pinch valve 163-1A is opened；It will
The pinch valve 163-1B of second three-way device 16B is closed, and pinch valve 163-2B is opened；By the pinch valve of third three-way device 16C
163-1C is closed, and pinch valve 163-2C is opened.Pass through the constriction to 16 roads of three-way device --- pinch valve (including clamp
Valve 163-2A, pinch valve 163-1A, pinch valve 163-1B, pinch valve 163-2B, pinch valve 163-1C, pinch valve 163-2C)
The on-off of controlling brancher, the support system 1 enter abiotic purification pattern.
Under the abiotic purification pattern, participate in abiotic purification pattern in the support system 1 is blood input
11, first points of slurry branch pipelines 12 of branch pipeline, abiotic purification branch pipeline 13 return slurry branch pipeline 15.Blood plasma is by blood pump 112 through blood
Input terminal 111 flows into blood input branch pipeline 11, the parallel injecting heparin of drug loader 113 and by blood mixer 114
It is uniformly mixed.Under the power for dividing stock pump 122 to provide, blood passes through the first blood separator 121, and haemocyte goes out by haemocyte
Mouth 121-3 enters haemocyte mixer 152, and the blood plasma after separation is flowed out from plasma outlet port 121-2, passes through the first three-way device
The valve 163-1A of 16A enters plasma perfusion device 131 and bilirubin adsorption device 132, and purified blood plasma is via the first purification
Branch 133 enters by the valve 163-2B (or valve 163-1C of third three-way device 16C) of the second three-way device 16B
Slurry branch pipeline 15 is returned, whole blood is mixed into haemocyte mixer 152 and the haemocyte from haemocyte outlet 121-3, through bubble
After monitor 153 detects, pass through 151 returning to external of blood output end.Blood passes through the above process, completes abiotic cleaned
Journey.
2. please referring to Fig. 1, Fig. 3, Fig. 4, Fig. 6 and Figure 11, described Figure 11 illustrates the biological cleaning of the support system 1
Mode.The pinch valve 163-2A of first three-way device 16A of the support system 1 is opened, pinch valve 163-1A is closed；By
The pinch valve 163-1B of two three-way device 16B is opened, and pinch valve 163-2B is closed；By the pinch valve of third three-way device 16C
163-1C is closed, and pinch valve 163-2C is opened.Pass through the constriction to 16 roads of three-way device --- pinch valve (including clamp
Valve 163-2A, pinch valve 163-1A, pinch valve 163-1B, pinch valve 163-2B, pinch valve 163-1C, pinch valve 163-2C)
The on-off of controlling brancher, the support system 1 enter biological cleaning mode.
Under the biological cleaning mode, participate in biological cleaning mode in the support system 1 is that blood input is in charge of
11, first points of road slurry branch pipeline 12, biological cleaning branch pipeline 14 return slurry branch pipeline 15.Blood plasma is by blood pump 112 through blood input terminal
111, which flow into the blood, inputs branch pipeline 11, and the parallel injecting heparin of drug loader 113 is simultaneously mixed by blood mixer 114
It is even.Under the power for dividing stock pump 122 to provide, blood passes through the first blood separator 121, and haemocyte exports 121- by haemocyte
3 enter haemocyte mixer 152, and the blood plasma after separation is flowed out from plasma outlet port 121-2, pass through the valve of the first three-way device 16A
Door 163-2A enters the oxygenator 142 of biological cleaning branch pipeline 14.Blood plasma flows into liquid storage bottle after oxygen closes sufficiently in oxygenator 142
Flow velocity to be adjusted is temporarily stored or waited in 18 first chamber 181, and the blood plasma in the first chamber 181 is mentioned in circulating pump 143
Hepatocyte cultures canister assembly 141 is entered by circulation branch road 143 under the power of confession.
The hepatocyte cultures canister assembly 141 forms the flowing side of two kinds of blood plasma by control valve component 141-2
Formula --- it flows from above to below and flows from bottom to top.
The second valve 141-2B and third valve 141-2C, the first valve 141- are closed in the valve member 141-2
2A and the 4th valve 141-2D are kept it turning on, and form pipeline that flows from above to below.Blood plasma passes through by circulation branch road 143-1
First interface 141-4A enters first circulation pipeline 141-3A and enters hepatocyte cultures tank body 141-1 by third interface 141-4C
One end, in hepatocyte cultures tank body 141-1, blood plasma is sufficiently reacted with liver cell.Blood plasma after reaction is from hepatocyte cultures
The other end of tank body 141-1 flows out, and flows into the 4th circulating line 141-3D by the 4th interface 141-4D, finally connects by second
Mouth 141-4B flow direction returns slurry branch 144-1.
