CN205038151U - A optical measurements device for biological sample test - Google Patents
A optical measurements device for biological sample test Download PDFInfo
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- CN205038151U CN205038151U CN201520816558.7U CN201520816558U CN205038151U CN 205038151 U CN205038151 U CN 205038151U CN 201520816558 U CN201520816558 U CN 201520816558U CN 205038151 U CN205038151 U CN 205038151U
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Abstract
The utility model provides an optical measurements device for biological sample test, including being configured as the light signal conducting subassembly that sets gradually to the light source subassembly of being surveyed biological sample transmission light beam, along transmission light beam direction of propagation and surveying the passageway subassembly, the light signal conducting subassembly is including collecing optical fiber bundle, light pipe, beam split optical fiber bundle, it places the measurement passageway of being surveyed biological sample and sets up optical signal detector in it and the leading processing circuit who is connected with optical signal detector output including being configured as to survey the passageway subassembly. The utility model provides a drawback that detects of single wavelength of prior art, single channel, provide a optical measurements device that has multi -wavelength's light optional, tests the passageway more, can accomplish the collection that multiple biological sample bore the optical signal of its physiology information in the extremely short time, have that measurement accuracy height, measuring time end, measurement of efficiency are high, increase of service life's characteristics, have very high market development and worth.
Description
Technical field
The utility model belongs to field of optical measurements, is specifically related to a kind of optical measuring device for detection of biological samples.
Background technology
Clinical diagnostic device field in vitro, such as but not limited to Biochemical Analyzer, enzyme-linked immuno assay instrument, hemoglobin determinator etc. need to be applied to various optical measuring device.Publication number is disclose a kind of style analytical equipment in the Chinese patent of CN201707295U and CN101213437B, this device adopts halogen light source, and use filter part, monochromatic light required for style is obtained by switching different filtering device, it is short to there is the life-span in the Halogen lamp LED that this device uses, and the problems such as difficult location, existence simultaneously cannot complete the optical signalling collection of the biological specimen under multiple wavelength in very short time.
Another publication number is that the Chinese patent of CN20415464U discloses a kind of absorbance measuring device, the feature of this device, comprise light source, position placed by sample and be placed on for detecting the sample light electric explorer that sample absorbance on position placed by sample, wherein light source comprises: light emitting diode and for providing the driving circuit of driving circuit to light emitting diode, this device to some extent solves the easy problem of aging of Halogen lamp LED, but this device can only be applied to the analyser of single Air conduct measurement, the occasion of many test channel cannot be applied to; There is optical axis eccentricity issues to a certain extent in this device in addition, and especially when the number of light emitting diode acquires a certain degree, the hot spot bias of irradiating sample will be more serious, easily occur test error, finally affect measuring accuracy.
Summary of the invention
For solving the problems of the technologies described above, the utility model provides a kind of optical measuring device for detection of biological samples, realizes the biological specimen optical signalling simultaneously measuring multiple wavelength, multiple test channel in very short time.
For achieving the above object, the technical solution of the utility model is as follows: a kind of optical measuring device for detection of biological samples, comprise the light source assembly be configured to tested biological specimen transmitted beam, it is characterized in that: it also comprises the light signal transduction assembly and detection channels assembly that set gradually along the transmitted beam direction of propagation, and described light signal transduction assembly comprises
-collection fibers bundle, its two ends are configured with several first incidence end and first exit end respectively;
-light pipe, it is the column structure that two ends are configured with second incidence end and second exit end respectively, and described second incidence end is docked with the first exit end and developed;
-light splitting fibre bundle, its two ends are configured with the 3rd incidence end and several the 3rd exit ends respectively, and described 3rd incidence end is docked with the second exit end and developed;
Described detection channels assembly comprises,
The Measurement channel that-port number is identical with described 3rd exit end quantity, the entrance of described Measurement channel all docks with the 3rd exit end, arranges described tested biological specimen in it;
-optical signalling the detector identical with described Measurement channel quantity, along the direction of propagation of described transmitted beam, described optical signalling detector is all arranged on the downstream of tested biological specimen;
-advance signal treatment circuit, its input end connects the output terminal of each described signal sensor.
In a preferred embodiment of the present utility model, comprise described light source assembly further and comprise
-light emitting diode matrix, it comprises at least one semiconductor light-emitting-diode;
-drive described semiconductor light-emitting-diode to close or the driving circuit opened.
In a preferred embodiment of the present utility model, comprise the direction of propagation along described transmitted beam further, the downstream of each described semiconductor light-emitting-diode is equipped with one first optical lens, and described first incidence end is arranged on the focus point of the first optical lens.
