CN201006051Y - Local porous and little polymer co-carried medicament releasing arrangement - Google Patents
Local porous and little polymer co-carried medicament releasing arrangement Download PDFInfo
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- CN201006051Y CN201006051Y CNU200620159781XU CN200620159781U CN201006051Y CN 201006051 Y CN201006051 Y CN 201006051Y CN U200620159781X U CNU200620159781X U CN U200620159781XU CN 200620159781 U CN200620159781 U CN 200620159781U CN 201006051 Y CN201006051 Y CN 201006051Y
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Abstract
The utility model relates to a drug-releasing structure of combination of partial cavity with holes and a few polyaromatics of the drug-eluting appliance, comprising a body, a plurality of cavity with holes of single size or double-size or multi-size directly produced from the original material of the body, which are n cavities with holes with a homogeneous size or two or more heterogeneous sizes comprising the statistic mean of aperture and aperture, hole-depth and hole-depth or aperture and hole-depth, and the active drugs distributed in the cavity with holes, no interlayer is arranged between the cavity with holes and the body, the cavity with holes is the structure of drug-loading slot or hole, the body comprises or does not comprises a film layer outside, at least one side of the partial surface of original material of the body contacting the sick tissue is provided with the cavity with holes containing the mixture of active drugs and a few polyaromatics, the aimed partial drug-giving makes the absorbability of drugs good, has nice releasing-control effect and reduces the risk of forming the forward thrombus.
Description
Technical field
This utility model belongs to the medicament eluting instrument field, relates to a kind of Local Porous hole of medicament eluting instrument and drug releasing structure that small amount of polymer is carried altogether of being used for.
Background technology
Medicament eluting instrument comprises intravascular stent, conduit, seal wire, cardiac pacemaker, cardiac valve, surgery embedded material, implants the medical apparatus and instruments of various needs release medicines such as sclerous tissues, wherein intravascular stent is a kind of metal net shaped apparatus that is used to support the human body pipeline, and the material that constitutes support has rustless steel, titanium alloy, cobalt alloy and Ultimum Ti etc.Intravascular stent is that cardiovascular and peripheral blood vessel block the main means that pathological changes is carried out interventional therapy, is characterized in and can enters predetermined position by tiny pipeline, can be expanded to the diameter of setting after the release, and tube chamber is played a supporting role, and tube chamber is kept clear.Intravascular stent can be divided into bare bracket, bracket for eluting medicament, polymer coating support, metal coating support, radiant stand and artificial blood vessel according to apparent condition and cover support, and the support that uses at first is bare bracket substantially.Because the relative blood vessel of support or other human body pipeline are a kind of heterologous materials, laying the back stimulates inducing reaction property of tunica intima hypertrophy, makes blood vessel generation restenosis.The incidence rate of restenosis is up to 30%～35%, and especially pathological changes is than long blood vessel and the less blood vessel of diameter.For solving the problem of restenosis, people develop radiant stand and bracket for eluting medicament subsequently, and wherein bracket for eluting medicament has been acknowledged as in interventional therapy of coronary heart disease, are the most effectual ways that can solve restenosis problem in the arteria coronaria blood vessel.
Consult shown in Figure 1, existing medicament eluting instrument, with the support is example, the polymer that adopt carry medicine and control its release as carrier more, the typical practice is: active medicine and polymer mixed are coated on the bare bracket all surfaces, apply the polymer coating 30 that one deck comprises active medicine 70 among the figure on the instrument body 10, apply one deck polymer coating 20 on the polymer coating 30 again.This drug stent that contains polymer coating can be reduced to the restenosis incidence rate below 10% in clinical practice.This utilize fully polymer as the support of medicament-carried carrier behind implant into body because the continuous minimizing of medicine and polymer concentration constantly increases accordingly, the use of number of polymers may cause the formation of thrombosis.
