CN203838156U - Quick diagnosis test system integrated with image sensing system and embedded system - Google Patents
Quick diagnosis test system integrated with image sensing system and embedded system Download PDFInfo
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- CN203838156U CN203838156U CN201320815438.6U CN201320815438U CN203838156U CN 203838156 U CN203838156 U CN 203838156U CN 201320815438 U CN201320815438 U CN 201320815438U CN 203838156 U CN203838156 U CN 203838156U
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Abstract
The utility model provides a quick diagnosis test system integrated with an image sensing system and an embedded system. The quick diagnosis test system comprises a gold-labeled numerical reading instrument module and the embedded system, wherein the gold-labeled numerical reading instrument module at least comprises a clamping slot part and an image picking unit; the clamping slot part is fixed in a shell and used for locating immune paper strips to be detected; the image picking unit is arranged relative to the clamping slot part and equipped with a wide-angle macro lens, a light filter, a light source part arranged relative to the clamping slot part and a display unit; the embedded system comprises an embedded processing unit, a storage unit, an interface unit and a power supply unit; the embedded processing unit is connected to the light source part, the image picking unit and the display unit and fixed in the shell; the storage unit is connected to the embedded processing unit; the interface unit is connected to the embedded processing unit; the power supply unit is connected to the embedded processing unit. The quick diagnosis test system is complete in functions, small in volume and light in weight and can be intuitively and conveniently used in laboratories or detection fields.
Description
Technical field
The utility model relates to examines detection field soon, and what relate in particular to that a kind of image sensing combines with embedded system examines detection system soon.
Background technology
Whole immuno analytical method is developing to both direction: a class is full-automatic immunoassay; Another kind of for take the POCT fast immune chromatographic technology that nitrocellulose membrane is carrier.Immunochromatography (Immunochromatography, IC) technology be having experienced radio-immunity mark, enzyme was exempted from after the stages such as mark, chemiluminescent labeling, a kind of tachysynthesis analytical approach that immunological technique and chromatography technology are combined growing up in the eighties in 20th century.The principle of fast immune chromatographic technology is to take fibre strip chromatographic material as solid phase, by capillary action, make sample solution swimming on chromatography strip, simultaneously, make the acceptor (as antibody or antigen) for determinand on determinand in sample and chromatographic material occur high special, the immune response of high-affinity, in chromatography process, immune complex is by enrichment or be trapped in the certain area (detect band) of chromatographic material, the colored marker (as collaurum) that can estimate by enzyme-catalytic chromogenic reaction or direct use, in the biological respinse time (5～10min) of short time, just can obtain experimental result intuitively.This analytical technology does not need to carry out the separated of binding label and free label, has saved loaded down with trivial details application of sample, washing step, simple to operate fast, analysis result is clear.Yet conventional judging means is range estimation at present, can only meet qualitative and semiquantitative test.Along with the rise of bedside diagnosis, quick diagnosis concept, the advantages such as contemporary quick diagnosis technology that the collaurum of take is representative is low with cost, preparation is simple, technical maturity are used widely at home, are domestic current topmost quick diagnosis technology.
Bedside in-vitro diagnosis (POCT) is to utilize portable set and reagent in several minutes, to draw a kind of check system of assay, be widely used in the fields such as hospital, nursing ward, rescue unit, insurance company, family health care network, the work that its appearance makes to be completed by Special Survey personnel has traditionally been given more non-reviewer and has been completed.This is a kind of check system fast, can meet people's requirement in time, adapts to the needs of modern social development.
POCT not only have fast obtain a result, simple to operate, easily use and the feature such as miniaturization, and again without traditional hospital's experimental site and equipment.This makes private clinic or the social therapeutic machine that do not satisfy the requirements also can correctly be diagnosed fast.Tool glamour be, appearance successively along with many family's disease self check (Homelab) products of developing based on POCT, make the detection operation that patient just can complete independently some diseases in own home, family's self check product of the type, will become the development trend in following real-time test field.
Domestic current gold mark readout instrument or gold mark detection system have following two kinds: 1, and sweep type, 2, camera method type.
