CN206063169U - A kind of Vltrasonic device - Google Patents
A kind of Vltrasonic device Download PDFInfo
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- CN206063169U CN206063169U CN201620649739.XU CN201620649739U CN206063169U CN 206063169 U CN206063169 U CN 206063169U CN 201620649739 U CN201620649739 U CN 201620649739U CN 206063169 U CN206063169 U CN 206063169U
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Abstract
This utility model provides a kind of Vltrasonic device, belong to technical field of medical instruments, including at least one miniature ultrasonic probe, and ultrasonic sending and receiving circuit and processor, miniature ultrasonic probe, ultrasonic sending and receiving circuit and processor are sequentially connected, also include the ultrasound imaging module being connected with processor, miniature ultrasonic probe includes at least one miniature single array element ultrasonic assembly or miniature many array element ultrasonic assemblies.The device using miniature ultrasonic probe intracranial brain surface Real-time Collection reflect deep cerebration reflectance ultrasound come complete ultrasound functions imaging, allow to be accurately positioned Epileptic focus in the ultrasonoscopy that the epilepsy phase gathers according to patient, or the diseased region of other brain diseasess is accurately positioned.The device can also utilize its miniature ultrasonic probe to be implanted in its hetero-organization the organizational information for accurately obtaining deep layer.
Description
Technical field
This utility model is related to technical field of medical instruments, and in particular to a kind of Vltrasonic device.
Background technology
Epilepticss are a kind of worldwide commonly encountered diseases, frequently-occurring disease.More than 4,000 ten thousand people being had in the world and suffering from epilepticss, China is about
There is ten thousand epileptic more than 1000, wherein 6,000,000 patients still have outbreak every year, and there is also 400,000 new cases every year.Medicine
Thing control is the preferred manner of epilepsy therapy, but about 30% epileptic patient to pressing down insane drug resistance, operation can only be selected to control
Treat.The principle of epilepsy surgery is excision Epileptic focus, that is, produce or propagate the dysfunction region of epilepsy, and then alleviate or eliminate
The outbreak of epilepsy.However, for the cure rate of the essential epilepsy corrective surgery of neopallium origin only has 10-30%.Low healing
The reason for rate is to lack a method that can be accurately positioned epileptogenic focus in clinic.
At this stage, cortical potential figure (ECoG) more can accurately measure the data of epileptic attack, and this is also this
The reason for method is set to " goldstandard " of epileptic foci by industry.But the spatial distribution of the electric field of ECoG records is led by volume
The impact of elephant is embodied, therefore the amplitude of current potential is unable to the distance of reaction electrode and signal source, this greatly reduces the theory of ECoG
The spatial discrimination limit.Existing ECoG is recorded with the electrode chip arrays (about 1 centimetre of resolution) of interval 1cm when epilepsy is provided
Electrophysiology activity, positions Epileptic focus.This method can only record the neural activity on brain surface, and the brain of people is height
Fold, the organ being made up of brain ditch and gyrus.ECoG can only position the Epileptic focus originated from gyrus, and cannot position and be located at
Epileptic focus at brain ditch, and then affect the success rate of operation.
Utility model content
Therefore, the technical problems to be solved in the utility model is that prior art detection technique is difficult to be accurately positioned cause epilepsy
Stove.
For this purpose, this utility model embodiment provides following technical scheme：
A kind of Vltrasonic device, including at least one miniature ultrasonic probe, and ultrasonic sending and receiving circuit and processor are miniature super
Sonic probe, ultrasonic sending and receiving circuit and processor are sequentially connected, and also include the ultrasound imaging module being connected with processor, miniature ultrasonic
Probe includes at least one miniature single array element ultrasonic assembly or miniature many array element ultrasonic assemblies.
Preferably, the Vltrasonic device is implanted.
Preferably, miniature ultrasonic probe can be implanted into intracranial.