The second valve 141-2B and third valve 141-2C, the first valve 141- are opened in the valve member 141-2
2A and the 4th valve 141-2D are remained turned-off, and form the pipeline flowed from bottom to top.Blood plasma passes through by circulation branch road 143-1
First interface 141-4A enters third circulation line 141-3C and enters hepatocyte cultures tank body 141-1 by the 4th interface 141-4D
One end, in hepatocyte cultures tank body 141-1, blood plasma is sufficiently reacted with liver cell.Blood plasma after reaction is from hepatocyte cultures
The other end of tank body 141-1 flows out, and flows into second circulation pipeline 141-3B by third interface 141-4C, finally connects by second
Mouth 141-4B flow direction returns slurry branch 144-1.
It flows from above to below and flows from bottom to top alternately, facilitate between blood plasma and liver cell adequately to connect
Touching reduces the dead space in hepatocyte cultures tank body 141-1, promotes the flowing of tank substance in vivo.
Blood plasma after biological cleaning, which enters, returns slurry branch pipeline 15, exports in haemocyte mixer 152 with from haemocyte
The haemocyte of 121-3 is mixed into whole blood, after the detection of bubble monitor 153, passes through 151 returning to external of blood output end.Blood
By the above process, abiotic purification process is completed.
3. please referring to Fig. 1, Fig. 3, Fig. 4, Fig. 6 and Figure 12, described Figure 12 illustrates the compound die of the support system 1
Formula.The pinch valve 163-2A of first three-way device 16A of the support system 1 is closed, and by the downstream of pinch valve 163-2A
Conduit is forwarded at pinch valve 163-1B, and pinch valve 163-1A is opened；The pinch valve 163-1B of second three-way device 16B is opened
It opens, pinch valve 163-2B is closed；The pinch valve 163-1C of third three-way device 16C is closed, pinch valve 163-2C is opened.Pass through
To the constriction of 16 roads of three-way device --- pinch valve (including pinch valve 163-2A, pinch valve 163-1A, pinch valve 163-
1B, pinch valve 163-2B, pinch valve 163-1C, pinch valve 163-2C) controlling brancher on-off, the support system 1 enters
Composite mode.
Under the composite mode, in the support system 1 participate in composite purification mode be blood input branch pipeline 11,
First point of slurry branch pipeline 12, biological cleaning branch pipeline 14, returns slurry branch pipeline 15 at abiotic purification branch pipeline 13.Blood plasma is by blood pump
112, which flow into the blood through blood input terminal 111, inputs branch pipeline 11, the parallel injecting heparin of drug loader 113 and by blood
Mixer 114 is uniformly mixed.Under the power for dividing stock pump 122 to provide, blood passes through the first blood separator 121, haemocyte warp
It crosses haemocyte outlet 121-3 and enters haemocyte mixer 152, the blood plasma after separation is flowed out from plasma outlet port 121-2, passes through first
The valve 163-1A of three-way device 16A enters plasma perfusion device 131 and bilirubin adsorption device 132, purified blood plasma via
First purification branch 133, by valve 163-2B (or the valve 163- of third three-way device 16C of the second three-way device 16B
1C), into the oxygenator 142 of biological cleaning branch pipeline 14.Blood plasma flows into liquid storage bottle 18 after oxygen closes sufficiently in oxygenator 142
Flow velocity to be adjusted is temporarily stored or waited in first chamber 181, what the blood plasma in the first chamber 181 was provided in circulating pump 143
Hepatocyte cultures canister assembly 141 is entered by circulation branch road 143 under power.Flowing side of the blood plasma in hepatocyte cultures tank 141
Formula please refers to the plasma flow mode of hepatocyte cultures tank 141 in biological cleaning mode.
Blood plasma after composite purification, which enters, returns slurry branch pipeline 15, exports in haemocyte mixer 152 with from haemocyte
The haemocyte of 121-3 is mixed into whole blood, after the detection of bubble monitor 153, passes through 151 returning to external of blood output end.Blood
By the above process, composite purification process is completed.
In the biological cleaning mode and composite mode of the present embodiment, also biological cleaning branch pipeline 14 and return slurry point
Second point of slurry branch pipeline 17 is additionally provided between pipeline 15.The blood plasma of second interface 141-4B outflow passes through the second plasma separator 17
Divide slurry again.Blood plasma enters the second plasma separator 17 via the second plasma inlet 171-1, and the blood plasma after dividing slurry again is from the
Two plasma outlet port 171-2 flow out through return stock pump 144 enter return slurry branch pipeline 15.Blood plasma with haemocyte passes through cell outlet
171-3 enters 18 second chamber of liquid storage bottle, 182 sedimentation cell and cell fragment, goes successively to hepatocyte cultures canister assembly 14
Circulation.
