CN201399158Y

CN201399158Y - Transdermal drug-permeating rolling type microneedle

Info

Publication number: CN201399158Y
Application number: CN2009203003379U
Authority: CN
Inventors: 翁春晓
Original assignee: 翁春晓
Current assignee: Beijing Noah TongZhou Medical Technology Co Ltd
Priority date: 2009-01-20
Filing date: 2009-01-20
Publication date: 2010-02-10
Anticipated expiration: 2019-01-20

Abstract

The utility model provides a transdermal drug-permeating rolling type microneedle and belongs to an instrument inputting a medium to a human body. The rolling type microneedle consists of a handle 1 with a shaft bracket, as well as a rolling shaft 8 and a needle roller 3 which is installed on the shaft bracket through the rolling shaft. The needle roller consists of a column-shaped roller body 4 and aculeate needle-shaped bulges 5 which are arranged in a radiated array and on the circumference surface of the roller body. The rolling shaft penetrates through the shaft holes 6 and 7 of the needle roller and two ends of the rolling shaft are respectively fixed on the shaft bracket 2, so that the needle roller can rotate on the rolling shaft and/or between the shaft brackets. The handle is held, and the needle roller is positioned on skin and pushed by pressurization, then the point of the microneedle can penetrate into the skin. The scarfskin inside an action range forms a split pore withdensity, depth and diameter corresponding to the microneedle, thus enhancing the permeability of the skin and being capable of greatly improving the transdermal permeating efficiency of drugs. The transdermal drug-permeating rolling type microneedle has the advantages of simple operation, convenient and safe application, lower manufacture cost, and stable and reliable pore-forming effect.

Description

A kind of roll-type micropin of percutaneous transdermal

Technical field

This utility model belongs to the apparatus of medium being imported human body, is specifically related to a kind of roll-type micropin of percutaneous transdermal.

Background technology

The percutaneous transdermal is the third the main route of administration after oral and injection.Make medicine see through skin smoothly and enter performance therapeutical effect in the body, at first will overcome the obstruction of skin barrier.After deliberation, this inhibition overwhelming majority comes from the horny layer of epidermis.Up to now, the method of nearly all promotion percutaneous transdermal that is studied, comprise chemical method, physics method, biological method and practice of pharmacy, all concentrate and be devoted to reduce and eliminate cuticular inhibition, can't cause damage and pain to skin simultaneously.

Micropin is one of short saturating method of the more physics of Recent study.It is to adopt the very little micropin in pin footpath to form array, puts on skin with certain method, with the stratum corneum piercing of skin, forms the minute fissure that intensive made drug molecule passes through, and is called the pore effect.Because its degree of depth that pierces through only limits to epidermis, so avoided pain and to corium and hypodermic damage.

ISSYS is at US Pat No.6,844, in 213, Kravitz etc. are at US.Pat No.7,132, in 054, Prausnitz etc. are at US.Pat No.6,503, in 231, Prausnitz etc. are at US.Pat No.6,749, in 792, Olson etc. are at US.Pat No.6,790, in 372, Douglas Sparks etc. are in 2004 J.Micromech.Microeng.141230-1233, and Zhejiang University is in the CN200320107817.6 Chinese patent, Fu Xin etc.＜＜the mechanical engineering journal 2006 years 02 interim, 3M Innovative Properties Company is in the 03817247.X Chinese patent, and Xu's hundred grades are in 200410031945.6 and No. 200610040876.4 Chinese patents, and Li Cheng is mediate in the CN200480002378.X Chinese patent, Zhou Zhaoying is in the CN03137552.9 Chinese patent, Zhang Junyong etc.＜＜Chinese medical apparatus magazine 01 phase in 2006, Ma Bin etc.＜＜semiconductor technology 12 phases in 2005 etc., disclose and adopted various structures, various materials, various manufacture methods and the various micropin technology that applies mode.

Known all disclosed micropins that are used for transdermal administration are the planar array structure at present, and the mechanics track of acupuncture is vertically to thrust.Needle points all when using all are stress point simultaneously.Equally distributed numerous stress point is formed a stress surface, and the impedance of generation is bigger, and the kinetic energy that overcomes the impedance needs is just bigger.Need higher dynamics and speed when therefore applying.Because staff is limited to the control ability of dynamics speed, and the influence of factors such as skin elasticity and tension force, makes the performance of the pore effect of micropin be subjected to certain restriction, particularly the homogeneity of pore can't guarantee.Be the problem that solution is used, some designer has also designed the micropin application device except that array chip." microneedle devices and micropin application equipment " patent as Graham Sodd method of investing M Clarke of U.S. 3M Innovative Properties Company etc. adopts elastomeric elastic force as driving force, and micropin is launched; " the sound wave inserting needle system of microneedle array paster " patent of Xu's hundred grades of NanoMed Devices(Suzhou) Inc., adopting ultrasound wave is the driving force of micropin.The driving device that these micropins are used may solve the influence of the homogeneity and the factors such as skin elasticity and tension force of driving force degree, but also exists structure and use complexity, makes and the higher problem of use cost.Therefore, at present micropin to use the problems that the aspect exists are the main causes that cause the micropin technology generally not adopted so far.

Utility model content the purpose of this utility model provides a kind of manual roll-type micropin that has easy application device, and the density by improving effect dynamics to skin, active area, pin hole and equal once control abilities improve the pore effect.And then improve drug transdermal speed, and reduce time lag, realize the macromolecular drug transdermal.

The technical solution of the utility model is: a kind of roll-type micropin of percutaneous transdermal, its structure comprise that pin rolls, the handle of roller bearing and tape spool frame.

