CN206167485U - Trinity wool knitting yarn formula bioartificial liver on -line monitoring and integrative system of constant temperature heating - Google Patents
Trinity wool knitting yarn formula bioartificial liver on -line monitoring and integrative system of constant temperature heating Download PDFInfo
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- CN206167485U CN206167485U CN201620809713.7U CN201620809713U CN206167485U CN 206167485 U CN206167485 U CN 206167485U CN 201620809713 U CN201620809713 U CN 201620809713U CN 206167485 U CN206167485 U CN 206167485U
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Landscapes
- External Artificial Organs (AREA)
Abstract
The utility model discloses a trinity wool knitting yarn formula bioartificial liver on -line monitoring and integrative system of constant temperature heating, including order continuous blood input port, blood pump, artery kettle, trinity bioreactor, vein kettle and blood bustback mouth, trinity bioreactor includes the cavity and sets up first baffle and second baffle in the cavity, first baffle and second baffle will the three independent space that is is from left to right separated to the cavity, is blood plasma separator, oxygenator and reactor in proper order, integrative system still is equipped with pipeline heating device. The beneficial effects of the utility model are that: be one through closing blood plasma separator, oxygenator and conventional bioreactor three, make the bioartificial liver support system structure more succinct, the simple operation, effect through pipeline heating device for cell heating among the bioartificial liver reactor is even, and pipeline heating device adopts outer hangingly, saves space for system simple structure.
Description
Technical field
This utility model belongs to bioartificial liver's technical field, more particularly to a kind of three-in-one lint wire type bioartificial liver
On-line monitoring and heated at constant temperature integrated system.
Background technology
China is the country of hepatopathy most serious in the world, annual liver failure neopathy number more than 1,000,000, wherein about 50%
Hepatic failure patient is dead because cannot get effectively treatment.Liver transplantation at present is the maximally effective treatment meanss of healing liver failure, but
Because liver source is difficult, the waiting time is long, or has no chance to obtain to supply liver at all, and most humans are not survived machine at all
Meeting.Therefore, it is badly in need of bioartificial liver system and maintains patients ' lives, waits liver transplantation chance, or the chance that patient itself liver recovers.
Biological artificial liver support system, it is main using the cell mass with liver metabolism function, to hepatic failure patients blood
Purified, realized the function that Vitro hepatic ramus splanchnicus is held, be that the quality time is won in liver regeneration or wait liver transplantation, with weight
Want clinical value.Existing bioartificial liver system structure is similar, and bioartificial liver's reactor is whole system
Core, for oxygen, appropriate nutrient substance and suitable pH environment that cell mass provides abundance, enables cell maximum limit
The performance of degree its biological activity, is to realize that efficient liver function expression provides safeguard.
At present, having been used for the biological artificial liver support system of clinical trial or treatment mainly includes plasma separator, and oxygen is closed
Device and the part of bioreactor three.After patient blood is derived in vitro, first menses slurry separator separates blood plasma and hemocyte；Point
The blood plasma for separating out enters bioreactor Jing after the enough oxygen of oxygenator load；Cell mass is basic with blood plasma in bioreactor
Nutrition carries out substance metabolism and exchange；Remove the blood plasma after biotoxin and separate blood cells mixing with plasma separator again, return
Transport in patient's body, realize external artificial liver function.Plasma separator, oxygenator and the departmental cost of bioreactor three compared with
Height, operation is cumbersome, needs further optimization.And at present existing bioartificial liver's reactor is increased just with heat booster
Temperature, can not carry out heated at constant temperature, plus thermally labile to biological artificial liver reactor, affect the effect of bioartificial liver's reactor
Rate.Also, at present conventional bioartificial liver's reactor is hollow fiber type reactor, and fiber pipe arrangement is tight in the reactor,
Volume is less between fiber pipe, and centre is difficult to be loaded into cell, easily causes cell distribution inequality, causes system detoxifying properties to drop
It is low, and cell easily blocks fiber pipe membranous wall micropore on fiber pipe during adherent growth, affect the mass exchange inside and outside fiber pipe, no
Therapeutic effect is had a strong impact on beneficial to the permanently effective maintenance of hepatocellular function and vigor.
Preferably bioartificial liver system should possess following characteristics：It is simple system, easy to operate；Can provide suitably for cell
Metabolism environment includes suitable dissolved oxygen and pH value, ensures cytoactive；The cell distribution of perfusion is uniform, hepatocellular stand density
And activity is high, cell can be fully contacted with blood plasma and carry out mass exchange.