For example; in China Patent No. 201120449209.8; on November 11st, 2011; in the utility model patent of applicant Hangzhou Nankai Rixin Bioisystech Co., Ltd and Shanghai Huguo Science Instrument Co., Ltd.'s application " gold mark readout instrument "; a kind of sweep type gold mark readout instrument has been described, the qualitative and quantitatively detection for colloidal gold immunochromatographimethod agent plate.This gold mark readout instrument is provided with cabinet, is provided with light-source system, scanister, signal acquiring system, signal processing system in cabinet; On cabinet, be provided with data display and output system, colloidal gold immunochromatographimethod agent plate pallet, power switch, adaptor spigot, dry cell placement mouthful.This gold mark readout instrument, except can qualitatively judging, can also provide the concrete concentration numerical value of contained drug in sample, has avoided personal error; In addition, can also to measurement result, immediately preserve, copy and export, be convenient for carrying, be applicable to different testing environments.
Yet the deficiency of this gold mark readout instrument is: owing to being a kind of reading device of scan-type, therefore it is consuming time too much to complete whole test process, and complex structure, dress, tune complex process, mechanical noise is large, and cost is high; In addition, be only applicable to the application of a certain specific gold test strip box, and can only be applied in the optical energy scan process of collaurum, do not comprise that the image of common fluorescence and time-resolved fluorescence is processed, function is comparatively single.
Again for example, Chinese Patent Application No. 201310025671.9, China Inst. of Quarantine Inspection Sciences, in the invention " a kind of collaurum gold mark detector " of application on January 21st, 2013, provides a kind of image pick-up type gold mark readout instrument.This collaurum gold mark detector comprise to test strips carry out image acquisition image capturing system, the image gathering is carried out to the central control system of analyzing and processing and the printing equipment that the result of analyzing and processing is printed.Although, this collaurum gold is marked the test strip information that detector can be qualitative, quantitative, and record analysis data result, but because it adopts the central processing unit of X86-based, and work under windows operating system, thereby cause that its hardware system cost is high, operation system of software version cost is also high, and whole system power consumption is larger; And equally also can only be applied in the optical energy scan process of collaurum, do not comprise that the image of common fluorescence and time-resolved fluorescence is processed.
Utility model content
The purpose of this utility model is to provide that a kind of multi-functional image sensing combines with embedded system examines soon detection system.
For reaching above-mentioned purpose and other objects, the image sensing that the utility model provides combines with embedded system examines detection system soon, and it comprises gold mark readout instrument module and connects the embedded system of described gold mark readout instrument module; Wherein, described gold mark readout instrument module at least comprises:
Be fixed in housing and for locating the clamp groove component of immune paper slip to be measured;
With respect to described clamp groove component setting and be fixed on the image capture unit in described housing, it disposes wide-angle micro-lens and optical filter;
With respect to described clamp groove component setting and be fixed on the light source part in described housing;
Part exposes to the display unit of described surface of shell;
Described embedded system comprises:
Be connected with described light source part, image capture unit and display unit and be fixed on the embedded processing unit in described housing;
Be connected with described embedded processing unit and be fixed on the storage unit in described housing;
Be connected with described embedded processing unit and be fixed on the interface unit in described housing;
Be connected with described embedded processing unit and be fixed on the power supply unit in described housing.
Preferably, above-mentioned gold mark readout instrument module also disposes at least one in individual event order paper box sample cell or individual event order test strips sample cell or entry paper box sample cell or entry test strips sample cell or dot matrix entry test strips or dot matrix entry paper box.Preferably, can be 2-4 individual event order test strips sample cell or an above individual event order test strips sample cell and an above entry paper box sample cell.
Preferably, above-mentioned light source part comprises LED light source and pulse/brightness adjusting unit.
Preferably, the display screen of above-mentioned display unit comprises touch-screen.
Preferably, said memory cells comprises SD card.
Preferably, above-mentioned interface unit comprises the unit that a plurality of USB interface are provided.Preferably, USB interface is two, three or four.
Preferably, above-mentioned interface unit comprises the communication unit that Ethernet interface is provided.
Preferably, above-mentioned interface unit comprises radio communication unit.
Preferably, the unit providing with host computer connecting interface is provided above-mentioned interface unit.
Preferably, above-mentioned power supply unit disposes portable power source.
As mentioned above, the detection system of examining soon that image sensing of the present utility model combines with embedded system has the following advantages: multiple functional, volume is little, lightweight, can be directly perceived, easily in laboratory or Test Field use.