The existing active medicine that all is coated with around the medicament eluting instrument, this is for some medical apparatus and instruments, as is used for treating the support of stenotic lesion in the blood vessel, has just introduced new problem; Drug releasing stent with medicine around this is not coated with the medicine that suppresses endothelial growth owing to directly do not contact the position of pathological changes yet, therefore the relative bare bracket in this position can postpone the time of endothelialization, yet rack surface endothelialization faster is a key link that occurs thrombus complication after avoiding support to implant, therefore the generation of comparing the restenosis thrombosis will be fatal, from this angle, the way of bare bracket helps endothelialization, if therefore only contain the anti-restenosis medicaments of small amount of polymer in the rack surface coating that contacts with blood vessel wall, polymer and multiple hole are medicament-carried jointly, need the one side of endothelialization to become the state of bare bracket, this is for the thrombosis at a specified future date that solves present drug stent, it all is useful that the relative bare bracket of endothelialization is crossed slow and effective controlled release drug.
Summary of the invention
The purpose of this utility model is to provide a kind of Local Porous hole of medicament eluting instrument and drug releasing structure that small amount of polymer is carried altogether of being used for, solve the thrombotic problem that the existing medicament eluting instrument that adopts polymer support to carry medicine fully causes behind the implant into body tissue, while is topical targetedly, can be more effective controlled release drug, use saferly, therapeutic effect is better.
The technical solution adopted in the utility model: the drug releasing structure that a kind of Local Porous hole and small amount of polymer are carried altogether, comprise instrument body, directly prepare the multiple hole that single size or two size or many sizes are arranged in the instrument body raw material, be that a kind of uniform-dimension distributes or comprise the aperture or/and two kinds and n multiple hole of above inhomogeneous distribution of sizes of the assembly average of hole depth, and be present in active medicine in the multiple hole, no any intermediate interlayer between multiple hole and the instrument body, multiple hole is medicine carrying groove or pore structure, instrument body comprises or does not comprise an outermost rete, the position preparation that one side at least in the described instrument body raw material local surfaces contacts with pathological tissues has multiple hole, has the mixture of active medicine and small amount of polymer in the multiple hole.
The mixture of described active medicine and small amount of polymer is made up of≤50% the polymer and the active medicine of all the other content.
Described multiple hole is arranged on the partial outer surface of instrument body and/or a side or two sides.
The multiple hole of described single size is any of uniform-dimension multiple hole, big size porous hole, small size multiple hole, dark multiple hole, shallow multiple hole, the mixture part of active medicine and small amount of polymer is carried in the multiple hole of single size, and another part sticks to the instrument body surface.
The multiple hole of described pair of size comprises the big size porous hole and the small size multiple hole in two kinds of different apertures, the mixture part of active medicine and small amount of polymer is carried in each big size porous hole and the small size multiple hole, and another part sticks to the instrument body surface.
The multiple hole of described pair of size comprises the dark multiple hole and the shallow multiple hole of two kinds of different hole depths, and the mixture part of active medicine and small amount of polymer is carried in each dark multiple hole and the shallow multiple hole, and another part sticks to the instrument body surface.
The multiple hole of described many sizes comprises big size porous hole, small size multiple hole, dark multiple hole, the shallow multiple hole of three kinds and above different aperture and hole depth, the mixture part of active medicine and small amount of polymer is carried in each big size porous hole and/or small size multiple hole and/or dark multiple hole and/or the shallow multiple hole, and another part sticks to the instrument body surface.
The multiple hole that described uniform-dimension multiple hole, big size porous hole, small size multiple hole, dark multiple hole, shallow multiple hole be open type stephanoporate hole, semi open model multiple hole, closed multiple hole, interconnect, embed mutually, the aperture d of multiple hole and the statistical average size value of hole depth h are 1nm～500 μ m, and multiple hole is nanometer porous hole and micrometer level porous hole.
Described active medicine comprises following one or more materials: the composite combined of rem, carrier therapeutic genes, bioactive substance or said medicine.