Utility model content
The purpose of this utility model is reconfiguration system structure, simplifies operation, realizes that blood plasma separation, oxygenator and biology are anti-
Answer device three-in-one；Realize that pH regulation and control, heated at constant temperature, cell are uniformly distributed and carry out sufficient mass exchange, improve hepatocellular
Stand density and activity；A kind of three-in-one lint wire type bioartificial liver on-line monitoring and heated at constant temperature integrated system are provided.
For achieving the above object, the three-in-one lint wire type bioartificial liver on-line monitoring and perseverance designed by this utility model
Temperature heating integrated system, including the connected blood input port of order, blood pump, tremulous pulse kettle, three-in-one bioreactor, venous chambers and
Blood recovery mouth；
The three-in-one bioreactor includes cavity and the first dividing plate being arranged in the cavity and second partition；The
The cavity is divided into three separate space from left to right for one dividing plate and second partition, is followed successively by plasma separator, oxygen and is closed
Device and reactor；
The plasma separator incites somebody to action both inner spaces, the device room by device room connecting tube with the oxygenator from outside
Connecting tube is provided with separation pump；The reactor will both inner chambers by the intercommunicating pore opened up on second partition with the oxygenator
Connection；
Left side cavity upper end at the plasma separator is provided with blood/priming fluid entrance, and lower end is provided with hemocyte
Outlet, with located at the doughnut of the inside of the plasma separator between the blood/priming fluid entrance and hemocyte outlet
Shu Liantong；
The cavity upper end of the mid portion at the oxygenator is provided with oxygen/carbon dioxide entrance, the oxygenator
Inside be provided with the permeable fiber membrane tube being connected with the oxygen/carbon dioxide entrance；
Right side cavity at the reactor is provided with nutritional solution/hepatocyte suspension entrance, nutritional solution/hepatocyte
Suspension is exported and blood plasma/priming fluid outlet, and the intercommunicating pore and blood plasma/priming fluid are exported with located at the inside of the reactor
Hollow fiber film tube connection；The inside reactor is additionally provided with many wool knitting yarns；During many wool knitting yarns are described with many
Hollow fiber membrane tube is arranged in parallel and alternate intervals are arranged；
The blood/priming fluid entrance is connected with the outlet of tremulous pulse kettle, and the blood plasma/priming fluid outlet is exported with hemocyte
It is connected with the entrance of the venous chambers in the lump；
The integrated system is additionally provided with pipeline heating device.
Further, the inlet end of device room connecting tube is located at the side wall lower ends of the plasma separator, liquid outlet
End is positioned at the lower end of the oxygenator；The intercommunicating pore is located at the upper end of second partition.
Further, it is additionally provided with for intercepting the close of blood plasma/priming fluid along its cross-sectional direction inside the oxygenator
Envelope supporting plate, the sealed support plate is located at the top of intercommunicating pore；Multiple apertures are offered on the sealed support plate, it is described
The upper end of gas fiber membrane tube is fastened in aperture, and the space formed by sealed support plate and oxygenator inner cavity top, with oxygen
Gas/carbon dioxide entrance is connected.
The beneficial effect of above-mentioned further scheme is：Permeable fiber membrane tube is fixed on by oxygenator by sealed support plate
It is interior, both can ensure that oxygen/carbon dioxide entrance was connected with permeable fiber membrane tube, gas is not intercepted, and obstruct blood can be played again
The effect of slurry/priming fluid.
Yet further, two are additionally provided with for intercepting cell and liquid along its cross-sectional direction inside the plasma separator
The polyurethane resin supporting plate that body passes through, two polyurethane resin supporting plates are located at respectively plasma separator upper and lower ends and and blood
Slurry separator end inner chamber is kept at a distance, and multiple through holes, the hollow fiber bundle are offered on the polyurethane resin supporting plate
Two ends be arranged in respectively in the through hole of different polyurethane resin supporting plates, the inlet end of device room connecting tube is located at two
Between polyurethane resin supporting plate.Arranging polyurethane resin supporting plate can realize hollow fiber bundle inside plasma separator
The purpose of even distribution, rather than blood/priming fluid entrance and hemocyte outlet are all filled in in the end of hollow fiber bundle.