Other aspects of the present utility model, due to disclosure herein, will be apparent to those skilled in the art.
Below in conjunction with accompanying drawing, the utility model is elaborated.
Accompanying drawing explanation
Fig. 1 be image sensing of the present utility model combine with embedded system examine soon detection system structural representation;
Fig. 2 a to 2c is the housing schematic diagram of examining soon detection system that image sensing of the present utility model combines with embedded system, and wherein, 2a is vertical view, and Fig. 2 b is left view, and Fig. 2 c is rear view;
Fig. 3 is the preferred schematic diagram of examining soon detection system that image sensing of the present utility model combines with embedded system.
Embodiment
As shown in Figure 1, the utility model provides that a kind of image sensing combines with embedded system examines detection system soon.The described detection system 1 of examining soon comprises: gold is marked readout instrument module 11 and connected the embedded system 12 of described gold mark readout instrument module.
Described gold mark readout instrument module 11 comprises: clamp groove component 111, image capture unit 112, light source part 113 and display unit 114; Described embedded system 12 comprises: embedded processing unit 121, storage unit 122, interface unit 123, power supply unit 124.
Described clamp groove component 111 is fixed in housing and for locating immunity test strip to be measured.Wherein, described housing is small and exquisite attractive in appearance, is easy to carry, and can adopt metal material or plastic material, and its shape is " bread board " shape preferably, and upper surface exposes display screen, and as shown in Fig. 2 a to 2c, wherein, Fig. 2 a is vertical view, and Fig. 2 b is left view, and Fig. 2 c is rear view.
Described image capture unit 112 arranges with respect to described clamp groove component 111, be fixed in housing, it disposes wide-angle micro-lens and optical filter, it also comprises the imageing sensor that CMOS camera chip forms, as shown in Figure 3, for absorbing the image of the immunity test strip to be measured that described clamp groove component 111 locates.
Described light source part 113 arranges with respect to described clamp groove component 111, and be fixed in housing, needed illuminance while being used for providing image capture, preferably, it comprises LED light source and pulse/brightness adjusting unit, as shown in Figure 3, described pulse/brightness adjusting unit is used for regulating LED light source, so that needed uniform source of light can provide image capture time.
Described display unit 114 is for showing test results etc., and its display screen comprising exposes to surface of shell, as shown in Figure 2 a.
Preferably, described display screen comprises touch-screen.
Preferably, described gold mark readout instrument module 11 also disposes paper box sample cell 115 and test strips sample cell 116, as shown in Figure 3; Certainly, also can configure as required a paper box sample cell or a test strips sample cell.
Described embedded processing unit 121 is connected with described light source part 113, image capture unit 112 and display unit 114, be fixed in housing, be used for controlling and data processing, comprised: the foundation of cloudy/positive and weak positive setting, the concentration readout mathematical model separately of the test strips of disparity items and correction etc.; Especially can be by the requirement of project to be measured (at most can preset 99 projects), the position of preset different paper boxes or test strips, different gold mark reaction bar, different reaction mechanisms (sandwich method or competition law), different decision threshold, so that concentration readout judge and direct-reading etc.; And, result and the condition of each reading, embedded processing unit 121 can automatically deposit the USB flash disk of SD card or extrapolation in or transmit to upper level data station by Ethernet interface or radio communication unit etc.; Described embedded processing unit 121 also can the instruction based on host computer be controlled image capture or be transmitted data.
Described storage unit 122 is connected with described embedded processing unit 121, and is fixed in housing, and for storing data, it is preferably SD card.
Described interface unit 123 is connected with described embedded processing unit 121, and is fixed in housing, for communicating with miscellaneous part or equipment etc.
Preferably, described interface unit 123 can comprise: (for example provide the unit of a plurality of USB interface, the unit of 4 USB interface), provide the communication unit, radio communication unit of Ethernet interface, with the unit of host computer connecting interface etc., thus, by those USB interface, can connect keyboard, mouse, USB flash disk, bar code scanner etc.; By Ethernet interface, can realize and being connected of Local Area Network; Can realization and the linking of 3G network, WiFi network etc. by radio communication unit, as shown in Figure 3.