Described rem comprises following one or more materials: heparin, aspirin, hirudin, colchicine, antiplatelet GPIIb/IIIa receptor is tied anti-agent, white methotrexate, the purine class, miazines, broken mycin (Epothilone) class of plant bases and dust slope, the Radix Tripterygii Wilfordii series compound, antibiotic, hormone, the antibody curing cancer drug, ciclosporin, tacrolimus and homologue (FK506), take off spergualin (15-deoxyspergualin), mycophenolic acid fat (MMF), rapamycin (Rapamycin) and derivant thereof, FR 900520, FR 900523, NK 86-1086, Dary pearl monoclonal antibody (daclizumab), pentanamide (depsidomycin), Kanglemycin C (kanglemycin C), Si Boge Eyring (spergualin), prodigiosin 25c (prodigiosin25-c), tranilast (tranilast), myriocin (myriocin), FR 651814, SDZ214-104, ciclosporin C, bredinin (bredinin), Mycophenolic Acid, the luxuriant and rich with fragrance rhzomorph A that gets of mine-laying, WS9482, glucocorticoid, tirofiban (tirofiban), abciximab, Eptifibatide (eptifibatide), paclitaxel, actinomycin D.
Described carrier therapeutic genes comprises following one or more materials: cell, virus, DNA, RNA, viral portable object, non-viral portable object.
Described bioactive substance comprises following one or more materials: cell, yeast, antibacterial, protein, peptide and hormone.
Polymer in the mixture of described active medicine and small amount of polymer is a Biodegradable high-molecular, as: polylactic acid (PLA), polycaprolactone (PLC), hydroxybutyric acid and-β hydroxyl pentanoate copolymer (PHBV), polyolefin elastomer (POE), polybutylene terephthalate (PBTB), or nondegradable polymer, as: polybutyl methacrylate (PBMA), polyvinyl vinyl acetate (PEVA), poly-ethyl-methyl ethyl acrylate (PEMA), polyurethanes (PU), silica gel (SIL), polyvinylpyrrolidone (PVP), polycarbonate (PC), or above-mentioned two or more mixture of polymers.
Described instrument body is support, conduit, seal wire, cardiac pacemaker, cardiac valve, surgery embedded material, implants sclerous tissues, and base material is the nonmetal medical apparatus and instruments of pottery, organic polymer, inorganic matter, metal-oxide; Described support is balloon-expandable support, self-expansion type support, intravascular stent, non-vessel stent, base material is the support of rustless steel, Ultimum Ti, cobalt-base alloys, pure titanium, titanium alloy, and the support of silk material braiding, tubing cut, die casting, welding.
The positive beneficial effect that this utility model had:
1. in the raw-material part of instrument body, promptly directly with surface that human lesion tissue contact on direct the preparation multiple hole is arranged, need not additionally to prepare drug-carried coat, no sharp interface can effective more controlled release drug;
2. in the multiple hole of instrument body, have active medicine and a small amount of (≤50%) mixture of polymers, making medicament-carried carrier no longer is simple multiple hole or polymer, but rely on multiple hole and small amount of polymer to be total to carrier medicine is carried out controlled release as active medicine, make drug adsorption strong, controlled-release effect is good, because polymer content is few, has reduced thrombotic risk at a specified future date;
3. in the part of instrument body near blood, the inner surface that does not promptly contact pathological changes does not have multiple hole and medicine, adopts topical targetedly, helps the endothelialization of vascular tissue, the time that can not postpone support inner surface endothelialization, thrombotic risk drops to minimum at once;
4. a large amount of multiple holes in the local preparation of instrument body raw material communicate with the apparatus outer surface, have constituted the miniature vessel of medicament-carried identical or different pore volume, and the active medicine in the multiple hole discharges under the combined effect of polymer and multiple hole slowly; And the medicament mixed that sticks to the top layer both can strengthen the adhesive strength of medicine in a spot of polymer, can discharge with fast speeds by a spot of polymer again;
5. the optimum organization of many sizes multiple hole and more effectively control what and the speed that discharges thereof of medicine bearing capacity in the local distribution on instrument body surface, thus reach ideal therapeutic effect.