Preferably, the inside reactor is additionally provided with two for intercepting cell and liquid passes through along its cross-sectional direction
Polyurethane resin rack plate, two polyurethane resin rack plates be located at respectively reactor upper and lower ends and with reactor end inner chamber
Keep at a distance, multiple through holes are offered on polyurethane resin rack plate, the two ends of the hollow fiber film tube are arranged in respectively not
In through hole with polyurethane resin rack plate, the intercommunicating pore is located at the top of polyurethane resin rack plate, nutritional solution/hepatocyte
Suspension inlet and nutritional solution/hepatocyte suspension outlet are located between two polyurethane resin rack plates.Polyurethane tree is set
Fat rack plate can realize hollow fiber film tube in the equally distributed purpose of inside reactor.
Preferably, multiple fine hair being made into by staple are evenly distributed with the wool knitting yarn；The fine hair is down.
Further, the integrated system is also included for the biomonioring device of continuous on-line monitoring biochemical indicator, institute
State the upstream reason that biomonioring device includes prison TT＆C system, signal feedback system and is connected with the prison TT＆C system signal of telecommunication
Biochemical indicator detecting head and downstream reason biochemical indicator detecting head；The upstream reason biochemical indicator detecting head is input into located at the blood
At mouthful, the downstream reason biochemical indicator detecting head is at the blood recovery mouth.
Yet further, on the tremulous pulse kettle, addition is respectively provided with venous chambers, between blood pump and blood input port
The arm of medicine or liquid；The heparin arm for injecting heparin is provided between the blood pump and tremulous pulse kettle；The venous chambers with
Whether the air monitoring device of air is had in being additionally provided with for monitoring pipeline between the blood recovery mouth.
Alternatively, the pipeline heating device is water-bath, and the three-in-one bioreactor is as in water-bath, its
It is connected with system using external hanging type.
Preferably, the integrated system also include multiple pressure-detecting devices, be respectively arranged on tremulous pulse kettle, on venous chambers,
Between blood input port and blood pump.
The beneficial effects of the utility model are：
1st, it is one by the way that traditional plasma separator, oxygenator and standard biologic reactor are closed into three, makes bioartificial liver
Support that system structure is more succinct, simple operation；
2nd, blood is entered after plasma separator, and the blood plasma isolated by hollow fiber bundle directly sequentially enters oxygenator and anti-
Device is answered, unnecessary pipeline is reduced；
3rd, the inside complications in oxygenator are provided with permeable fiber film, for reactor enough oxygen is provided, while
Carbon dioxide is participated in permeable fiber film timely and appropriate discovery and realize pH regulator, maintain pH environment more stable in bioreactor, energy
Suitable metabolism environment is provided for cell, cytoactive is ensured；
4th, by the effect of pipeline heating device so that the cell in bioartificial liver's reactor can carry out constant temperature water bath
Heating, homogeneous heating, thermal-stable is good；And pipeline heating device adopts external hanging type, save space so that system structure letter
It is single；
5th, by the effect of biomonioring device so that system can be carried out to the pressure of biochemical indicator, blood plasma or blood
On-line monitoring；
6th, wool knitting yarn provides support by the hepatocyte irrigated in reactor inner chamber, it is ensured that hepatocyte is in reactor inner chamber
There is suitable condition to carry out adherent growth, while reduction hepatocyte is adherent on hollow fiber film tube, and reduce cell to hollow
The blocking of micropore on the membranous wall of fiber membrane tube, is more beneficial for the normal exchange of material inside and outside hollow fiber film tube；
7th, wool knitting yarn and hollow fiber film tube is arranged in parallel and alternate intervals arrangement or in cellular arrangement or with three bags
The mode for enclosing one is arranged so that hepatocyte is evenly distributed in reactor inner chamber, improves hepatocyte activity and utilization rate；
8th, multiple fine hair are evenly distributed with wool knitting yarn, both increased hepatocyte can adherent area, hepatocyte is promoted again
Adherent growth；
9th, significantly increase hepatocyte in reactor can adherent area, improve hepatocyte distribution the uniformity, energy
Good cytoactive is enough kept, is conducive to the maximum performance of hepatocyte function, so as to reach optimal therapeutic effect.
Description of the drawings
Fig. 1 is the knot of the three-in-one lint wire type bioartificial liver on-line monitoring of this utility model and heated at constant temperature integrated system
Structure schematic diagram.
Fig. 2 is the structural representation of the three-in-one bioreactor in Fig. 1.
Fig. 3 is the cross section structure diagram of Fig. 2.
Fig. 4 is the dimensional structure diagram of the pipeline heating device in Fig. 1.
Fig. 5 is the cross section structure diagram of Fig. 4.