As shown in Figure 2 c, in housing rear surface, expose and have 4 USB interface, an Ethernet interface.
Described power supply unit 124 is connected with described embedded processing unit 121, and is fixed in housing, for electric energy is provided, preferably, it comprises portable power source, passes through rechargeable battery, for example, the unit of lithium battery power supply, it also can comprise the unit by mains-supplied.By adopting portable power source, can make this examine soon detection system 1 can be at different environment, and such as test site, laboratory, inspection vehicle etc. located to detect.
The above-mentioned course of work of examining soon detection system 1 is as follows:
During test, acceptor (as antibody or antigen) for determinand on determinand in sample and chromatographic material occurs high special, the immune response of high-affinity, after short time biological respinse, (in 5～10min) is just can obtain the common fluorescence that colored marker (as fluorescence latex particle or collaurum) produces, time-resolved fluorescence or chromogenic reaction, thus, by the location of 111 pairs of immunity test strips of clamp groove component, under the irradiation of light source part 113, by embedded processing unit 121, control image capture unit 112 image of color chips picked-up immunity test strip after filtration, subsequently, the image of the 121 pairs of picked-ups in embedded processing unit is processed and judges, finally result is presented on touch-screen, simultaneously, embedded processing unit 121 can be according to predetermined protocol respectively by Ethernet interface or radio communication unit link internet, or by connecting host computer, complete following operation: a) picked-up of control chart picture, b) obtain real time data, c) be stored in host computer internal memory, in addition, embedded processing unit 121 also can, according to making an appointment, deposit in connected USB flash disk or the SD card such as data and corresponding steering order, have, whole system also can be by connected mouse action again, and corresponding immunity test strip information as required can be by providing after connected bar code scanner collection.
In sum, the detection system of examining soon that image sensing of the present utility model combines with embedded system adopts the CMOS camera of being furnished with wide-angle micro-lens, the illumination that adds optical filter and LED regulates, the common collaurum colour developing optical imagery photography producing except completing the reaction of immunity test strip, can also complete at the optical filter or the LED light source that adapt with color latex fluorescent particles/time resolution nano particle, through pulse/illumination, regulate and control the lower label image processing that completes common fluorescence or time-resolved fluorescence, except completing paper box/bar channel mould piece of general individual event order (wall scroll T), also comprise the test of entry paper box/bar channel mould piece that can once complete in many test strips, and can be suitable for different paper boxes and naked, also be suitable for different single inspections, the test paper of two inspections and three joint inspections, wide application, the demand that is suitable for different inspection bodies, can be used for cardiovascular disease (miocardial infarction, in heart failure), infectious diseases (HBV, HIV, H1N1), tumor marker, drugs, residues of pesticides, food security (Melamine, clenbuterol hydrochloride, trace antibiotic residue) etc. detection, the utility model is powerful, low in energy consumption, has very big competitive power, also have, its profile is flat attractive in appearance, is convenient to hand-held and carries.
All documents of mentioning at the utility model are all quoted as a reference in this application, just as each piece of document, are quoted as a reference separately.In addition should be understood that those skilled in the art can make various changes or modifications the utility model after having read above-mentioned instruction content of the present utility model, these equivalent form of values fall within the application's appended claims limited range equally.
Claims (10)
1. image sensing combines with embedded system examines a detection system soon, it is characterized in that, comprises gold mark readout instrument module and connects the embedded system of described gold mark readout instrument module; Wherein,
Described gold mark readout instrument module at least comprises:
Be fixed in housing and for locating the clamp groove component of immune paper slip to be measured;
With respect to described clamp groove component setting and be fixed on the image capture unit in described housing, it disposes wide-angle micro-lens and optical filter;
With respect to described clamp groove component setting and be fixed on the light source part in described housing;
Part exposes to the display unit of described surface of shell;
Described embedded system comprises:
Be connected with described light source part, image capture unit and display unit and be fixed on the embedded processing unit in described housing;
Be connected with described embedded processing unit and be fixed on the storage unit in described housing;
Be connected with described embedded processing unit and be fixed on the interface unit in described housing;
Be connected with described embedded processing unit and be fixed on the power supply unit in described housing.