Description of drawings
The cross section view of the drug releasing structure sketch map that Fig. 1 is all carried by polymer for existing medicine;
Fig. 2 is the cross section view of this utility model structural representation;
Fig. 3 is the cross section view of this utility model embodiment 1 structural representation;
Fig. 4 is the cross section view of this utility model embodiment 2 structural representations;
Fig. 5 is the cross section view of this utility model embodiment 3 structural representations;
Fig. 6 is the cross section view of this utility model embodiment 4 structural representations;
Fig. 7 is the drug releasing structure statistical distribution curve chart of single size multiple hole of preparing in the instrument body raw material of the present utility model;
Fig. 8 is the drug releasing structure statistical distribution curve chart of many sizes multiple hole of preparing in the instrument body raw material of the present utility model.
The specific embodiment
Consult shown in Figure 2, a kind of Local Porous hole of medicament eluting instrument and drug releasing structure that small amount of polymer is carried altogether of being used for mainly comprises in instrument body 10, rete 40, the instrument body 10 raw-material local surfaces multiple hole 50 of directly preparation and is present in the formations such as mixture 60 of active medicine 70 and small amount of polymer in the multiple hole 50; Described instrument body 10 can have a good medical material manufacturing of better biocompatibility by any, can be metal or alloy materials such as rustless steel, cobalt-base alloys, titanium alloy; Described multiple hole 50 is meant the surface of solids because a variety of causes is always uneven, and pit depth becomes multiple hole (pore) greater than pit diameter person's definition, and multiple hole 50 is a large amount of; Described Local Porous hole 50 is arranged on outer surface 101 and/or a side 102 or the two sides 102 that instrument body 10 contacts with pathological tissues, does not need coating, and the inner surface 103 that contacts with blood does not then prepare the medicine carrying micropore, does not apply medicine yet; Chemistry or physical method can be passed through in described Local Porous hole, the instrument body 10 raw-material local surfaces that are combined in as method such as burn into anodic oxidation, differential arc oxidation, differential of the arc nitrogenize or these methods directly prepare and form multiple hole 50, and no any intermediate interlayer between the instrument body 10, multiple hole 50 can be medicine carrying groove or pore structure, has the mixture 60 of active medicine 70 and small amount of polymer in the multiple hole 50; The mixture 60 of described active medicine and small amount of polymer is made up of≤50% the polymer and the active medicine 70 of all the other content, is present in multiple hole 50 neutralizations and sticks to instrument body 10 surfaces; Described instrument body 10 can comprise or not comprise an outermost rete 40.
The position is set can determines of described Local Porous hole 50 according to the concrete position of different apparatuses and treatment, and be not limited to outer surface and/or a side or two sides of instrument body 10.
On the basis of said structure, provide following preferred embodiment:
Embodiment 1
Consult shown in Figure 3, present embodiment is 70% in the direct preparation of instrument body 10 raw-material local surfaces the multiple hole 50 of single size and active medicine 70 being arranged, polymer is 30% mixture 60 drug releasing structure as carrier, the multiple hole 50 of single size is a kind of uniform-dimension multiple hole 501 that uniform-dimension distributes that is, mixture 60 parts of active medicine and small amount of polymer are carried in each uniform-dimension multiple hole 501, and another part sticks to instrument body 10 surfaces.
