CN203777388U - Container for freezing and drying human platelet - Google Patents
Container for freezing and drying human platelet Download PDFInfo
- Publication number
- CN203777388U CN203777388U CN201420091593.2U CN201420091593U CN203777388U CN 203777388 U CN203777388 U CN 203777388U CN 201420091593 U CN201420091593 U CN 201420091593U CN 203777388 U CN203777388 U CN 203777388U
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- container
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- plastic bag
- platelet
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Abstract
The utility model discloses a container for freezing and drying a human platelet. The container consists of a plastic bag body, a hard plastic filling opening, a rubber plug, a plastic cover, an infusion pipe, a hanging hole, a compressing strip and the like. A freeze-dried suspension of the human platelet is injected into a blood bag through the hard plastic filling opening; after the container filled with the freeze-dried suspension is frozen and dried on a shelf of a freeze dryer, the container can be directly plugged and sealed for storage, before the freeze-dried suspension is used, the rubber plug is removed, a porous plug covers for pre-hydration, hydrated solution fills the container through the hard plastic filling opening, and then the tail end of the infusion pipe is sheared for infusion of the solution. The container disclosed by the utility model can be used for storing the human platelets with the curative dose (blood platelet count is not smaller than 2.5*10<11>) by freeze drying.
Description
Technical field
This utility model relates to a kind of disposable use medical device product, especially human blood platelets lyophilization container.
Background technology
Platelet transfusion is the Therapeutic Method that a kind of effective prevention and treatment cause because of thrombocytopenia or platelet function defect, clinical being applicable to: 1) bone marrow depression or exhaustion; 2) platelet function abnormality; 3) blood transfusion in a large number; 4) cardiopulmonary bypass surgery; 5) neonatal alloimmune thrombocytopenia, after preventative platelet transfusion can reduce cancer patient radiation and chemotherapy, thrombocytopenia causes hemorrhage case fatality rate.The human blood platelets of current clinical use mainly adopts 22 DEG C of vibrations to preserve, and needs special preservation equipment, and the Platelet Concentrate of preserving with this understanding, due to the progressively forfeiture of activity and the pollution of microorganism, can only ensure at most 5 days according to national standard.Under the low temperature of-80 DEG C or-196 DEG C, preserve platelet and can extend the pot-life; dimethyl sulfoxide is still the optimum selection of cryoprotective agent at present; but use Cryopreservation not only to need there is expensive cryopreservation equipment; and platelet after rewarming also must remove the cryoprotective agent that human body is had to potential injury by washing, can cause larger platelet counts and loss function.Due to the limitation of above-mentioned two kinds of methods, easily there is deficiency in the hematoblastic storage capacity of each blood bank, thereby cause seasonal medical blood supply anxiety, on the other hand, because of preservation equipment limited, some can not get the platelet of the separator well using in time and can be thrown away, or only needing the occasion platelet of red blood cell transfusion also together by infusion, cause hematoblastic a large amount of waste.If can solve the problem of platelet deposit, will bring glad tidings to countless patients.The hematoblastic long-term preservation of freeze-drying behaviour provides a kind of potential Perfected process.Lyophilization is by low temperature by the moisture freezes Cheng Bing in flowing product, and then under vacuum, heating constantly distils ice, the final dried product with porous loose structure that obtains.Freeze-dried products possesses and can stablely for a long time at ambient temperature store, conveniently transport, be easy to the advantages such as rehydration, and therefore Freeze Drying Technique is also widely used in the long-term preservation of various gourmet foods, medicine and biomaterial.
In clinical practice, collection or the hematoblastic capacity using are normally larger.For example the platelet number of 200 milliliters of separation of whole blood, 1 unit is out 2 × 10
10above, as being 1 × 10 by hematoblastic concentration in lyophilizing suspension
9individual/ml calculates, and suspension vol needs more than 20 milliliters, if (infusion amount of adult generally, platelet number is 2.5 × 10 for 1 bag of freeze dryer blood sampling platelet
11above), suspension vol is more than 250 milliliters.Hematoblastic concentration in lyophilizing suspension is brought up to 4 × 10
9individual/ml, suspension vol is more than 62.5 milliliters.Conventional lyophilized biological is all very limited by the available capacity of cillin bottle, is difficult to use in the platelet of an infusion amount of lyophilizing adult.