In figure, three-in-one bioreactor 1, plasma separator 1.1, blood/priming fluid entrance 1.1.1, hemocyte outlet
1.1.2, the standby adding mouth 1.1.3 of plasma separator, the standby outlet 1.1.4 of plasma separator, oxygenator 1.2, oxygen/dioxy
Change carbon entrance 1.2.1, adding mouth 1.2.2, the standby adding mouth 1.2.3 of oxygenator, oxygenator adding mouth 1.2.4, reactor 1.3,
Nutritional solution/hepatocyte suspension entrance 1.3.1, nutritional solution/hepatocyte suspension outlet 1.3.2, blood plasma/priming fluid outlet
1.3.3, cavity 1.4, the first dividing plate 1.5, second partition 1.6, blood input port 2, blood pump 3, tremulous pulse kettle 4, pipeline heating device
5th, support 5.1, venous chambers 6, blood recovery mouth 7, hollow fiber bundle 8, permeable fiber membrane tube 9, hollow fiber film tube 10, device room connect
Adapter 11, intercommunicating pore 12, biomonioring device 13, prison TT＆C system 13.1, signal feedback system 13.2, upstream reason biochemical indicator
Detecting head 13.3, downstream is managed biochemical indicator detecting head 13.4, polyurethane resin supporting plate 14, polyurethane resin rack plate 15, is gathered
Ether sulfone filter membrane 16, arm 17, heparin arm 18, air monitoring device 19, pressure-detecting device 20, sealed support plate 21, hair
Knitting wool 22, fine hair 23, separation pump 24, Micropump spare interface 25.
Specific embodiment
This utility model is described in further detail below in conjunction with the drawings and specific embodiments.
Three-in-one lint wire type bioartificial liver on-line monitoring and heated at constant temperature integrated system as shown in Fig. 1~5, including
The connected blood input port 2 of order, blood pump 3, tremulous pulse kettle 4, three-in-one bioreactor 1, venous chambers 6 and blood recovery mouth 7；
Three-in-one bioreactor 1 includes cavity 1.4 and the first dividing plate 1.5 being arranged in cavity 1.4 and second partition
1.6；Cavity 1.4 is divided into three separate space from left to right for first dividing plate 1.5 and second partition 1.6, is followed successively by blood plasma
Separator 1.1, oxygenator 1.2 and reactor 1.3；
Plasma separator 1.1 passes through device room connecting tube 11 from outside by both inner spaces with oxygenator 1.2, and device room connects
Pipe 11 is provided with separation pump 24；Reactor 1.3 incite somebody to action both with oxygenator 1.2 by the intercommunicating pore 12 opened up on second partition 1.6
Inner space；
The upper end of left side cavity 1.4 at plasma separator 1.1 is provided with blood/priming fluid entrance 1.1.1, and lower end is provided with
Hemocyte exports 1.1.2, with located at plasma separator 1.1 between blood/priming fluid entrance 1.1.1 and hemocyte outlet 1.1.2
The hollow fiber bundle 8 of inside connect；
The upper end of cavity 1.4 of the mid portion at oxygenator 1.2 is provided with oxygen/carbon dioxide entrance 1.2.1, and oxygen is closed
The inside of device 1.2 is provided with the permeable fiber membrane tube 9 being connected with oxygen/carbon dioxide entrance 1.2.1；
Right side cavity 1.4 at reactor 1.3 is provided with nutritional solution/hepatocyte suspension entrance 1.3.1, nutrition
Liquid/hepatocyte suspension outlet 1.3.2 and blood plasma/priming fluid outlet 1.3.3, intercommunicating pore 12 and blood plasma/priming fluid outlet 1.3.3
Connected with the hollow fiber film tube 10 of the inside located at reactor 1.3；Many wool knitting yarns 22 are additionally provided with inside reactor 1.3；It is many
Root wool knitting yarn 22 is arranged in parallel with many hollow fiber film tubes 10 and alternate intervals are arranged；
Blood/priming fluid entrance 1.1.1 is connected with the outlet of tremulous pulse kettle 4, and blood plasma/priming fluid exports 1.3.3 and hemocyte
Outlet 1.1.2 is connected in the lump with the entrance of venous chambers 6；
Integrated system is additionally provided with pipeline heating device 5.
The inlet end of device room connecting tube 11 is located at the side wall lower ends of plasma separator 1.1, and liquid outlet end is located at oxygenator
1.2 lower end；Intercommunicating pore 12 is located at the upper end of second partition 1.6.