In a preferred embodiment of the present utility model, comprise the direction of propagation along described transmitted beam further, the downstream of each described first optical lens is equipped with an interference filter.
In a preferred embodiment of the present utility model, comprise the direction of propagation along described transmitted beam further, the upstream of each described tested biological specimen is equipped with one second optical lens.
For achieving the above object, the utility model also provides a kind of technical scheme as follows: a kind of optical measuring device for detection of biological samples, comprise the light source assembly be configured to tested biological specimen transmitted beam, it is characterized in that: described light source assembly is independent two groups of arranging, be respectively the first light source assembly and secondary light source assembly, it also comprises the light signal transduction assembly and detection channels assembly that set gradually along the transmitted beam direction of propagation, and described light signal transduction assembly comprises
-collection fibers bundle, its two ends are configured with several first incidence end and first exit end respectively;
-light pipe, it is the column structure that two ends are configured with second incidence end and second exit end respectively, and described second exit end docks with the first exit end and develops;
Described second incidence end is developed with jointly holding to dock;
-having and converge the composite fiber bundle that light and light splitting combine, it is configured with several first incidence end, several first exit ends and one end jointly, and described common end docks with the second incidence end and develops;
-optical mirror, its docking is developed described second exit end and is arranged;
The beam emissions end of described first light source assembly docks with composite fiber bundle, and the beam emissions end of described secondary light source assembly docks with collection fibers bundle;
Described detection channels assembly comprises,
The Measurement channel that-port number is identical with described first exit end quantity, the entrance of described Measurement channel all docks with the first exit end, arranges described tested biological specimen in it;
-optical signalling the detector identical with described Measurement channel quantity, along the direction of propagation of described transmitted beam, described optical signalling detector is all arranged on the downstream of tested biological specimen;
-advance signal treatment circuit, its input end connects the output terminal of each described signal sensor.
In a preferred embodiment of the present utility model, comprise described first light source assembly further identical with the structure of second light source assembly, it includes
-light emitting diode matrix, it comprises at least one semiconductor light-emitting-diode;
-drive described semiconductor light-emitting-diode to close or the driving circuit opened.
In a preferred embodiment of the present utility model, comprise described first light source assembly further and comprise,
-light emitting diode matrix, it comprises at least one semiconductor light-emitting-diode;
-drive described semiconductor light-emitting-diode to close or the driving circuit opened;
The switch that described secondary light source assembly comprises Halogen lamp LED and drives described Halogen lamp LED to close or open.
In a preferred embodiment of the present utility model, comprise the direction of propagation along described transmitted beam further, the downstream of each described semiconductor light-emitting-diode is equipped with one first optical lens, described first incidence end is arranged on the focus point of the first optical lens, along the direction of propagation of described transmitted beam, the upstream of each described tested biological specimen is equipped with one second optical lens.
In a preferred embodiment of the present utility model, comprise the direction of propagation along described transmitted beam further, the downstream of each described first optical lens is equipped with an interference filter.
The beneficial effects of the utility model are: the utility model solves the Single wavelength of prior art, the drawback that single channel detects, there is provided one to have multi-wavelength's light can select, the optical measuring device of many test channel, the optical signalling carrying its physiologic information of multiple biological specimen can be gathered within the extremely short time simultaneously, optical signalling obtains the measurement data representing biological specimen physiologic information after treatment, after whole measurement mechanism uses while raising measuring accuracy, have and can shorten Measuring Time, improve and measure efficiency, extend the feature in measurement mechanism serviceable life, there is the very high market development be worth.
Accompanying drawing explanation
In order to be illustrated more clearly in the technical scheme in the utility model embodiment technology, be briefly described to the accompanying drawing used required in the description of embodiment technology below, apparently, accompanying drawing in the following describes is only embodiments more of the present utility model, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to these accompanying drawings.
Fig. 1 is the structural representation of the utility model preferred embodiment;
Fig. 2 is the switch control time sequence schematic diagram of the semiconductor light-emitting-diode of the utility model preferred embodiment;
Fig. 3 is the structural representation of the collection fibers bundle of the utility model preferred embodiment;
Fig. 4 is the distribution schematic diagram of the incidence end optical fiber wire of the collection fibers bundle of the utility model preferred embodiment;
Fig. 5 is the structural representation of the light splitting fibre bundle of the utility model preferred embodiment;
Fig. 6 is the theory diagram of advance signal treatment circuit;
Fig. 7 is the structural representation of the utility model second embodiment;
Fig. 8 is the curve of spectrum schematic diagram of optical mirror in the utility model second embodiment;
Fig. 9 is the structural representation of the utility model the 3rd embodiment
Wherein, 2-biological specimen, 4-first optical lens, 6-interference filter, 7-optical fiber wire, 8-second optical lens;
1-light source assembly, 1a-first light source assembly, 1b-secondary light source assembly, 11-semiconductor light-emitting-diode, 12-driving circuit, 13-Halogen lamp LED;
3-light signal transduction assembly, 31-collection fibers bundle, 31a-first incidence end, 31b-first exit end;
32-light pipe, 32a-second incidence end, 32b-second exit end; 33-light splitting fibre bundle, 33a-the 3rd incidence end, 33b-the 3rd exit end; 34-composite fiber bundle, 34a-holds jointly; 35-optical mirror;
5-detection channels assembly, 51-optical signalling detector, 52-advance signal treatment circuit.