Utility model content
The purpose of this utility model is to provide a kind of human blood platelets lyophilization container.
A kind of for human blood platelets lyophilization container, its main body is plastic bag, the top of described plastic bag is provided with hanging hole, and bottom is provided with tube for transfusion, and the side at top is provided with filler, described filler is supporting porous plug or rubber stopper, described filler is further provided with vinyl cover, described rubber stopper, plastic cap sealed filler, and described porous plug makes filler ventilative, described plastic bag is further provided with compression bar, is used for compressing tube for transfusion.
Length 200～the 300mm of described plastic bag, width 80～120mm, height 8～12mm, internal capacity 100～200ml.
Described filler is the filler of duroplasts, the thickening of other parts of the relative bag of chamber wall of adjacent plastic bag, thickness between 3～4mm, other local wall thickness relative thin of plastic bag, thickness is between 1～2mm.
The beneficial effects of the utility model: human blood platelets lyophilizing suspension can inject blood bag by duroplasts filler, on the shelf of freeze dryer, complete after lyophilization, the sealed storage of can directly jumping a queue, before using, rubber stopper is removed, cover porous plug and carry out pre-rehydration, then inject after complex aqueous solution by duroplasts filler, tube for transfusion end is cut off and be can be used for infusion.This utility model can be used in therapeutic dose human blood platelets (platelet count>=2.5 × 10
11) lyophilization preserve.
Brief description of the drawings
Fig. 1 is human blood platelets lyophilization container top view, and compacted 4 of tube for transfusion 5 fastens;
Fig. 2 is the container cutaway view that lyophilizing suspension is housed, and between freezing and dry period, rubber stopper is in half upper state;
Fig. 3 is for the hematoblastic container cutaway view of Lyophilized Human is housed, and after being dried, rubber stopper is in complete upper state, and vinyl cover 7 has been twisted;
Fig. 4 is for being equipped with the hematoblastic container cutaway view of rehydration Lyophilized Human, and in infusion state, rubber stopper is removed, and porous plug 8 has covered, and tube for transfusion 5 ends are cut;
In figure, hanging hole 1, rubber stopper 2, filler 3, compression bar 4, tube for transfusion 5, vinyl cover 7, plastic bag 6, porous plug 8.
Detailed description of the invention
Use the container that provides of this utility model to carry out the implementation step of human blood platelets lyophilization, storage, pre-rehydration, rehydration and infusion of larger capacity as follows:
1, fill: the container that human blood platelets lyophilizing suspension (comprising human blood platelets, freeze drying protectant, PH buffer agent) is placed by filler 3 Injection Levels; liquid level is no more than the half of internal tank height; note not making solution enter tube for transfusion 5; fill and covered filler 3 with rubber stopper afterwards; make plug in half upper state; in dry run, steam can be overflowed by the breach of plug side like this, as Fig. 2.
2, pre-freeze: the container that installs solution is transferred to above the shelf of freezer dryer, in transfer process, keep container in level, shelf temperature can be down to-40 DEG C (being down to the minimum temperature that can reach as freezer dryer can not reach this temperature value) in advance, determine the length of cooling time according to the number of filled amount of solution, the solution in the time of freezing end in container should all freeze reality.
3, primary drying and redrying: the vacuum pump of open cold lyophilizer and heating system, make Pressure Drop in drying baker to 10Pa, shelf temperature maintains following 1～2 DEG C of solution eutectic temperature or glass transition temperature, carry out primary drying, continuing to all ice all distils and becomes steam, carry out subsequently redrying, slowly rising shelf temperature is to room temperature, continue 8～24 hours again according to the number of filled amount of solution, to remove part in conjunction with water, make lyophilized platelet water content not higher than 3%.
