CN202342011U - Reflecting laser confocal skin microscope - Google Patents
Reflecting laser confocal skin microscope Download PDFInfo
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- CN202342011U CN202342011U CN2011204278499U CN201120427849U CN202342011U CN 202342011 U CN202342011 U CN 202342011U CN 2011204278499 U CN2011204278499 U CN 2011204278499U CN 201120427849 U CN201120427849 U CN 201120427849U CN 202342011 U CN202342011 U CN 202342011U
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- 239000013307 optical fiber Substances 0.000 claims abstract description 40
- 238000001514 detection method Methods 0.000 claims abstract description 30
- 230000003287 optical effect Effects 0.000 claims abstract description 30
- 230000005540 biological transmission Effects 0.000 claims abstract description 25
- 238000007334 copolymerization reaction Methods 0.000 claims description 32
- 239000000835 fiber Substances 0.000 claims description 13
- 238000004458 analytical method Methods 0.000 claims description 11
- 238000006243 chemical reaction Methods 0.000 claims description 3
- 238000012546 transfer Methods 0.000 claims description 3
- 238000010191 image analysis Methods 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 37
- 206010028980 Neoplasm Diseases 0.000 description 8
- 238000003745 diagnosis Methods 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 5
- 238000003384 imaging method Methods 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 201000011510 cancer Diseases 0.000 description 3
- 238000013459 approach Methods 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000004899 motility Effects 0.000 description 2
- 206010004146 Basal cell carcinoma Diseases 0.000 description 1
- 206010048768 Dermatosis Diseases 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 208000003373 basosquamous carcinoma Diseases 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 238000004624 confocal microscopy Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 238000012014 optical coherence tomography Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 201000009442 piebaldism Diseases 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 201000008261 skin carcinoma Diseases 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
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Abstract
The utility model relates to a reflecting laser confocal skin microscope. The microscope comprises a laser source system, an optical fiber coupler, a vibrating mirror scanning unit, a scanning lens, an image transmission optical fiber, an objective, an optical detection system and an image analysis and reconstruction system, wherein the scanning lens is connected with the objective through a linear flexible structure; and the image transmission optical fiber is arranged in the linear flexible structure. By the reflecting laser confocal skin microscope, the operation flexibility of equipment and the image resolution of a biological image are improved, so that the structure and state of the reconstructed image are similar to the actual structure and state of cell tissue.
Description
Technical field
This utility model belongs to biologic medical apparatus manufacturing technology field, the burnt skin microscope of particularly a kind of reflective copolymerization of biomedical cell detection technology.
Background technology
On the modern medicine, the clinical common malignancy of department of dermatologry comprises melanoma, basal cell carcinoma and squamous cell carcinoma.Dermatologist's clinical diagnosis cutaneous tumor mainly relies on naked eyes diagnosis and pathology to make a definite diagnosis, yet even the probability of the clinical correct diagnosis cutaneous tumor of exper ienced doctor also has only 75% ~ 80%.This is to lack some auxiliary diagnosis measures because the department of dermatologry diagnostic method of tumors is compared with other section office's clinical tumor diagnosis, like B ultrasonic, MRI and CT etc.These auxiliary diagnosis measures not only can be carried out the tentative diagnosis analysis to tumor, and can accurately locate tumor and and guide pathologic finding.Along with the develop rapidly of science and technology, it is clinical that noinvasive auxiliary detection means are applied to department of dermatologry successively, and for example skin mirror, skin are ultrasonic, magnetic resonance, optical coherence tomography, the burnt micro-skin mirror of reflective copolymerization.The burnt micro-skin mirror of particularly reflective copolymerization has only it can observe the variation of Skin Cell level, and imaging approaches histopathology most.
Reflective Laser Scanning Confocal Microscope at department of dermatologry Clinical detection applied research for over ten years, external Clinical detection application report has comprised that inflammatory skin is sick, infectious skin is sick, pigmented dermatosis, skin innocent and malignant tumour and skin carcinoma.The man large hospital of domestic number has also carried out part Study with this technology to piebaldism, psoriasis etc.The burnt micro-skin mirror of reflective copolymerization is embodying compellent advantage aspect the early diagnosis of cancer, but in clinical practice, still has many problems of needing solution badly.At present, the lucid-tech company of the U.S. has produced based on the burnt three-dimensional skin CT equipment VivaScope series of copolymerization, and has dropped into clinical use, and its general configuration is as shown in Figure 1.Show that through practice the gage beam of these series of products is owing to adopt frame for movement, and is comparatively heavy, the operation underaction, and then return and have influence on image quality.