Embodiment
Below in conjunction with the accompanying drawing in the utility model embodiment, be clearly and completely described the technical scheme in the utility model embodiment, obviously, described embodiment is only the utility model part embodiment, instead of whole embodiments.Based on the embodiment in the utility model, those of ordinary skill in the art are not making the every other embodiment obtained under creative work prerequisite, all belong to the scope of the utility model protection.
Embodiment one
As shown in figures 1 to 6, a kind of optical measuring device for detection of biological samples is disclosed in the present embodiment, comprise and be configured to the light source assembly 1 of tested biological specimen 2 transmitted beam, the light signal transduction assembly 3 set gradually along the transmitted beam direction of propagation and detection channels assembly 5, the optical signalling detector 51 being provided with the test channel for placing tested biological specimen 2 in detection channels assembly 5 and being arranged in test channel.Light source assembly 1 transmitted beam, transmitted beam conducts to direct irradiation through light signal transduction assembly 3 and is configured in tested biological specimen 2 in detection channels assembly 5, itself there is certain optical characteristics in biological specimen 2, transmitted beam is carried out to the optical effect of extinction or scattering etc., light beam after biological specimen 2 optical effect carries the biological information that biological specimen 2 characterizes, the light beam carrying biological information enters optical signalling detector 51, completes the information acquisition of biological specimen 2.
Wherein, light source assembly 1 comprises light emitting diode matrix, with driving circuit 12, light emitting diode matrix in the utility model preferred embodiment comprises at least one semiconductor light-emitting-diode 11, the quantity forming the semiconductor light-emitting-diode 11 of light emitting diode matrix can be one, can be the multiple of the same model of row's setting, can be multiple (wherein multiple models of same row's setting are identical) of the different model that many rows are arranged, the quantity that one row arranges same model semiconductor light-emitting-diode 11 is determined according to the light intensity size measuring needs, the row that many rows are arranged is determined according to the number of wavelengths measuring needs, a kind of model correspondence of semiconductor light-emitting-diode 11 sends a kind of light of wavelength, the model of semiconductor light-emitting-diode 11 preferably adopts the monochromatic LED with certain narrow-band spectrum, certainly also can select according to the needs of actual measurement the white LED model sending mixed spectra.Fig. 1 shows the structural drawing of the light source assembly with four semiconductor light-emitting-diodes 11, wherein the corresponding a kind of model of each semiconductor light-emitting-diode 11.
Driving circuit 12 controls turning on light and turning off the light of semiconductor light-emitting-diode 11 in light emitting diode matrix, a kind of semiconductor light-emitting-diode 11 of wavelength at a time can only be had to open, the Control timing sequence figure that driving circuit controls four semiconductor light-emitting-diodes 11 and turns on light and turn off the light has been shown in Fig. 2, four semiconductor light-emitting-diodes 11 are turned on light successively in turn and turn off the light under the Control timing sequence of driving circuit 12, in this enforcement, the cycle of preferred switch control time sequence is 50ms, the lighting time of each semiconductor light-emitting-diode 11 is 6.25ms, to realize the object measured within the extremely short time.
As further improvement of the utility model, in order to improve levels of light energy, along the direction of propagation of described transmitted beam, one first optical lens 4 is equipped with in the downstream of each described semiconductor light-emitting-diode 11, first optical lens 4, for focusing on the light beam of semiconductor light-emitting-diode 11, guarantees that more light enters measurement mechanism.
As further improvement of the utility model, in order to improve the monochromaticity level of light, along the direction of propagation of described transmitted beam, an interference filter 6 is equipped with in the downstream of each described first optical lens 4, interference filter 6 preferably arrowband interfere type optical filter herein, its half-wave bandwidth is generally less than and equals 12nm, the use of interference filter 6 can carry out filtering process to the spectrum of the semiconductor light-emitting-diode 11 under this passage, remove unexpected wavelength, and the optics background depth of lifting gear, improve the optical s/n ratio of device, the detection accuracy of final raising biological specimen.