Embodiment 2
Consult shown in Figure 4, present embodiment has big size porous hole for directly preparing in instrument body 10 raw-material local surfaces, the multiple hole 50 of two sizes of two kinds of inhomogeneous distribution of sizes of small size multiple hole and active medicine 70 are 80%, polymer is 20% mixture 60 drug releasing structure as carrier, the multiple hole 50 of two sizes is the multiple hole 50 of n two distribution of sizes of two kinds of different different average-sizes of the assembly average in aperture, the multiple hole 50 of two sizes comprises the big size porous hole 502 and the small size multiple hole 503 in two kinds of different apertures, mixture 60 parts of active medicine and small amount of polymer are carried in each big size porous hole 502 and the small size multiple hole 503, and another part sticks to instrument body 10 surfaces.All the other structures are with embodiment 1.
Embodiment 3
Consult shown in Figure 5, present embodiment has dark multiple hole for directly preparing in instrument body 10 raw-material local surfaces, the multiple hole 50 and the active medicine 70 of two sizes of two kinds of inhomogeneous distribution of sizes of shallow multiple hole are 90%, polymer is 10% mixture 60 drug releasing structure as carrier, the multiple hole 50 of two sizes is the multiple hole 50 of n two distribution of sizes of two kinds of different different average-sizes of the assembly average of hole depth, the multiple hole 50 of two sizes comprises the dark multiple hole 504 and the shallow multiple hole 505 of two kinds of different hole depths, mixture 60 parts of active medicine and small amount of polymer are carried in each dark multiple hole 504 and the shallow multiple hole 505, and another part sticks to instrument body 10 surfaces.All the other structures are with embodiment 1.
Embodiment 4
Consult shown in Figure 6, present embodiment in instrument body 10 raw materials directly preparation the multiple hole 50 of the many sizes that comprise three kinds and above inhomogeneous distribution of sizes is arranged is 98% with active medicine 70, polymer is 2% mixture 60 drug releasing structure as carrier, the multiple hole 50 of many sizes is the multiple hole 50 of n many distribution of sizes of assembly average of aperture and hole depth all different three kinds and above different average-sizes thereof, the multiple hole 50 of many sizes comprises the big size porous hole 502 of three kinds and above different aperture and hole depth, small size multiple hole 503, dark multiple hole 504, shallow multiple hole 505, mixture 60 parts of active medicine and small amount of polymer are carried in each big size porous hole 502 and/or small size multiple hole 503 and/or dark multiple hole 504 and/or the shallow multiple hole 505, and another part sticks to instrument body 10 surfaces.All the other structures are with embodiment 1.
The multiple hole 50 of described single size can be any of uniform-dimension multiple hole 501, big size porous hole 502, small size multiple hole 503, dark multiple hole 504, shallow multiple hole 505.
The various ways such as multiple hole that described uniform-dimension multiple hole 501, big size porous hole 502, small size multiple hole 503, dark multiple hole 504, shallow multiple hole 505 can be open type stephanoporate hole, semi open model multiple hole, closed multiple hole, interconnect, embed mutually, the different needs of Cheng Zai drug dose or medical apparatus and instruments and selecting for use as required.
Described rem comprises following one or more materials: heparin, aspirin, hirudin, colchicine, antiplatelet GPIIb/IIIa receptor is tied anti-agent, white methotrexate, the purine class, miazines, broken mycin (Epothilone) class of plant bases and dust slope, the Radix Tripterygii Wilfordii series compound, antibiotic, hormone, the antibody curing cancer drug, ciclosporin, tacrolimus and homologue (FK506), take off spergualin (15-deoxyspergualin), mycophenolic acid fat (MMF), rapamycin (Rapamycin) and derivant thereof, FR 900520, FR 900523, NK 86-1086, Dary pearl monoclonal antibody (daclizumab), pentanamide (depsidomycin), Kanglemycin C (kanglemycin C), Si Boge Eyring (spergualin), prodigiosin 25c (prodigiosin25-c), tranilast (tranilast), myriocin (myriocin), FR 651814, SDZ214-104, ciclosporin C, bredinin (bredinin), Mycophenolic Acid, the luxuriant and rich with fragrance rhzomorph A that gets of mine-laying, WS9482, glucocorticoid, tirofiban (tirofiban), abciximab, Eptifibatide (eptifibatide), paclitaxel, actinomycin D, arsenicum (As
2O
3), 17 beta estradiols etc.But be not limited thereto.
