CN202619915U - Lumbar vertebra fusion cage - Google Patents
Lumbar vertebra fusion cage Download PDFInfo
- Publication number
- CN202619915U CN202619915U CN2012200421350U CN201220042135U CN202619915U CN 202619915 U CN202619915 U CN 202619915U CN 2012200421350 U CN2012200421350 U CN 2012200421350U CN 201220042135 U CN201220042135 U CN 201220042135U CN 202619915 U CN202619915 U CN 202619915U
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- China
- Prior art keywords
- bone
- plant
- processed
- lumbar vertebra
- lumbar fusion
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- Expired - Lifetime
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
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- Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
The utility model relates to the technical field of bone grafting and discloses a lumbar vertebra fusion cage. The lumbar vertebra fusion cage is a warhead-shaped or square bone graft processed by allograft cortical bones, the bone graft is provided with an instrument clamping portion and a hollow cavity with a filling port, the instrument clamping portion is arranged at one end of the bone graft, and a group of opposite side faces of the bone graft is parallel while another group of opposite side faces forms an included angle. Requirements of clinical bone grafting are met by adopting the warhead-shaped or square bone graft processed by the allograft cortical bones, and the hollow cavity is arranged for autogenous bone filling, so that the lumbar vertebra fusion cage is easily degraded by a human body and excellent in fusion effect, and rejection is reduced greatly. Further, the lumbar vertebra fusion cage is disinfected, and accordingly risks of pestiferous viruses or microorganisms of the cortical bones and risks of immunological rejection varying in degree are decreased.
Description
Technical field
This utility model relates to the bone grafting technical field, particularly relates to a kind of lumbar fusion cages of handling through physics, chemical method.
Background technology
Be used for the fixed product of Lumbar Fusion at present and mainly contain class of metal materials, high score subclass and biomaterial class.The advantage of metal species material and high score subclass material is an intensity stabilization; Can support and keep interpyramidal pressure and height, but major defect is to retain for a long time in vivo as foreign body, produces side reactions such as foreign body stimulation; Need carry out second operation it is taken out, it is convenient inadequately to use.
Ideal threaded fusion cage should be to have intact mechanical property and biological activity.The allograph bone ring is a method commonly used clinically as lumbar vertebra intervertebral fusion embedded material, though have good biological activity, because the defective of mechanical property and contour structures causes that plant bone mass subsides, dislocates, causes correction degree to be lost.Use simultaneously from the body bone and have the complication of getting the bone district.Though and the fusion device stable mechanical property of employing metal species or macromolecular material class does not have biological activity, there is rejection in implantation as foreign body, can not be by the human body degraded and absorbed.
Carry out converged fixed though also can adopt on a small quantity from body or allosome ilium in the orthopaedics clinical operation, its advantage is that fusion efficiencies is high, and degraded and absorbed fully.Adopt allosome or xenogeneic fibula, tibia or humerus etc. as bone-grafting material, can overcome the shortcoming of bone grafting undercapacity, do not subtract but slippage goes out the danger of position.And there is the risk that has pathophorous virus or microorganism in allograph bone and xenogenesis bone, and immunologic rejection risk in various degree.Adopt at present the fusion device of bone loop-shaped in addition, this kind fusion device can not meet clinical instructions for use, and syncretizing effect is not good.
The utility model content
The technical problem that (one) will solve
The technical problem that this utility model will solve is to solve existing lumbar fusion cages not meet clinical requirement, be difficult for not good by human body degraded, syncretizing effect, cause the problem of rejection easily.
(2) technical scheme
In order to solve the problems of the technologies described above; This utility model provides a kind of lumbar fusion cages; For be processed into bullet-shaped or quadrate plant bone mass by cortical bone, said plant bone mass is provided with the apparatus retaining part and has the hollow chamber of filling mouth, and said apparatus retaining part is positioned at an end of said plant bone mass; One group of relative side of said plant bone mass parallels, and another relative side of group has angle.
Wherein, the side that joins of said plant bone mass and lumbar vertebra is provided with non-slipping block.
Wherein, said plant bone mass is processed by allogeneic cortex bone.
Wherein, said plant bone mass is processed by the cortical bone one or is spliced by at least two bone pieces that are processed into by cortical bone.
Wherein, said at least two bone pieces that are processed into by cortical bone are through the splicing of securing member riveted.
Wherein, the both sides of said apparatus retaining part are provided with groove.
Wherein, the width of said plant bone mass is: 8～14mm; Length is: 18～25; Highly be: 7～13mm; In four sides wherein one group of relative lateral angle be: 0～8 °.
(3) beneficial effect
A kind of lumbar fusion cages that technique scheme provides; Be the bullet-shaped or quadrate plant bone mass that processes by cortical bone; Meet the requirement of clinical bone grafting; And be provided with and have hollow chamber and carry out the filling from the body bone, it is good to make that this lumbar fusion cages is prone to by human body degraded, syncretizing effect, thereby greatly reduces rejection.Further, this lumbar fusion cages has reduced the risk of pathophorous virus of cortical bone or microorganism through sterilisation step, and immunologic rejection risk in various degree.
Description of drawings
Fig. 1 is the structural representation of this utility model lumbar fusion cages;
Fig. 2 is the vertical view of this utility model lumbar fusion cages.
Wherein, 1, plant bone mass; 1-1, hollow chamber; 1-2, apparatus retaining part; 1-3, non-slipping block; A, side; B, side; C, side; D, side; A, front end; B, end.
The specific embodiment
Below in conjunction with accompanying drawing and embodiment, the specific embodiment of this utility model is described in further detail.Following examples are used to explain this utility model, but are not used for limiting the scope of this utility model.
Like Fig. 1 and Fig. 2, a kind of lumbar fusion cages of this utility model is implanted to the impaired position of lumbar vertebra, for be processed into the bullet-shaped or quadrate plant bone mass 1 that meets clinical requirement by cortical bone, for the physiological bending angle according to the lumbar vertebra position requires design.For preventing that this lumbar fusion cages from pushing in the canalis spinalis, the A place is made as front end among Fig. 1, and this plant bone mass 1 has the terminal B of being made as of circular arc end face, and one group of relative side of plant bone mass 1 parallels, and is made as side a and side b; Another relative side of group has angle, is made as side c and side d.This plant bone mass 1 is provided with apparatus retaining part 1-2 and has the 1-1 of hollow chamber that fills mouthful, the 1-1 of this hollow chamber be used to fill required carry out the bone grafting experiment from the body bone, to strengthen the amalgamation with this human body, to improve bone conduction and bone-inducting active; This apparatus retaining part 1-2 is positioned at the front-end A place of plant bone mass 1, and its both sides have the groove that makes things convenient for the apparatus clamping.In order to prevent that lumbar fusion cages from the lumbar vertebra of being implanted the displacement slippage taking place in fusion process after the implantation, side c and side d that the plant bone mass 1 and the lumbar vertebra of present embodiment join are provided with non-slipping block 1-3.
This plant bone mass 1 can be processed by allogeneic cortex bone, and according to the size of cortical bone, this plant bone mass 1 can be processed perhaps by the cortical bone one and is spliced by at least two bone pieces that are processed into by cortical bone.The connecting method of bone piece adopts the connected mode of securing member, can be the connected mode of being riveted by the screw of cortical bone processing.
The width D of this plant bone mass 1 is: 8～14mm; Length L is: 18～25; Height H is: 7～13mm; The angle R of side c and side d is: 0～8 °.
This utility model provides a kind of manufacture method of lumbar fusion cages, comprising:
Step 2, with the cortical bone at key position; Transverse cuts squarely bone piece; Can become to meet the bullet-shaped or quadrate plant bone mass 1 of clinical requirement by a bone piece or by at least two bone piece splicing back Precision Machining; Make that wherein one group of relative side has certain angle, process the apparatus retaining part 1-2 and the 1-1 of hollow chamber of plant bone mass 1 simultaneously with filling mouth;
The threaded fusion cage support of step 3, preparation part deproteinization and surperficial decalcification: defat is 72 hours in 38 ℃ of 30% hydrogen peroxide, changes liquid once in per 24 hours; After the defat with water for injection embathe clean after, in 0.6M hydrochloric acid 4 ℃ of lower surface decalcifications 8 hours, after cleaning up with water for injection; In 75% ethanol, removed residual hydrogen peroxide 24 hours; With water for injection embathe clean after, under room temperature, through chloroform: methanol is part deproteinization 4 hours in the solution of 3:1; After embathing totally with water for injection, after the gamma-rays of 25kGy is handled the antigenicity of sterilization and removing residue collagen protein.The part deproteinization that obtains at last and the threaded fusion cage support of surperficial decalcification are preserved the framework of original osseous tissue, have certain biomechanics function, remove antigenicity.
The effect of above-mentioned surperficial decalcification bone is: make this lumbar fusion cages not only have bone-inducting active, also have stronger mechanical support power, and then can promote vertebral fusion.