The light beam that semiconductor light-emitting-diode 11 sends is launched and is entered light signal transduction assembly 3 after the filtering of the focusing of the first optical lens 4, interference filter 6.
In order to complete the light conduction of light source assembly 1 transmitted beam, the light signal transduction assembly 3 of the present embodiment comprises the collection fibers bundle 31, light pipe 32 and the light splitting fibre bundle 33 that set gradually,
Wherein, collection fibers bundle 31 is a kind of fibre-optic bundles with several first incidence end 31a, a first exit end 31b, optical fiber in order to ensure more described semiconductor light-emitting-diode 11 enters collection fibers bundle 33, and the utility model preferably described first incidence end 31a is arranged on the focus point of the first optical lens 4.
Multiple optical fiber wire 7 is uniformly distributed in first incidence end 31a of collection fibers bundle 31, an at least corresponding semiconductor light-emitting-diode 11 of first incidence end 31a, when the luminous energy abundance of a semiconductor light-emitting-diode 11, a corresponding first incidence end 31a of semiconductor light-emitting-diode 11, when the luminous energy deficiency of the semiconductor light-emitting-diode 11 of certain wavelength, the number of the semiconductor light-emitting-diode 11 of suitable this wavelength of increase, to improve the luminous energy entering the first incidence end 31a, a now corresponding multiple semiconductor light-emitting-diode 11 of the first incidence end 31a, , the semiconductor light-emitting-diode 11 of these co-wavelengths distributes around the central shaft of the first transmitting terminal 31a of correspondence.The light that semiconductor light-emitting-diode 11 sends collects by several first incidence end 31a, launch through the first exit end 31b that conducts to of optical fiber wire 7, enter light pipe 32, light pipe 32 carries out the conduction of hot spot homogenising to light, wherein, the quantity of optical fiber wire 7 is determined according to the luminous intensity size of this passage lower semiconductor light emitting diode 11, when the luminous intensity of this passage lower semiconductor light emitting diode 11 is more weak, then suitably can improve the quantity of corresponding optical fiber wire 7, to increase the luminous flux of access to plant.
Wherein, light pipe 32 a kind ofly utilizes optical total-reflection principle and the column structure made, column structure includes but not limited to sexangle column structure, reducing column structure, the cylindrical structure of composite parabolic, the utility model preferably adopts equilateral hexagon column structure, in addition, when the clear aperature of the clear aperature of the first exit end 31b of collection fibers bundle 31 and the 3rd incidence end 33a of light splitting fibre bundle 33 is inconsistent, light pipe 32 preferably adopts column structure, guarantee the clear aperature of the second incidence end clear aperature of light pipe 32 slightly larger than the first exit end 31b of collection fibers bundle 31, second exit end clear aperature of light pipe 32 is slightly larger than the clear aperature of the 3rd incidence end 33a of light splitting fibre bundle 33.
The two ends of light pipe 32 are configured with an a second incidence end 32a and second exit end 32b respectively, described second incidence end 32a docks with the first exit end 31b and develops, docking is developed and can be reduced space, prevents optical fiber from leaking from gap and is shot out, thus affect luminous energy.Light, after light pipe 32, forms uniform light spots at its second exit end 32b and launches, enter light splitting fibre bundle 33.
Wherein, light splitting fibre bundle 33 is a kind of fibre-optic bundles with a 3rd incidence end 33a and several the 3rd exit end 33b, 3rd incidence end 33a docks with the second exit end 33b of light pipe 32 and develops, docking is developed and can be reduced space, prevent from optical fiber from leaking from gap to be shot out, thus affect luminous energy.3rd incidence end 33a of light splitting fibre bundle 33 is uniformly distributed multiple optical fiber wire 7, these optical fiber wires 7 will be divided into many parts of segmentation light uniform light spots, each segmentation light is launched independent from a 3rd exit end 33b of light splitting fibre bundle 33, enters detection channels assembly 5.
In order to complete reception and the detection of light signal, the detection channels assembly 5 of the present embodiment comprises Measurement channel, be arranged on optical signalling detector 51 in Measurement channel and advance signal treatment circuit 52,
Wherein, the quantity of the Measurement channel of configuration is identical with the quantity of the 3rd exit end 33b, and the entrance of each Measurement channel is all corresponding to be docked with a 3rd exit end 33b, and tested biological specimen 2 is placed in Measurement channel;
The quantity of the optical signalling detector 51 of configuration is identical with the port number of Measurement channel, a configuration optical signalling detector 51 in a Measurement channel, and along the direction of propagation of described transmitted beam, the optical signalling detector 51 in same passage is all arranged on the downstream of tested biological specimen 2.In single Measurement channel, the light emitted from a 3rd exit end 33b of light splitting fibre bundle 33 enters in Measurement channel, at Measurement channel internal radiation biological specimen 2, optical signalling detector 51 gathers the optical signalling of the biological specimen 2 under light irradiation, and the signal of collection exports advance signal treatment circuit 52 to.Optical signalling detector 51 of the present utility model includes but not limited to silicon photo diode, photoelectric cell or photomultiplier, preferred silicon photo diode.