The present embodiment makes illustrative demonstration to the specific structure of the support system 1.The branch of the utility model
The on-off that system 1 controls different branch pipelines by three-way device 16 is held, enters the support system 1 in different modes, just
In pointedly to blood progress differentiation processing.The utility model pass through further adjust the quantity of the three-way device 16 with
And position, it can also increase or delete the branch pipeline with different function, further adjust the integrated function of the support system 1
Energy.Support system described in the utility model also passes through the circulation line (including of Reasonable Arrangement hepatocyte cultures canister assembly 14
One circulation line 141-3A, second circulation pipeline 141-3B, third circulation line 141-3C, the 4th circulation line 141-3D) with
And the on-off of reasonable control valve component 141-2, two kinds of fluid-flow modes in hepatocyte cultures canister assembly may be implemented.
The above is only some embodiments of the utility model, it is noted that for the common skill of the art
For art personnel, without departing from the principle of this utility model, can also make several improvements and retouch, these improve and
Retouching also should be regarded as the protection scope of the utility model.
Claims (14)
1. a kind of combination type biological Artificial Liver Support System, the support system includes at least sequentially connected branch pipeline: upstream
End be set as blood input terminal blood input branch pipeline, including at least the first plasma separator first point of slurry branch pipeline,
Including at least plasma perfusion device, the abiotic purification branch pipeline of bilirubin adsorption device, including at least hepatocyte cultures canister assembly
What biological cleaning branch pipeline, downstream end were set as blood output end returns slurry branch pipeline, it is characterised in that: first point of slurry point
Pipeline and the biological cleaning branch pipeline, abiotic purification branch pipeline arrival end between, the abiotic purification branch pipeline
Between outlet end and the biological cleaning branch pipeline, it is described it is abiotic purification branch pipeline outlet end and return slurry branch pipeline between lead to
Three-way device connection is crossed, the three-way device includes three-way connection and the branch that connect respectively with the three-way connection, and at least two
Branch described in item is respectively equipped with constriction and connecting parts.
2. combination type biological Artificial Liver Support System as described in claim 1, it is characterised in that: first point of slurry branch pipeline
It include: to be equipped with the first plasma separator and go out by conduit and the blood plasma that blood entry port, plasma outlet port, haemocyte export
Mouthful connection divides stock pump, divides stock pump to extend to dividing slurry branch and be connected to and described dividing the of slurry branch end for downstream from described
One three-way device, wherein described point of slurry branch is directly connected to the first three-way connection of first three-way device, from this first
Remaining branch that three-way connection extends is equipped with the constriction and connecting parts.
3. combination type biological Artificial Liver Support System as claimed in claim 2, it is characterised in that: the abiotic purification is in charge of
Road includes: the plasma perfusion device exported equipped with perfusion entrance, perfusion, and the bilirubin adsorption device of perfusion outlet is connected by conduit,
The first purification branch in downstream is extended to from the bilirubin adsorption device and is connected to the of first purification branch end
Two three-way devices；Wherein, the first purification branch is directly connected to the second three-way connection of second three-way device, from this
Remaining branch that second three-way connection extends is equipped with the constriction and connecting parts.
4. combination type biological Artificial Liver Support System as claimed in claim 3, it is characterised in that: the biological cleaning branch pipeline
It include: to close the oxygenator of outlet equipped with oxygen, pass through circulation branch road with the circulating pump of oxygen conjunction outlet connection, with the circulating pump
The hepatocyte cultures canister assembly of connection and stock pump is returned with what hepatocyte cultures canister assembly was connect, is extended to down from the stock pump that returns
Slurry branch is returned in trip.
5. combination type biological Artificial Liver Support System as claimed in claim 4, it is characterised in that: described to return slurry branch pipeline at least
It include: the bubble prison that the connection haemocyte exported and be equipped with the haemocyte mixer of whole blood outlet, the connection whole blood outlet
Device is surveyed, the bubble monitor is also connected with the blood output end, and the upstream termination for returning slurry branch pipeline is connected to third threeway
Device, the third three-way connection of the third three-way device, the upstream of the third three-way connection extend branch and pass through respectively
The constriction and connecting parts, connection first purify branch and return slurry branch.