This utility model provides a kind of manufacture method of lumbar fusion cages, comprising:
Step 2, with the cortical bone at key position; Transverse cuts squarely bone piece; Can become to meet the bullet-shaped or quadrate plant bone mass of clinical requirement by a bone piece or by at least two bone piece splicing back Precision Machining; Make that wherein one group of relative side has certain angle, process the apparatus retaining part 1-2 and the 1-1 of hollow chamber of plant bone mass 1 simultaneously with filling mouth;
The threaded fusion cage support of step 3, preparation part deproteinization and surperficial decalcification: defat is 72 hours in 38 ℃ of 30% hydrogen peroxide, changes liquid once in per 24 hours; After the defat with water for injection embathe clean after, soaked 8 hours for 4 ℃ in 0.5M acetic acid, and after cleaning up with water for injection; In 75% ethanol, removed residual hydrogen peroxide 24 hours; With water for injection embathe clean after, under room temperature, through chloroform: methanol is part deproteinization 4 hours in the solution of 3:1; And after embathing totally with water for injection, after the gamma-rays of 25kGy is handled the antigenicity of sterilization and removing residue collagen protein.The part deproteinization that obtains at last and the threaded fusion cage support of surperficial decalcification are preserved the framework of original osseous tissue, have certain biomechanics function, remove antigenicity.
The effect of above-mentioned surperficial decalcification bone is: make this lumbar fusion cages not only have bone-inducting active, also have stronger mechanical support power, and then can promote vertebral fusion.
This utility model provides a kind of manufacture method of lumbar fusion cages, comprising:
Step 2, with the cortical bone at key position; Transverse cuts squarely bone piece; Can become to meet the bullet-shaped or quadrate plant bone mass 1 of clinical requirement by a bone piece or by at least two bone piece splicing back Precision Machining; Make that wherein one group of relative side has certain angle, process the apparatus retaining part 1-2 and the 1-1 of hollow chamber of said plant bone mass 1 simultaneously with filling mouth;
The threaded fusion cage support of step 3, preparation part deproteinization and surperficial decalcification: defat is 72 hours in 38 ℃ of 30% hydrogen peroxide, changes liquid once in per 24 hours; After embathing totally with water for injection after the defat, soaked 6 hours for 4 ℃ in 0.5M formic acid, after cleaning up with water for injection; In 75% ethanol, removed residual hydrogen peroxide 24 hours; And with water for injection embathe clean after, under room temperature, through chloroform: methanol is part deproteinization 4 hours in the solution of 3:1; After embathing totally with water for injection, after the gamma-rays of 25kGy is handled the antigenicity of sterilization and removing residue collagen protein.The part deproteinization that obtains at last and the threaded fusion cage support of surperficial decalcification are preserved the framework of original osseous tissue, have certain biomechanics function, remove antigenicity.
The effect of above-mentioned surperficial decalcification bone is: make this lumbar fusion cages not only have bone-inducting active, also have stronger mechanical support power, and then can promote vertebral fusion.
The lumbar fusion cages that technique scheme provided, the effect below having obtained:
1. this lumbar fusion cages structure meets vertebral body intervertebral anatomic characteristic fully; Meet clinical requirement, have excellent biological compatibility, reduced lumbar fusion cages at the intravital rejection of people; Improved amalgamation with skeleton; After treating vertebral fusion, this lumbar fusion cages can be fully absorbed by explanation, form repair from the body bone;
2. mechanical property meets the lumbar vertebra mechanical property requirements:
| Lumbar fusion cages | Yield stress/mPa | Young's modulus/mPa | Bending strength/mPa |
| Matched group | 170.03±12.07 | 50.25±4.38 | 160.22±16.15 |
| Experimental group | 128.82±67 | 182.55±9.39 | 148.55±13.24 |
Above-mentioned matched group is undressed deep-frozen homogenic cortex bone; The threaded fusion cage of experimental group for handling through processing technique.
Normal person's vertebral body bone yield stress 5mPa, Young's modulus is 300mPa, and the material after the processed not only satisfies comprcssive strength, and Young's modulus more approaches the normal vertebral body bone, and can not causing because material is really up to the mark subsides gets in the vertebral body spongy bone.
3. Organic substance and the inorganic matter part by weight in the contained component of this lumbar fusion cages is 1:2～1:2.5, makes it have good mechanical intensity and osteogenic activity.