2. image sensing as claimed in claim 1 combines with embedded system examines detection system soon, it is characterized in that, described gold mark readout instrument module also disposes: in individual event order paper box sample cell or individual event order test strips sample cell or entry paper box sample cell or entry test strips sample cell or dot matrix entry test strips or dot matrix entry paper box at least one.
3. image sensing as claimed in claim 1 combines with embedded system examines detection system soon, it is characterized in that, described light source part comprises LED light source and pulse/brightness adjusting unit.
4. image sensing as claimed in claim 1 combines with embedded system examines detection system soon, it is characterized in that, the display screen of described display unit comprises touch-screen.
5. image sensing as claimed in claim 1 combines with embedded system examines detection system soon, it is characterized in that, described storage unit comprises SD card.
6. the image sensing as described in claim as arbitrary in claim 1-5 combines with embedded system examines detection system soon, it is characterized in that, described interface unit comprises the unit that a plurality of USB interface are provided.
7. the image sensing as described in claim as arbitrary in claim 1-5 combines with embedded system examines detection system soon, it is characterized in that, described interface unit comprises the communication unit that Ethernet interface is provided.
8. the image sensing as described in claim as arbitrary in claim 1-5 combines with embedded system examines detection system soon, it is characterized in that, described interface unit comprises radio communication unit.
9. the gold of the portable multi-function based on embedded system as described in claim as arbitrary in claim 1-5 mark examines that detector image sensing combines with embedded system soon examines detection system soon, it is characterized in that, the unit providing with host computer connecting interface is provided described interface unit.
10. the image sensing as described in claim as arbitrary in claim 1-5 combines with embedded system examines detection system soon, it is characterized in that, described power supply unit disposes portable power source.
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| CN201320815438.6U CN203838156U (en) | 2013-12-10 | 2013-12-10 | Quick diagnosis test system integrated with image sensing system and embedded system |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104914239A (en) * | 2015-06-29 | 2015-09-16 | 上海交通大学 | Immunochromatographic test strip detection equipment |
| CN104954639A (en) * | 2014-09-23 | 2015-09-30 | 天津起跑线生物信息技术有限公司 | Digital-imaging-technology-based distributed medical detection system |
| CN105259148A (en) * | 2015-11-02 | 2016-01-20 | 深圳市锦瑞电子有限公司 | Fluorescence immunoassay quantitative analyzer |
| CN106680439A (en) * | 2015-11-09 | 2017-05-17 | 北京艾旗斯德科技有限公司 | Miniature food safety and in-vitro diagnosis analyzer |
| CN109738622A (en) * | 2018-12-29 | 2019-05-10 | 北京化工大学 | Lateral flow paper slip device for fast detecting based on micro-fluidic chip |
| CN111337683A (en) * | 2020-03-24 | 2020-06-26 | 北京万泰生物药业股份有限公司 | Portable HIV detection device |
-
2013
- 2013-12-10 CN CN201320815438.6U patent/CN203838156U/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104954639A (en) * | 2014-09-23 | 2015-09-30 | 天津起跑线生物信息技术有限公司 | Digital-imaging-technology-based distributed medical detection system |
| CN104914239A (en) * | 2015-06-29 | 2015-09-16 | 上海交通大学 | Immunochromatographic test strip detection equipment |
| CN105259148A (en) * | 2015-11-02 | 2016-01-20 | 深圳市锦瑞电子有限公司 | Fluorescence immunoassay quantitative analyzer |
| CN106680439A (en) * | 2015-11-09 | 2017-05-17 | 北京艾旗斯德科技有限公司 | Miniature food safety and in-vitro diagnosis analyzer |
| CN109738622A (en) * | 2018-12-29 | 2019-05-10 | 北京化工大学 | Lateral flow paper slip device for fast detecting based on micro-fluidic chip |
| CN109738622B (en) * | 2018-12-29 | 2020-12-11 | 北京化工大学 | Lateral flow paper strip rapid detection device based on micro-fluidic chip |
| CN111337683A (en) * | 2020-03-24 | 2020-06-26 | 北京万泰生物药业股份有限公司 | Portable HIV detection device |
| CN111337683B (en) * | 2020-03-24 | 2024-02-09 | 北京万泰生物药业股份有限公司 | Portable HIV detection device |
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Granted publication date: 20140917 Termination date: 20191210 |