Described carrier therapeutic genes comprises following one or more materials: cell, virus, DNA, RNA, viral portable object, non-viral portable object etc., but be not limited thereto.
Described bioactive substance comprises following one or more materials: cell, yeast, antibacterial, protein, peptide and hormone etc., but be not limited thereto.
Polymer in the mixture 60 of described active medicine and small amount of polymer can be a Biodegradable high-molecular, as: polylactic acid (PLA), polycaprolactone (PLC), hydroxybutyric acid and-β hydroxyl pentanoate copolymer (PHBV), polyolefin elastomer (POE), polybutylene terephthalate (PBTB), or nondegradable polymer, as: polybutyl methacrylate (PBMA), polyvinyl vinyl acetate (PEVA), poly-ethyl-methyl ethyl acrylate (PEMA), polyurethanes (PU), silica gel (SIL), polyvinylpyrrolidone (PVP), polycarbonate (PC), or above-mentioned two or more mixture of polymers.
Consult Fig. 7, shown in Figure 8, described aperture d is meant the effective diameter of multiple hole, promptly by certain how much rules, the multiple hole of different shape is converted to the circular hole of equivalent diameter after, the diameter of its circular hole; Described hole depth h is meant the distance of the bottom of multiple hole apart from the coating reference surface; Described distribution of sizes is meant can describe the multiple hole size, comprises the statistical models of the aperture d and the hole depth h regularity of distribution, because the size of multiple hole can not equate fully, all is statistical distribution according to certain rules; Described average-size is meant the assembly average of the aperture d and the hole depth h of multiple hole.
The multiple hole of Fig. 7 is single size multiple hole, and these multiple holes have only an average-size, the set of the multiple hole that the size aperture d of multiple hole and the enough single regularities of distribution of hole depth h energy are described.
The multiple hole of Fig. 8 is two size multiple holes or many sizes multiple hole, and these multiple holes generally have two or n average-size, is two size multiple holes during quantity n=2, and n＞2 are many sizes multiple hole.Described pair of size multiple hole, a kind of can be nanometer porous hole, another kind can be micrometer level porous hole.Described many sizes multiple hole optimum structure is micron order macropore and nanoscale aperture and the form of depositing.Described many sizes multiple hole is meant the set of the multiple hole that the aperture d of multiple hole or hole depth h size must be described with n 〉=2 kind of the regularity of distribution, and it has two or more average-size statistically, i.e. the assembly average of aperture d or hole depth h; The multiple hole size is that the average-size value of aperture d and hole depth h can be selected between 1nm～500 μ m; The shape of multiple hole can be arbitrarily.
This utility model is intended to protect the direct preparation of one side at least by in the instrument body 10 raw material local surfaces that multiple hole 50 is arranged; the mixture 60 of multiple hole 50 and small amount of polymer is as the drug releasing structure of active drug carrier; the mixture 60 of wherein a part of active medicine and small amount of polymer is present in the multiple hole of the single size or two sizes or the many sizes that directly prepare in instrument body 10 raw materials; another part active medicine only is carried in the small amount of polymer, adheres to instrument body 10 surfaces by polymer.For deciding as the case may be at which local preparation drug storage multiple hole 50, for the aperture of other form, hole depth and more than four kinds the drug releasing structure of the multiple hole of different size differ and one enumerate, be not subjected to the restriction of this utility model embodiment; Be not subjected to the restriction of this utility model embodiment for the medicine 70 in the mixture 60 that is different from the foregoing description and small amount of polymer percentage composition yet.