The utility model content
The purpose of this utility model is to overcome the deficiency that above-mentioned prior art exists, and a kind of burnt skin microscope of reflective laser copolymerization of new structure type is provided.The burnt skin microscope of the reflective laser copolymerization of this utility model want can the operation of raising equipment motility, also want can improve the image resolution ratio of biological image, the image of while reconstruct more approaches real structure of cell tissue and state.
In order to reach above-mentioned utility model purpose, the technical scheme that this utility model provides is following:
The burnt skin microscope of a kind of reflective laser copolymerization; This microscopical structure includes laser source system, fiber coupler, galvanometer scanning unit, scanning lens, image transmission optical fibre, object lens, optical detection system and graphical analysis and reconfiguration system; It is characterized in that; Said scanning lens is linked to each other by a soft structure of linearity with object lens, and the soft structure of said linearity contains image transmission optical fibre.
In the burnt skin microscope of the reflective laser copolymerization of this utility model; The laser that said laser source system provides is gone forward side by side into the optical fiber bonder by the tail optical fiber outgoing; Go out to inject collimator; Behind collimation, enter to galvanometer scanning unit, be coupled in the image transmission optical fibre through scanning lens after the outgoing, on object lens outgoing to the human body skin histology that is fixed in the image transmission optical fibre tail end; Laser irradiation is passed through object lens, image transmission optical fibre, scanning lens, galvanometer scanning unit, collimator and fiber coupler successively at the reflected light that human skin tissue produces; Transfer in the optical detection system; Optical detection system is converted into the signal of telecommunication with optical signal; And the realization digital-to-analogue conversion, obtaining catoptrical digital signal, digital signal is accomplished image reconstruction through graphical analysis in the main frame and reconfiguration system again.
In the burnt skin microscope of the reflective laser copolymerization of this utility model; Described laser source system comprises power supply, laser driver, laser instrument and tail optical fiber; Described power supply is that the laser driver power supply is sent laser with drive laser, and the laser that sends is through outgoing behind the tail optical fiber.
In the burnt skin microscope of the reflective laser copolymerization of this utility model, described galvanometer scanning unit comprises quick galvanometer, galvanometer and battery of lens at a slow speed, and described battery of lens is in quick galvanometer and at a slow speed between the galvanometer.
In the burnt skin microscope of the reflective laser copolymerization of this utility model, include optical signal detection and amplifying device in the described optical detection system.
In the burnt skin microscope of the reflective laser copolymerization of this utility model, described photo-detector is avalanche photodide or photomultiplier tube.
In the burnt skin microscope of the reflective laser copolymerization of this utility model, the graphical analysis that is arranged in the main frame is reduced into two dimension or three-dimensional image with the single point signals that reconfiguration system collects optical detection system, reappears by cells of tissues structure in the detection sample.
Based on technique scheme, the burnt skin microscope of the reflective laser copolymerization of this utility model compared with prior art has following technological merit:
1. this utility model also substitutes traditional mechanical arm structure with linear soft structure, between scanning lens and object lens, forms a motion arm flexibly, and is flexible in practice, is convenient to be applicable to various types of skins and position.
2. in the burnt skin microscope of the reflective laser copolymerization of this utility model; Adopt optical fiber confocal microscopy and image reconstruction technique; Overcome the shortcoming of prior art confocal scanning micro-endoscope, had operability, high, the little many-sided technical advantage of probe physical size of image resolution ratio flexibly.
Description of drawings
Fig. 1 is the microscopical structural representation of the burnt skin of reflective laser copolymerization in the prior art.
Fig. 2 is the microscopical system construction drawing of the burnt skin of this utility model reflective laser copolymerization.
The specific embodiment
Below we combine accompanying drawing and concrete embodiment to come the burnt skin microscope of the reflective laser copolymerization of this utility model is done further description; In the hope of understanding its structure and application more cheer and brightly, but can not limit the protection domain of this utility model with this.
As shown in Figure 2, the burnt skin microscope of the reflective laser copolymerization of this utility model includes laser source system, fiber coupler, galvanometer scanning unit, scanning lens, image transmission optical fibre, object lens, optical detection system and graphical analysis and reconfiguration system in structure.Topmost characteristics of this utility model are: linked to each other by a soft structure of linearity with object lens at scanning lens, the soft structure of said linearity contains image transmission optical fibre.