Preferably, miniature ultrasonic probe includes at least two miniature single array element ultrasonic assemblies.
Preferably, miniature ultrasonic probe includes 2 × 2 or 4 × 4 or 5 × 5 or 6 × 6 miniature single array element ultrasonic assemblies.
Preferably, the distance between two neighboring miniature single array element ultrasonic assembly is not more than 10mm.
Preferably, miniature ultrasonic probe is fixed on flexible strutting piece.
Preferably, flexible strutting piece adopts biocompatible materialses.
Preferably, miniature ultrasonic probe includes at least two miniature many array element ultrasonic assemblies, miniature many array element ultrasonic assemblies
At least string is lined up side by side.
Preferably, also including wireless transport module, miniature ultrasonic probe passes through wireless transport module with ultrasonic sending and receiving circuit
Carry out signal transmission.
Technical solutions of the utility model, have the advantage that：
1. the Vltrasonic device that this utility model embodiment is provided, blood vessel when being sent out according to epilepticss near epileptogenic focus is rapidly
Hyperemia is to meet this theory of medicine basis of energy required for epilepsy, it is determined that ultrasonic reflection in cerebral tissue can be passed through
The blood circumstance of change reflection is determining Epileptic focus.Miniature ultrasonic probe in the device can be implanted into intracranial, solve
Cranium outer ultrasonic can not pass through the defect of skull, while make use of ultrasound that there is in cerebral tissue certain penetration depth, from
And accurate (high resolution) position of Epileptic focus can be determined by way of in the multiple probe assemblies of intracranial brain surface distributed.Separately
Outward, the Vltrasonic device is in addition to it can apply to epilepsy localization, can be applied in the measurement of cerebral blood flow flow velocity, and brain is molten
In the diseased region detection of other brain diseasess such as bolt, cerebroma.
2. the Vltrasonic device that this utility model embodiment is provided, each component of its implantation intracranial are all integrally fixed at bio-compatible
On the flexible strutting piece of property material, thus can in intracranial real-time monitoring brain Condition In The Depth, without because rejection etc. it is right
Human body causes larger harm.In addition, the miniature ultrasonic probe of implantation intracranial is by the ultrasound outside wireless transport module and cranium
Sending and receiving circuit completes signal transmission, therefore, can further reduce the impact to human body.
Description of the drawings
In order to be illustrated more clearly that this utility model specific embodiment or technical scheme of the prior art, below will be right
Needed for specific embodiment or description of the prior art, accompanying drawing to be used is briefly described, it should be apparent that, describe below
In accompanying drawing be some embodiments of the present utility model, for those of ordinary skill in the art, do not paying creativeness
On the premise of work, can be with according to these other accompanying drawings of accompanying drawings acquisition.
Fig. 1 is a kind of structured flowchart of Vltrasonic device in this utility model embodiment 1；
Fig. 2 is the structured flowchart of another kind of Vltrasonic device in this utility model embodiment 1；
Fig. 3 is miniature dot matrix structure of ultrasonic schematic diagram in this utility model embodiment 1；
Fig. 4 is miniature linear array structure of ultrasonic schematic diagram in this utility model embodiment 2.
Specific embodiment
The technical solution of the utility model is clearly and completely described below in conjunction with accompanying drawing, it is clear that described
Embodiment is a part of embodiment of this utility model, rather than the embodiment of whole.Based on the embodiment in this utility model, this
The every other embodiment obtained under the premise of creative work is not made by field those of ordinary skill, belongs to practical
Novel protected scope.
In description of the present utility model, it should be noted that term " " center ", " on ", D score, "left", "right", " perpendicular
Directly ", the orientation or position relationship of the instruction such as " level ", " interior ", " outward " is, based on orientation shown in the drawings or position relationship, to be only
For the ease of describe this utility model and simplify description, rather than indicate or imply indication device or element must have it is specific
Orientation, with specific azimuth configuration and operation, therefore it is not intended that to restriction of the present utility model.Additionally, term " the
One ", " second ", " the 3rd " are only used for describing purpose, and it is not intended that indicating or implying relative importance.