Claims (14)
1. the drug releasing structure that carries altogether of Local Porous hole and small amount of polymer, comprise instrument body, directly prepare the multiple hole that single size or two size or many sizes are arranged in the instrument body raw material, be that a kind of uniform-dimension distributes or comprise the aperture or/and two kinds and n multiple hole of above inhomogeneous distribution of sizes of the assembly average of hole depth, and be present in active medicine in the multiple hole, no any intermediate interlayer between multiple hole and the instrument body, multiple hole is medicine carrying groove or pore structure, instrument body comprises or does not comprise an outermost rete, it is characterized in that the position preparation that the one side at least in described instrument body (10) the raw material local surfaces contacts with pathological tissues has multiple hole (50), has the mixture (60) of active medicine and small amount of polymer in the multiple hole (50).
2. the drug releasing structure that Local Porous according to claim 1 hole and small amount of polymer are carried altogether, the mixture (60) that it is characterized in that described active medicine and small amount of polymer is made up of≤50% the polymer and the active medicine (70) of all the other content.
3. the drug releasing structure that Local Porous according to claim 1 hole and small amount of polymer are carried altogether is characterized in that described multiple hole (50) is arranged on the partial outer surface of instrument body (10) (101) and/or a side or two sides (102).
4. the drug releasing structure that Local Porous according to claim 1 hole and small amount of polymer are carried altogether, the multiple hole (50) that it is characterized in that described single size is any of uniform-dimension multiple hole (501), big size porous hole (502), small size multiple hole (503), dark multiple hole (504), shallow multiple hole (505), the mixture of active medicine and small amount of polymer (a 60) part is carried in the multiple hole (50) of single size, and another part sticks to instrument body (10) surface.
5. the drug releasing structure that Local Porous according to claim 1 hole and small amount of polymer are carried altogether, the multiple hole (50) that it is characterized in that described pair of size comprises the big size porous hole (502) and the small size multiple hole (503) in two kinds of different apertures, the mixture of active medicine and small amount of polymer (a 60) part is carried in each big size porous hole (502) and the small size multiple hole (503), and another part sticks to instrument body (10) surface.
6. the drug releasing structure that Local Porous according to claim 1 hole and small amount of polymer are carried altogether, the multiple hole (50) that it is characterized in that described pair of size comprises the dark multiple hole (504) and the shallow multiple hole (505) of two kinds of different hole depths, the mixture of active medicine and small amount of polymer (a 60) part is carried in each dark multiple hole (504) and the shallow multiple hole (505), and another part sticks to instrument body (10) surface.
7. the drug releasing structure that Local Porous according to claim 1 hole and small amount of polymer are carried altogether, the multiple hole (50) that it is characterized in that described many sizes comprises the big size porous hole (502) of three kinds and above different aperture and hole depth, small size multiple hole (503), dark multiple hole (504), shallow multiple hole (505), the mixture of active medicine and small amount of polymer (a 60) part is carried in each big size porous hole (502) and/or small size multiple hole (503) and/or dark multiple hole (504) and/or the shallow multiple hole (505), and another part sticks to instrument body (10) surface.
8. the drug releasing structure that carries altogether according to claim 4,5,6 or 7 described Local Porous holes and small amount of polymer, it is characterized in that described uniform-dimension multiple hole (501), big size porous hole (502), small size multiple hole (503), dark multiple hole (504), shallow multiple hole (505) for open type stephanoporate hole, semi open model multiple hole, closed multiple hole, the multiple hole that interconnects, embed mutually, the aperture d of multiple hole and the statistical average size value of hole depth h are 1nm～500 μ m, and multiple hole is nanometer porous hole and micrometer level porous hole.
9. the drug releasing structure that Local Porous according to claim 2 hole and small amount of polymer are carried altogether is characterized in that described active medicine (70) comprises following one or more materials: the composite combined of rem, carrier therapeutic genes, bioactive substance or said medicine.