Advance signal treatment circuit 52, its input end connects the output terminal of each described signal sensor 51, as shown in Figure 6, advance signal treatment circuit 52 of the present utility model carries out opto-electronic conversion successively to gathering the biological specimen optical signalling come, light intensity is converted to electric signal, again successively the process such as filtering, amplification and analog to digital conversion are carried out to electric signal, the final control terminal being uploaded to advance signal treatment circuit 52 with digital quantity, the data of carrying out the physiologic information of biological specimen 2 are extracted, are calculated and output report process.
As further improvement of the utility model, in order to improve levels of light energy, along the direction of propagation of described transmitted beam, the upstream of each described tested biological specimen 2 is equipped with one second optical lens 8, second optical lens 8, for focusing on segmentation light, guarantees more light irradiating biological samples 2.
Embodiment two
Embodiment two is compared to the difference of embodiment one: the testing requirement that can complete the biological specimen of greater number.
As illustrated in figs. 2 through 8, disclose a kind of optical measuring device for detection of biological samples in the present embodiment, comprise and being configured to tested biological specimen transmitted beam and work independently the first light source assembly 1a and secondary light source assembly 1b, the light signal transduction assembly 3 set gradually along the transmitted beam direction of propagation and detection channels assembly 5.The optical signalling detector 51 being provided with the test channel for placing tested biological specimen 2 in detection channels assembly 5 and being arranged in test channel.Light source assembly 1 transmitted beam, transmitted beam conducts to direct irradiation through light signal transduction assembly 3 and is configured in tested biological specimen 2 in detection channels assembly 5, itself there is certain optical characteristics in biological specimen 2, transmitted beam is carried out to the optical effect of extinction or scattering etc., light beam after biological specimen 2 optical effect carries the biological information that biological specimen 2 characterizes, the light beam carrying biological information enters optical signalling detector 51, completes the information acquisition of biological specimen 2.
Wherein, described first light source assembly 1a is identical with the structure of second light source assembly 1b, specific as follows:
First light source assembly 1a comprises light emitting diode matrix, with driving circuit 12, light emitting diode matrix in the utility model second embodiment comprises at least one semiconductor light-emitting-diode 11, the quantity forming the semiconductor light-emitting-diode 11 of light emitting diode matrix can be one, can be the multiple of the same model of row's setting, can be multiple (wherein multiple models of same row's setting are identical) of the different model that many rows are arranged, the quantity that one row arranges same model semiconductor light-emitting-diode 11 is determined according to the light intensity size measuring needs, the row that many rows are arranged is determined according to the number of wavelengths measuring needs, a kind of model correspondence of semiconductor light-emitting-diode 11 sends a kind of light of wavelength, the model of semiconductor light-emitting-diode 11 preferably adopts the monochromatic LED with certain narrow-band spectrum, certainly also can select according to the needs of actual measurement the white LED model sending mixed spectra.Fig. 1 shows the structural drawing of the light source assembly with four semiconductor light-emitting-diodes 11, wherein the corresponding a kind of model of each semiconductor light-emitting-diode 11.
Separately, the luminescent spectrum of the first light source assembly 1a of the present utility model and secondary light source assembly 1b does not have overlap.
Driving circuit 12 controls turning on light and turning off the light of semiconductor light-emitting-diode 11 in light emitting diode matrix, a kind of semiconductor light-emitting-diode 11 of wavelength at a time can only be had to open, the Control timing sequence figure that driving circuit controls four semiconductor light-emitting-diodes 11 and turns on light and turn off the light has been shown in Fig. 2, four semiconductor light-emitting-diodes 11 are turned on light successively in turn and turn off the light under the Control timing sequence of driving circuit 12, in this enforcement, the cycle of preferred switch control time sequence is 50ms, the lighting time of each semiconductor light-emitting-diode 11 is 6.25ms, to realize the object measured within the extremely short time.
As further improvement of the utility model, in order to improve levels of light energy, along the direction of propagation of described transmitted beam, one first optical lens 4 is equipped with in the downstream of each described semiconductor light-emitting-diode 11, first optical lens 4, for focusing on the light beam of semiconductor light-emitting-diode 11, guarantees that more light enters measurement mechanism.