The sealed support plate 21 for intercepting blood plasma/priming fluid is additionally provided with along its cross-sectional direction inside oxygenator 1.2, it is close
Envelope supporting plate 21 is located at the top of intercommunicating pore 12；Multiple apertures, the upper end of permeable fiber membrane tube 9 are offered on sealed support plate 21
It is fastened in aperture, and the space formed by sealed support plate 21 and the inner cavity top of oxygenator 1.2, with oxygen/carbon dioxide
Entrance 1.2.1 is connected.
Inside plasma separator 1.1 two are additionally provided with for intercepting the poly- ammonia that cell and liquid pass through along its cross-sectional direction
Ester resin scaffold plate 14, two polyurethane resin supporting plates 14 are located at respectively the upper and lower ends of plasma separator 1.1 and divide with blood plasma
Keep at a distance from the end inner chamber of device 1.1, multiple through holes, the two ends of hollow fiber bundle 8 are offered on polyurethane resin supporting plate 14
It is arranged in respectively in the through hole of different polyurethane resin supporting plates 14, the inlet end of device room connecting tube 11 is located at two polyurethane
Between resin scaffold plate 14.
Inside reactor 1.3 two are additionally provided with for intercepting the polyurethane tree that cell and liquid pass through along its cross-sectional direction
Fat rack plate 15, two polyurethane resin rack plates 15 be located at respectively the upper and lower ends of reactor 1.3 and with the end of reactor 1.3 in
Chamber is kept at a distance, and multiple through holes are offered on polyurethane resin rack plate 15, and the two ends of hollow fiber film tube 10 are arranged in respectively
In the through hole of different polyurethane resin rack plates 15, intercommunicating pore 12 is located at the top of polyurethane resin rack plate 15, nutritional solution/liver
Cell suspending liquid entrance 1.3.1 and nutritional solution/hepatocyte suspension outlet 1.3.2 be located at two polyurethane resin rack plates 15 it
Between.
Multiple fine hair 23 being made into by staple are evenly distributed with wool knitting yarn 22；Fine hair 23 on wool knitting yarn 22 is short flannel
Hair.Wherein, a wool knitting yarn 22 is surrounded per three hollow fiber film tubes 10, per three wool knitting yarns 22 hollow-fibre membrane is surrounded
Pipe 10；Or many wool knitting yarns 22 and many hollow fiber film tubes 10 are in cellular arrangement；Hollow fiber film tube 10 and wool knitting yarn 22
It is equidistant evenly distributed.Adjacent hollow fiber film tube 10 and the spacing of wool knitting yarn 11 is preferably 50~200 microns.Wool knitting yarn 22 is
With p-phthalic acid or dimethyl terephthalate (DMT) and ethylene glycol as raw material, Jing esterifications or ester exchange and polycondensation reaction are obtained poly-
Ethylene glycol terephthalate, then polyester fiber made by Jing after spinning and Fibronectin bio-modification.
Left side cavity 1.4 at plasma separator 1.1 be additionally provided between two polyurethane resin supporting plates 14 with
The plasma separator standby adding mouth 1.1.3 and plasma separator outlet 1.1.4 of the inner space of plasma separator 1.1；Oxygen is closed
The lower end of device 1.2 is provided with oxygenator adding mouth 1.2.4；The inlet end of device room connecting tube 11 and plasma separator outlet
1.1.4 connection；The liquid outlet end of device room connecting tube 11 connects with oxygenator adding mouth 1.2.4.On oxygenator adding mouth 1.2.4 also
It is provided with the Micropump spare interface 25 for feeding the nutrient substance such as glucose for communicating therewith.
The upper end of cavity 1.4 of the mid portion at oxygenator 1.2 is additionally provided with the standby adding mouth 1.2.3 of oxygenator, oxygen
The standby adding mouth 1.2.3 of clutch is connected with the space of the lower section of sealed support plate 21；Mid portion at oxygenator 1.2
The lower end of cavity 1.4 is provided with the adding mouth 1.2.2 for infusion medicine-feeding.
Permeable fiber membrane tube 9 is tortuous to be arranged, and shape can be helical form, snakelike shape or other curved shapes, its upper end with
Oxygen/carbon dioxide entrance 1.2.1 is connected, and lower end is blind end.
Blood plasma/priming fluid outlet 1.3.3 is provided with polyethersulfone filter film 16, polyethylene filter membrane or poly ethylene vinyl alcohol and filters
Film, its thickness is 100 μm ± 25 μm, and membrane aperture is 0.5 μm ± 0.1 μm.