10. the drug releasing structure that Local Porous according to claim 9 hole and small amount of polymer are carried altogether, it is characterized in that described rem comprises following one or more materials: heparin, aspirin, hirudin, colchicine, antiplatelet GPIIb/IIIa receptor is tied anti-agent, white methotrexate, the purine class, miazines, broken mycin (Epothilone) class of plant bases and dust slope, the Radix Tripterygii Wilfordii series compound, antibiotic, hormone, the antibody curing cancer drug, ciclosporin, tacrolimus and homologue (FK506), take off spergualin (15-deoxyspergualin), mycophenolic acid fat (MMF), rapamycin (Rapamycin) and derivant thereof, FR 900520, FR 900523, NK 86-1086, Dary pearl monoclonal antibody (daclizumab), pentanamide (depsidomycin), Kanglemycin C (kanglemycin C), Si Boge Eyring (spergualin), prodigiosin 25c (prodigiosin25-c), tranilast (tranilast), myriocin (myriocin), FR 651814, SDZ214-104, ciclosporin C, bredinin (bredinin), Mycophenolic Acid, the luxuriant and rich with fragrance rhzomorph A that gets of mine-laying, WS9482, glucocorticoid, tirofiban (tirofiban), abciximab, Eptifibatide (eptifibatide), paclitaxel, actinomycin D.
11. the drug releasing structure that Local Porous according to claim 9 hole and small amount of polymer are carried altogether is characterized in that described carrier therapeutic genes comprises following one or more materials: cell, virus, DNA, RNA, viral portable object, non-viral portable object.
12. the drug releasing structure that Local Porous according to claim 9 hole and small amount of polymer are carried altogether is characterized in that described bioactive substance comprises following one or more materials: cell, yeast, antibacterial, protein, peptide and hormone.
13. the drug releasing structure that Local Porous according to claim 1 hole and small amount of polymer are carried altogether, it is characterized in that the polymer in the mixture (60) of described active medicine and small amount of polymer is a Biodegradable high-molecular, as: polylactic acid (PLA), polycaprolactone (PLC), hydroxybutyric acid and-β hydroxyl pentanoate copolymer (PHBV), polyolefin elastomer (POE), polybutylene terephthalate (PBTB), or nondegradable polymer, as: polybutyl methacrylate (PBMA), polyvinyl vinyl acetate (PEVA), poly-ethyl-methyl ethyl acrylate (PEMA), polyurethanes (PU), silica gel (SIL), polyvinylpyrrolidone (PVP), polycarbonate (PC), or above-mentioned two or more mixture of polymers.
14. the drug releasing structure that Local Porous according to claim 1 hole and small amount of polymer are carried altogether, it is characterized in that described instrument body (10) is support, conduit, seal wire, cardiac pacemaker, cardiac valve, surgery embedded material, implantation sclerous tissues, and base material is the nonmetal medical apparatus and instruments of pottery, organic polymer, inorganic matter, metal-oxide; Described support is balloon-expandable support, self-expansion type support, intravascular stent, non-vessel stent, base material is the support of rustless steel, Ultimum Ti, cobalt-base alloys, pure titanium, titanium alloy, and the support of silk material braiding, tubing cut, die casting, welding.
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| CNU200620159781XU CN201006051Y (en) | 2006-11-29 | 2006-11-29 | Local porous and little polymer co-carried medicament releasing arrangement |
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| CNU200620159781XU CN201006051Y (en) | 2006-11-29 | 2006-11-29 | Local porous and little polymer co-carried medicament releasing arrangement |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106620897A (en) * | 2016-12-22 | 2017-05-10 | 石佳明 | Anti-restenosis intraluminal stent material |
-
2006
- 2006-11-29 CN CNU200620159781XU patent/CN201006051Y/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106620897A (en) * | 2016-12-22 | 2017-05-10 | 石佳明 | Anti-restenosis intraluminal stent material |
| CN106620897B (en) * | 2016-12-22 | 2019-10-18 | 湖南省人民医院 | A kind of endoluminal stent material of anti-restenosis |
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