4, gas-flow closure: in drying baker, inject dry noble gas if nitrogen is with removal vacuum, and the system of jumping a queue manually or automatically of open cold lyophilizer, make the whole compactings of rubber stopper 2, open drying baker, screw on vinyl cover 7 to as early as possible each container.
5, store: the container that lyophilized platelet is housed is placed in the medical refrigerator of 4 DEG C of left and right and stores, as Fig. 3.
6, pre-rehydration: after the container that lyophilized platelet is housed is taken out from refrigerator, back out vinyl cover 7 and rubber stopper 2, screw on porous plug 8, container is placed in to 37 DEG C of waters bath with thermostatic control top processing 15～20 minutes, allow the pre-rehydration of lyophilized platelet.
7, rehydration: screw off porous plug 8, inject and the initial isometric complex aqueous solution of lyophilizing suspension (as 50% human plasma solution), rock gently container, dry is fully dissolved.
8, infusion: tube for transfusion 5 is taken out for 4 from compression bar, end is cut off, container is hung from hanging hole 1, under action of gravity, platelet suspension enters tube for transfusion 5, for clinical infusion, in infusion process, amount of solution constantly reduces, and air enters container through porous plug, avoid forming vacuum, as Fig. 4.
Claims (3)
1. the cryodesiccated container of human blood platelets, it is characterized in that: its main body is plastic bag (6), the top of described plastic bag (6) is provided with hanging hole (1), bottom is provided with tube for transfusion (5), the side at top is provided with filler (3), described filler (3) is supporting porous plug (8) or rubber stopper (2), described filler (3) is further provided with vinyl cover (7), described rubber stopper (2), vinyl cover (7) sealing filler (3), described porous plug (8) makes filler (3) ventilative, described plastic bag (6) is further provided with compression bar (4), be used for compressing tube for transfusion (5).
2. container according to claim 1, is characterized in that: the length 200～300mm of described plastic bag (6), width 80～120mm, height 8～12mm, internal capacity 100～200ml.
3. container according to claim 1, it is characterized in that: the filler that described filler (3) is duroplasts, other part thickenings of the relative bag of chamber wall of adjacent plastic bag (6), thickness is between 3～4mm, other local wall thickness relative thin of plastic bag, thickness is between 1～2mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420091593.2U CN203777388U (en) | 2014-03-03 | 2014-03-03 | Container for freezing and drying human platelet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420091593.2U CN203777388U (en) | 2014-03-03 | 2014-03-03 | Container for freezing and drying human platelet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203777388U true CN203777388U (en) | 2014-08-20 |
Family
ID=51313625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420091593.2U Expired - Fee Related CN203777388U (en) | 2014-03-03 | 2014-03-03 | Container for freezing and drying human platelet |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203777388U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109136080A (en) * | 2018-09-25 | 2019-01-04 | 新乡医学院 | A kind of detection kit and its application for the early diagnosis of straight colon cancer |
| CN109642772A (en) * | 2016-08-05 | 2019-04-16 | 巴克姆股份公司 | Drying receptacle |
| CN113069613A (en) * | 2021-03-22 | 2021-07-06 | 广州市天河诺亚生物工程有限公司 | Navel cord blood rewarming leak protection box |
-
2014
- 2014-03-03 CN CN201420091593.2U patent/CN203777388U/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109642772A (en) * | 2016-08-05 | 2019-04-16 | 巴克姆股份公司 | Drying receptacle |
| CN109642772B (en) * | 2016-08-05 | 2022-06-24 | 巴克姆股份公司 | Drying container |
| CN109136080A (en) * | 2018-09-25 | 2019-01-04 | 新乡医学院 | A kind of detection kit and its application for the early diagnosis of straight colon cancer |
| CN113069613A (en) * | 2021-03-22 | 2021-07-06 | 广州市天河诺亚生物工程有限公司 | Navel cord blood rewarming leak protection box |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140820 Termination date: 20170303 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |