CN203502413U - Biological sample detection exposure system based on terahertz - Google Patents
Biological sample detection exposure system based on terahertz Download PDFInfo
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- CN203502413U CN203502413U CN201320668617.1U CN201320668617U CN203502413U CN 203502413 U CN203502413 U CN 203502413U CN 201320668617 U CN201320668617 U CN 201320668617U CN 203502413 U CN203502413 U CN 203502413U
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- terahertz
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Abstract
The utility model provides a biological sample detection exposure system based on terahertz. The system comprises a terahertz generating device used for generating a terahertz signal, an activity maintaining device used for maintaining the activity of a biological sample, and a sample detection exposure device which is arranged in the activity maintaining device and connected with the terahertz generating device. According to the biological sample detection exposure system based on terahertz, on one hand, the activity of the biological sample to be detected is always maintained, so that the changes of cells, tissue blocks, protein molecules and DNA (Desoxvribose Nucleic Acid) of the biological sample are dynamically observed and analyzed so as to improve the accuracy of a detection result; on the other hand, the adverse influence of the terahertz to an organism is researched by exposing the terahertz of the biological sample, so that the safe dose of the terahertz in exposure is effectively evaluated so as to provide an experimental basis for people exposed to a terahertz environment instantaneously and for a long time.
Description
Technical field
The utility model relates to a kind of detection exposure system, relates in particular to a kind of detection of biological samples exposure system based on Terahertz.
Background technology
THz wave refers to that frequency arrives the electromagnetic wave of 3THz scope at 0.3THz, wavelength probably arrives 1mm scope at 0.1mm (100um), THz wave has following features: one, the typical pulse-widths of terahertz pulse is at picosecond magnitude, not only can carry out easily the research of time explanation, and by sampling and measuring technology, can effectively suppress the interference of far infrared ground unrest; Two, terahertz pulse source only comprises the electromagnetic oscillation in several cycles conventionally, the frequency band of individual pulse can cover from GHz until the scope of tens Terahertzs, the vibration of many biomacromolecules and rotational energy level drop on THz wave segment limit, be very suitable for measuring material absorption spectrum, can be used for carrying out the work of qualitative discriminating; Three, the energy of Terahertz photon is low, only has a few milli electron-volts, is therefore not easy to destroy detected material; Four, many nonmetal non-polar materials are less to the absorption of Terahertz ray, therefore, in conjunction with corresponding technology, make detecting material internal information become possibility.Above-mentioned advantage based on THz wave, Terahertz Technology is widely used at present, and is also applied at biomedical sector.
At present, Terahertz Technology mainly concentrates on the aspects such as medical imaging and biology sample detection in the application of biomedical sector, when biology sample detection, generally cultured cell is exposed in Terahertz environment, then observe the protein molecular of biological specimen, the variation of DNA etc., yet, current detection technique all can not make biological specimen (as cell) remain active, as everyone knows, if biological specimen loses activity, the various functions itself having is (such as the permeability of cell membrane, film potential changes etc.) all no longer exist, therefore will make the testing result out of true to the sample after inactivation, on the other hand, development along with Terahertz Technology, increasing people can be engaged in the work relevant to Terahertz, thereby increase people and be exposed to the chance in Terahertz environment, because current Terahertz is still not clear the security implication of human body, this just increases the security risk that has related personnel greatly.
Therefore, a kind of novel pattern detection exposure system based on Terahertz need to be proposed, can make on the one hand detected biological specimen remain all the time active, thereby realize the variation of the cell of biological specimen, tissue block, protein molecular and DNA is done to dynamic observation and analysis, improve the accuracy of testing result; On the other hand can be by the Terahertz of biological specimen being exposed to study the adverse effect of Terahertz to biosome, thus the safe dose that Efficient Evaluation Terahertz exposes, for instantaneous and the personnel of long term exposure in Terahertz environment provide experimental basis.
Utility model content
In view of this, the purpose of this utility model is to provide a kind of detection of biological samples exposure system based on Terahertz, can make on the one hand detected biological specimen remain all the time active, thereby realize the variation of the cell of biological specimen, tissue, protein molecular and DNA is done to dynamic observation and analysis, improve the accuracy of testing result; On the other hand can be by the Terahertz of biological specimen being exposed to study the adverse effect of Terahertz to biosome, thus the safe dose that Efficient Evaluation Terahertz exposes, for instantaneous and the personnel of long term exposure in Terahertz environment provide experimental basis.
A kind of detection of biological samples exposure system based on Terahertz that the utility model provides, comprises Terahertz generating means for generation of terahertz signal, for maintaining the dimension removable mounting of biological specimen activity, puts and be arranged at described dimension removable mounting and put pattern detection exposing device interior and that be connected with described Terahertz generating means;
Further, described dimension removable mounting put comprise dimension live case and be arranged at described dimension live in case for placing the sample platform of biological specimen, described dimension case alive comprises interior layer box body and outer layer box body, between described interior layer box body and outer layer box body, form interlayer cavity, in described interlayer cavity, be filled with heating medium;
Further, in described interlayer cavity, be provided with heating arrangement;
Further, described pattern detection exposing device comprises waveguide and Terahertz receiving trap, and described waveguide is connected with described Terahertz generating means, and described Terahertz receiving trap and waveguide lay respectively at the both sides up and down of described sample platform;
Further, described pattern detection exposing device also comprises radome, and described sample platform, waveguide and Terahertz receiving trap are all arranged in described radome;
Further, described pattern detection exposing device is two and is all arranged in described interior layer box body;
Further, described Terahertz generating means comprises Terahertz generator, the amplifier being connected with described Terahertz generator, the Terahertz detector being connected with described amplifier and the transmitting switch being connected with described Terahertz detector, and described transmitting switch is connected with described waveguide;
Further, described detection system also comprises central controller, and described central controller is connected with Terahertz detector with described Terahertz receiving trap;
Further, also comprise appliance for applying carbon dioxide, the internal communication of described appliance for applying carbon dioxide and described interior layer box body;
Further, described detection system also comprises the concentration sensor for detection of gas concentration lwevel that is arranged in described interior layer box body and for detection of the temperature sensor of temperature, described concentration sensor is connected with described central controller with temperature sensor.
The utility model beneficial effect: the detection of biological samples system based on Terahertz of the present utility model, can make on the one hand detected biological specimen remain all the time active, thereby realize the variation of the cell of biological specimen, tissue block, protein molecular and DNA is done to dynamic observation and analysis, improve the accuracy of testing result; On the other hand can be by the Terahertz of biological specimen being exposed to study the adverse effect of Terahertz to biosome, thus the safe dose that Efficient Evaluation Terahertz exposes, for instantaneous and the personnel of long term exposure in Terahertz environment provide experimental basis.
Accompanying drawing explanation
Below in conjunction with drawings and Examples, the utility model is further described:
Fig. 1 is structural representation of the present utility model.
Fig. 2 is the utility model principle schematic.
Embodiment
Fig. 1 is structural representation of the present utility model, Fig. 2 is the utility model principle schematic, as shown in the figure, a kind of detection of biological samples exposure system based on Terahertz that the utility model provides, comprises Terahertz generating means 10 for generation of terahertz signal, for maintaining the dimension removable mounting of biological specimen activity, puts and be arranged at described dimension removable mounting and put pattern detection exposing device interior and that be connected with described Terahertz generating means 10; Described Terahertz generating means and pattern detection exposing device can be realized by existing equipment, do not repeat them here; Detection of biological samples exposure system based on Terahertz of the present utility model, can make detected biological specimen remain all the time active, can do dynamic observation and analysis to the variation of interaction, protein molecular and the DNA of the cell as biological specimen, tissue block etc., improve the accuracy of testing result; On the other hand can be by the Terahertz of biological specimen being exposed to study the adverse effect of Terahertz to biosome, thus the safe dose that Efficient Evaluation Terahertz exposes, for instantaneous and the personnel of long term exposure in Terahertz environment provide experimental basis.