It is with hard materials such as metal, pottery, silicon crystal or plastics that pin rolls, with process technologies such as cutting, engraving or chemical attacks, adopt the way of whole processing or bulk-breaking processing combination, the array of the nadel of making columniform roll body and on the roll body periphery, arranging, and at axis hole of roll body axis part processing.

The density of the array nadel that pin rolls on is 50 ~ 50000/cm ², shape can be circular cone or pyramid, and height is less than 2mm.

Described roller bearing is that pin roller bearing hole is passed at the middle part, and two ends connect the club of the axis hole of pedestal.

A shaft-like handle, the one end connects the base portion of U profile shaft frame, and the two ends of pedestal are processed with concentric axis hole.

A bar-shaped roller bearing is passed pin roller bearing hole, be installed between the axis hole of pedestal, pin is rolled can rotated on the roller bearing and/or between the pedestal.

With being hold by one hand handle, pin being rolled place skin surface during use, push away or spur pin on certain pressure-based and roll applying, make it to form and roll at skin surface.

Because the enforcement of technique scheme makes this utility model have the following advantages than other prior aries:

1, using the instant stress point that hour hands roll is linear distribution, and the impedance of generation is less, and it is also less to overcome the kinetic energy that impedance needs.When therefore applying dynamics and speed are controlled easily.

The motion of micropin needle point is non-perpendicular track during 2, owing to rolling, can produce the dual function that punctures and tear to epidermis, make its pore effect stronger.

3, be to roll to exert pressure impact and the discomfort of having avoided Vertical Launch to cause owing to pin rolls skin to skin.

4, pin rolls that the rolling of skin is exerted pressure is a lasting process of gradually going, and therefore the uniformity of exerting pressure is impacted the mode of exerting pressure and controlled easily.

5, whole system is formed simply, and easy to operate, cost of manufacture is lower.

Description of drawings

Fig. 1: the front view of this practical sexual type

Fig. 2: the side view of this practical sexual type

Fig. 3: the profile of this practical sexual type

Fig. 4: the circular gear piece that has the needle-like tooth

Fig. 5: round pad

Wherein: 1, handle, 2, pedestal, 3, pin rolls, 4, roll body, 5, nadel, 6,7, axis hole, 8, roller bearing,

The specific embodiment

Below with embodiment and accompanying drawing this utility model is described further:

Embodiment one: as shown in Figure 1, a kind of micropin of percutaneous transdermal comprises that the pin that is made of integrally-built roll body 4 and nadel 5 arrays rolls 3, the handle 1 of tape spool frame 2 be connected pin and roll 3 and the roller bearing 8 of pedestal 2.

In the present embodiment, preferably making pin, to roll 3 material be the hard bar section of stainless steel.Can adopt means such as laser engraving, etching, directly the periphery at cylindrical roll body 4 processes nadel 5 arrays.The density of nadel 5 is 500/cm ², be shaped as pyramid, height 1.2mm.Pin rolls 3 the axis part axis hole 6 that to process a diameter be 1.5mm.The handle 1 of tape spool frame 2 can be processed the axis hole 7 that it is 1.45mm that the two ends of U profile shaft frame 2 respectively process a concentric diameter with the method that injection moulding or metal pattern are annotated; Roller bearing 8 usefulness diameters are 1.45 metal wire rod processing.By Fig. 1 roller bearing 8 is penetrated pin and roll 4 axis hole 6, roller bearing 8 two ends are fixed in the axis hole 7 of pedestal 2.

Embodiment two: as Fig. 4, shown in Figure 5, it is to be formed by stacking by circular gear piece and round pad that periphery has nadel 5 that the pin of micropin rolls 3.Other structure is with embodiment one.

In the present embodiment, the preferred material of making the disk of band nadel 5 is that thickness is the hard stainless sheet steel of 0.1mm.Can adopt means such as line cutting, cut, etching, directly processing diameter is 15mm, has tooth depth 1.5mm, the round gear piece of tooth pitch 1.2mm nadel 5 arrays.The circular hole that it is 1.5mm that the center of knuckle-tooth sheet processes a diameter.Making diameter with metal or plastic sheet punching press is 12mm, and thickness is the circular gasket that there is 1.5mm diameter circular hole at the center of 0.2mm.Several gear pieces and pad are alternate to stack with one heart, fixes with glue, and the pin of making cylinder shape belt nadel 5 arrays and axis hole 6 rolls 3.The making of other assemblies and the installation of each assembly are with embodiment one.

Claims

1. the roll-type micropin of a percutaneous transdermal, it is characterized in that: its structure comprises that handle, roller bearing that has pedestal and the pin that is placed on the pedestal by roller bearing roll.

2. the roll-type micropin of a kind of percutaneous transdermal according to claim 1 is characterized in that: described pin rolls by cylindrical roll body and is the sharp-pointed nadel that radial array is arranged in the roll body periphery and constitutes.

3. the roll-type micropin of a kind of percutaneous transdermal according to claim 2 is characterized in that: the density of the array nadel that described pin rolls on is 50 ~ 50000/cm2, and shape can be circular cone or pyramid, and height is less than 2mm.

4. the roll-type micropin of a kind of percutaneous transdermal according to claim 1 is characterized in that: described roller bearing is to connect the round club of respectively forming structure, and its diameter should be less than or equal to axis hole.

5. the roll-type micropin of a kind of percutaneous transdermal according to claim 1 is characterized in that: the handle of described tape spool frame is a shaft, and the one end is connected in the base portion of U profile shaft frame.

6. the roll-type micropin of a kind of percutaneous transdermal according to claim 1 is characterized in that: the described connected mode of respectively forming structure is for to pass pin roller bearing hole with roller bearing, and two ends are placed in the axis hole of pedestal, and pin is rolled can rotated on the roller bearing and/or between the pedestal.