In description of the present utility model, it should be noted that unless otherwise clearly defined and limited, term " peace
Dress ", " being connected ", " connection " should be interpreted broadly, for example, it may be fixedly connected, or be detachably connected, or integratedly
Connection；Can be mechanically connected, or electrically connect；Can be joined directly together, it is also possible to be indirectly connected to by intermediary,
The connection of two element internals is can also be, can be wireless connection, or wired connection.For the common skill of this area
For art personnel, concrete meaning of the above-mentioned term in this utility model can be understood with concrete condition.
As long as additionally, technical characteristic involved in this utility model different embodiments disclosed below is each other
Do not constitute conflict can just be combined with each other.
Embodiment 1
A kind of Vltrasonic device is present embodiments provided, as shown in figure 1, including at least one miniature ultrasonic probe 1, Yi Jichao
Sound sending and receiving circuit 2 and processor 3, miniature ultrasonic probe 1, ultrasonic sending and receiving circuit 2 and processor 3 are sequentially connected, and also include and place
The ultrasound imaging module 4 of the reason connection of device 3, miniature ultrasonic probe 1 include at least one miniature single array element ultrasonic assembly 11 or miniature
Many array element ultrasonic assemblies 12.
Preferably, the Vltrasonic device can be implanted into biological internal for implanted, i.e. miniature ultrasonic probe 1；Further, it is micro-
Type ultrasonic probe 1 can be implanted into intracranial, to obtain the accurate information of intracerebral deep layer.
The research of neural blood vessel coupling mechanism under Status Epilepticus, demonstrates the presence that neural blood vessel is coupled under Status Epilepticus,
And demonstrate the space coupling between hemodynamic parameter and epilepsy neural activity.When epilepticss are sent out, near epileptogenic focus
Blood vessel is rapidly congested meeting the energy required for epilepsy.At present, can by the change of ultrasonic reflection in tissue come
Blood flow change in reflection tissue.Therefore epileptic focus episode process blood volume and blood flow rate meeting Variation Features, this reality are directed to
Example is applied there is provided a kind of Vltrasonic device, epileptogenic focus is determined by the blood circumstance of real-time monitoring intracranial.
Further, since the entrant sound sex chromosome mosaicism of skull, the ultrasonic thin location for being only capable of penetrating skull and natural duct, therefore in cranium
Outer ultrasound detection (resolution is low) is difficult to be accurately positioned Epileptic focus, especially the Epileptic focus at brain ditch.So as to the present embodiment is carried
For Vltrasonic device be implanted Vltrasonic device, specifically refer to intracranial brain surface place miniature ultrasonic probe 1 to detect its institute
In the cerebral blood flow situation of areas adjacent, as ultrasound has certain penetration depth in cerebral tissue, depth can be accurately detected
The blood circumstance of brain, such that it is able to be accurately positioned out the Epileptic focus of deep brain (at brain ditch).After Epileptic focus are accurately positioned just
Epileptic focus place position can only be cut off and not injure normal portions, reduce injury, mitigation sequela of the operation to patient, profit
In post-operative recovery.
In order to improve the degree of accuracy of detection, the Vltrasonic device that the present embodiment is provided forms micro- using multiple miniature ultrasonic components
Type ultrasonic probe array.The miniature ultrasonic probe array of formation can spread all over whole cerebral tissue surface, but specific implementation process
In, in order to reduce operation wound, first can go out the Position Approximate of Epileptic focus using other Non-invasive detection technology for detection, then in the position
Put and be implanted into a certain size miniature ultrasonic probe array on demand.Only it is being difficult to position the big of Epileptic focus using existing detection technique
Position approximate puts Shi Caihui using the miniature ultrasonic probe array for spreading all over whole cerebral tissue.The miniature ultrasonic probe battle array that the present embodiment is provided
Row, by the blood circumstance in intracranial real-time monitoring deep cerebration, especially epilepsy phase gyrus and brain ditch, and utilize
Ultra sonic imaging helps doctor to be accurately positioned the epileptogenic focus of patient.Specifically, the positioning of epileptogenic focus is mainly in terms of two realizing：
1. the physiological phenomenon for increasing for epileptic attack blood flow rate, using ultrasonic doppler measurements blood flow rate；2. epilepsy is directed to
During outbreak, blood flow increases this physiological phenomenon, and changing containing blood volume for cerebral tissue is detected using the change of ultrasonic echo amplitude,
I.e. by the change of blood flow rate in cerebral tissue and two aspects of change of blood volume come the position of comprehensive descision epileptogenic focus.This leads to
Cross in intracranial brain surface implantable miniature ultrasonic probe array detection cerebration to determine the localization method of Epileptic focus, can reach
The temporal resolution of 100 microns of spatial resolution and 10 Milliseconds, it is possible to while monitoring record in large-scale brain domain
(possessing good spatial coverage).Therefore, the device can improve the cure rate of epilepsy surgery, and expand intractable hidden source
Property epilepsy operation adaptation population, the patient that epileptic focus can not be specified before making can determine that Epileptic focus and controls so as to undergo surgery
Treat.
In addition, the Vltrasonic device is in addition to it can apply to epilepsy localization, the survey of cerebral blood flow flow velocity can also be applied to
Amount, and the diseased region detection and localization of other brain diseasess on.Brain diseasess refer to the inflammation of intracranial tissue organ, angiopathy,
Obstacle or the plant mental function disorders such as the general name of tumor, degeneration, deformity, heredopathia etc., its often performance is realized, feels, motion
Etc. symptom, current brain diseasess have become the common disease of the mankind or animal, have a strong impact on orthobiosiss and the study of patient,
Direct threat to life when most brain diseasess are serious.Research accordingly, with respect to brain diseasess has become grinding for whole medical circle
Study carefully emphasis.In brain diseasess, most of disease can cause neuroelectricity, the change of blood flow mechanics, be related to neural blood vessel idol
Online system, such as：The cerebral disorder disease such as the cerebral tumor, epilepticss, parkinson.Therefore, it can carry using the present embodiment
For Vltrasonic device be accurately positioned out the concrete diseased region of brain, targetedly treated such that it is able to be directed to the diseased region.
It is ultrasonic as the Vltrasonic device that specific embodiment, the present embodiment are provided, including the miniature single array element of two or more
The miniature dot matrix ultrasonic probe (miniature ultrasonic probe array is constituted by miniature single array element ultrasonic assembly 11) of the composition of component 11, specifically
Can be 2 × 2 miniature single array element ultrasonic assemblies 11, or 4 × 4 miniature single array element ultrasonic assemblies 11, such as Fig. 3 institutes
Show.In other implementations, miniature dot matrix ultrasonic probe can also be 5 × 5 miniature single array element ultrasonic assemblies 11 or 6 ×
6 miniature single array element ultrasonic assemblies 11, or miniature single array element ultrasonic assembly 11 of other quantity and arrangement mode.
As preferred embodiment, two neighboring miniature single array element ultrasonic assembly 11 of miniature dot matrix ultrasonic probe is constituted
Between spacing be not more than 5mm.Spacing between adjacent miniature single array element ultrasonic assembly 11 is less, and which detects the accurate of epileptogenic focus
Degree is higher, and in the case where required precision is not high, the spacing between two neighboring miniature single array element ultrasonic assembly 11 can also be big
In 5mm, such as between 5mm-10mm.