In the present embodiment, described dimension removable mounting put comprise dimension live case and be arranged at described dimension live in case for placing the sample platform 6 of biological specimen, described dimension case alive comprises interior layer box body 2 and outer layer box body 1, between described interior layer box body 2 and outer layer box body 1, form interlayer cavity 3, in described interlayer cavity 3, be filled with heating medium; In described interlayer cavity 3, be provided with heating arrangement 4; Described heating medium generally adopts water, by the heating to water, make temperature can act on equably interior layer box body, and then make temperature in casing evenly and within remaining on suitable temperature range, described interior layer box body adopts transcalent material to make, such as metal material, described outer layer box body generally adopts the material of poor thermal conductivity to make, prevent that heat is dispersed into rapidly in ambient air, prevent thermal loss and the consumption that reduces energy, described heating arrangement 4 adopts resistance wire, draws materials conveniently, with low cost; By above-mentioned structure, can make to tie up in casing alive maintaining in the suitable temperature range of biological specimen, be beneficial to and make biological specimen keep active; Described outer layer box body is provided with the freeing port 11 for injection or draining in described interlayer cavity, described sample platform 6 is generally organic glass or tempered glass is made, to prevent that metal material is to the shielding of THz wave or absorption, affect experimental result, for placing the double dish that the biological specimens such as cell or tissue piece are housed.
In the present embodiment, described pattern detection exposing device comprises waveguide 5 and Terahertz receiving trap 7, described waveguide 5 is connected by optical fiber with described Terahertz generating means, described Terahertz receiving trap 7 and waveguide 5 lay respectively at the both sides up and down of described sample platform 6, described Terahertz receiving trap is arranged at the top of described sample platform, described waveguide is arranged at the below of described sample platform and directly acts on described sample platform, described Terahertz receiving trap reflects by biological specimen for receiving, THz wave after scattering and transmission is also calculated Terahertz wave intensity, and to central processing unit Output rusults, by said structure, be beneficial to and make THz wave can fully act on biological specimen, and be beneficial to the accuracy that improves testing result.
In the present embodiment, described pattern detection exposing device also comprises radome 8, and described sample platform 6, waveguide 5 and Terahertz receiving trap 7 are all arranged in described radome; Described pattern detection exposing device is two and is all arranged in described interior layer box body 2, when carrying out biological specimen exposure experiment, by two pattern detection exposing devices, wherein only have a biological specimen to be exposed in Terahertz environment, another is sample as a comparison, and by radome, carry out the isolation of THz wave, and can guarantee that the biological specimen of sample can not be subject to the interference of THz wave as a comparison, improve objectivity, the accuracy of experiment.
In the present embodiment, described Terahertz generating means 10 comprises Terahertz generator, the amplifier being connected with described Terahertz generator, the Terahertz detector being connected with described amplifier and the transmitting switch being connected with described Terahertz detector, described transmitting switch is connected with described waveguide 5, connection in above-mentioned all adopts optical fiber to connect, to reduce the loss of THz wave, the terahertz signal intensity that described Terahertz detector is used for producing is measured to assess the safety limit of Terahertz when Terahertz mine tailings, described transmitting switch can be exported by two-way, in mine tailings process, make wherein arbitrary road output, does not export on another road, be beneficial to and test contrast, described Terahertz generator, amplifier, Terahertz detector and transmitting switch can adopt existing techniques in realizing, do not repeat them here.
In the present embodiment, described detection exposure system also comprises central controller 9, described central controller 9 is connected with Terahertz detector with described Terahertz receiving trap 7, pass through central controller, can to before acting on biological specimen and the THz wave acting on after biological specimen carry out record, analyze.
In the present embodiment, also comprise appliance for applying carbon dioxide 12, the internal communication of described appliance for applying carbon dioxide 12 and described interior layer box body 2, described appliance for applying carbon dioxide is carbon dioxide cylinder, can make to tie up the concentration that keeps biological specimen dimension necessary carbon dioxide alive in case alive, be beneficial to biological specimen and keep active; In order to strengthen controllability, can set up the solenoid valve by central controller controls with the pipeline of tieing up the case of living is middle at carbon dioxide cylinder, be beneficial to the automatic adjusting of tieing up the gas concentration lwevel in the case of living.
In the present embodiment, described detection system also comprises the concentration sensor for detection of gas concentration lwevel that is arranged in described interior layer box body 2 and for detection of the temperature sensor of temperature, described concentration sensor is connected with described central controller 9 with temperature sensor, pass through said structure, be beneficial to tieing up the control of concentration and the temperature of the carbon dioxide in case alive, be beneficial to biological specimen and keep active, thereby can realize dynamic observation.
Finally explanation is, above embodiment is only unrestricted in order to the technical solution of the utility model to be described, although the utility model is had been described in detail with reference to preferred embodiment, those of ordinary skill in the art is to be understood that, can modify or be equal to replacement the technical solution of the utility model, and not departing from aim and the scope of technical solutions of the utility model, it all should be encompassed in the middle of claim scope of the present utility model.