As further improvement of the utility model, in order to improve the monochromaticity level of light, along the direction of propagation of described transmitted beam, an interference filter 6 is equipped with in the downstream of each described first optical lens 4, interference filter 6 preferably arrowband interfere type optical filter herein, its half-wave bandwidth is generally less than and equals 12nm, the use of interference filter 6 can carry out filtering process to the spectrum of the semiconductor light-emitting-diode 11 under this passage, remove unexpected wavelength, and the optics background depth of lifting gear, improve the optical s/n ratio of device, the detection accuracy of final raising biological specimen.
The light beam that first light source assembly 1a and secondary light source assembly 1b sends separately is all successively through the focusing of the first optical lens 4, the laggard optical signal conducting subassembly 3 of filtering of interference filter 6.
In order to complete the light conduction of light source assembly 1 transmitted beam, the light signal transduction assembly 3 of the present embodiment comprises the composite fiber bundle 34 docked with the first light source assembly 1a, the collection fibers bundle 31 docked with secondary light source assembly 1b, and the light pipe 32 that two ends are docked with collection fibers bundle 31 and composite fiber bundle 34 respectively, the two ends of light pipe 32 are configured with an a second incidence end 32a and second exit end 32b respectively, second exit end 32b is provided with an optical mirror 35, second incidence end 32a docks with composite fiber bundle 34, second exit end 32b docks with collection fibers bundle 31.
Wherein, composite fiber bundle 34 of the present utility model to be synthesized by the light splitting fibre bundle having the collection fibers bundle that collects beam functions and have a light splitting function according to specific manufacture craft to be wholely set, it is made up of multi-channel optical fibre branch, and different fiber branch is used for realizing fiber collection function and light splitting function.Composite fiber bundle 34 after making is a kind of fibre-optic bundle more than a turn, it is configured with several the 3rd incidence end 33a, several the 3rd exit end 33b and hold 34c jointly, common end 34c converges the optical fiber wire having the 3rd incidence end 33a and the 3rd exit end 33b, wherein the 3rd exit end 33b optical fiber wire is uniformly distributed in the inner ring of common end, and the optical fiber wire of the 3rd incidence end 33a is uniformly distributed outer shroud.
Several the 3rd incidence end 33a dock with the transmitting terminal of the first light source assembly 1a respectively, and several the 3rd exit end 33b dock with detection channels assembly, and common end 34c develops with the second incidence end 32a and docks.
Collection fibers bundle 31, its two ends are configured with several first incidence end 31a and first exit end 31b respectively, described first exit end 31b to be developed with the second exit end 32b by optical mirror 35 and docks, and several first incidence end 31a dock with the transmitting terminal of secondary light source assembly 1b respectively.
Optical mirror 35 of the present utility model has the special curve of spectrum, the reflectance spectrum of optical mirror 35 comprises the luminescent spectrum of the first light source assembly 1a, the transmitted spectrum of optical mirror 35 comprises the luminescent spectrum of secondary light source assembly 1b, as shown in Figure 8, the optical mirror 35 that the utility model uses, its curve of spectrum controls below 5% at the transmittance of spectrum separatrix left-half, and object is that the light-emitting line of prevention first group of light source assembly 1a is gone out from optical mirror 35 transmission; Its curve of spectrum controls more than 95% at the transmittance of spectrum separatrix right half part, and object allows the light-emitting line of secondary light source assembly 1b enter light pipe 32 transmitted through optical mirror 35.
Based on the said structure of light signal transduction assembly 3, after optical mirror 35 is set, the travel path sending light beam in first light source assembly 1a and secondary light source assembly 1b is as follows: after the light beam of the first light source assembly 1a is conducted to the 3rd exit end 33b by composite fiber bundle 34, import in light pipe 32 from the second incidence end 32a of light pipe 32, reflected by optical mirror 35 when propagating into the second exit end 32b of light pipe 32, light beam turns back from the 3rd exit end 33b of composite fiber bundle 34 after reflection and launches in light pipe 32 is reverse, enters detection channels assembly 5; After the light beam of secondary light source assembly 1b is conducted to the first exit end 31b by collection fibers bundle 31, imported in light pipe 32 by from the second exit end 32b through optical mirror 35, launch when propagating into the 3rd exit end 33b of composite fiber bundle 34 in light pipe 32 and enter detection channels assembly 5.
In order to complete reception and the detection of light signal, the detection channels assembly 5 of the present embodiment comprises Measurement channel, be arranged on optical signalling detector 51 in Measurement channel and advance signal treatment circuit 52,
Wherein, the quantity of the Measurement channel of configuration is identical with the quantity of the 3rd exit end 33b, and the entrance of each Measurement channel is all corresponding to be docked with a 3rd exit end 33b, and tested biological specimen 2 is placed in Measurement channel;
The quantity of the optical signalling detector 51 of configuration is identical with the port number of Measurement channel, a configuration optical signalling detector 51 in a Measurement channel, and along the direction of propagation of described transmitted beam, the optical signalling detector 51 in same passage is all arranged on the downstream of tested biological specimen 2.In single Measurement channel, the light emitted from a 3rd exit end 33b of light splitting fibre bundle 33 enters in Measurement channel, at Measurement channel internal radiation biological specimen 2, optical signalling detector 51 gathers the optical signalling of the biological specimen 2 under light irradiation, and the signal of collection exports advance signal treatment circuit 52 to.Optical signalling detector 51 of the present utility model includes but not limited to silicon photo diode, photoelectric cell or photomultiplier, preferred silicon photo diode.
Advance signal treatment circuit 52, its input end connects the output terminal of each described signal sensor 51, as shown in Figure 6, advance signal treatment circuit 52 of the present utility model carries out opto-electronic conversion successively to gathering the biological specimen optical signalling come, light intensity is converted to electric signal, again successively the process such as filtering, amplification and analog to digital conversion are carried out to electric signal, the final control terminal being uploaded to advance signal treatment circuit 52 with digital quantity, the data of carrying out the physiologic information of biological specimen 2 are extracted, are calculated and output report process.
As further improvement of the utility model, in order to improve levels of light energy, along the direction of propagation of described transmitted beam, the upstream of each described tested biological specimen 2 is equipped with one second optical lens 8, second optical lens 8, for focusing on segmentation light, guarantees more light irradiating biological samples 2.
Embodiment three
Embodiment three is different from only being of embodiment two: the structure of secondary light source assembly 1b is different from the first light source assembly 1a, specific as follows:
The structure of the first light source assembly 1a and associated description, with embodiment two, are not repeating herein.
The switch that secondary light source assembly 1b comprises Halogen lamp LED 13 and drives described Halogen lamp LED 13 to close or open, use Halogen lamp LED 13 can solve the problem that semiconductor light-emitting-diode 11 cannot produce ultraviolet spectrum, the spectrum usable range of this device can be expanded, to meet the biological specimen testing requirement of ultraviolet wavelength after using.
To the above-mentioned explanation of the disclosed embodiments, professional and technical personnel in the field are realized or uses the utility model.To be apparent for those skilled in the art to the multiple amendment of these embodiments, General Principle as defined herein when not departing from spirit or scope of the present utility model, can realize in other embodiments.Therefore, the utility model can not be restricted to these embodiments shown in this article, but will meet the widest scope consistent with principle disclosed herein and features of novelty.
Claims (10)
1. the optical measuring device for detection of biological samples, comprise the light source assembly be configured to tested biological specimen transmitted beam, it is characterized in that: it also comprises the light signal transduction assembly and detection channels assembly that set gradually along the transmitted beam direction of propagation, and described light signal transduction assembly comprises
-collection fibers bundle, its two ends are configured with several first incidence end and first exit end respectively;
-light pipe, it is the column structure that two ends are configured with second incidence end and second exit end respectively, and described second incidence end is docked with the first exit end and developed;
-light splitting fibre bundle, its two ends are configured with the 3rd incidence end and several the 3rd exit ends respectively, and described 3rd incidence end is docked with the second exit end and developed;
Described detection channels assembly comprises,
The Measurement channel that-port number is identical with described 3rd exit end quantity, the entrance of described Measurement channel all docks with the 3rd exit end, arranges described tested biological specimen in it;
-optical signalling the detector identical with described Measurement channel quantity, along the direction of propagation of described transmitted beam, described optical signalling detector is all arranged on the downstream of tested biological specimen;
-advance signal treatment circuit, its input end connects the output terminal of each described signal sensor.
2. a kind of optical measuring device for detection of biological samples according to claim 1, is characterized in that: described light source assembly comprises
-light emitting diode matrix, it comprises at least one semiconductor light-emitting-diode;
-drive described semiconductor light-emitting-diode to close or the driving circuit opened.
3. a kind of optical measuring device for detection of biological samples according to claim 2, it is characterized in that: along the direction of propagation of described transmitted beam, the downstream of each described semiconductor light-emitting-diode is equipped with one first optical lens, and described first incidence end is arranged on the focus point of the first optical lens.
4. a kind of optical measuring device for detection of biological samples according to claim 3, is characterized in that: along the direction of propagation of described transmitted beam, and the downstream of each described first optical lens is equipped with an interference filter.