Integrated system is also included for the biomonioring device 13 of continuous on-line monitoring biochemical indicator, biomonioring device 13
Refer to including prison TT＆C system 13.1, signal feedback system 13.2 and the upstream reason biochemistry being connected with the prison signal of telecommunication of TT＆C system 13.1
Biochemical indicator detecting head 13.4 is managed in mark detecting head 13.3 and downstream；Upstream reason biochemical indicator detecting head 13.3 is located at blood input port
At 2, downstream reason biochemical indicator detecting head 13.4 is at blood recovery mouth 7.
Addition medicine or liquid are respectively provided with tremulous pulse kettle 4, on venous chambers 6, between blood pump 3 and blood input port 2
Arm 17；The heparin arm 18 for injecting heparin is provided between blood pump 3 and tremulous pulse kettle 4.
Whether the air monitoring device of air is had in being additionally provided between venous chambers 6 and blood recovery mouth 7 for monitoring pipeline
19。
Pipeline heating device 5 is water-bath, and three-in-one bioreactor 1 is as in water-bath, its adopt external hanging type with
System connects.A support 5.1 that can be taken off is may also set up in water-bath, three-in-one bioreactor 1 is put into support during heating
5.1 it is interior.
Integrated system also include multiple pressure-detecting devices 20, be respectively arranged on tremulous pulse kettle 4, on venous chambers 6, blood input
Between mouth 2 and blood pump 3.
During using three-in-one bioreactor 1, be first turned on oxygen/carbon dioxide entrance 1.2.1, then open blood/
Priming fluid entrance 1.1.1 and blood plasma/priming fluid outlet 1.3.3, and by blood/priming fluid entrance 1.1.1 saline injections
With the three-in-one bioreactor 1 of pre-flush；Blood/priming fluid entrance 1.1.1 is turned off, aseptically will be with hepatocyte
Microcarrier suspension makes whole reactor 1.3 be full of micro- load from nutritional solution/hepatocyte suspension entrance 1.3.1 injecting reactors 1.3
Somatic cell suspension；Subsequently the blood of acute hepatic failure pig model is introduced into plasma separator from blood/priming fluid entrance 1.1.1
1.1, blood after hollow fiber bundle 8, from hemocyte outlet 1.1.2 discharge, and remaining blood plasma exists by hemocyte and part blood plasma
Separate and the inner chamber of oxygenator 1.2 is entered by device room connecting tube 11 in the presence of pump 24, and reactor 1.3 is entered by intercommunicating pore 12
Inner chamber, last menses slurry/priming fluid outlet 1.3.3 discharges reactor 1.3；Hemocyte and portion that hemocyte outlet 1.1.2 is discharged
Divide the blood plasma that blood plasma is discharged with blood plasma/priming fluid outlet 1.3.3 to be fed back in pig body after mixing, form a treatment and loop back
Road.Over the course for the treatment of, to the inner chamber insufflation gas of oxygenator 1.2, gas is from permeable fiber for oxygen/carbon dioxide entrance 1.2.1
The upper end of membrane tube 9 is entered in permeable fiber membrane tube 9, because permeable fiber membrane tube 9 is placed in the inner chamber of oxygenator 1.2, so as to ensure one
In the case of fixed dissolved oxygen, pH (carbon dioxide regulation), the circulation treatment of blood plasma can be maintained up to dozens of hour, terminate to control
Treat, Kaplan-Meier survival analysises show that this treatment can significantly extend the time-to-live of animal subject.
Treatment starts, and after the blood of liver failure patient is drawn in vitro, enters three-in-one by blood/priming fluid entrance 1.1.1
Lint wire type bioartificial liver monitors on-line and heated at constant temperature integrated system, and blood is entered in three-in-one bioreactor 1 and detoxified,
Jing blood recoveries mouth 7 is back in patient or laboratory animal body after having detoxified.
During treatment is carried out, biochemical indicator detecting head 13.3, downstream is managed using the upstream at its two ends by biomonioring device 13
Reason biochemical indicator detecting head 13.4 monitors respectively blood plasma bilirubin, ammonia, creatinine, the carbamide of the three-in-one bioreactor 1 of turnover
The change of the biochemical indicators such as nitrogen, liver enzyme, albumin, hemoglobin, erythrocyte, leukocyte, prison TT＆C system 13.1 is obtained immediately
With process institute Monitoring Data, and whole system is fed back by signal feedback system 13.2 implement control.