Claims (10)
1. the detection of biological samples exposure system based on Terahertz, is characterized in that: comprise Terahertz generating means for generation of terahertz signal, for maintaining the dimension removable mounting of biological specimen activity, put and be arranged at described dimension removable mounting and put pattern detection exposing device interior and that be connected with described Terahertz generating means.
2. the detection of biological samples exposure system based on Terahertz according to claim 1, it is characterized in that: described dimension removable mounting put comprise dimension live case and be arranged at described dimension live in case for placing the sample platform of biological specimen, described dimension case alive comprises interior layer box body and outer layer box body, between described interior layer box body and outer layer box body, form interlayer cavity, in described interlayer cavity, be filled with heating medium.
3. the detection of biological samples exposure system based on Terahertz according to claim 2, is characterized in that: in described interlayer cavity, be provided with heating arrangement.
4. the detection of biological samples exposure system based on Terahertz according to claim 3, it is characterized in that: described pattern detection exposing device comprises waveguide and Terahertz receiving trap, described waveguide is connected with described Terahertz generating means, and described Terahertz receiving trap and waveguide lay respectively at the both sides up and down of described sample platform.
5. the detection of biological samples exposure system based on Terahertz according to claim 4, is characterized in that: described pattern detection exposing device also comprises radome, and described sample platform, waveguide and Terahertz receiving trap are all arranged in described radome.
6. the detection of biological samples exposure system based on Terahertz according to claim 5, is characterized in that: described pattern detection exposing device is two and is all arranged in described interior layer box body.
7. the detection of biological samples exposure system based on Terahertz according to claim 6, it is characterized in that: described Terahertz generating means comprises Terahertz generator, the amplifier being connected with described Terahertz generator, the Terahertz detector being connected with described amplifier and the transmitting switch being connected with described Terahertz detector, and described transmitting switch is connected with described waveguide.
8. the detection of biological samples exposure system based on Terahertz according to claim 7, is characterized in that: described detection exposure system also comprises central controller, and described central controller is connected with Terahertz detector with described Terahertz receiving trap.
9. the detection of biological samples exposure system based on Terahertz according to claim 8, is characterized in that: also comprise appliance for applying carbon dioxide, the internal communication of described appliance for applying carbon dioxide and described interior layer box body.
10. the detection of biological samples exposure system based on Terahertz according to claim 9, it is characterized in that: described detection exposure system also comprises the concentration sensor for detection of gas concentration lwevel that is arranged in described interior layer box body and for detection of the temperature sensor of temperature, described concentration sensor is connected with described central controller with temperature sensor.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201320668617.1U CN203502413U (en) | 2013-10-28 | 2013-10-28 | Biological sample detection exposure system based on terahertz |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201320668617.1U CN203502413U (en) | 2013-10-28 | 2013-10-28 | Biological sample detection exposure system based on terahertz |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105486625A (en) * | 2016-01-28 | 2016-04-13 | 中国科学院重庆绿色智能技术研究院 | Cell counting device and method based on Terahertz time-domain spectroscopy technology |
| CN105962880A (en) * | 2016-04-18 | 2016-09-28 | 浙江大学 | Terahertz endoscope applicable to intestinal tract lesion detection and detection method |
| CN109593652A (en) * | 2018-12-24 | 2019-04-09 | 中国人民解放军军事科学院军事医学研究院 | The vertical exposure system of THz wave for cell experiment |
-
2013
- 2013-10-28 CN CN201320668617.1U patent/CN203502413U/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105486625A (en) * | 2016-01-28 | 2016-04-13 | 中国科学院重庆绿色智能技术研究院 | Cell counting device and method based on Terahertz time-domain spectroscopy technology |
| CN105962880A (en) * | 2016-04-18 | 2016-09-28 | 浙江大学 | Terahertz endoscope applicable to intestinal tract lesion detection and detection method |
| CN109593652A (en) * | 2018-12-24 | 2019-04-09 | 中国人民解放军军事科学院军事医学研究院 | The vertical exposure system of THz wave for cell experiment |
| CN109593652B (en) * | 2018-12-24 | 2023-09-26 | 中国人民解放军军事科学院军事医学研究院 | Terahertz wave vertical exposure system for cell experiment |
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Granted publication date: 20140326 Termination date: 20211028 |