Laser source system in this utility model is that whole microscope provides LASER Light Source.Fiber coupler is realized the purpose of beam split, substitutes traditional Amici prism.Galvanometer scanning unit is coupled into different fiber in image transmission optical fibre with laser beam with different angles according to the Different control signal.Image transmission optical fibre is made up of a lot of optical fiber, and each independent optical fiber is all the same with traditional optical fiber, has the characteristic that passes light, and image transmission optical fibre is used for substituting the light path of parts of traditional, makes whole microscope have better motility and portability.Object lens then are that the imaging beam emitting laser is focused on the human skin tissue.
The Optics in Microscope principle of this utility model is; The LASER Light Source that laser source system provides is through fiber coupler; Outgoing after the entering galvanometer scanning unit; Be coupled in the image transmission optical fibre through scanning lens, through behind the image transmission optical fibre, on object lens outgoing to the human body skin histology that is fixed in image transmission optical fibre one end; Laser irradiation produces reflection behind human skin tissue, reflected light is again through behind object lens, image transmission optical fibre, scanning lens, galvanometer scanning unit and the fiber coupler; Transfer in the optical detection system; Optical detection system is converted into the signal of telecommunication with optical signal, and realizes digital-to-analogue conversion, obtains catoptrical digital signal; Digital signal is accomplished image reconstruction through graphical analysis in the main frame and reconfiguration system again, and then on visual interface, shows.
Laser source system in the burnt skin microscope of the reflective laser copolymerization of this utility model comprises power supply, laser driver, laser instrument and tail optical fiber, and power supply is that the laser driver power supply is sent laser with drive laser, and the laser that sends is through the tail optical fiber outgoing.Confocal scanning unit wherein comprises quick galvanometer, galvanometer and the battery of lens between the two at a slow speed.Optical detection system comprises lens, optical signal detection and amplifying device, surveys skin and under the irradiation of laser, produces reflected light signal.This optical signal is finally converted into the signal of telecommunication by photo-detector through object lens, image transmission optical fibre, confocal scanning unit, optical signal detection and amplifying device.Graphical analysis and reconfiguration system are arranged in the main frame, and its single point signals that optical detection system is collected is reduced into two dimension or three-dimensional image, reappear the cellularity of being surveyed sample inner tissue.
Be directed to the concrete practical structures situation of this utility model, the microscopical workflow of the burnt skin of reflective laser copolymerization is following:
Be provided with laser instrument in the microscopical inside of the burnt skin of reflective laser copolymerization, this laser instrument sends laser by the laser driver driving and surveys, and laser driver then connects power supply.The laser instrument 1 that is driven by laser driver in this utility model, laser are by the tail optical fiber outgoing, and laser enters in the galvanometer scanning unit through collimating lens 3 through fiber coupler 2.
In galvanometer scanning unit, incident laser is earlier through galvanometer 4 reflections fast, then from battery of lens 5 transmissions, is incident at a slow speed on the galvanometer 6, through galvanometer 6 reflections at a slow speed, is incident to then on the coupled lens group 7 again.Incident laser beam is coupled in the simple optical fiber in the imaging beam 8 through coupled lens group 7, through imaging beam 8 transmission, again through being incident on the skin histology 10 behind the object lens 9.
Laser irradiation is behind skin histology 10; The reflected light signal that produces at first transmits from object lens 9, passes through the transmission of the optical fiber in the imaging beam 8 then, again through coupled lens group 7 and confocal scanning unit A; From fiber coupler 2 outgoing, enter into optical detection system again.
In optical detection system, incident optical signal is converted into the signal of telecommunication by photo-detector 11, and this signal of telecommunication inputs in motherboard circuit 13 and the main frame 14 after converting digital signal into through A/D converter 12 again.
In above-mentioned main frame 14, be provided with described graphical analysis and reconfiguration system, the single point signals that this system collects optical detection system B is reduced into two dimension or three-dimensional image, reappears and is surveyed the cells of tissues structure.
The burnt skin microscope of the reflective laser copolymerization of this utility model replaces cold light source through LASER Light Source, and fiber coupler substitutes Amici prism, the fibre bundle images; The optical texture of while autonomous Design; Under the precondition that improves image resolution, reduce the physical size of object lens termination, through substituting the mechanical arm structure with soft soft structure; Increase the operating flexibility of instrument, improve its range of application and image quality.Overcome the heavy underaction of operation and the not high shortcoming of image quality of prior art confocal scanning micro-endoscope in the burnt skin microscope of the reflective laser copolymerization of this utility model, had operability, high, the little many-sided technical advantage of probe physical size of image resolution ratio flexibly.