After treatment end, used consumptive material is processed；By polyethersulfone filter film 16, transducer potector etc. from artificial liver
Remove on machine equipment and the discarded step according to hospital facility is discarded.
Claims (10)
1. a kind of three-in-one lint wire type bioartificial liver monitors on-line and heated at constant temperature integrated system, it is characterised in that：Including
The connected blood input port (2) of order, blood pump (3), tremulous pulse kettle (4), three-in-one bioreactor (1), venous chambers (6) and blood
Feed back mouth (7)；
The three-in-one bioreactor (1) includes cavity (1.4) and the first dividing plate being arranged in the cavity (1.4)
And second partition (1.6) (1.5)；First dividing plate (1.5) and second partition (1.6) by the cavity (1.4) be divided into from a left side to
Three right separate space, are followed successively by plasma separator (1.1), oxygenator (1.2) and reactor (1.3)；
The plasma separator (1.1) is connected both inner chambers from outside by device room connecting tube (11) with the oxygenator (1.2)
Logical, device room connecting tube (11) is provided with separation pump (24)；The reactor (1.3) is with the oxygenator (1.2) by
The intercommunicating pore (12) opened up on two dividing plates (1.6) will both inner spaces；
Blood/priming fluid entrance (1.1.1) is provided with positioned at left side cavity (1.4) upper end at the plasma separator (1.1) place, under
End is provided with hemocyte outlet (1.1.2), and the blood/priming fluid entrance (1.1.1) and hemocyte export between (1.1.2) to set
Hollow fiber bundle (8) in the inside of the plasma separator (1.1) is connected；
Cavity (1.4) upper end positioned at the mid portion at the oxygenator (1.2) place is provided with oxygen/carbon dioxide entrance
(1.2.1), the inside of the oxygenator (1.2) is provided with the ventilative fibre being connected with the oxygen/carbon dioxide entrance (1.2.1)
Dimension membrane tube (9)；
Right side cavity (1.4) positioned at the reactor (1.3) place be provided with nutritional solution/hepatocyte suspension entrance (1.3.1),
Nutritional solution/hepatocyte suspension outlet (1.3.2) and blood plasma/priming fluid outlet (1.3.3), the intercommunicating pore (12) and blood plasma/
Priming fluid exports (1.3.3) with located at the connection of the hollow fiber film tube (10) of the inside of the reactor (1.3)；The reactor
(1.3) it is internal to be additionally provided with many wool knitting yarns (22)；The many wool knitting yarns (22) are flat with many hollow fiber film tubes (10)
Row arrangement and alternate intervals arrangement；
The blood/priming fluid entrance (1.1.1) is connected with the outlet of tremulous pulse kettle (4), the blood plasma/priming fluid outlet
(1.3.3) it is connected with the entrance of the venous chambers (6) in the lump with hemocyte outlet (1.1.2)；
The integrated system is additionally provided with pipeline heating device (5).
2. three-in-one lint wire type bioartificial liver according to claim 1 monitors on-line and heated at constant temperature integrated system,
It is characterized in that：The inlet end of device room connecting tube (11) is located at the side wall lower ends of the plasma separator (1.1), goes out liquid
Mouth end is located at the lower end of the oxygenator (1.2)；Upper end of the intercommunicating pore (12) positioned at second partition (1.6).
3. three-in-one lint wire type bioartificial liver according to claim 2 monitors on-line and heated at constant temperature integrated system,
It is characterized in that：The internal sealing being additionally provided with along its cross-sectional direction for intercepting blood plasma/priming fluid of the oxygenator (1.2)
Frame plate (21), top of the sealed support plate (21) positioned at intercommunicating pore (12)；Offer on the sealed support plate (21) many
Individual aperture, the upper end of the permeable fiber membrane tube (9) is fastened in aperture, and by sealed support plate (21) and oxygenator
(1.2) space that inner cavity top is formed, is connected with oxygen/carbon dioxide entrance (1.2.1).
4. the three-in-one lint wire type bioartificial liver according to Claims 2 or 3 monitors on-line and the system of heated at constant temperature one
System, it is characterised in that：The plasma separator (1.1) is internal to be additionally provided with two for intercepting cell and liquid along its cross-sectional direction
The polyurethane resin supporting plate (14) that body passes through, two polyurethane resin supporting plates (14) are located at respectively plasma separator (1.1)
Upper and lower ends and keep at a distance with plasma separator (1.1) end inner chamber, offer on the polyurethane resin supporting plate (14)
Multiple through holes, the two ends of the hollow fiber bundle (8) are arranged in respectively in the through hole of different polyurethane resin supporting plates (14), institute
The inlet end for stating device room connecting tube (11) is located between two polyurethane resin supporting plates (14).