In the present embodiment, in order that the miniature ultrasonic probe 1 in the device can be implanted into biological internal, such as intracranial, because
This, the present embodiment fixes each miniature single array element ultrasonic assembly 11 preferably using flexible strutting piece, and is electrically connected using very thin
Connect silk to realize the electrical connection between each implanted component (including miniature single array element ultrasonic assembly 11).Also, in order to reduce biology
Rejection of the body to implant, the flexible strutting piece in the present embodiment preferably adopt biocompatible materialses.
It is as further preferred embodiment, in order to reduce impact of the implantable miniature ultrasonic probe 1 to organism, convenient
Its activity, as shown in Fig. 2 the device also includes wireless transport module 5, for realizing miniature ultrasonic probe 1 with ultrasonic sending and receiving electricity
Between road 2, signal is wirelessly transferred.That is, it is also associated with micro radio in miniature ultrasonic probe 1 (miniature ultrasonic probe array) to connect
Module is sent out, the flexible strutting piece of biocompatible materialses is fixed on together with miniature ultrasonic probe 1 (miniature ultrasonic probe array)
Go up and be implanted into and be biological internal.It is arranged on the ultrasonic sending and receiving circuit 2 of in vitro and is correspondingly provided with wireless sending and receiving module, with implantation
Biological internal micro radio sending and receiving module carries out transmission of wireless signals.In other specific embodiments, miniature ultrasonic is visited
The transmission of signal can also be realized between 1 and ultrasonic sending and receiving circuit 2 by wired connection.
In other specific embodiments, second can be also provided between ultrasonic sending and receiving circuit 2 and processor 3 and be wirelessly transferred
Module, for realizing being wirelessly transferred for signal between ultrasonic sending and receiving circuit 2 and processor 3.
In addition, the principle of the device is based on neural blood vessel coupling mechanism, therefore can be widely applied to nervous function
In the experiment of research, for example, using toy carry out brain function imaging side face have wide scientific research and it is actual should
Use prospect.Implanted micro ultrasonic probe array can follower freely activity prolonged work(is carried out to the brain of animal in real time
Can imaging, monitor which and brain electro-acoustic principal and hemodynamic parameter of various incentive conditions understood below the waking state
The activity of brain, determines the function of brain zones of different.The device can also carry out related brain functional diagnosis treatment with toy
The absorption distribution situation detection of medicine, to cerebral tumor new vesselses high-resolution imaging analysis etc..
Embodiment 2
Originally apply example and a kind of Vltrasonic device is provided, the difference with above-described embodiment 1 is, miniature ultrasonic probe in the present embodiment
1 includes more than one miniature many array element ultrasonic assembly 12, and miniature many array element ultrasonic assemblies 12 line up at least string side by side.Tool
Body is as shown in figure 4,8 miniature many array element ultrasonic assemblies 12 line up two row, each column four.Alternatively, it is also possible to according to using needs
Select miniature many array element ultrasonic assemblies 12 of other quantity and form the miniature linear array ultrasonic probe of other arrangement modes.Specifically
Ground, the quantity of miniature many array element ultrasonic assemblies 12 can be 2,4,6 or 10 etc., and the quantity can be according to using existing nothing
The Position Approximate of the diseased region that wound detection technique is detected determines, determines also dependent on other practical situations.
The present embodiment reflects the reflection of deep cerebration using miniature linear array ultrasonic probe in intracranial brain surface Real-time Collection
Ultrasound is completing ultrasound functions imaging so that the ultrasonoscopy that can be gathered in the epilepsy phase according to patient is distinguishing therein
Blood circumstance, so as to be accurately positioned Epileptic focus.
As preferred embodiment, two neighboring miniature many array element ultrasonic assemblies 12 of miniature linear array ultrasonic probe are constituted
Between spacing be not more than 10mm, more preferably no more than 5mm.Spacing between adjacent miniature many array element ultrasonic assemblies 12
Less, the degree of accuracy of its detection epileptogenic focus is higher.