Claims (6)
1. the burnt skin microscope of a reflective laser copolymerization; This microscopical structure includes laser source system, fiber coupler, galvanometer scanning unit, scanning lens, image transmission optical fibre, object lens, optical detection system and graphical analysis and reconfiguration system; It is characterized in that; Said scanning lens is linked to each other by a soft structure of linearity with object lens, and the soft structure of said linearity contains image transmission optical fibre, and the laser that said laser source system provides is gone forward side by side into the optical fiber bonder by the tail optical fiber outgoing; Go out to inject collimator; Behind collimation, enter to galvanometer scanning unit, be coupled in the image transmission optical fibre through scanning lens after the outgoing, on object lens outgoing to the human body skin histology that is fixed in the image transmission optical fibre tail end; Laser irradiation is passed through object lens, image transmission optical fibre, scanning lens, galvanometer scanning unit, collimator and fiber coupler successively at the reflected light that human skin tissue produces; Transfer in the optical detection system; Optical detection system is converted into the signal of telecommunication with optical signal; And the realization digital-to-analogue conversion, obtaining catoptrical digital signal, digital signal is accomplished image reconstruction through graphical analysis in the main frame and reconfiguration system again.
2. the burnt skin microscope of a kind of reflective laser copolymerization according to claim 1; It is characterized in that; Described laser source system comprises power supply, laser driver, laser instrument and tail optical fiber; Described power supply is that the laser driver power supply is sent laser with drive laser, and the laser that sends is through outgoing behind the tail optical fiber.
3. the burnt skin microscope of a kind of reflective laser copolymerization according to claim 1 is characterized in that, described galvanometer scanning unit comprises quick galvanometer, galvanometer and battery of lens at a slow speed, and described battery of lens is in quick galvanometer and at a slow speed between the galvanometer.
4. the burnt skin microscope of a kind of reflective laser copolymerization according to claim 1 is characterized in that, includes optical signal detection and amplifying device in the described optical detection system.
5. the burnt skin microscope of a kind of reflective laser copolymerization according to claim 4 is characterized in that the photo-detector in described optical signal detection and the amplifying device is avalanche photodide or photomultiplier tube.
6. the burnt skin microscope of a kind of reflective laser copolymerization according to claim 1; It is characterized in that; The graphical analysis that is arranged in the main frame is reduced into two dimension or three-dimensional image with the single point signals that reconfiguration system collects optical detection system, reappears by cells of tissues structure in the detection sample.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011204278499U CN202342011U (en) | 2011-11-02 | 2011-11-02 | Reflecting laser confocal skin microscope |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011204278499U CN202342011U (en) | 2011-11-02 | 2011-11-02 | Reflecting laser confocal skin microscope |
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| CN202342011U true CN202342011U (en) | 2012-07-25 |
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| CN2011204278499U Expired - Fee Related CN202342011U (en) | 2011-11-02 | 2011-11-02 | Reflecting laser confocal skin microscope |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103393392A (en) * | 2013-06-19 | 2013-11-20 | 西安电子科技大学 | Depth and intensity adjustable type probe laser confocal micro endoscope system |
| CN105424601A (en) * | 2015-12-22 | 2016-03-23 | 佛山市南海区欧谱曼迪科技有限责任公司 | Handheld confocal skin microscopic method and handheld confocal skin microscopic device |
| CN107049242A (en) * | 2017-01-24 | 2017-08-18 | 青岛大学 | Scan-type human microvascular ultra microstructure 3-D imaging system |
| CN107257935A (en) * | 2015-02-24 | 2017-10-17 | 莱卡微系统Cms有限责任公司 | Apparatus and method for detecting light |
| CN107367487A (en) * | 2017-06-12 | 2017-11-21 | 中国科学院苏州生物医学工程技术研究所 | A kind of handheld portable disease of skin auxiliary detection device |
| CN107726053A (en) * | 2016-08-12 | 2018-02-23 | 通用电气公司 | Probe system and detection method |
| CN108209860A (en) * | 2016-12-12 | 2018-06-29 | 中国科学院苏州生物医学工程技术研究所 | A kind of reflective confocal microscopic image system |