5. the three-in-one lint wire type bioartificial liver according to Claims 2 or 3 monitors on-line and the system of heated at constant temperature one
System, it is characterised in that：Reactor (1.3) inside is additionally provided with two and leads to for intercepting cell and liquid along its cross-sectional direction
The polyurethane resin rack plate (15) crossed, two polyurethane resin rack plates (15) are located at respectively reactor (1.3) upper and lower ends
And keep at a distance with reactor (1.3) end inner chamber, multiple through holes are offered on polyurethane resin rack plate (15), it is described hollow
The two ends of fiber membrane tube (10) are arranged in respectively in the through hole of different polyurethane resin rack plates (15), intercommunicating pore (12) position
In the top of polyurethane resin rack plate (15), nutritional solution/hepatocyte suspension entrance (1.3.1) and nutritional solution/hepatocyte are outstanding
Supernatant liquid outlet (1.3.2) is located between two polyurethane resin rack plates (15).
6. the three-in-one lint wire type bioartificial liver according to Claims 2 or 3 monitors on-line and the system of heated at constant temperature one
System, it is characterised in that：Multiple fine hair (23) being made into by staple are evenly distributed with the wool knitting yarn (22)；The wool knitting yarn
(22) fine hair (23) on is down.
7. three-in-one lint wire type bioartificial liver according to claim 1 monitors on-line and heated at constant temperature integrated system,
It is characterized in that：The integrated system is also included for the biomonioring device (13) of continuous on-line monitoring biochemical indicator, described
Biomonioring device (13) including prison TT＆C system (13.1), signal feedback system (13.2) and with the prison TT＆C system
(13.1) upstream reason biochemical indicator detecting head (13.3) and downstream reason biochemical indicator detecting head (13.4) of signal of telecommunication connection；It is described
Biochemical indicator detecting head is managed located at the blood input port (2) place, the downstream in upstream reason biochemical indicator detecting head (13.3)
(13.4) located at blood recovery mouth (7) place.
8. three-in-one lint wire type bioartificial liver according to claim 1 monitors on-line and heated at constant temperature integrated system,
It is characterized in that：It is respectively provided with the tremulous pulse kettle (4), on venous chambers (6), between blood pump (3) and blood input port (2)
The arm (17) of addition medicine or liquid；The heparin arm for injecting heparin is provided between the blood pump (3) and tremulous pulse kettle (4)
(18)；Whether the air of air is had in being additionally provided with for monitoring pipeline between the venous chambers (6) and the blood recovery mouth (7)
Monitoring device (19).
9. three-in-one lint wire type bioartificial liver according to claim 1 monitors on-line and heated at constant temperature integrated system,
It is characterized in that：The pipeline heating device (5) is water-bath, and the three-in-one bioreactor (1) is as in water-bath,
It adopts external hanging type to be connected with system.
10. three-in-one lint wire type bioartificial liver according to claim 1 monitors on-line and heated at constant temperature integrated system,
It is characterized in that：The integrated system also including multiple pressure-detecting devices (20), is respectively arranged on tremulous pulse kettle (4), venous chambers
(6) on, between blood input port (2) and blood pump (3).
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| CN201620809713.7U CN206167485U (en) | 2016-07-29 | 2016-07-29 | Trinity wool knitting yarn formula bioartificial liver on -line monitoring and integrative system of constant temperature heating |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108051577A (en) * | 2017-12-05 | 2018-05-18 | 徐州果姿电子商务有限公司 | A kind of animal blood component detection apparatus |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108051577A (en) * | 2017-12-05 | 2018-05-18 | 徐州果姿电子商务有限公司 | A kind of animal blood component detection apparatus |
| CN108051577B (en) * | 2017-12-05 | 2019-10-11 | 陕西宝马生物科技有限公司 | A kind of animal blood component detection apparatus |
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Address after: 4th floor, podium building, Gongtou Building, No. 433-505 Chunhui Road, Lingxi Town, Cangnan County, Wenzhou City, Zhejiang Province, 325000 Patentee after: Zhejiang Tonggan Medical Technology Co.,Ltd. Country or region after: China Address before: No. 818, Gaoxin Avenue, Donghu high tech Development Zone, Wuhan, Hubei 430206 Patentee before: WUHAN TOGO MEDITECH Co.,Ltd. Country or region before: China |
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