The present embodiment fixes each miniature many array element ultrasonic assembly 12 preferably using flexible strutting piece, and adopts very thin electricity
Property connecting filament realizing the electrical connection between each implanted component (include miniature many array element ultrasonic assemblies 12).In order to reduce human body
The rejection of (organism) to implant, the flexible strutting piece in the present embodiment preferably adopt biocompatible materialses.
It is in other specific embodiments, such as in the case of brain area domain to be monitored is less, miniature in this device
Ultrasonic probe 1 can also only include miniature many array element ultrasonic assemblies 12, and realize by way of Mechanical Moving is scanned little
The supersonic sounding of scope.
Obviously, above-described embodiment is only intended to clearly illustrate example, and the not restriction to embodiment.It is right
For those of ordinary skill in the art, can also make on the basis of the above description other multi-forms change or
Change.There is no need to be exhaustive to all of embodiment.And thus it is extended obvious change or
Among changing still in the protection domain of the invention.
Claims (10)
1. a kind of Vltrasonic device, it is characterised in that including at least one miniature ultrasonic probe (1), and ultrasonic sending and receiving circuit (2)
With processor (3), the miniature ultrasonic probe (1), ultrasonic sending and receiving circuit (2) and processor (3) are sequentially connected, also include and institute
The ultrasound imaging module (4) that processor (3) connects is stated, the miniature ultrasonic probe (1) is super including at least one miniature single array element
Sound component (11) or miniature many array element ultrasonic assemblies (12).
2. Vltrasonic device according to claim 1, it is characterised in that the Vltrasonic device is implanted.
3. Vltrasonic device according to claim 2, it is characterised in that the miniature ultrasonic probe (1) can be implanted into intracranial.
4. the Vltrasonic device as any one of claim 1-3, it is characterised in that the miniature ultrasonic probe (1) includes
Miniature single array element ultrasonic assembly (11) described at least two.
5. Vltrasonic device as claimed in claim 4, it is characterised in that the miniature ultrasonic probe (1) including 2 × 2 or 4 ×
4 or 5 × 5 or 6 × 6 miniature single array element ultrasonic assemblies (11).
6. Vltrasonic device as claimed in claim 4, it is characterised in that two neighboring miniature single array element ultrasonic assembly (11)
The distance between be not more than 10mm.
7. Vltrasonic device as claimed in claim 1, it is characterised in that the miniature ultrasonic probe (1) is fixed on flexible support
On part.
8. Vltrasonic device as claimed in claim 7, it is characterised in that the flexible strutting piece adopts biocompatible materialses.
9. the Vltrasonic device as any one of claim 1-3, it is characterised in that the miniature ultrasonic probe (1) includes
Miniature many array element ultrasonic assemblies (12) described at least two, miniature many array element ultrasonic assemblies (12) line up at least one side by side
Row.
10. Vltrasonic device as claimed in claim 1, it is characterised in that also including wireless transport module (5) is described miniature super
Sonic probe (1) carries out signal transmission by the wireless transport module (5) with the ultrasonic sending and receiving circuit (2).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201620649739.XU CN206063169U (en) | 2016-06-27 | 2016-06-27 | A kind of Vltrasonic device |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201620649739.XU CN206063169U (en) | 2016-06-27 | 2016-06-27 | A kind of Vltrasonic device |
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| CN206063169U true CN206063169U (en) | 2017-04-05 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105877782A (en) * | 2016-06-27 | 2016-08-24 | 中国科学院苏州生物医学工程技术研究所 | Ultrasonic device |
-
2016
- 2016-06-27 CN CN201620649739.XU patent/CN206063169U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105877782A (en) * | 2016-06-27 | 2016-08-24 | 中国科学院苏州生物医学工程技术研究所 | Ultrasonic device |
| CN105877782B (en) * | 2016-06-27 | 2020-03-10 | 中国科学院苏州生物医学工程技术研究所 | Ultrasonic device |
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