| CN108490597A (en) * | 2018-06-05 | 2018-09-04 | 张红明 | A kind of confocal microscope system based on fiber coupler |
| CN108882920A (en) * | 2016-02-13 | 2018-11-23 | 普渡研究基金会 | Optoacoustic conduit and the imaging system for using the optoacoustic conduit |
| CN109222897A (en) * | 2018-08-01 | 2019-01-18 | 中日友好医院 | Skin Laser Scanning Confocal Microscope probe pressure measuring unit |
| CN110338768A (en) * | 2019-08-21 | 2019-10-18 | 西北工业大学 | The scanning head of the changeable lesion locking three-dimensional cutaneous imaging system of multi-mode |
| CN114815205A (en) * | 2022-04-01 | 2022-07-29 | 北京航空航天大学 | Portable confocal microscopic imaging system |
-
2011
- 2011-11-02 CN CN2011204278499U patent/CN202342011U/en not_active Expired - Fee Related
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103393392B (en) * | 2013-06-19 | 2015-08-26 | 西安电子科技大学 | The probe laser confocal micro endoscope of the degree of depth and intensity adjustable |
| CN103393392A (en) * | 2013-06-19 | 2013-11-20 | 西安电子科技大学 | Depth and intensity adjustable type probe laser confocal micro endoscope system |
| CN107257935A (en) * | 2015-02-24 | 2017-10-17 | 莱卡微系统Cms有限责任公司 | Apparatus and method for detecting light |
| US10527835B2 (en) | 2015-02-24 | 2020-01-07 | Leica Microsystems Cms Gmbh | Device and method for detecting light using a silicon photomultiplier and flat-top optical system |
| CN105424601A (en) * | 2015-12-22 | 2016-03-23 | 佛山市南海区欧谱曼迪科技有限责任公司 | Handheld confocal skin microscopic method and handheld confocal skin microscopic device |
| CN105424601B (en) * | 2015-12-22 | 2018-02-16 | 广东欧谱曼迪科技有限公司 | A kind of hand-held is copolymerized burnt skin microscopic method and device |
| CN108882920A (en) * | 2016-02-13 | 2018-11-23 | 普渡研究基金会 | Optoacoustic conduit and the imaging system for using the optoacoustic conduit |
| CN107726053B (en) * | 2016-08-12 | 2020-10-13 | 通用电气公司 | Probe system and detection method |
| CN107726053A (en) * | 2016-08-12 | 2018-02-23 | 通用电气公司 | Probe system and detection method |
| CN108209860A (en) * | 2016-12-12 | 2018-06-29 | 中国科学院苏州生物医学工程技术研究所 | A kind of reflective confocal microscopic image system |
| CN107049242A (en) * | 2017-01-24 | 2017-08-18 | 青岛大学 | Scan-type human microvascular ultra microstructure 3-D imaging system |
| CN107049242B (en) * | 2017-01-24 | 2023-08-29 | 青岛大学 | Scanning type human body microvascular ultrastructural three-dimensional imaging system |
| CN107367487A (en) * | 2017-06-12 | 2017-11-21 | 中国科学院苏州生物医学工程技术研究所 | A kind of handheld portable disease of skin auxiliary detection device |
| CN108490597A (en) * | 2018-06-05 | 2018-09-04 | 张红明 | A kind of confocal microscope system based on fiber coupler |
| CN109222897A (en) * | 2018-08-01 | 2019-01-18 | 中日友好医院 | Skin Laser Scanning Confocal Microscope probe pressure measuring unit |
| CN110338768A (en) * | 2019-08-21 | 2019-10-18 | 西北工业大学 | The scanning head of the changeable lesion locking three-dimensional cutaneous imaging system of multi-mode |
| CN114815205A (en) * | 2022-04-01 | 2022-07-29 | 北京航空航天大学 | Portable confocal microscopic imaging system |
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| C14 | Grant of patent or utility model | ||
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Denomination of utility model: Reflecting laser confocal skin microscope Effective date of registration: 20141216 Granted publication date: 20120725 Pledgee: Bank of Shanghai Limited by Share Ltd Pudong branch Pledgor: Shanghai Bohui Communication Technology Co., Ltd. Registration number: 2014310000080 |
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Address after: 201203 room 177, No. 203 blue wave road, Zhangjiang hi tech park, Shanghai Patentee after: SHANGHAI BANDWEAVER TECHNOLOGIES CO., LTD. Address before: Shanghai city 201203 Bibo Road, Zhangjiang High Tech Park of Pudong New Area No. 177 Huahong science and Technology Park B District 203 Patentee before: Shanghai Bohui Communication Technology Co., Ltd. |
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Date of cancellation: 20161213 Granted publication date: 20120725 Pledgee: Bank of Shanghai Limited by Share Ltd Pudong branch Pledgor: SHANGHAI BANDWEAVER TECHNOLOGIES CO., LTD. Registration number: 2014310000080 |
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Address after: Room 103, Building 299, Zhongchen Road, Songjiang District, Shanghai, 20113 Patentee after: Shanghai Bohui Technology Co., Ltd. Address before: Room 203, 177 Bibo Road, Zhangjiang High-tech Park, Shanghai, 201203 Patentee before: Shanghai Bandweaver Technology Co., Ltd. |
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