Wherein, inorganic matter is that calcium, P elements are formed, and fusion device is played the mechanics supporting role.Organic substance is the bone collagen and the BMP isoreactivity factor, can promote ossification, improves fusion rate.Through controlling the population proportion of the two, in order to mechanical strength and two fundamental characteristics of osteogenic activity of keeping fusion device.
The above only is the preferred implementation of this utility model; Should be understood that; For those skilled in the art; Under the prerequisite that does not break away from this utility model know-why, can also make some improvement and replacement, these improvement and replacement also should be regarded as the protection domain of this utility model.
Claims (7)
1. lumbar fusion cages; It is characterized in that; For be processed into bullet-shaped or quadrate plant bone mass by cortical bone, said plant bone mass is provided with the apparatus retaining part and has the hollow chamber of filling mouth, and said apparatus retaining part is positioned at an end of said plant bone mass; One group of relative side of said plant bone mass parallels, and another relative side of group has angle.
2. lumbar fusion cages as claimed in claim 1 is characterized in that the side that said plant bone mass and lumbar vertebra join is provided with non-slipping block.
3. lumbar fusion cages as claimed in claim 1 is characterized in that, said plant bone mass is processed by allogeneic cortex bone.
4. lumbar fusion cages as claimed in claim 3 is characterized in that, said plant bone mass is processed by the cortical bone one or is spliced by at least two bone pieces that are processed into by cortical bone.
5. lumbar fusion cages as claimed in claim 4 is characterized in that, said at least two bone pieces that are processed into by cortical bone are through the splicing of securing member riveted.
6. lumbar fusion cages as claimed in claim 1 is characterized in that the both sides of said apparatus retaining part are provided with groove.
7. lumbar fusion cages as claimed in claim 1 is characterized in that the width of said plant bone mass is: 8～14mm; Length is: 18～25; Highly be: 7～13mm; In four sides wherein one group of relative lateral angle be: 0～8 °.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012200421350U CN202619915U (en) | 2012-02-09 | 2012-02-09 | Lumbar vertebra fusion cage |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012200421350U CN202619915U (en) | 2012-02-09 | 2012-02-09 | Lumbar vertebra fusion cage |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202619915U true CN202619915U (en) | 2012-12-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012200421350U Expired - Lifetime CN202619915U (en) | 2012-02-09 | 2012-02-09 | Lumbar vertebra fusion cage |
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| Country | Link |
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| CN (1) | CN202619915U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102551926A (en) * | 2012-02-09 | 2012-07-11 | 北京大清生物技术有限公司 | Lumbar fusion cage and manufacturing method thereof |
| CN103610522A (en) * | 2013-12-12 | 2014-03-05 | 广州聚生生物科技有限公司 | Lumbar vertebra posterior approach fusion device |
-
2012
- 2012-02-09 CN CN2012200421350U patent/CN202619915U/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102551926A (en) * | 2012-02-09 | 2012-07-11 | 北京大清生物技术有限公司 | Lumbar fusion cage and manufacturing method thereof |
| CN103610522A (en) * | 2013-12-12 | 2014-03-05 | 广州聚生生物科技有限公司 | Lumbar vertebra posterior approach fusion device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address |
Address after: 100085 C, block, 3rd Street, Beijing, Haidian District, China C701 Patentee after: Beijing Daqing biotechnology Limited by Share Ltd Address before: 100085 Haidian District, 3rd floor, 3rd floor, Wah Wah building, block B, Beijing, 701, China Patentee before: Beijing Daqing Biotechnology Co., Ltd. |
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| CP03 | Change of name, title or address | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20170921 Address after: 100094, room 1, building 538, No. 351, Yongfeng Tun, Haidian District, Beijing Patentee after: Beijing Kejian Biotechnology Co., Ltd. Address before: 100085 C, block, 3rd Street, Beijing, Haidian District, China C701 Patentee before: Beijing Daqing biotechnology Limited by Share Ltd |
|
| TR01 | Transfer of patent right | ||
| CB03 | Change of inventor or designer information |
Inventor after: Li Cihui Inventor after: Wu Shu Inventor after: Li Xiangjie Inventor after: Li Zhifeng Inventor after: Zhang Zhenyong Inventor before: Xu Jianzhong Inventor before: Li Cihui Inventor before: Wu Shu Inventor before: Li Xiangjie Inventor before: Li Zhifeng Inventor before: Zhang Zhenyong |
|
| CB03 | Change of inventor or designer information | ||
| CX01 | Expiry of patent term |
Granted publication date: 20121226 |
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| CX01 | Expiry of patent term |