5. a kind of optical measuring device for detection of biological samples according to claim 1, is characterized in that: along the direction of propagation of described transmitted beam, and the upstream of each described tested biological specimen is equipped with one second optical lens.
6. the optical measuring device for detection of biological samples, comprise the light source assembly be configured to tested biological specimen transmitted beam, it is characterized in that: described light source assembly is independent two groups of arranging, be respectively the first light source assembly and secondary light source assembly, it also comprises the light signal transduction assembly and detection channels assembly that set gradually along the transmitted beam direction of propagation, and described light signal transduction assembly comprises
-collection fibers bundle, its two ends are configured with several first incidence end and first exit end respectively;
-light pipe, it is the column structure that two ends are configured with second incidence end and second exit end respectively, and described second exit end docks with the first exit end and develops;
Described second incidence end is developed with jointly holding to dock;
-having and converge the composite fiber bundle that light and light splitting combine, it is configured with several first incidence end, several first exit ends and one end jointly, and described common end docks with the second incidence end and develops;
-optical mirror, its docking is developed described second exit end and is arranged;
The beam emissions end of described first light source assembly docks with composite fiber bundle, and the beam emissions end of described secondary light source assembly docks with collection fibers bundle;
Described detection channels assembly comprises,
The Measurement channel that-port number is identical with described first exit end quantity, the entrance of described Measurement channel all docks with the first exit end, arranges described tested biological specimen in it;
-optical signalling the detector identical with described Measurement channel quantity, along the direction of propagation of described transmitted beam, described optical signalling detector is all arranged on the downstream of tested biological specimen;
-advance signal treatment circuit, its input end connects the output terminal of each described signal sensor.
7. a kind of optical measuring device for detection of biological samples according to claim 6, is characterized in that: described first light source assembly is identical with the structure of second light source assembly, and it includes
-light emitting diode matrix, it comprises at least one semiconductor light-emitting-diode;
-drive described semiconductor light-emitting-diode to close or the driving circuit opened.
8. a kind of optical measuring device for detection of biological samples according to claim 6, is characterized in that: described first light source assembly comprises,
-light emitting diode matrix, it comprises at least one semiconductor light-emitting-diode;
-drive described semiconductor light-emitting-diode to close or the driving circuit opened;
The switch that described secondary light source assembly comprises Halogen lamp LED and drives described Halogen lamp LED to close or open.
9. a kind of optical measuring device for detection of biological samples according to claim 7 or 8, it is characterized in that: along the direction of propagation of described transmitted beam, the downstream of each described semiconductor light-emitting-diode is equipped with one first optical lens, described first incidence end is arranged on the focus point of the first optical lens, along the direction of propagation of described transmitted beam, the upstream of each described tested biological specimen is equipped with one second optical lens.
10. a kind of optical measuring device for detection of biological samples according to claim 9, is characterized in that: along the direction of propagation of described transmitted beam, and the downstream of each described first optical lens is equipped with an interference filter.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105223137A (en) * | 2015-10-20 | 2016-01-06 | 希肯医疗技术（苏州）有限公司 | A kind of optical measuring device for detection of biological samples |
| CN106546166A (en) * | 2016-12-09 | 2017-03-29 | 中国科学技术大学 | A kind of interference system and its multi-coated interference instrument, monolayer interferometer, strip interferometer |
| CN108663255A (en) * | 2018-08-01 | 2018-10-16 | 希肯医疗技术（苏州）有限公司 | Full-automatic immunohistochemical staining machine |
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2015
- 2015-10-20 CN CN201520816558.7U patent/CN205038151U/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105223137A (en) * | 2015-10-20 | 2016-01-06 | 希肯医疗技术（苏州）有限公司 | A kind of optical measuring device for detection of biological samples |
| CN105223137B (en) * | 2015-10-20 | 2017-10-24 | 希肯医疗技术（苏州）有限公司 | A kind of optical measuring device for detection of biological samples |
| CN106546166A (en) * | 2016-12-09 | 2017-03-29 | 中国科学技术大学 | A kind of interference system and its multi-coated interference instrument, monolayer interferometer, strip interferometer |
| CN106546166B (en) * | 2016-12-09 | 2019-06-11 | 中国科学技术大学 | A kind of interference system and its multi-coated interference instrument, single layer interferometer, strip interferometer |
| CN108663255A (en) * | 2018-08-01 | 2018-10-16 | 希肯医疗技术（苏州）有限公司 | Full-automatic immunohistochemical staining machine |
| CN108663255B (en) * | 2018-08-01 | 2023-11-21 | 希肯医疗技术（苏州）有限公司 | Full-automatic immunohistochemical dyeing machine |
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