6. combination type biological Artificial Liver Support System as claimed in claim 5, it is characterised in that: the biological cleaning branch pipeline
Second point of slurry branch pipeline is additionally provided between slurry branch pipeline with returning, second point of slurry branch pipeline is included at least to be entered equipped with the second blood plasma
Second plasma separator of mouth, the second plasma outlet port, cell outlet, second plasma inlet connect hepatocyte cultures tank group
Part returns slurry branch pipeline described in second plasma outlet port connection.
7. combination type biological Artificial Liver Support System as claimed in claim 6, it is characterised in that: the cell outlet is connected with
To deposition of cells or cell fragment and the liquid storage bottle of adjustment flow velocity difference, the liquid storage bottle is also connected with oxygen and closes outlet and follow
The entrance of ring pump.
8. combination type biological Artificial Liver Support System as claimed in claim 7, it is characterised in that: the cell outlet connection storage
The second chamber of liquid bottle is equipped with cell fragment or cell of the partition sedimentation is isolated between first chamber and second chamber.
9. combination type biological Artificial Liver Support System as claimed in claim 5, it is characterised in that: hepatocyte cultures canister assembly institute
The circulation line that hepatocyte cultures canister assembly includes hepatocyte cultures tank body and connects by conduit with valve member is stated, it is described
The entrance of circulation line connects the circulating pump, returns slurry branch pipeline described in the outlet connection of the circulation line.
10. combination type biological Artificial Liver Support System as claimed in claim 9, it is characterised in that: the valve member includes
First valve, the second valve, third valve, the 4th valve, the circulation line include the first circulation connecting with the first valve
Pipeline, the third circulation line connecting with third valve, is connect with the 4th valve the second circulation pipeline connecting with the second valve
The 4th circulation line, the first circulation pipeline connect with second circulation pipeline by first interface, and the first interface connects
The circulation branch road is connect, the third circulation line is connect with the 4th circulation line by second interface, and the second interface connects
Stock pump is returned described in connecing, the first circulation pipeline is connect with third circulation line by third interface, the third interface access
One end of hepatocyte cultures tank body, the second circulation pipeline are connect with the 4th circulation line by the 4th interface, and the described 4th
The other end of interface access hepatocyte cultures tank body.
11. combination type biological Artificial Liver Support System as claimed in claim 10, it is characterised in that: the third interface and
The fluid flow direction of four interfaces is incorgruous.
12. combination type biological Artificial Liver Support System as described in claim 1, it is characterised in that: the branch of the three-way device
At least one connection type that road is connect with the conduit for the branch pipeline being connected by screw member, sleeve component connects.
13. combination type biological Artificial Liver Support System as claimed in claim 12, it is characterised in that: the screw member connection
Structure include the branch being externally threaded and one end is tapped with the branch pipeline of the internal screw thread to match with external screw thread and leads
Pipe.
14. combination type biological Artificial Liver Support System as claimed in claim 13, it is characterised in that: the conduit and branch connect
The place of connecing is additionally provided with to screw branch pipeline and branch and provide the casing of resistance and enhancing leakproofness.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820190166.8U CN208770520U (en) | 2018-02-01 | 2018-02-01 | Combination type biological Artificial Liver Support System |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820190166.8U CN208770520U (en) | 2018-02-01 | 2018-02-01 | Combination type biological Artificial Liver Support System |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208770520U true CN208770520U (en) | 2019-04-23 |
Family
ID=66140629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201820190166.8U Withdrawn - After Issue CN208770520U (en) | 2018-02-01 | 2018-02-01 | Combination type biological Artificial Liver Support System |
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| CN (1) | CN208770520U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108211032A (en) * | 2018-02-01 | 2018-06-29 | 南方医科大学珠江医院 | Combination type biological Artificial Liver Support System |
| CN112604051A (en) * | 2020-12-04 | 2021-04-06 | 广东乾晖生物科技有限公司 | Total-liver type bioartificial liver system |
-
2018
- 2018-02-01 CN CN201820190166.8U patent/CN208770520U/en not_active Withdrawn - After Issue
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108211032A (en) * | 2018-02-01 | 2018-06-29 | 南方医科大学珠江医院 | Combination type biological Artificial Liver Support System |
| CN108211032B (en) * | 2018-02-01 | 2023-11-17 | 南方医科大学珠江医院 | Combined bioartificial liver support system |
| US11911552B2 (en) | 2018-02-01 | 2024-02-27 | Southern Medical University Zhujiang Hospital | Combined bio-artificial liver support system |
| CN112604051A (en) * | 2020-12-04 | 2021-04-06 | 广东乾晖生物科技有限公司 | Total-liver type bioartificial liver system |
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